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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

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Frontiers of Medicine 2014年第1期8卷 96-100页

作者： Xianxian li hui xing lin li Yanli Huang Min Zhou Qiong liu Xiaomin Qin Min He Department of Obstetrics and Gynecology Xiangyang Central Hospital Hospital Affiliated to Hubei University of Arts and ScienceXiangyang 441021 China

Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node （PAN） removal on patient prognosis is still unclear. In this study, 80 patients were divided into groups A and B. Group A consisted of 30 patients who underwent PAN ＋ pelvic lymph node （PLN） dissection, whereas group B consisted of 50 patients who only underwent PLN dissection. Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conducted. Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive for PAN, three cases for PLN, and nine cases for both PAN and PLN. In group B, 13 cases were positive for lymph node metastasis. Our study suggested that the metastatic rate of lymph node is 40.0%. Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological type both in groups A and B （P 〈 0.05）. In groups A and B, the three-year survival rates were 77.9% and 69.0%, and the five-year survival rates were 46.7% and 39.2%, respectively. However, the difference was not statistically significant （P 〉 0.05）. The three-year survival rates of PLN metastasis in groups A and B were 68.5% and 41.4%, and the five-year survival rates were 49.7% and 26.4%, respectively. Furthermore, PLN-positive patients who cleared PAN had significantly higher survival rate （P = 0.044）. In group A, the three-year survival rates of positive and negative lymph nodes were 43.5% and 72.7%, and the five-year survival rates were 27.2% and 58.5%, respectively. The difference was statistically significant （P= 0.048）. Cox model analysis of single factor suggested that lymph node status affected the survival rate （P 〈 0.01）, which was the death risk factor. Consequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, which has an important function in clinical treatment and prognosis of patients with ovaria

关键词： ovarian cancer para-aortic lymph node pelvic lymph node

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li hui-Min xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Modal Experiments and Finite Element Analysis of the Bolted Structure Considering Interface Stiffness and Prtension

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International Journal of Plant Engineering and Management 2012年第2期17卷 87-94页

作者： WEI li-dui DUAN Shu-lin WU Ji WU Qi-li xing hui Marine Engineering College Dalian Maritime University Dalian 116026 P. R. China

It is particularly important to evaluate natural frequencies and natural modes of the structure of bolted joints to avoid the failures of the structure due to the resonance. The vibration characteristics of bolted structures are closely connected to surface roughness of contact interfaces, the magnitude of pretension of the bolts and the number of clamping bolts. In this paper, the effect of the factors above on the natural frequencies of bolted structures is sys- tematically investigated by experiments. Then, the finite element method is applied to analyze the effect. Finally, the numerical method is validated by experimental measurements of the natural frequencies.

关键词： surface roughness pretension natural frequency FEM bolted structures

Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury

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Chinese Journal of Traumatology 2015年第5期18卷 293-295页

作者： Hou-Qing Long Guang-Sheng li xing Cheng Jing-hui Xu Fo-Bao li Department of Spinal Surgery The First Affiliated Hospital of Sun Yat-Sen University China

Chronic spinal cord lesions （CSCL） which result in irreversible neurologic deficits remain one of tbe most devastating clinical problems. Its patbophysiological mechanism has not been fully clarified. As a crucial factor in the outcomes following traumatic spinal cord injury （SCI）, the blood-spinal cord barrier （BSCB） disruption is considered as an important pathogenic factor contributing to the neurologic impairment in SCI. Vascular endothelial growth factor （VEGF） is a multirole element in the spinal cord vascular event. On one hand, VEGF administrations can result in rise of BSCB permeability in acute or sub-acute periods and even last for chronic process. On the other band, VEGF is regarded to be correlated with anglo- genesis, neurogenesis and improvement of locomotor ability. Hypoxia inducible factor-I （HIFq） is a primary regulator of VEGF during hypoxic conditions. Therefore, hypoxia-mediated up-regulation of VEGF may play multiple roles in the BSCB disruption and react on functional restoration of CSCL. The purpose of this article is to further explore the relationship among HIF-1, hypoxia-mediated VEGF and BSCB dysfunction, and investigate the roles of these elements on CSCL.

