检索结果-南通市图书馆

Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

Bioactive Materials 2022年第11期7卷 289-299页

作者： Muxue Wang Xi Zhou Yunhong li Yuqing Dong Jiashen Meng Shuai Zhang linbo Xia Zhaozhi He Lei Ren Zhiwei Chen xingcai Zhang Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen361005People’s Republic of China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various antibacterial strategies based on ROS have been developed, many of them are still limited by insufficient antibacterial efficiency. Here, we have developed an acid-enhanced dual-modal antibacterial strategy based on zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn2+, is chosen as the carrier to integrate glucose oxidase (GOx) and gold nanoparticles (Au NPs) which can produce ROS via a cascade catalytic reaction. Thus, the bactericidal capability of ROS and Zn2+ have been integrated. More importantly, gluconic acid, a “by-product” of the catalytic reaction, can generate an acidic environment to promote both the ROS-producing and Zn2+-releasing, enhancing the overall antibacterial performance further. This triple-synergistic strategy exhibits extraordinary bactericidal ability at a low dosage of 4 μg/mL (for S. aureus) and 8 μg/mL (for E. coli), which shows a great potential of MOF-derived nanozyme for efficient bacterial eradication and diverse biomedical applications.

关键词： Metal-organic frameworks Nanozyme Reactive oxygen species Antibacterial Zinc ion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

37Mn5管坯的裂纹研究

引用

河北冶金 2014年第7期 25-32页

作者：李兴才田宝生刘军利董志强德龙钢铁有限公司炼钢厂河北邢台054009

用金相检验、化学分析、SEM高倍检测等手段对37Mn5管坯的裂纹进行了系统的研究。结果表明:管坯裂纹在连铸坯上已经存在;管坯裂纹是夹杂物型裂纹;由于管坯存在硅、硫、锰等元素的聚集,钙和镁等元素形成的氧化质点,再加上晶粒不均匀的柱... 详细信息

用金相检验、化学分析、SEM高倍检测等手段对37Mn5管坯的裂纹进行了系统的研究。结果表明:管坯裂纹在连铸坯上已经存在;管坯裂纹是夹杂物型裂纹;由于管坯存在硅、硫、锰等元素的聚集,钙和镁等元素形成的氧化质点,再加上晶粒不均匀的柱状晶区晶界结合力比较弱,易于连铸坯上微观裂纹的生成。基体中尺寸较大的硅酸盐和Al2O3的存在使得微观裂纹以及疏松在加工时难以焊合,从而形成宏观裂纹。

关键词：管坯裂纹氧化质点焊合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

引用

National Science Review 2022年第3期9卷 42-51页

作者： Hongjun li Zejun Wang Edikan A.Ogunnaike Qing Wu Guojun Chen Quanyin Hu Tianyuan Ci Zhaowei Chen Jinqiang Wang Di Wen Hongwei Du Jie Jiang Jie Sun xingcai Zhang Gianpietro Dotti Zhen Gu College of Pharmaceutical Sciences Zhejiang University liangzhu Laboratory Zhejiang University Medical Center Department of Bioengineering University of California Jonsson Comprehensive Cancer Center University of California California Nano Systems Institute University of California Center for Nanotechnology in Drug Delivery Eshelman School of Pharmacy University of North Carolina lineberger Comprehensive Cancer Center University of North Carolina Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Department of Microbiology and Immunology University of North Carolina Department of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital Zhejiang University School of Medicine John A. Paulson School of Engineering and Applied Sciences Harvard University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

Chimeric antigen receptor T cell(CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.

