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An effective catalyst carrier SiO_(2):Enhancing catalytic and combustion properties of CuFe_(2)O_(4)on energetic components

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Defence Technology（防务技术） 2024年第2期32卷 383-392页

作者： li Ding Chong Wan Suhang Chen Zhao qin Kangzhen xu School of Chemical Engineering/Xi'an Key Laboratory of Special Energy Materials Northwest UniversityXi'an710069China Xi’an Modern Chemistry Research Institute Xi'an710065China

To enhance the catalytic activity of copper ferrite(CuFe_(2)O_(4))nanoparticle and promote its application as combustion catalyst,a low-cost silicon dioxide(SiO_(2))carrier was employed to construct a novel CuFe_(2)O_(4)/SiO_(2)binary composites via solvothermal *** phase structure,morphology and catalytic activity of CuFe_(2)O_(4)/SiO_(2)composites were studied firstly,and thermal decomposition,combustion and safety performance of ammonium perchlorate(AP)and 1,3,5-trinitroperhydro-1,3,5-triazine(RDX)with it affecting were then systematically *** results show that CuFe_(2)O_(4)/SiO_(2)composite can remarkably either advance the decomposition peak temperature of AP and RDX,or reduce the apparent activation energy at their main decomposition ***,the flame propagation rate of RDX was promoted by about 2.73 times with SiO_(2)content of 3 wt%,and safety property of energetic component was also improved greatly,in which depressing the electrostatic discharge sensitivity of pure RDX by about 1.89 *** addition,the effective range of SiO_(2)carrier content in the binary catalyst is found to be 3 to 5 wt%.Therefore,SiO_(2)opens a new insight on the design of combustion catalyst carrier and will promote the application of CuFe_(2)O_(4)catalyst in solid propellant.

关键词： Copper ferrite Silicon dioxide Combustion catalyst Thermal decomposition Laser ignition

Cancer organoids:A platform in basic and translational research

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Genes & Diseases 2024年第2期11卷 614-632页

作者： Xin Ma qin Wang Guozheng li Hui li Shouping xu Da Pang Department of Breast Surgery Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Sino-Russian Medical Research Center Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Heilongjiang Academy of Medical Sciences HarbinHeilongjiang 150086China Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China) College of Pharmacy of Harbin Medical UniversityHarbinHeilongjiang 150086China

An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical *** are changing the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the complex tissue environment and structure found in clinical tumors than in vitro cell lines and animal ***,the potential applications of cancer organoids remain to be comprehensively *** the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological ***,the present challenges faced by organoid technology in clinical practice and its prospects are *** review highlights that organoids may offer a novel therapeutic strategy for cancer research.

关键词： Drug assays Immunotherapy Mechanism research Organoids Precision medicine

Enhancing the mechanical properties of casting eutectic high -entropy alloys via W addition

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1364-1372页

作者： xu Yang Dezhi Chen li Feng Gang qin Shiping Wu Ruirun Chen National Key Laboratory for Precision Hot Processing of Metals School of Material Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

The effect of W element on the microstructure evolution and mechanical properties of Al_(1.25)CoCrFeNi3 eutectic high-entropy alloy and Al_(1.25)CoCrFeNi_(3-x)W_(x)(x=0,0.05,0.1,0.3,and 0.5;atomic ratio)high-entropy alloys(HEAs)were *** show that the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs are composed of face-centered cubic and body-centered cubic(BCC)*** W content increases,the microstructure changes from eutectic to *** addition of W lowers the nucleation barrier of the BCC phase,decreases the valence electron concentration of the HEAs,and replaces Al in the BCC phase,thus facilitating the nucleation of the BCC *** results show that the addition of W greatly improves the mechanical properties,and solid-solution,heterogeneous-interface,and second-phase strengthening are the main strengthening *** yield strength,tensile strength,and elongation of the Al_(1.25)CoCrFeNi2.95W0.05 HEA are 601.44 MPa,1132.26 MPa,and 15.94%,respectively,realizing a balance between strength and *** fracture mode of the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs is ductile–brittle mixed fracture,and the crack propagates and initiates in the BCC *** eutectic lamellar structure impedes crack propagation and maintains plasticity.

