检索结果-南通市图书馆

Galectin 2 regulates JAK/STAT3 signaling activity to modulate oral squamous cell carcinoma proliferation and migration in vitro

引用

BIOCELL 2024年第5期48卷 793-801页

作者： XINRU FENG li xiao Medical School University of Electronic Science and Technology of ChinaChengdu610072China Department of Stomatology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Background:Galectin 2(LGALS2)is a protein previously reported to serve as a mediator of disease progression in a range of *** function of LGALS2 in oral squamous cell carcinoma(OSCC),however,has yet to be explored,prompting the present study to address this literature ***:Overall,144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western *** LGALS2 coding sequence was introduced into the pcDna3.0 vector,to enable the overexpression of this gene,while an LGALS2-specific shRna and corresponding controls were also *** functionality of LGALS2 as a regulator of the ability of OSCC cells to grow and undergo apoptotic death in vitro was assessed through EdU uptake and CCK-8 assays,and flow cytometer,whereas a Transwell system was used to assess migratory activity and *** agonist of the Janus Kinase 2(JAK2)/Signal Transducer and Activator of Transcription 3(STAT3)pathway was also used to assess the role of this pathway in the context of LGALS2 ***:Here,we found that lower LGALS2 protein and mRna expression were evident in OSCC tumor tissue samples,and these expression levels were associated with clinicopathological characteristics and patient survival *** LGALS2 enhanced proliferation in OSCC cells while rendering these cells better able to resist *** opposite was instead observed after LGALS2 was ***,the ability of LGALS2 to suppress the progression of OSCC was related to its ability to activate the JAK/STAT3 signaling ***:Those results suggest a role for LGALS2 as a suppressor of OSCC progression through its ability to modulate JAK/STAT3 signaling,supporting the potential utility of LGALS2 as a target for efforts aimed at treating OSCC patients.

关键词： LGALS2 Oral squamous cell carcinoma(OSCC) Janus Kinase 2/Signal Transducer and Activator of Transcription 3(JAK2-STAT3) Progression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temporal assembly patterns of microbial communities in three parallel bioreactors treating low-concentration coking wastewater with differing carbon source concentrations

引用

Journal of Environmental Sciences 2024年第3期137卷 455-468页

作者： Weijia li Yu Xia na li Jie Chang Jing liu Pei Wang Xuwen He School of Chemical and Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China

Carbon source is an important factor of biological treatment systems, the effects of which on their temporal community assembly patterns are not sufficiently understood *** this study, the temporal dynamics and driving mechanisms of the communities in three parallel bioreactors for low-concentration coking wastewater(CWW) treatment with differing carbon source concentrations(S0 with no glucose addition, S1 with 200 mg/L glucose addition and S2 with 400 mg/L glucose addition) were comprehensively studied. Highthroughput sequencing and bioinformatics analyses including network analysis and Infer Community Assembly Mechanisms by Phylogenetic bin-based null model(iCAMP) were used. The communities of three systems showed turnover rates of 0.0029~0.0034 every 15days. Network analysis results showed that the S0 network showed higher positive correlation proportion(71.43%) and clustering coefficient(0.33), suggesting that carbon source shortage in S0 promoted interactions and cooperation of microbes. The neutral community model analysis showed that the immigration rate increased from 0.5247 in S0 to 0.6478in S2. The iCAMP analysis results showed that drift(45.89%) and homogeneous selection(31.68%) dominated in driving the assembly of all the investigated microbial *** contribution of homogeneous selection increased with the increase of carbon source concentrations, from 27.92% in S0 to 36.08% in S2. The OTUs participating in aerobic respiration and tricarboxylic acid(TCA) cycle were abundant among the bins mainly affected by deterministic processes, while those related to the metabolism of refractory organic pollutants in CWW such as alkanes, benzenes and phenols were abundant in the bins dominated by stochastic processes.