关键词： drug delivery CAR T therapy microneedle patch solid tumor treatment cell delivery

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Gasoline-diesel dual fuel intelligent charge compression ignition(ICCI)combustion:Conceptual model and comparison with other advanced combustion modes

引用

Science China(Technological Sciences) 2021年第4期64卷 719-728页

作者： li ZiLong QIAN Yong HUANG Guan ZHAO WenBin ZHANG YaoYuan LU xingcai Key Laboratory for Power Machinery and Engineering of M.O.E. Shanghai Jiao Tong UniversityShanghai 200240China

The internal combustion engines can remain the advantage over competitor technologies for automotive driven,especially the engine efficiency,exceeded 50%while maintaining ultra-low *** this paper,a novel combustion mode characterized by dual high-pressure common-rail direct injection systems,denoted as intelligent charge compression ignition(ICCI)combustion,is proposed to realize high efficiency and clean combustion in wide engine operating ***,commercial gasoline and diesel,which are considered to be complementary in physical and chemical properties,are directly injected into the cylinder by the two independent injection systems,*** this unique design,the in-cylinder air-fuel mixtures can be flexibly adjusted by regulating injection timing and duration of different fuels,consequently obtaining suitable combustion phase and heat release *** ICCI mode can widely run from indicated mean effective pressure 2 bar to 16 bar with an utterly controllable cylinder pressure rising rate,around 50%indicated thermal efficiency and low NOxemissions.A series of experiments were carried out to compare the combustion and emissions of ICCI with other combustion modes(including conventional diesel combustion,reactivity-controlled compression ignition,partially premixed combustion,and gasoline compression ignition).The results show that at the medium engine loads,ICCI mode can reach much high indicated thermal efficiency,especially up to 52%along with extremely low ***,ICCI mode can realize real-time adjustments of in-cylinder mixture stratification and instantaneous combustion mode switch in one cycle at any operating conditions,and has an excellent commercial application prospect for energy conservation and environmental improvement.

关键词： intelligent charge compression ignition(ICCI) dual-fuel direct injection system gasoline diesel high-efficiency clean combustion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肯尼亚Olkaria地热资源井口分布式地热电站抽真空系统的优选

引用

清洁煤与能源 2015年第1期3卷 1-5页

作者：蔡正敏李雪宁隆强李兴财朱继伟何永龙中国石油集团长城钻探工程有限公司工程服务公司北京

本文对地热电站中的抽真空系统设计方案进行了对比分析,给出了地热电站不同的抽真空系统的设计方案。最后以肯尼亚Olkaria地区的地热蒸汽参数为例对地热电站中的抽真空系统进行了对比分析并给出了结论,为该地区的地热电站的设计提供了... 详细信息

本文对地热电站中的抽真空系统设计方案进行了对比分析,给出了地热电站不同的抽真空系统的设计方案。最后以肯尼亚Olkaria地区的地热蒸汽参数为例对地热电站中的抽真空系统进行了对比分析并给出了结论,为该地区的地热电站的设计提供了理论基础。

关键词：地热电站地热蒸汽蒸汽参数抽真空系统

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

P-E hysteresis loop going slim in Ba0.3Sr0.7TiO3-modified Bi0.5Na0.5TiO3 ceramics for energy storage applications

引用

Journal of Advanced Ceramics 2020年第2期9卷 183-192页

作者： Dongxu li Zong-Yang SHEN Zhipeng li Wenqin LUO xingcai WANG Zhumei WANG Fusheng SONG Yueming li Energy Storage and Conversion Ceramic Materials Engineering Laboratory of Jiangxi Province China National Light Industry Key Laboratory of Functional Ceramic MaterialsSchool of Materials Science and EngineeringJingdezhen Ceramic InstituteJingdezhen333000China Chengdu Hongke Electronic Technology Co. Ltd.Chengdu610000China

