检索结果-南通市图书馆

同方期刊数据库

Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled MALDI-Q-TOF/MS imaging

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第2期14卷 284-286页

作者： lixing Nie lieyan Huang Xiaofei Jia Shuai Kang lingwen Yao Yanpei Wu Hao Yuan Yongli liu Feng Wei Hongyu Jin xiang li Shuangcheng Ma National Institutes for Food and Drug Control Beijing102629China Chinese Academy of Medical Science and Peking Union Medical College Beijing100006China Waters Corporation Beijing102600China Hebei Institute for Drug and Medical Device Control Shijiazhuang050227China Department of Pharmacy Medical Supplies Center of the PLA General HospitalBeijing100853China

Unraveling the distribution of metabolites in traditional Chinese medicine(TCM)provides direct indications for understanding their regulatory and functional basis,which is of paramount significance for better utilization and quality control of medicinal plants[1].Recently,imaging techniques such as near-infrared spectroscopy,Raman spectroscopy,and mass spectrometry(MS)were explored to reveal the spatial context of component accumulation and localization[2,3].

关键词： medicine(TCM) Radix Scutellaria

Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang ling Ji Yong-liang Lou xiang li School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

2023:A year of accomplishments for the 13 Science Citation Index Expanded-and Emerging Sources Citation Index-indexed Baishideng journals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第1期30卷 9-16页

作者： Jin-Lei Wang Jia-Ping Yan Jia-Ru Fan xiang li Xu Guo Jia-Wei li Yun-Xiaojian Wu Jing-Jie Wang Yu-Lu Chen li li Cong lin Xin-liang Qu Ji-Hong liu Yan-liang Zhang Ying-Yi Yuan Hua-Ge Yu Yu-Xi Chen Yi-Xuan Cai xiang-Di Zhang Si Zhao Zi-Hang Xu li Ma Na Ma Diao-Mei Guo lian-Sheng Ma Baishideng Publishing Group Inc PleasantonCA 94566United States

In 2023,Baishideng Publishing Group(Baishideng)routinely published 47 openaccess journals,including 46 English-language journals and 1 Chinese-language *** successes were accomplished through the collective dedicated efforts of Baishideng staffs,Editorial Board Members,and Peer *** these 47 Baishideng journals,7 are included in the Science Citation Index Expanded(SCIE)and 6 in the Emerging Sources Citation Index(ESCI).With the support of Baishideng authors,company staffs,Editorial Board Members,and Peer Reviewers,the publication work of 2023 is about to be successfully *** editorial summarizes the 2023 activities and accomplishments of the 13 SCIEand ESCI-indexed Baishideng journals,outlines the Baishideng publishing policy changes and additions made this year,and highlights the unique advantages of Baishideng journals.

关键词： Baishideng Publishing Group Journal Impact Factor Open access Policy changes Policy additions Unique advantages Anxiety disorders Colorectal cancer Inflammatory bowel disease Hepatocellular carcinoma Gut microbes Atrial fibrillation

SMEC:Scene Mining for E-Commerce

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2024年第1期39卷 192-210页

作者：王罡李翔郭子义殷大伟马帅 State Key Laboratory of Software Development Environment Beihang UniversityBeijing 100191China School of Data Science and Engineering East China Normal UniversityShanghai 200062China *** Inc.Beijing 100176China Baidu Inc.Beijing 100085China

Scene-based recommendation has proven its usefulness in E-commerce,by recommending commodities based on a given ***,scenes are typically unknown in advance,which necessitates scene discovery for *** this article,we study scene discovery for E-commerce *** first formalize a scene as a set of commodity cate-gories that occur simultaneously and frequently in real-world situations,and model an E-commerce platform as a heteroge-neous information network(HIN),whose nodes and links represent different types of objects and different types of rela-tionships between objects,*** then formulate the scene mining problem for E-commerce as an unsupervised learning problem that finds the overlapping clusters of commodity categories in the *** solve the problem,we pro-pose a non-negative matrix factorization based method SMEC(Scene Mining for E-Commerce),and theoretically prove its *** six real-world E-commerce datasets,we finally conduct an extensive experimental study to evaluate SMEC against 13 other methods,and show that SMEC consistently outperforms its competitors with regard to various evaluation measures.