关键词： Coking wastewater treatment Temporal dynamics Network analysis Deterministic processes Stochastic processes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural and Behavioral Measures of Stress-induced Impairment in Error Awareness and Post-error Adjustment

引用

Neuroscience Bulletin 2024年第7期40卷 937-951页

作者： na Hu Quanshan Long xiaoxi Wang Quan li Qing li Antao Chen School of Preschool and Special Education Kunming UniversityKunming 650214China Faculty of Education Yunnan Normal UniversityKunming 650214China College of Teacher Education Qujing Normal UniversityQujing 655099China Key Laboratory of Cognition and Personality of Ministry of Education Faculty of PsychologySouthwest UniversityChongqing 400715China School of Psychology Shanghai University of SportShanghai 200438China

Exposure to stress negatively affects error processing,but the impact of stress on error awareness remains to be *** the present study,we examined the temporal dynamics of error awareness and post-error adjustment following acute ***-nine healthy men were randomly assigned to the control(n=26)or stress group(n=23).After stress induction,participants completed the error awareness task,and their brain activity was assessed by *** to the control group,the stress group demonstrated lower error awareness accuracy and smaller Pe(error positivity)and ΔPe amplitudes following aware error responses,which indicated impairment of error awareness following ***,the stress group had lower accuracy in post-aware error responses than in post-unaware error responses and the control group,which indicated poor post-error adjustment following *** results showed a stress effect on sequential stages of error *** induces impaired error identification,which further generates maladaptive post-error performance.

关键词： Acute stress Error awareness Post-error adjustment Error positivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The microbial community and flavour substances of off-flavoured rice sour soup during storage

引用

Food Science and Human Wellness 2024年

作者： Xiuli li na liu likang Qin Ting Zhu Ruyue xiao Song Miao School of liquor and Food Engineering， Guizhou University Majiang Mingyang Foods Co. Teagasc Food Research Centre， Moorepark， Fermoy， Co.Cork

Fermented sour soup is a unique traditional sour food of the Miao and Dong ethnic groups in China. However， due to the commonly used traditional fermentation， the unstable fluctuation of microbial community often leads to some unpleasant inherent off-flavours in rice sour soup. In this study， the microbial composition and volatile flavour components of off-flavour and normal rice sour soup were examined by high-throughput sequencing (HTS) and headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS). Then， based on Pearson correlation coefficients， the correlations between fungi and bacteria and those between core microorganisms and key volatile flavour components were investigated. The dominant fungal genera included Candida， Dekkera， Pichia， Rhizopus， and Issatchenkia， whereas the dominant bacterial genera included Lactobacillus， Pectinatus， Bifidobacterium， Pseudomonas， and Acetobacter. Compared to normal rice sour soup， off-flavoured rice sour soup contained the significantly increased relative abundance of Candida and the significantly decreased relative abundance of Dkkera. In addition， 80 volatile flavour compounds detected in off-flavoured rice sour soup， mainly including esters， acids， and alcohols， were different from those detected in normal rice sour soup. Especially， some substances were only detected in off-flavoured rice sour soup， such as 1-hexanol (68-207 μg/kg)， butyric acid (20-91 μg/kg) and heptanoic acid (11-44 μg/kg)， which might be the main source of off-flavours. These results provide new ideas and strategies of removing or abating odour from fermented rice sour soup.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

“爱而不亲”:留守儿童的亲子关系体验与建构

引用

华东师范大学学报（哲学社会科学版） 2022年第1期54卷 108-117,174,175页

作者：肖莉娜华东理工大学华东社会发展研究所上海200237

综合儿童的视角和结构的视角,可以对留守儿童研究中流行的问题取向叙说进行再平衡。基于在湖南乡村的田野调查,可以发现留守儿童充满矛盾的亲子关系体验,从而揭示出他们创造性建构的打工-留守情境下“爱而不亲”的亲子关系。在此基础上... 详细信息

综合儿童的视角和结构的视角,可以对留守儿童研究中流行的问题取向叙说进行再平衡。基于在湖南乡村的田野调查,可以发现留守儿童充满矛盾的亲子关系体验,从而揭示出他们创造性建构的打工-留守情境下“爱而不亲”的亲子关系。在此基础上,可以进一步分析“爱而不亲”内在的情感张力是扎根于追求“过好日子”的家庭生活实践的,这样的生活实践既是物质性的,也是情感性的;既是被社会结构和文化所塑造,也是结构和文化变迁的推动力。