关键词： high-entropy alloy microstructure mechanical property fracture behavior

Effect of JIANPI HUOxuE decoction on inflammatory cytokine secretion pathway in rat liver with lipopolysaccharide challenge

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World Journal of Gastroenterology 2008年第12期14卷 1851-1857页

作者： Jing-Hua Peng Yi-Yang Hu Yang Cheng Chong Han li-li xu qin Feng Shao-Dong Chen qing Tao Hong-Shan li xue-Mei li Institute of liver Diseases Shuguang HospitalShanghai University of Traditional Chinese Medicine Shanghai201203 China

AIM： To evaluate the effect of Chinese traditional medicinal prescription, JIANPI HUOxuE decoction （JHD） on cytokine secretion pathway in rat liver induced by lipopolysaccharide （LPS）. METHODS： Twenty-four male SD rats were divided into normal group （n = 4）, model group （n = 10） and JHD group （n = 10） randomly. Rats in model group and JHD group were administrated with normal saline or JHD via gastrogavage respectively twice a day for 3 d. One hour after the last administration, rats were injected with LPS via tail vein, 50 μg/kg. Simultaneously, rats in normal group were injected with equivalent normal saline. After LPS stimulation for 1.5 h, serum and liver tissue were collected. Pathological change of liver tissues was observed through hematoxylineosin （H.E.） staining. Tumor necrosis factor alpha （TNF-α） in serum were assayed by enzyme linked immunosorbent assay （EliSA）. The protein expression of TNF-α, phosphorylated inhibit-κB （p-κB） and CD68 in liver were assayed by Western blot. The distribution of CD68 protein in liver was observed through immunohistochemical staining. The mRNA expression of TNF-α, interleukin-6 （IL-6）, CD14, toll-like receptor 2 （TLR2） and TLR4 in liver were assayed by real-time ***： Predominant microvesicular change, hepatocyte tumefaction and cytoplasm dilution were observed in liver tissues after LPS administration as well as obvious CD68 positive staining in hepatic sinusoidal. After LPS stimulation, serum TNF-α （31.35 ± 6.06 vs 12225.40 ± 9007.03, P 〈 0.05）, protein expression of CD68 （1.13 ± 0.49 vs 3.36 ±1.69, P 〈 0.05）, p-IκB （0.01 ±0.01 vs 2.07 ＋ 0.83, P 〈 0.01） and TNF-α （0.27 ± 0.13 vs 1.29 ± 0.37, P 〈 0.01） in liver and mRNA expression of TNF-α （1.96 ± 2.23 vs 21.45 ±6.00, P 〈 0.01）, IL-6 （4.80 ± 6.42 vs 193.50 ± 36.36, P 〈 0.01） and TLR2 （1.44 ± 0.62 vs 4.16 ± 0.08, P 〈 0.01） in liver were also increased significantly. These pathological changes were all improved in .1HD group. On the other hand, TLR4 mRNA （1.22 ± 0.3

关键词： JIANPI HUOxuE decoction lipopolysaccharide Kupffer cell, Cytokine Endotoxin receptor

Pufferfish gasdermin Ea is a significant player in the defense against bacterial pathogens

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Marine life Science & Technology 2024年第3期6卷 462-474页

作者： Hang xu Kunpeng qin Kangwei Hao Zihao Yuan li Sun CAS and Shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyCAS Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China School of Marine Science University of Chinese Academy of SciencesQingdao 266400China

