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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song xiaoguang li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Accumulation conditions and key exploration&development technologies of heavy oil in Huanxiling oilfield in liaohe depression,Bohai Bay Basin

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Petroleum Research 2020年第1期5卷 18-38页

作者： xiaoguang li Exploration and Development Research Institute PetroChina Liaohe Oilfield CompanyLiaoning124010China

The Huanxiling oilfield is located in the southern part of the western slope of the western sag in liaohe *** west side of this oilfield is connected with two sets of high-quality source rocks of Member 3 and Member 4 of Shahejie Formation in Qingshui *** oilfield has fan delta,turbidite fan and other types of reservoirs,it also has cap rock of thick mudstone in Member 3 and Member 4 of Shahejie *** background of the warped basement,the warped fault-block draped compound trap zone are developed,which includes nine types of *** perspective of hydrocarbon accumulation,the slope of this area has always been the target area for hydrocarbon migration and *** analysis shows that there are multiple stages of hydrocarbon charging in this area,and the main reservoir forming period is the sedimentary period of Member 3 of Shahejie Formation and the sedimentary period of Dongying ***-quality source-reservoir-cap conditions ensure large-scale hydrocarbon accumulation in this *** on the theory of compound hydrocarbon accumulation,many types of oil and gas reservoirs,including light oil reservoir and heavy oil reservoir,have been found in this area,with total reserves of 500 million *** view of the oilfield characterized by large reservoir burial span,multiple oil-bearing strata,strong heterogeneity and various types of oils,multi-batch seismic data processing&interpretation technology and thin reservoir inversion technology based on geological model are established in the preliminary exploration period,steam-flooding physical simulation technology of heavy oil,oil-reservoir fine description technology of thermal recovery heavy oil,steam huff and puff technology of ordinary heavy oil and steam-flooding technology of mid-deep buried heavy oil are developed in the development period,and technologies such as separate-layer injection,selective injection,sand control and lifting of heavy oil are matched and

关键词： Heavy oil exploration and development Reservoir-forming conditions Steam huff and puff Steam flooding Huanxiling oilfield liaohe depression Bohai Bay Basin

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A Novel Blind Motion Blur Restoration Algorithm for Text Images

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Chinese Journal of Electronics 2020年第1期29卷 161-167页

作者： WANG Simin li xiaoguang ZHANG Hui ZHUO li Faculty of Information Technology Beijing University of Technology

Text images captured by the surveillance system or hand-hold cameras often suffer from motion blur due to the complex relative motion between the camera and the target during the exposure time. The accuracy of the kernel estimation and the effective priors for clear text images are two important keys in blind motion deblurring.A novel blind motion deblurring algorithm is proposed for text images in a complex scene. A criterion for selecting informative edges and an L0constraint are combined to improve the accuracy of the kernel estimation. Then, a fast non-blind deconvolution scheme is applied to accelerate the algorithm. Experimental results on text images show that the proposed method can achieve high-quality results with low computational complexity.

关键词： Text image deblurring Informative edges selection L0-Regularized prior Blind motion restoration

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A Face Hallucination Algorithm via an LLE Coefficients Prior Model

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Chinese Journal of Electronics 2018年第6期27卷 1234-1240页

作者： li xiaoguang JIA Guangheng li Jiafeng ZHUO li Signal and Information Processing Laboratory Beijing University of Technology

In the most of exiting Local linear embedding(LLE)-based image super-resolution methods, a Low resolution(LR) image can be represented as a linear combination of LR training samples. In these methods, the combination coefficients of the LR image are directly used to estimate the High resolution(HR) image. However, experimental results show that the LR-LLE coefficients are different from the corresponding HR-LLE coefficients. To bridge the gap between LR and HR images, a novel LLEbased face hallucination algorithm is proposed. An LLE coefficients prior model is introduced to reduce the coefficient errors. In this prior model, the LLE coefficients of the interpolated LR face image are used to constraint the reconstructed coefficients. Experimental results show that the proposed method can provide improved performance over the compared methods.

