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A General Description for Chinese Medicine in Treating Premature Ovarian Failure

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Chinese Journal of Integrative Medicine 2017年第2期23卷 91-97页

作者： liN Jing li xue-lian SONG Hui li Qian WANG Ming-yan QIU xue-min li Da-jin WANG ling Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and GynecologyInstitutes of Biomedical SciencesIBSFudan University Shanghai MedicaJ CollegeShanghai200032China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai200011China The Academy of Integrative Medicine of Fudan University Shanghai200032China

Premature ovarian failure（POF） is a kind of gynecological disease that causes amenorrhea, infertility, menopause and urogenital symptoms. Currently hormone replacement therapy（HRT） is the most popular choice for women with POF to get rid of menopausal syndrome. However, as the popularization of Chinese herbs made Chinese medicine（CM） shine new lights, physicians are able to treat POF with both meno-herbs and integrated therapy. HRT has its own indications and contraindications. For example, unexplained vaginal bleeding, acute liver damage, liver dysfunction, vascular embolization, and breast cancer are all contraindications of HRT, and CM is taken by more physicians as an adjuvant therapy. This review, including a range of common Chinese herbs and formulations according to the existing literature, provides a general description of CM treating POF from the aspects of mechanisms and clinical application. It also highlights acupuncture as a unique physiotherapy for POF. Although the validity of CM has been supported by the evidence of many preclinical trials, clinical trials and meta-analysis, the adverse events with CM therapy still exist and no guarantee has been made for its safety. This review concludes the updated information for CM treating POF contributing to further studies.e

关键词： Chinese medicine Chinese herbal medicine premature ovarian failure infertility acupuncture

Ammonium-dependent regulation of ammonium transporter ZmAMT1s expression conferred by glutamine levels in roots of maize

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Journal of Integrative Agriculture 2022年第8期21卷 2413-2421页

作者： HUI Jing liU Zhi DUAN Feng-ying ZHAO Yang li xue-lian AN Xia WU Xiang-yu YUAN li-xing College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193P.R.China

In maize,two root epidermis-expressed ammonium transporters ZmAMT1;1a and ZmAMT1;3 play major roles in highaffinity ammonium ***,the transcriptional regulation of ZmAMT1s in roots for ensuring optimal ammonium acquisition remains largely ***,using a split root system we showed that ZmAMT1;1a and ZmAMT1;3transcript levels were induced by localized ammonium supply to nitrogen-deficient *** enhanced expression of Zm AMT1s correlated with increases in ^(15)NH_(4)^(+)influx rates and tissue glutamine concentrations in *** ammonium was supplied together with methionine sulfoximine,an inhibitor of glutamine synthase,ammonium-induced expression of ZmAMT1s disappeared,suggesting that glutamine rather than ammonium itself regulated ZmAMT1s *** glutamine was supplied to nitrogen-deficient roots,expression levels of ZmAMT1s were enhanced,and negative feedback regulation could subsequently occur by supply of glutamine at a high ***,our results indicated an ammonium-dependent regulation of ZmAMT1s at transcript levels,and a dual role of glutamine was suggested in the regulation of ammonium uptake in maize roots.

关键词： ammonium transporter pH glutamine maize roots nitrogen transcriptional regulation

Research on catastrophe control in 1-D system

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Journal of Marine Science and Application 2003年第2期2卷 82-86页

作者： Yao Sun li-ping Tang and xue-lian li School of Automation Harbin Engineering University Harbin China

A new method of catastrophe control is described in one dimension nonlinear system. Catastrophe control based on catastrophe theory is a brand new area for control theory. A certain catastrophe is created at a desired location by appropriate control, which has preferred properties. Washout filter is presented and applied to preserve the original equilibrium of a system. Washout filter aided dynamic feedback controller is developed for the creation of catastrophe, and an example is given to illustrate the process. Catastrophe control may provide a new way of designing warning signals of impending collapse or catastrophe for monitoring and control purposes.

关键词： catastrophe control Washout filter nonlinear system

Diagnostic Value of Cerebrospinal Fluid *** for Tuberculousis Meningitis in China

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Biomedical and Environmental Sciences 2017年第9期30卷 681-684页

作者： li xue lian XIE Na WANG Song Wang WU Qian Hong MA Yan SHU Wei CHEN Hong Mei ZHANG li Qun WU Xiao Guang MA li Ping CHE Nan Ying GAO Meng Qiu Beijing Chest Hospital Capital Medical UniversityBeijing 101149China Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149China Administration Office Clinical Center on Tuberculosis ControlChinese Center for Disease Control and PreventionBeijing 101149China Public Health Monitor and Information Service Center Chinese Center for Disease Control and PreventionBeijing 102206China Department of Tuberculosis Prevention and Treatment HosDital of Shanxi Province.Xian 7101130.Shanxi China

The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid（CSF） T‐*** test for the diagnosis of TB meningitis（TBM）. A retrospective analysis of 96 patients with manifested meningitis was conducted; T‐*** test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value（PPV）, and negative predictive value（NPV）. A receiver operating characteristic（ROC） curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T‐*** test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients（54.2%） of the 96 enrolled patients. The area under the curve（AUC） was 0.910, and the sensitivities of CSF T‐*** for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T‐*** test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.