Gasdermins(GSDMs)are proteins cleaved by caspase(CASP)to trigger *** teleosts,pyroptosis is mediated by gasdermin E(GSDME).The Pufferfish,Takifugu rubripes,possesses two GSDME orthologs:named TrGSDMEa and *** is cleaved by CASP3/7 to liberate the N-terminal(NT)domain that can trigger pyroptosis in mammalian ***,the biological function of TrGSDMEa in pufferfish is unknown,and TrGSDMEb is poorly *** found that TrGSDMEb was cleaved by CASP1/3/6/7/8,but the resulting NT domain,despite its similarity to TrGSDMEa-NT domain in sequence and structure,failed to induce *** and TrGSDMEb exhibited similar expression patterns in pufferfish under normal physiological conditions but were up-and downregulated,respectively,in expression during Vibrio harveyi and Edwardsiella tarda *** infection induced the activation of TrGSDMEa and CASP3/7 in pufferfish cells,resulting in pyroptosis accompanied with IL-1βproduction and *** of TrGSDMEa-mediated pyroptosis via TrCASP3/7 reduced the death of pufferfish cells and augmented bacterial dissemination in fish ***-oriented mutagenesis identified 16 conserved residues in teleost GSDMEa that were required for the pore formation or auto-inhibition of *** study illustrates the role of GSDMEa-mediated pyroptosis in teleost defense against bacterial pathogens and provides new insights into the structure-based function of vertebrate GSDME.

关键词： GSDME Caspase Takifugu rubripes Bacterial infection Immune defense

A New Compound with C_2-Symmetry 3R,3'R-Dihydroxy-6,6',6,6'-tetramethyl-2R,2'R,-bis-4H-pyran

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Chinese Chemical Letters 1997年第8期8卷 653-654页

作者： li Bing Yu li xu and Zhi qin WANG(Shanghai Institute of Organic Chemistry. Chinese Acadmey of Sciences 354 Fenglin Road. Shanghai 200032) Shanghai Inst. of Organic Chemistry Chinese Acadmey of Sciences 354 Fenglin Road Shanghai 200032 China

The title compound 1 was synthesized from 1.2:5,6-dianhydro-3,4-dianhydro-3,4-isopropylideneD-mannitol 2 through four steps in a total yield of 53%. The absolute configuration of this compound was confirmed by X-ray d... 详细信息

关键词： tetramethyl-2R,2’R Rev Cl bis-4H-pyran A New Compound with C2-Symmetry 3R,3’R-Dihydroxy-6,6

Standardized Volume Power Density Boost in Frequency-Up Converted Contact-Separation Mode Triboelectric Nanogenerators

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Research 2024年第2期2023卷 691-702页

作者： Zhongjie li Chao Yang qin Zhang Geng Chen Jingyuan xu Yan Peng Hengyu Guo School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444P.R.China Institute of Artificial Intelligence Shanghai UniversityShanghai 200444P.R.China National Engineering Research Center of Turbo-Generator Vibration School of Energy and EnvironmentSoutheast UniversityNanjing 210096P.R.China institute of Microstructure Technology Karlsruhe Institute of TechnologyKarlsruhe 76344Germany Shanghai Artificial Intelligence Laboratory Shanghai 200444P.R.China Department of Applied Physics Chongqing UniversityChongqing 400044P.R.China

The influence of a mechanical structure's volume increment on the volume power density (VPD) of triboelectric nanogenerators (TENGs) is often neglected when considering surface charge density and surface power density. This paper aims to address this gap by introducing a standardized VPD metric for a more comprehensive evaluation of TENG performance. The study specifically focuses on 2 frequency-up mechanisms, namely, the integration of planetary gears (PG-TENG) and the implementation of a double-cantilever structure (DC-TENG), to investigate their impact on VPD. The study reveals that the PG-TENG achieves the highest volume average power density, measuring at 0.92 W/m^(3). This value surpasses the DC-TENG by 1.26 times and the counterpart TENG by a magnitude of 69.9 times. Additionally, the PG-TENG demonstrates superior average power output. These findings introduce a new approach for enhancing TENGs by incorporating frequency-up mechanisms, and highlight the importance of VPD as a key performance metric for evaluating TENGs.

