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细胞之间线粒体转移的主要途径、主要作用及主要调控机制

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中国组织工程研究 2025年第25期29卷 5443-5453页

作者：李兴福周光前陆伟深圳大学医学部生物医学工程学院医学超声关键技术国家地方联合工程实验室广东省生物医学信息检测与超声成像重点实验室广东省深圳市518060 深圳市第二人民医院运动医学科广东省深圳市518035

背景:线粒体功能障碍导致细胞衰老凋亡,可加重组织损伤。细胞之间线粒体转移促进损伤细胞恢复线粒体功能,有助于治疗线粒体相关疾病。目的:综述细胞之间线粒体转移的作用及调控机制。方法:检索中国知网和PubMed数据库2014-2024年关于细... 详细信息

背景:线粒体功能障碍导致细胞衰老凋亡,可加重组织损伤。细胞之间线粒体转移促进损伤细胞恢复线粒体功能,有助于治疗线粒体相关疾病。目的:综述细胞之间线粒体转移的作用及调控机制。方法:检索中国知网和PubMed数据库2014-2024年关于细胞之间线粒体转移的文献,以“线粒体转移,隧道纳米管,缝隙连接,微囊泡,细胞融合”为中文检索词,以“Mitochondrial transfer,Tunneling nanotubes,gap junctions,microvesicles,cell fusion”为英文检索词,最终共纳入74篇文献进行分析。结果与结论:①总结了细胞之间线粒体转移的4个主要途径:包括隧道纳米管、缝隙连接、细胞融合和微囊泡。②梳理了细胞之间线粒体转移的主要作用,包括物质交换、信息传递、改善宿主细胞线粒体功能、抑制氧化应激、提高细胞增殖活力及抗炎抗衰老等。③总结了细胞之间线粒体转移的主要调控机制,包括Miro 1促进隧道纳米管形成和线粒体转移、隧道纳米管转移线粒体依赖宿主细胞环状ADP核糖水解酶表达、氧化应激环境诱导隧道纳米管形成、缝隙连接具有Ca^(2+)依赖性、缝隙连接蛋白43影响缝隙连接形成、激活Ras1蛋白和肌动蛋白有助于细胞融合、肌动蛋白和Rab6参与调控线粒体出胞、激活肌动蛋白和NAD+-CD38-cADPR-Ca^(2+)信号通路促进线粒体入胞等。④在细胞信号传导蛋白、细胞动力学相关蛋白及氧化应激环境的影响下,细胞通过隧道纳米管、缝隙连接、微囊泡及细胞融合进行线粒体转移。⑤线粒体转移是细胞之间物质交换和信息交流的重要途径,与疾病的发生发展息息相关,可为治疗线粒体相关疾病提供新的思路,但对细胞间线粒体转移的作用及调控机制仍需进一步探究。

关键词：线粒体转移隧道纳米管缝隙连接微囊泡细胞融合干细胞氧化应激衰老

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基于神经网络集成学习和语义增强特征的需求跟踪方法

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武汉大学学报（理学版） 2024年第3期70卷 317-328页

作者：万红艳李幸阜王帮超蒋涵邓洋武汉纺织大学计算机与人工智能学院湖北武汉430200 湖北省服装信息化工程技术研究中心湖北武汉430200

现有的基于机器学习的需求跟踪方法存在稳定性差的问题。为了缓解上述问题,提出了一种基于神经网络集成学习和语义增强特征的需求跟踪方法(Ensemble Learning Trace Approach,EMTrace)。该方法将需求跟踪问题转化为分类问题,集成了多个... 详细信息

现有的基于机器学习的需求跟踪方法存在稳定性差的问题。为了缓解上述问题,提出了一种基于神经网络集成学习和语义增强特征的需求跟踪方法(Ensemble Learning Trace Approach,EMTrace)。该方法将需求跟踪问题转化为分类问题,集成了多个机器学习分类器进行预测,并对这些预测结果进行加权生成跟踪链接。为了自动获取各个基模型的权重,构建了一种基于神经网络的元学习器并利用每个基模型的预测结果进行训练。为了更准确地表达制品之间的跟踪链接,EMTrace方法使用多个词嵌入和句子嵌入模型提取软件制品的语义信息来增强跟踪链接特征的语义表示。实验结果表明,EMTrace方法能够有效提高需求跟踪的稳定性和性能,相比最优的基线方法,EMTrace方法在F1上提升了0.162。

关键词：需求跟踪集成学习语义增强特征链接表示

Construction of Multilayer Porous Scaffold Based on Magnetically Guided Assembly of Microfiber

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Journal of Systems Science & Complexity 2018年第3期31卷 581-595页