关键词： Face hallucination Local linear embedding(LLE) Coefficients prior model Manifold learning

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A Naturalness-Preserved Low-light Enhancement Algorithm for Intelligent Analysis

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Chinese Journal of Electronics 2019年第2期28卷 316-324页

作者： ZHUO li HU Xiaochen li Jiafeng ZHANG Jing li xiaoguang Signal & Information Processing Laboratory Beijing University of Technology Collaborative Innovation Center of Electric Vehicles

Images/videos captured in low-light conditions often present low luminance and *** the existing low-light enhancement algorithms can improve the subjective perception, color distortion and over-enhancement are extremely obvious, which will disturb the subsequent intelligent analysis. Therefore,a naturalness-preserved low-light enhancement algorithm for intelligent analysis is proposed in this paper. An enhancement model is established in RGB color *** of ColorChecker color chart are captured under a series of light conditions. To preserve the naturalness,the factors of the proposed enhancement model are estimated by the images captured in practical illumination environment. Experimental results demonstrate that the proposed algorithm can produce natural enhanced results and improve the performance of vehicle license plate localization and skin color detection compared to the existing algorithms. Furthermore, the proposed algorithm can process the 720p videos at the speed of 28.3 fps on average.

关键词： Low-light enhancement Intelligent analysis Naturalness-preserved Vehicle license plate localizations Skin color detection

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Theoretical System of Sandstone-Type Uranium Deposits in Northern China

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Journal of Earth Science 2022年第2期33卷 257-277页

作者： Ruoshi Jin Huajian liu xiaoguang li Tianjin Centre China Geological SurveyTianjin 300170China Key Laboratory of Uranium Geology China Geological SurveyTianjin 300170China

Many theoretical results on sandstone-type uranium mineralization in northern China obtained by the uranium research team of the Tianjin Center of Geological Survey in recent years are *** the source sink system of uranium-producing basins,sedimentary environment of uranium-bearing rock series,ore-forming fluid information,evolution of tectonic events,basin formation and development,we redefine and classify uranium orebodies,redox zoning,and ore-controlling structural *** then systematically propose a theoretical system of sandstone-type uranium deposits in northern *** conclude that sandstone-type uranium deposits in northern China are mainly found in sedimentary environments such as rivers,deltas,and alluvial fans in the Mesozoic and Cenozoic lowstand systems tract and in gray sandstone layers in the vertical redox *** orebodies are controlled by the tectonic slope belt,which is in the shape of a strip on the plane,and spreads in a layer or plate on the ***(ups and downs)tectonic movement triggers large-scale phreatic flow in the basin,which is the real driving force for controlling the ore-forming *** theoretical system of sandstone-type uranium deposits in northern China should be based on global tectonic movement and environmental changes and take into account factors such as basins as a unit to study mineralization background,ore concentration areas as objects to study mineralization,and the correlation between regional tectonic movement and metallogenic process as a breakthrough point to study tectonic events and metallogenic *** should also be based on different basin types to establish metallogenic *** innovative research results and ideas are summarized with the aim of promoting the continuous improvement of sandstone-type uranium mineralization theory in northern China.

关键词： theoretical system metallogenic background mineralization metallogenic model vertical(ups and downs)tectonic movement sandstone-type uranium deposits ore deposit geology

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Decolorization of Methyl Orange by a new clay-supported nanoscale zero-valent iron:Synergetic effect,efficiency optimization and mechanism

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Journal of Environmental Sciences 2017年第2期29卷 8-17页

作者： xiaoguang li Ying Zhao Beidou Xi xiaoguang Meng Bin Gong Rui li Xing Peng Hongliang liu School of Environment Beijing Normal UniversityBeijing 100875China State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution Chinese Research Academy of Environmental SciencesBeijing 100012China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China School of Environmental and Municipal Engineering Lanzhou Jiaotong UniversityLanzhou 730070China Center for Environmental Systems Stevens Institute of TechnologyHobokenNJ 07030USA

