检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

应用低密度SNP芯片解析玉米遗传多样性

玉米科学 2024年第1期32卷 26-32页

作者：高嵩张楠何欢郑淑波赵桐周小辉代秀云黄威王薪淇吉林省农业科学院长春130033 吉林农业大学长春130118

利用1K低密度SNP标记,对不同亚群的95份自交系材料进行群体遗传结构、遗传多样性和类群间遗传关系分析。结果表明,来自不同玉米亚群的95份自交系可划分为4个主要类群,符合血缘背景;主等位基因频率平均值为0.7607,基因多样性平均值为0.31... 详细信息

利用1K低密度SNP标记,对不同亚群的95份自交系材料进行群体遗传结构、遗传多样性和类群间遗传关系分析。结果表明,来自不同玉米亚群的95份自交系可划分为4个主要类群,符合血缘背景;主等位基因频率平均值为0.7607,基因多样性平均值为0.3178,杂合度观测值平均值为0.0734,PIC值平均值为0.2570。在1249个SNP标记中,多态性较好的占比72.06%。基于GenoBaits的基因型鉴定技术可低成本且高效地解析种质的遗传背景和亲缘关系,为专、特用玉米分子标记辅助育种提供了可靠的技术依托。

关键词：玉米 SNP 类群划分聚类分析

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-long Chen Shaomin Chen shiqiang Chen Tianlu Chen wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun dai Xinchen dai Xuwen dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille dalian Minzu University DalianLiaoning dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Design of Tough, yet Strong, Heat-resistant PLA/PBAT Blends with Reconfigurable Shape Memory Behavior by Engineering Exchangeable Covalent Crosslinks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2023年第12期41卷 1868-1878,I0007页

作者： xiao-Wen Zhou Jing huang Xu-hui Zhang Ting li Yang wang shi-Bo wang Bi-Hua Xia wei-Fu dong The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China

Polylactide(PLA)has often been blended with biodegradable poly(butylene adipate-co-terephthalate)(PBAT)to improve its ***,the strength and heat resistance of PLA are always ***,exchangeable hydroxyl-ester crosslinks are constructed in PLA/PBAT blends by successively introducing a tertiary amine-containing polyol,bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane(BTM)and 4,4’-diphenylmethane diisocyanate(MDI)via reactive *** can react with both PLA and PBAT by transesterification,generating PLA or PBAT chains with terminal or pendant hydroxyl groups,which can then react with MDI to form *** internal catalysis of tertiary amine moiety in BTM,transesterification between the residual hydroxyl groups and ester bonds can occur at high temperatures,endowing the PLA/PBAT network with vitrimeric *** to the transesterification and chain extension reactions with MDI between PLA and PBAT,the interfacial adhesion is greatly *** a result of the excellent interfacial adhesion and the network structure,the prepared PLA/PBAT blends show greatly enhanced heat resistance and toughness(more than 40 times that of PLA)while maintaining high stiffness comparable to ***,the prepared PLA/PBAT blends exhibit promising reconfigurable shape memory *** present work provides a new and facile way to achieve high-performance and functional biodegradable polymeric materials.

关键词： Polylactide Dynamic covalent bonds Strengthening and toughening Heat resistance Shape memory

在线全文

学校读者我要写书评

暂无评论

口服中成药临床应用药物警戒指南

中国中药杂志 2024年第16期49卷 4273-4278页

作者：王连心杨硕魏瑞丽黎元元崔鑫赵晓晓彭文茜刘福梅王萌萌李秀惠王志飞谢雁鸣中国中医科学院中医临床基础医学研究所北京100700 首都医科大学附属北京佑安医院北京100069

口服中成药是我国历代医药学家经过几千年医疗实践创造、总结的有效方剂的精华,具有疗效显著、便于携带、使用方便等特点。但目前,口服中成药剂型丰富、种类繁多、作用机制复杂、临床定位宽泛,临床应用中常出现超说明书用药、重复用药... 详细信息