作者： li xingfu WANG Huaping SHI Qing SUN Tao HUANG Qiang FUKUDA Toshio Intelligent Robotics Institute School of Mechatronical Engineering Beijing Institute of Technology Beijing 100081 China Key Laboratory of Biomimetic Robots and Systems Ministry of Education Beijing 100816 China Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081 China

This paper proposes a novel method of magnetically guided assembly to construct multi- layer porous scaffold for three-dimensional cell culture by apply magnetic microfibers. Microfibers are composed of biocompatible and biodegradable alginate solution with homogeneous magnetic nanopar- ticles, which are continuously spun from a microfluidic device by precise pressure control of the syringe pump. Magnetic nanoparticles enable the control of magnetic field on microfibers. Meanwhile, mag- netized device combining with a round permanent magnet are utilized to guide the distribution of spouted microfibers. The device is composed by pure iron wire arrays and wax, which stimulates pow- erful magnetic flux density and magnetic field gradients for the capture and assembly of microfibers. Thus, magnetic microfibers are spun on desired places of the magnetized device by motion control of the micromanipulation robot, and precise locations are adjusted by magnetic force couple with the assist of glass micropipette. Afterwards, microfibers are spatially organized by periodic magnetic force and crossed layer-by-layer to form micro-pore structure with both length and width of 650μm. Finally, the authors construct a multilayer microfiber-based scaffold with high porosity to provide a satisfactory environment for long-term cell culture. The experimental results demonstrate the effectiveness of the proposed method.

关键词： Magnetically guided assembly magnetic microfiber magnetized device periodic magneticforce multilayer porous scaffold.

Quantitative Evaluation on Urban Ecosystem Carrying Capacity in Tianjin Binhai New Area

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Chinese Journal of Population,Resources and Environment 2009年第4期7卷 64-68页

作者： li xingfu Xu He Institute of Environmental Science and Engineering Nankai University Tianjin 300071 China

Based on the concept of ecosystem carrying capacity,the indicator system of quantitative assessment was set up,which consisted of support indicator system and pressure indicator *** the factor analysis method was used to screen the indicator *** from the traditional indicator weight determination based on the absolute values of the coefficients of regression equation,the squares of factor loadings in the rotated component matrix were attempted to determine the weights of 40 assessment *** result shows that ecological support system and pressure system in Binhai New Area are relatively balanced among six years,and the developing level of urban ecosystem is basically healthy on the ***,due to continuously increasing pressure of the resources consumption caused by the rapid growth of the second industry,which is the Leading Industry of Binhai New Area,the ecosystem carrying capacity reached the minimum in 2005.

关键词： ecosystem carrying capacity factor analysis Binhai New Area

目标树经营对香合欢天然次生林林分生长的影响

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桉树科技 2024年第3期41卷 74-78页

作者：韩俊学欧汉彪李兴富韦铄星黄康庭李佳男广西壮族自治区国有雅长林场广西百色533000 广西壮族自治区林业科学研究院广西南宁530002 广西壮族自治区国有大桂山林场广西贺州542800 广西大学广西南宁530004

以香合欢天然次生中龄林为研究对象,探讨不同目标树经营模式对香合欢天然次生林林木生长的影响,以期促进香合欢天然次生林的恢复与可持续经营。结果表明:目标树经营可显著提高林木生长量,随着目标树保留密度增大,树高和胸径增长量呈现... 详细信息

以香合欢天然次生中龄林为研究对象,探讨不同目标树经营模式对香合欢天然次生林林木生长的影响,以期促进香合欢天然次生林的恢复与可持续经营。结果表明:目标树经营可显著提高林木生长量,随着目标树保留密度增大,树高和胸径增长量呈现出逐渐减小的趋势;树高和胸径增长量随着施肥量的增加而逐渐增加。目标树保留株数相同时,不同施肥量处理间冠幅增长量无显著差异,但整体表现为东西和南北冠幅增长量随施肥量增加而增加。单株材积和林分蓄积量随着目标树保留株数减少而增加,随着施肥量的增加而增加;在实施1年后,目标树保留株数对单株材积增长量、林分蓄积增长量、胸径增长量、树高增长量的影响均极显著;施肥对香合欢中龄林单株材积增长量、林分蓄积增长量的影响不显著,而对胸径增长量、树高增长量的影响极显著。林分蓄积在目标树保留10株,施肥量1kg·株^(-1)时林分蓄积增长量最大,是该实验阶段表现出最佳的目标树经营模式。

关键词：目标树经营香合欢中龄林增长量

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Copper-based nanodots as efficient biomimetic antibiotics for the treatment of oral bacterial infections Author links open overlay panel

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Particuology 2024年第8期91卷 190-201页

作者： Ying li Nan Tang lingling Zhao xingfu Bao Yuzhuo Wang Zhanxin Wang Min Hu Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of StomatologyJilin UniversityChangchunChina Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijingChina

Oral infectious diseases caused by a variety of pathogenic bacteria seriously affect the quality of ***,these diseases remain a clinical challenge because of the lack of simple,safe,and universal *** address these limitations,we synthesize CuO_(x)nanodots(CuO_(x)NDs)with excellent Fenton-like reaction activity and utilize them in the treatment of oral bacterial *** from other complicated approaches,CuO_(x)NDs are rationally prepared using a facile one-pot aqueous *** the presence of H_(2)O_(2),these well-developed CuO_(x)NDs can efficiently catalyze the generation of hydroxyl radicals(·OH)around oral pathogens,leading to the death of various ***,results of biosafety indicate the high biocompatibility and extremely low toxicity of these CuO_(x)*** understanding the admirable in vitro antibacterial effect of CuO_(x)NDs in the presence of H_(2)O_(2),we further explore their in vivo antibacterial performance on several classical animal models including oral mucosal wound model,intragingival bacteria-infected model,and the periodontal infection *** expected,these CuO_(x)NDs with wide-spectrum antibacterial activity can serve as high-performance antibacterial reagents for the treatment of various oral bacterial infections with the help of H_(2)O_(2).In brief,current nanoplatform can act as efficient antibiotics against oral pathogens with broadening the biomedical applications of copper-based nanomaterials.

关键词： Antibacterial treatment Oral diseases Fenton-likecatalytic reaction Reactive oxygen species

Wavefield continuation datuming using a near surface model

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Applied Geophysics 2007年第2期4卷 94-100页

作者： Cui xingfu li Hongbing Hu Ying liang Hong Qi li Geophysical Technology Department Research Institute of Petroleum Exploration ＆ Development PetroChina. Beijing（100083）

When topography and low velocity zone differences vary greatly, conventional vertical static time shifts will cause wavefield distortion and influence wave equation seismic imaging for seismic data acquired on a complex near surface. In this paper, we propose an approach to datum correction that combines a joint tomography inversion with wavefield continuation to solve the static problem for seismic data on rugged acquisition topography. First, the near surface model is obtained by refracted wave tomography inversion. Second, the wavefield of sources and receivers are continued downward and upward to accomplish datum correction starting from a flat surface and locating the datum above topography. Based on the reciprocal theorem, Huygens＇ and Fresnel principles, the location of sources and receivers, and regarding the recorded data on the surface as a secondary emission, the sources and receivers are upward-continued to the datum above topography respectively. Thus, the datum correction using joint tomography inversion and wavefield continuation with the condition of a complex near surface is accomplished.

关键词： Complex near surface tomography inversion wavefield continuation datum correction.

CT平扫一阶纹理分析在腮腺多形性腺瘤与Warthin瘤中的鉴别价值

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现代医用影像学 2024年第1期33卷 13-17,21页

作者：师达石亚男汪时雨夏锐李兆勇李兴付梁俊生东莞东华医院放射科广东东莞523110 东莞松山湖东华医院放射科广东东莞523808

目的:探讨CT平扫图像的一阶纹理分析特征参数对腮腺多形性腺瘤和Warthin瘤的鉴别价值。方法:收集2019年7月至2021年12月经临床病理证实的腮腺多形性腺瘤和Warthin瘤患者各35例的CT平扫图像,在纹理分析软件中勾画全瘤灶的感兴趣区,得到... 详细信息

目的:探讨CT平扫图像的一阶纹理分析特征参数对腮腺多形性腺瘤和Warthin瘤的鉴别价值。方法:收集2019年7月至2021年12月经临床病理证实的腮腺多形性腺瘤和Warthin瘤患者各35例的CT平扫图像,在纹理分析软件中勾画全瘤灶的感兴趣区,得到一阶纹理特征参数。应用统计学分析以上参数在腮腺多形性腺瘤和Warthin瘤中差异有无统计学意义,并对有统计学意义的纹理特征参数制作ROC曲线,求得其诊断效能。结果:腮腺CT平扫图像的一阶纹理特征的18项参数中,以下9项参数有统计学意义(P<0.05):Percentile10(P=0.000)、Percentile90(P=0.000)、Energy(P=0.000)、Maximum(P=0.000)、Mean(P=0.000)、Median(P=0.000)、RootMeanSquared(P=0.000)、TotalEnergy(P=0.000)、Variance(P=0.046)其中Percentile90、RootMeanSquared、Mean、Median等4项参数诊断效能较好,AUC分别为94.80%、94.20%、93.80%、93.80%。结论:腮腺CT平扫一阶纹理分析在多形性腺瘤与Warthin瘤中的有一定鉴别价值。

关键词：体层摄影术螺旋计算机纹理分析腮腺多形性腺瘤腺淋巴瘤

Analysis and Design of Property Management System Based on B/S

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Analysis and Design of Property Management System Based on B...