关键词：留守儿童亲子关系儿童的视角能动性

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the properties of solar cell under bias condition by using impedance spectroscopy

引用

Optoelectronics Letters 2024年第9期20卷 518-522页

作者： xiao Wenbo li Ao xiao Bangzhi Key Laboratory of Nondestructive Test Ministry of EducationNanchang Hangkong UniversityNanchang 330063China Science and Technology College Nanchang Hangkong UniversityGongqingcheng 332020China School of Engineering and Construction Nanchang UniversityNanchang 330031China

This paper investigates the properties of silicon cells(SI)and perovskite solar cells(PSC)under bias condition by using impedance *** parallel resistances R_(p) of SI and PSC are found to decrease with increasing bias,but the capacitance C_(p) shows the opposite *** Rp with C_(p),bias has a greater impact on the C_(p) of both cells.

关键词： spectroscopy impedance condition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process

引用

Petroleum Science 2024年第2期21卷 1369-1384页

作者： Chong-Zheng Sun Yu-Xing li Hui Han xiao-Yi Geng xiao Lu College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation Safety China University of PetroleumQingdao 266580ShandongChina

liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat *** results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow.

关键词： Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mesoscale Mechanical Properties and Influencing Factors of Concrete under Uniaxial Tension

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1156-1168页

作者： CHEN Tao li Kungang xiao Shiyun State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Monte Carlo simulations were carried out to generate a mesoscale model of concrete with randomly packed aggregates with different shapes and *** mechanical properties of concrete specimens under uniaxial tensile loads were studied using statistical *** results indicated that the entire process of damage and failure of specimens exhibited mainly two failure types:fracture patternsⅠandⅡ.Furthermore,the influences of the aggregate content ratio,aggregate shape,aggregate size,interfacial transition zone(ITZ)strength,and porosity ratio on the concrete specimens were *** numerical simulation results showed that the elastic modulus of the concrete specimens increased approximately linearly with the aggregate volume ratio but decreased linearly with the porosity and was not affected by the ITZ *** tensile strength decreased with the increases in the aggregate content and porosity of the sample,but increased linearly with the ITZ *** addition,the aggregate shape led to a difference in the tensile strength of the concrete.

关键词： concrete mechanical behavior aggregate interfacial transition zone pore

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Double stabilizations and convergence analysis of a second-order linear numerical scheme for the nonlocal Cahn-Hilliard equation

引用

Science China Mathematics 2024年第1期67卷 187-210页

作者： xiao li Zhonghua Qiao Cheng Wang Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong KongChina Department of Mathematics The University of MassachusettsNorth DartmouthMA 02747USA

In this paper,we study a second-order accurate and linear numerical scheme for the nonlocal CahnHilliard *** scheme is established by combining a modified Crank-Nicolson approximation and the Adams-Bashforth extrapolation for the temporal discretization,and by applying the Fourier spectral collocation to the spatial *** addition,two stabilization terms in different forms are added for the sake of the numerical *** conduct a complete convergence analysis by using the higher-order consistency estimate for the numerical scheme,combined with the rough error estimate and the refined *** regarding the numerical solution as a small perturbation of the exact solution,we are able to justify the discrete?^(∞)bound of the numerical solution,as a result of the rough error ***,the refined error estimate is derived to obtain the optimal rate of convergence,following the established?∞bound of the numerical ***,the energy stability is also rigorously proved with respect to a modified *** proposed scheme can be viewed as the generalization of the second-order scheme presented in an earlier work,and the energy stability estimate has greatly improved the corresponding result therein.

关键词： nonlocal Cahn-Hilliard equation second-order stabilized scheme higher-order consistency analysis rough and refined error estimate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

引用

Zoological Research 2024年第5期45卷 1001-1012页

作者： li-na Cha Juan Yang Jin-Ai Gao Xin Lu xiao-Long Chang Rebecca Caroline Thuku Qi liu Qiu-Min Lu Dong-Sheng li Ren Lai Ming-Qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：