关键词： VEGF Blood-spinal cord barrier Chronic spinal cord lesions

Green channel of human organ transport improved the utilization rate of Chinese citizens’donated lungs:a single-center data analysis

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Chinese Medical Journal 2021年第2期134卷 222-224页

作者： Xiao-Shan li Chun-Xiao Hu Feng liu Jian Huang Dong liu Zhi-hui Yu hui-xing li Jin Zhao Qian-li Ma Jing-Yu Chen Department of Lung Transplant Center Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxiJiangsu 214023China Department of Anesthesiology Wuxi People's Hospital Affiliated to Nanjing Medical UniversityWuxiJiangsu 214023China Department of Thoracic Surgery China-Japan Friendship HospitalBeijing 100029China

To the Editor:Organ donation after the citizen’s death program was fully launched in China in *** to the allocation regulations of donated organs,all donated lungs must be allocated through the China Organ Transplant Response System(COTRS,***).[1]To fully optimize the implementation of organ transportation sharing policy and coordinate multiple government departments and social groups involved in the process,the"Green Channel of Human Organ Transport(GCHOT)"was established on May 6th,2016 in China[Supplementary Figure 1,http://***/CM9/A431].[2]In this study,we reviewed and compared the status of lung transportation between the pre-and post-GCHOT periods based on data collected from the largest lung transplantation(LT)center in Wuxi,Jiangsu,China,with the aim of introducing the detailed process and implementation of GCHOT in China.

关键词： center Figure policy

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湖南江华平地瑶话端组字今读[l]声母

语言研究 2015年第4期35卷 97-101页

作者：李星辉中南大学文学与新闻传播学院长沙410083

江华平地瑶话是江华瑶族说的汉语方言,带有明显的瑶族勉语的痕迹。在湘粤桂交界的土话区中,端组读[l]的现象出现在江永、江华、钟山、富川等瑶族集中分布的小片地带。勉语中存在tl、dl→l或d→l或n?的演变过程。湘桂粤交界地带这一小片... 详细信息

江华平地瑶话是江华瑶族说的汉语方言,带有明显的瑶族勉语的痕迹。在湘粤桂交界的土话区中,端组读[l]的现象出现在江永、江华、钟山、富川等瑶族集中分布的小片地带。勉语中存在tl、dl→l或d→l或n?的演变过程。湘桂粤交界地带这一小片土话端组读[l]的现象是这一地带的瑶族说汉语土话时的语音特色。

关键词：平地瑶话勉语端组声母[l] 成因

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《语言翻译文化》介评

语言与翻译 2008年第1期 79-80页

作者：李新惠新疆大学语言学院乌鲁木齐830008

翻译是跨语言、跨文化的交际活动，是各民族间进行文化交流不可或缺的重要桥梁。一部好的翻译理论作品，不仅能丰富翻译学理论研究，而且可以从实践上指导人们从事具体的翻译活动。新疆大学史震天教授的《语言翻译文化——汉维翻译理论... 详细信息

翻译是跨语言、跨文化的交际活动，是各民族间进行文化交流不可或缺的重要桥梁。一部好的翻译理论作品，不仅能丰富翻译学理论研究，而且可以从实践上指导人们从事具体的翻译活动。新疆大学史震天教授的《语言翻译文化——汉维翻译理论与实践探索》就是这样一部力作。该文集包含了作者近三十年来关于翻译理论研究方面的主要成果，

关键词：翻译理论研究跨语言跨文化实践探索交际活动文化交流译学理论翻译活动

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华东电网智能变电站运行管理模式研究

华东电力 2010年第6期38卷 808-811页

作者：李慧星华东电网有限公司上海200002

介绍了国内外关于智能变电站的理念,分析了数字化变电站与智能变电站的区别。从我国电网实际出发,对智能电网条件下的变电站运行和管理模式进行探讨,从电网运行和设备管理两个方面提出智能变电站的基本架构。阐述了构建基于智能电网的... 详细信息

介绍了国内外关于智能变电站的理念,分析了数字化变电站与智能变电站的区别。从我国电网实际出发,对智能电网条件下的变电站运行和管理模式进行探讨,从电网运行和设备管理两个方面提出智能变电站的基本架构。阐述了构建基于智能电网的设备管理决策模式。

关键词：智能电网智能变电站变电站运行管理