口服中成药是我国历代医药学家经过几千年医疗实践创造、总结的有效方剂的精华,具有疗效显著、便于携带、使用方便等特点。但目前,口服中成药剂型丰富、种类繁多、作用机制复杂、临床定位宽泛,临床应用中常出现超说明书用药、重复用药、用药时间过长等情况,使不良反应、肝肾毒性等安全性问题凸显,口服中成药药物警戒工作面临挑战。世界卫生组织(WHO)发布了《WHO药物警戒体系草药安全性监测指南》,国际人用药品注册技术协调会(ICH)发布了《ICH E2药物警戒指南系列》,美国出台《药物警戒管理规范与药物流行病学评估指南》,欧盟出台《药物警戒实践指南》,亚太地区的日本、韩国等已构建了自己的药物警戒体系,但目前国内尚无口服中成药相关的药物警戒指南。因此,邀请来自全国众多学科领域的专家共同研制了《口服中成药临床应用药物警戒指南》,旨在制订符合中国国情和突出口服中成药特点的临床应用药物警戒指南,为医疗机构临床安全、合理用药提供指导。

关键词：团体标准口服中成药指南临床应用药物警戒

桔梗特异DNA条形码筛选、种质资源鉴定及遗传多样性分析

在线全文

学校读者我要写书评

暂无评论

药学学报 2024年第1期59卷 243-252页

作者：王馨石玥满金辉黄钰莹张晓芹安克露何高洁刘子齐关范圆郑语嫣王晓晖魏胜利北京中医药大学中药学院北京102488 北京中医药大学北京中医药研究院中药现代研究中心北京102488 北京中医药大学生命科学院北京102488 黑龙江诺初中药材种植有限公司黑龙江哈尔滨150600

中药材桔梗为桔梗科植物桔梗的干燥根,具有多种药理作用,是常用的大宗中药材。本研究利用Illumina HiSeq X Ten平台对6份来自不同产地的桔梗进行叶绿体基因组测序,筛选特异性DNA条形码,基于特异性DNA条形码对不同产区的桔梗样品的种质... 详细信息

中药材桔梗为桔梗科植物桔梗的干燥根,具有多种药理作用,是常用的大宗中药材。本研究利用Illumina HiSeq X Ten平台对6份来自不同产地的桔梗进行叶绿体基因组测序,筛选特异性DNA条形码,基于特异性DNA条形码对不同产区的桔梗样品的种质资源和遗传多样性进行分析。6份桔梗叶绿体基因组全长为172260~172275 bp,均呈现典型的环状四分体结构,编码141个基因。根据比较基因组学分析和扩增效率分析发现trnG-UCC和ndhG_ndhF可作为潜在的桔梗种内种质资源鉴定的特异性DNA条形码。对来自9省15个产地305份桔梗样品的trnG-UCC和ndhG_ndhF进行PCR扩增和序列分析,结果表明trnG-UCC和ndhG_ndhF分别有5和11个变异位点,分别鉴定到5和7个单倍型;两段序列联合分析鉴定13个单倍型(Hap1~Hap13),其中占比最多的是Hap4,其次是Hap1。3个产地拥有的特异单倍型,可作为该产地的DNA分子标签与其他产地的桔梗种质资源进行区分。单倍型多样性、核苷酸多样性和遗传距离分别为0.94、4.79×10^(-3)和0.0000~0.0203,表明桔梗在物种水平上有较高的遗传多样性,种内各单倍型之间亲缘关系比较接近。本研究为桔梗产地鉴定、种质资源保护利用和分子育种等工作奠定基础。

关键词：桔梗叶绿体基因组 DNA条形码种质资源遗传多样性

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

在线全文

学校读者我要写书评

暂无评论

基于DNA条形码及HPLC对市售刺五加的种质资源鉴定和质量评价

动物学研究 2024年第2期 242页

作者： xiu-Sheng Chen Rui Han Yan-Ting liu wei huang Qi wang Xin Xiong ying Zhang Jian-Guo Zhao shi-Hua li xiao-Jiang li wei-li Yang

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

药学学报 2024年第7期59卷 2171-2178页

作者：刘珊瑚张志飞黄钰莹刘子齐陈文沁阿木拉哈王馨石玥张晓芹何高洁安克露王晓晖魏胜利北京中医药大学中药学院北京102488 北京中医药大学北京中医药研究院中药现代研究中心北京102488 中药材规范化生产教育部工程研究中心北京100102 黑龙江北草堂中药材有限责任公司黑龙江哈尔滨150900

刺五加Acanthopanax senticosus(*** Maxim.)Harms是我国东北道地药材之一,本研究根据之前的叶绿体基因组测序结果,选取atpI和atpB_rbcL基因片段对市售刺五加样品进行种质资源鉴定,并利用HPLC对其紫丁香苷含量进行测定,以期确定市售刺... 详细信息