关键词： increment neglected considering

β-Carboline alkaloids from the roots of Peganum harmala L.

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Chinese Journal of Natural Medicines 2024年第2期22卷 171-177页

作者： li Shengge ZHANG qin WANG Yuetong liN Bin li Dahong HUA Huiming HU xu Henan Key Laboratory of Zhang Zhongjing Formulate and Herbs for Immunoregulation Zhang Zhongjing Traditional School of Chinese MedicineNanyang Institute of TechnologyNanyang 473004China Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

This study reports the isolation of four newβ-carboline alkaloids(1−4)and six previously identified alkaloids(5−10)from the roots of Peganum harmala *** these compounds,1 and 2 were characterized as rareβ-carboline-quinazoline dimers exhibiting axial *** 3 possessed a unique 6/5/6/7 tetracyclic ring system with an azepine ring,and compound 4 was a novel annomontineβ-*** structures of these compounds were elucidated by spectroscopic data and quantum mechanical *** biosynthetic pathways of 1−3 were ***,the cytotoxicity of some isolates against four cancer cell lines(HL-60,A549,MDA-MB-231,and DU145)was ***,compound 4 exhibited significant cytotoxicity against HL-60,A549,and DU145 cells with IC_(50) values of 12.39,12.80,and 30.65μmol·L^(−1),***,compound 2 demonstrated selective cytotoxicity against HL-60 cells with an IC_(50) value of 17.32μmol·L^(−1).

关键词： β-Carboline alkaloids Peganum harmala Structure elucidation Cytotoxic activity

Electrically-driven ultrafast out-of-equilibrium light emission from hot electrons in suspended graphene/hBN heterostructures

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International Journal of Extreme Manufacturing 2024年第1期6卷 328-338页

作者： Qiang liu Wei xu Xiaoxi li Tongyao Zhang Chengbing qin Fang Luo Zhihong Zhu Shiqiao qin Mengjian Zhu Kostya S Novoselov College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano-optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaHunan 410073People’s Republic of China Nanhu Laser Laboratory National University of Defense TechnologyChangshaHunan 410073People’s Republic of China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006People’s Republic of China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006People’s Republic of China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006People’s Republic of China Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Nanoscale light sources with high speed of electrical modulation and low energy consumption are key components for nanophotonics and *** record-high carrier mobility and ultrafast carrier dynamics of graphene make it promising as an atomically thin light emitter which can be further integrated into arbitrary platforms by van der Waals ***,due to the zero bandgap,graphene is difficult to emit light through the interband recombination of carriers like conventional ***,we demonstrate ultrafast thermal light emitters based on suspended graphene/hexagonal boron nitride(Gr/hBN)*** in biased graphene are significantly heated up to 2800 K at modest electric fields,emitting bright photons from the near-infrared to the visible spectral *** eliminating the heat dissipation channel of the substrate,the radiation efficiency of the suspended Gr/hBN device is about two orders of magnitude greater than that of graphene devices supported on SiO2or *** demonstrate that hot electrons and low-energy acoustic phonons in graphene are weakly coupled to each other and are not in full thermal *** cooling ofhigh-temperature hot electrons to low-temperature acoustic phonons is enabled by the significant near-field heat transfer at the highly localized Gr/hBN interface,resulting in ultrafast thermal emission with up to 1 GHz bandwidth under electrical *** is found thatsuspending the Gr/hBN heterostructures on the SiO2trenches significantly modifies the light emission due to the formation of the optical cavity and showed a~440%enhancement inintensity at the peak wavelength of 940 nm compared to the black-body thermal *** demonstration of electrically driven ultrafast light emission from suspended Gr/hBNheterostructures sheds the light on applications of graphene heterostructures in photonicintegrated circuits,such as broadband light sources and ultrafast thermo-optic phase modulat

关键词： suspended graphene ultrafast light emitter van der Waals heterostructures thermal radiation electron–phonon interaction