(Ba0.3Sr0.7)x(Bi0.5Na0.5)1-xTiO3(BSxBNT,x=0.3–V0.8)ceramics were prepared to investigate their structure,dielectric and ferroelectric *** ceramics possess pure perovskite structure accompanied from a tetragonal symmetry to pseudo-cubic one with the increase of x value,being confirmed by X-ray diffraction(XRD)and Raman *** Tm corresponding to a temperature in the vicinity of maximum dielectric constant gradually decreases from 110℃(x=0.3)to-45℃(x=0.8),across Tm=36℃(x=0.5)with a maximum dielectric constant(ɛr=5920@1 kHz)around room *** saturated polarization Ps gradually while the remnant polarization Pr sharply decreases with the increase of x value,making the P-E hysteresis loop of BSxBNT ceramics goes slim.A maximum difference between Ps and Pr(Ps-Pr)is obtained for BSxBNT ceramics with x=0.5,at which a high recoverable energy density(Wrec=1.04 J/cm3)is achieved under an applied electric field of 100 kV/cm with an efficiency ofη=77%.Meanwhile,the varied temperature P-E loops,fatigue measurements,and electric breakdown characteristics for the sample with x=0.5 indicate that it is promising for pulsed power energy storage capacitor candidate materials.

关键词： energy storage ceramics Ba0.3Sr0.7TiO3(BST) Bi0.5Na0.5TiO3(BNT) relaxor ferroelectrics pulsed power capacitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Auto-ignition of biomass synthesis gas in shock tube at elevated temperature and pressure

引用

Science Bulletin 2015年第22期60卷 1935-1946页

作者： linqi Ouyang Hua li Shuzhou Sun Xiaole Wang xingcai Lu Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong University

Ignition delay times of multi-component biomass synthesis gas （bio-syngas） diluted in argon were measured in a shock tube at elevated pressure （5, 10and 15 bar, 1 bar = 105 Pa）, wide temperature ranges （1,100-1,700 K） and various equivalence ratios （0.5, 1.0, 2.0）. Additionally, the effects of the variations of main constituents （H2：CO = 0.125-8） on ignition delays were investigated. The experimental results indicated that the ignition delay decreases as the pressure increases above certain temperature （around 1,200 K） and vice versa. The ignition delays were also found to rise as CO concentration increases, which is in good agreement with the literature. In addition, the ignition delays of bio-syngas were found increasing as the equivalence ratio rises. This behavior was primarily discussed in present work. Experimental results were also compared with numerical predictions of multiple chemical kinetic mechanisms and li＇s mechanism was found having the best accuracy. The logarithmic ignition delays were found nonlinearly decrease with the H2 concentration under various conditions, and the effects of temperature, equivalence ratio and H2 concentration on the ignition delays are all remarkable. However, the effect of pressure is rela- tively smaller under current conditions. Sensitivity analysis and reaction pathway analysis of methane showed that R1 （H ＋O2= O -9 OH） is the most sensitive reaction promot- ing ignition and R13 （H ＋O2 （＋M） = HO2 （＋M））, R53（CH3＋H （＋M）= CH4 （＋M））, R54 （CH4＋H= CH3 ＋ H2） as well as R56 （CH4 ＋ OH = CH3 ＋ H2O） are key reactions prohibiting ignition under current experimental conditions. Among them, R53 （CH3 ＋ H （＋M） = CH4 （＋M））, R54 （CH4 ＋ H = CH3 ＋ H2） have the largest posi- tive sensitivities and the high contribution rate in rich mixture. The rate of production （ROP） of OH of R1 showed that OH ROP of R1 decreases sharply as the mixture turns rich. Therefore, the ignition delays become longer as the equiva- lence ratio increases.

关键词： Shock tube Biomass synthesis gas Ignition delay time Sensitivity analysis Reactionpathway analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Active fuel design A way to manage the right fuel for HCCI engines

引用

Frontiers in Energy 2016年第1期10卷 14-28页

作者： Zhen HUANG Zhongzhao li Jianyong ZHANG xingcai LU Junhua FANG Dong HAN Key Laboratory of Power Machinery and Engineering Ministry of Education Shanghai Jiao Tong University Shanghai 200240 China