刺五加Acanthopanax senticosus(*** Maxim.)Harms是我国东北道地药材之一,本研究根据之前的叶绿体基因组测序结果,选取atpI和atpB_rbcL基因片段对市售刺五加样品进行种质资源鉴定,并利用HPLC对其紫丁香苷含量进行测定,以期确定市售刺五加的主流种质和质量。本研究从24省47市收集80份刺五加样品并提取DNA,通过PCR扩增atpI和atpB_rbcL基因片段,分析结果表明,2个基因片段联合分析形成7个单倍型(H2、H5、H8、H10、H12、H14、H23),其中来自黑龙江伊春、哈尔滨尚志、黑龙江绥化、辽宁抚顺、辽宁本溪、吉林长白和吉林靖宇的单倍型H2是主流单倍型,占总样本量的58.75%。H14和H23为产地独有单倍型,分别来自黑龙江省双鸭山市饶河县和黑龙江省绥化市明水县。通过HPLC检测市售刺五加样品中的紫丁香苷含量,结果表明73.96%样品紫丁香苷含量符合药典标准。样品间的紫丁香苷含量差异显著,在0.0037%~0.5245%之间,相差0.5208%,说明刺五加市场样品质量参差不齐,但是不同单倍型之间市售刺五加紫丁香苷含量没有显著性差异。市场样品中单倍型H23中的紫丁香苷含量比较高,因此可能是质量比较好的种质。本文对刺五加市场样品的种质资源和药材质量进行研究,有利于指导刺五加市场样品流通、临床合理用药和后续优良品种筛选。

关键词：刺五加 DNA条形码分子鉴定紫丁香苷质量评价

Mechanical properties of a microalloyed bainitic steel after hot forging and tempering

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2017年第11期24卷 1085-1094页

作者： zhi-bao Xu wei-jun hui Zhan-hua wang Yong-jian Zhang xiao-li Zhao xiu-ming Zhao School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China z School of Materials Engineering Nanjing Institute of TechnologyNanjing 211167JiangsuChina

Mechanical properties of a newly developed microalloyed bainitic steel were investigated after the hot forging, air cooling and tempering process. The microstructure of the as forged bainitic steel mainly consists of granular bainite and -20 vol. % martensite. The fraction of retained austenite remains unchanged until tempering at 200 ℃, above which it decreases significantly. The increase of tempering temperature leads to decreases of both ultimate tensile strength and total elongation but decreases of both yield strength and reduction of area. The maximum and mini- mum values of impact toughness were observed after tempering at around 200 and 400 ℃, respectively. These effects are mainly attributed to the decomposition of martensite/austenite con stituents and the tempering effects in martensite. The tempering of the forged bainitic steel at around 200 ℃ results in an excellent combination of strength and toughness, which is comparable to that of the conventional quenched and-tempered 40Cr steel. Therefore, low-tempering treatment coupled with post-forging residual stress relieving is a feasible method to further improve the mechanical prooerties of the bainitic foging steel.

关键词： Bainitic forging steel Mechanical property Tempering Microstructure Granular bainite

A QTC-based signal readout for position-sensitive multi-output detectors

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2016年第5期27卷 208-214页

作者： wei Zhou zhi-Ming Zhang dao-Wu li Pei-lin wang Bao-Tong Feng Xian-Chao huang Ting-Ting Hu xiao-hui li Yan Chen ying-Jie wang Yan-Tao liu Yi-Wen Zhang shi-Feng Sun xiao-Yue Gu Ming-Jie Yang Xiong xiao long wei Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Beijing Engineering Research Center of Radiographic Techniques and Equipment Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049

A new signal readout method for position-sensitive multi-output detectors,such as those in high-energy spectroscopy measurement and nuclear imaging,was developed by combining the charge division circuit,summing circuit and charge-to-time conversion(QTC) *** 64 outputs of a Hamamatsu H8500 position-sensitive photomultiplier tube were processed,and three digital pulses were *** widths of digital pulses were determined using the time-to-digital converter in an field programmable gate *** energy and position information of incident y-rays is estimated based on the proportionality between the width of digital pulses and input charge created by y-photons.A prototype was built using discrete components and tested,and the energy and position resolutions were improved compared with that obtained with standard *** method greatly simplifies the front-end electronics and the digital *** enables a compact electronics system and an easy integration into an ASIC.

关键词：输出信号位置灵敏探测器多输出读出位置灵敏光电倍增管现场可编程门阵列时间-数字转换器位置敏感探测器