关键词： T‐SPOT TB Tuberculous meningitis Cerebrospinal fluid Diagnosis

通货膨胀目标制在我国的适用性分析:货币错配的视角

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财经论丛 2007年第6期 34-41页

作者：李雪莲四川大学经济学院四川成都610064

随着经济全球化、金融一体化浪潮的兴起以及金融创新的不断推进,传统的货币政策框架日益受到冲击和挑战,近年来在许多国家已取得良好效果的通货膨胀目标制正受到越来越多的关注,很多学者认为我国也应该采取通货膨胀目标制。本文正是在... 详细信息

随着经济全球化、金融一体化浪潮的兴起以及金融创新的不断推进,传统的货币政策框架日益受到冲击和挑战,近年来在许多国家已取得良好效果的通货膨胀目标制正受到越来越多的关注,很多学者认为我国也应该采取通货膨胀目标制。本文正是在这种背景下,在考察了我国货币错配现状并界定通货膨胀目标制内涵的基础上,从分析货币错配影响通货膨胀目标制实施的内在机制这一视角,结合我国特殊的国情对通货膨胀目标制在我国的适用性进行了研究。

关键词：通货膨胀目标制货币错配适用性

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对具有高代数免疫度布尔函数的新型代数攻击

西安电子科技大学学报 2009年第4期36卷 702-707页

作者：李雪莲胡予濮西安电子科技大学理学院陕西西安710071 西安电子科技大学计算机网络与信息安全教育部重点实验室陕西西安710071

代数免疫度是衡量布尔函数抵抗代数攻击的重要性能指标,具有低代数免疫度的布尔函数是不能抵抗代数攻击的.利用分拆布尔函数的方法证明了如下结论:(1)对于对称布尔函数,即使它们具有高代数免疫度,如果使用不当仍然不能抵抗新型代数攻击;... 详细信息

代数免疫度是衡量布尔函数抵抗代数攻击的重要性能指标,具有低代数免疫度的布尔函数是不能抵抗代数攻击的.利用分拆布尔函数的方法证明了如下结论:(1)对于对称布尔函数,即使它们具有高代数免疫度,如果使用不当仍然不能抵抗新型代数攻击;(2)对于由旋转对称函数和低次布尔函数的直和构成的布尔函数即便具有高代数免疫度,如果使用不当,也会受到新型代数攻击.提出的代数攻击需要一段连续的密钥流.

关键词：流密码代数免疫度对称布尔函数旋转对称布尔函数

Simultaneous determination of quetiapine and three metabolites in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry

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Acta Pharmacologica Sinica 2004年第1期 112-116页

作者： Kun-yan li, Ze-neng CHENG, Xin li, xue-lian BAI, Bi-kui ZHANG, Feng WANG, Huan-de liClinical Pharmaceutical Research Institute, Xiangya Second Hospital, Central South University, Changsha 410011, China

AIM: To develop a high performance liquid chromatography-electrospray mass spectrometry (HPLC-MS/ESI) method for simultaneous determination of quetiapine and its sulfoxide-, 7-hydroxy-, 7-hydroxy-N-dealkyl-metabo-lites in human plasma. METHODS: The HPLC separation of the compounds was performed on a Kromasil C18, (5 urn, 4.6 mm×150 mm) column, using water (formic acid: 1.70 mmol/L, ammonium acetate: 5.8 mmol/L)-acetoni trile (65:35) as mobile phase, with a flow-rate of 0.95 mL/min. The compounds were ionized in the electrospray ionization (ESI) ion source of the mass spectrometer and detected in the selected ion recording (SIR) mode. The samples were extracted using solid-phase extraction columns. RESULTS: The calibration curves were linear in the ranges of 10-2000 μg/L for quetiapine, 1-200 μg/L for its metabolites, respectively. The average extraction recoveries for all the four samples were above 85 %.

关键词： quetiapine high pressure liquid chromatography electrospray ionization mass spectrometry metabolism

面向32mm系统成组优化的家具基型模块变型设计研究

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包装工程 2015年第4期36卷 55-59,92页

作者：李雪莲南京林业大学浙江理工大学

目的针对家具32 mm系统实现成组优化,提出基型模块变型设计方法。方法先对核心模块、基型模块及其变型设计等核心概念进行定义;再按成组技术要求分析各模块间的相似性和关联度,确定基型模块及其设计参数,对基型模块做变型设计;并以柜类... 详细信息

目的针对家具32 mm系统实现成组优化,提出基型模块变型设计方法。方法先对核心模块、基型模块及其变型设计等核心概念进行定义;再按成组技术要求分析各模块间的相似性和关联度,确定基型模块及其设计参数,对基型模块做变型设计;并以柜类家具为实例阐述具体设计过程。结论对比柜类家具在使用变型设计之前与之后的核心模块孔位加工时间,验证了基型模块变型设计方法的有效性。

关键词：家具设计 32 mm系统设计成组技术基型模块变型设计

Cornel iridoid glycoside induces autophagy to protect against tau oligomer neurotoxicity induced by activation of glycogen synthase kinase-3β

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Cornel iridoid glycoside induces autophagy to protect agains...