Homogenous charge compression ignition （HCCI） engines feature high thermal efficiency and ultralow emissions compared to gasoline engines. However, unlike SI engines, HCCI combustion does not have a direct way to trigger the in-cylinder combustion. Therefore, gasoline HCCI combustion is facing challenges in the control of ignition and, combustion, and operational range extension. In this paper, an active fuel design concept was proposed to explore a potential pathway to optimize the HCCI engine combustion and broaden its operational range. The active fuel design concept was realized by real time control of dual-fuel （gasoline and n-heptane） port injection, with exhaust gas recirculation （EGR） rate and intake temperature adjusted. It was found that the cylinder- to-cylinder variation in HCCI combustion could be effectively reduced by the optimization in fuel injection proportion, and that the rapid transition process from SI to HCCI could be realized. The active fuel design technology could significantly increase the adaptability of HCCI combustion to increased EGR rate and reduced intake temperature. Active fuel design was shown to broaden the operational HCCI load to 9.3 bar indicated mean effective pressure （IMEP）. HCCI operation was used by up to 70% of the SI mode load while reducing fuel consumption and nitrogen oxides emissions. Therefore, the active fuel design technology could manage the right fuel for clean engine combustion, and provide a potential pathway for engine fuel diversification and future engine concept.

关键词： active fuel design HCCI gasoline n-heptane engine combustion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pre-chamber turbulent jet ignition of methane/air mixtures with multiple orifices in a large bore constant volume chamber: effect of air-fuel equivalence ratio and pre-mixed pressure

引用

Frontiers in Energy 2019年第3期13卷 483-493页

作者： Xiang li Wenzheng ZHANG Zhong HUANG Dehao JU li HUANG Mingzhi FENG xingcai LU Zhen HUANG Key Laboratory of Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China Shanghai Marine Diesel Engine Research Institute Shanghai 201108China

liquefied natural gas (LNG), mainly composed of methane, is in progress to substitute diesel fuel in heavyduty marine engine for practical, economic, and environmental considerations. However, natural gas is relatively difficult to be ignited in a large bore combustion chamber. A combustion enhancement technique called prechamber turbulent jet ignition (TJI) can permit combustion and flame propagation in a largebore volume. To investigate the effect of air-fuel equivalence ratio and pre-mixed pressure on pre-chamber TJI of methane/air mixtures with multiple orifices in a large bore volume, experimental tests and computational simulations were implemented to study the discharge of hot turbulent jets from six orifices of the pre-chamber. Different initial pressures and air-fuel equivalence ratios were considered to analyze the characteristics of TJI. The asymmetry of the turbulent jet actuated from six different orifices were found due to the asymmetric orientation of the spark plug, resulting in the inhomogeneous distribution of combustion in the constant volume chamber, which should be considered seriously in the marine engine design. Besides,as the premixed pressure increases, it has more effect on the flame propagation and plays a more important role, as it further increases.

关键词： marine engine natural gas methane turbulent jet ignition (TJI) pre-chamber

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress and perspectives in dielectric energy storage ceramics

引用

Journal of Advanced Ceramics 2021年第4期10卷 675-703页

作者： Dongxu li Xiaojun ZENG Zhipeng li Zong-Yang SHEN Hua HAO Wenqin LUO xingcai WANG Fusheng SONG Zhumei WANG Yueming li Energy Storage and Conversion Ceramic Materials Engineering Laboratory of Jiangxi Province China National Light Industry Key Laboratory of Functional Ceramic MaterialsSchool of Materials Science and EngineeringJingdezhen Ceramic UniversityJingdezhen 333403China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Chengdu Hongke Electronic Technology Co. Ltd.Chengdu 610000China

Dielectric ceramic capacitors,with the advantages of high power density,fast chargedischarge capability,excellent fatigue endurance,and good high temperature stability,have been acknowledged to be promising candidates for solid-state pulse power *** review investigates the energy storage performances of linear dielectric,relaxor ferroelectric,and antiferroelectric from the viewpoint of chemical modification,macro/microstructural design,and electrical property *** progress of ceramic bulks and films for Pb-based and/or Pb-free systems is ***,we propose the perspectives on the development of energy storage ceramics for pulse power capacitors in the future.

关键词： energy storage ceramics dielectric relaxor ferroelectric antiferroelectric pulse power capacitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：