In this study, a novel nanoscale zero-valent iron（n ZVI） composite material was successfully synthesized using a low-cost natural clay, ＂Hangjin 2~#clay＂（HJ clay） as the support and tested for the decolorization of the azo dye Methyl Orange（MO） in aqueous solution by n ZVI particles. According to the characterization and MO decolorization experiments, the sample with 5：1 HJ clay-supported n ZVI（HJ/n ZVI） mass ratio（HJ-n ZVI5） showed the best dispersion and reactivity and the highest MO decolorization efficiency. With the same equivalent Fe0 dosage, the HJ-n ZVI1 and HJ-n ZVI5 samples demonstrated a synergetic effect for the decolorization of MO： their decolorization efficiencies were much higher than that achieved by physical mixing of HJ clay and n ZVIs, or the sum of HJ clay and n ZVIs alone. The synergetic effect was primarily due to the improved dispersion and more effective utilization of the n ZVI particles on/in the composite materials. Higher decolorization efficiency of MO was obtained at larger HJ-n ZVI dosage, higher temperature and under N2 atmosphere, while the MO initial concentration and p H were negatively correlated to the efficiency. HJ clay not only works as a carrier for n ZVI nanoparticles, but also contributes to the decolorization through an ＂adsorption-enhanced reduction＂ mechanism. The high efficiency of HJ-n ZVI for decontamination gives it great potential for use in a variety of remediation applications.

关键词： Nanoscale zero-valent iron Clay Material optimization Methyl Orange

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The graph limit of the minimizer of the Onsager-Machlup functional and its computation

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Science China Mathematics 2021年第2期64卷 239-280页

作者： Qiang Du Tiejun li xiaoguang li Weiqing Ren Department of Applied Phgysics and Applied Mathematics Columbia UniversityNeu YorkNY 10027USA LMAM and School of Mathematical Sciences Peking UniversityBeijing 100871China Beijing Computational Science Research Certer Beijing 100193China MOE-LCSM School of Mathematics and StatisticsHunan Normal UniversityChangsha 410081China Department of Mathematics National University of SingaporeSingapore 119076Singapore

The Onsager-Machlup(OM)functional is well known for characterizing the most probable transition path of a diffusion process with non-vanishing ***,it suffers from a notorious issue that the functional is unbounded below when the specified transition time T goes to *** hinders the interpretation of the results obtained by minimizing the OM *** provide a new perspective on this *** mild conditions,we show that although the infimum of the OM functional becomes unbounded when T goes to infinity,the sequence of minimizers does contain convergent subsequences on the space of *** graph limit of this minimizing subsequence is an extremal of the abbreviated action functional,which is related to the OM functional via the Maupertuis principle with an optimal *** further propose an energy-climbing geometric minimization algorithm(EGMA)which identifies the optimal energy and the graph limit of the transition path *** algorithm is successfully applied to several typical examples in rare event *** interesting comparisons with the Freidlin-Wentzell action functional are also made.

关键词： Onsager-Machlup functional Freidlin-Wentzell functional graph limit geometric minimization Maupertuis principle

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Regeneration strategies after the adult mammalian central nervous system injury—biomaterials

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Regenerative Biomaterials 2016年第2期3卷 115-122页

作者： Yudan Gao Zhaoyang Yang xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China

The central nervous system(CNS)has very restricted intrinsic regeneration ability under the injury or disease *** repair strategies,therefore,are urgently needed to facilitate tissue regeneration and functional *** published tissue repair/regeneration strategies,such as cell and/or drug delivery,has been demonstrated to have some therapeutic effects on experimental animal models,but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells,difficulty in integrating with the host or restriction of blood-brain barriers to administration *** biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area,but also sustainably deliver bioproducts to the local injured area,thus improving the microenvironment in that *** review mainly introduces the advances of various strategies concerning facilitating CNS regeneration.

关键词： central nervous system injury neurogenesis biomaterials axonal regeneration neural stem/precursor cell

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