关键词： graph clustering E-commerce heterogeneous information network(HIN) scene mining

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新时代国家安全法学论纲

中国法学 2024年第3期 144-163页

作者：李翔华东政法大学刑事法学院、国家安全研究院

国家安全法治化是国家安全现代化的核心要义。新形势下推进国家安全体系和能力现代化、完善国家安全法治体系、服务国家安全法治化新需求,亟需贯彻总体国家安全观和习近平法治思想,构建新时代国家安全法学。一是立足“国家安全”这一基... 详细信息

国家安全法治化是国家安全现代化的核心要义。新形势下推进国家安全体系和能力现代化、完善国家安全法治体系、服务国家安全法治化新需求,亟需贯彻总体国家安全观和习近平法治思想,构建新时代国家安全法学。一是立足“国家安全”这一基石范畴,构建由国家重大利益、危害国家安全因素、国家安全体系和能力、国家安全职责与义务、国家安全行为等构成的国家安全法学基本范畴体系;二是围绕国家安全法治化主线和国家安全法律制度体系主要内容,形成两大基础领域、三大贯通领域、二十余个重点安全领域相结合的次级学科群;三是针对国家安全法学研究对象的特点,应注重运用法教义学、跨学科研究方法;四是通过比较借鉴,探索我国自主的国家安全法学知识体系和学科建设路径。

关键词：总体国家安全观习近平法治思想国家安全法治化国家安全法学

同方期刊数据库

R-PP/BM/SEP复合材料的制备及其性能

在线全文

学校读者我要写书评

暂无评论

合成树脂及塑料 2024年第2期41卷 26-29页

作者：李湘湖南化工职业技术学院湖南株洲412000

以日杂聚丙烯废塑料(简称R-PP)为原料,海泡石(SEP)和勃姆石(BM)为阻燃剂,通过熔融挤出制备了R-PP/BM/SEP复合材料,对复合材料的极限氧指数(LOI)、垂直燃烧等级(UL 94)及力学性能进行测试与分析。结果表明:w(BM)为25%时,R-PP/BM复合材料... 详细信息

以日杂聚丙烯废塑料(简称R-PP)为原料,海泡石(SEP)和勃姆石(BM)为阻燃剂,通过熔融挤出制备了R-PP/BM/SEP复合材料,对复合材料的极限氧指数(LOI)、垂直燃烧等级(UL 94)及力学性能进行测试与分析。结果表明:w(BM)为25%时,R-PP/BM复合材料的LOI提高到26.9%,厚度为3.2 mm的试样阻燃等级达UL 94 V-1级,质量损失5%时的温度(t_(5%))、质量损失速率最大时的温度(t_(max))和残炭量都相应提高;SEP与BM在R-PP中有协同阻燃效果,w(SEP)为3%,w(BM)为22%时,复合材料的LOI为31.4%,厚度为3.2,2.0 mm的试样阻燃等级分别达到UL 94 V-0,V-1级,与单独添加25%(w)BM的R-PP/BM复合材料相比,其热释放速率峰值、平均热释放速率、总热释放量和总生烟量较低,点燃时间,火灾性能指数,t_(5%),t_(max)和残炭量较高;添加SEP可以提高R-PP/BM的力学性能。

关键词：日杂聚丙烯废塑料海泡石勃姆石锥形量热

在线全文

学校读者我要写书评

暂无评论

刑事案例指导制度统一法律适用的机制完善

东方法学 2024年第1期 179-188页

作者：李翔华东政法大学刑事法学院

案例指导制度的功能定位在于统一法律适用。法教义学的理论供给缺位、司法解释的抽象性、新兴的疑难案件和传统的边缘案件都可能给法律的统一适用造成阻碍,而案例指导制度对这些阻碍因素均有化解作用。指导性案例的生命力在于其所建议... 详细信息

案例指导制度的功能定位在于统一法律适用。法教义学的理论供给缺位、司法解释的抽象性、新兴的疑难案件和传统的边缘案件都可能给法律的统一适用造成阻碍,而案例指导制度对这些阻碍因素均有化解作用。指导性案例的生命力在于其所建议的处理方案的优越性,不应赋予其强制效力。为实现该制度的应然的功能定位,指导性案例必须具备翔实的说理。此外,还应当以“统一法律适用”为准绳,优化当前指导性案例的选编制度以及相关的配套机制。

关键词：案例指导制度法律适用强制适用选编制度疑难案件法教义学

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

“清党”后国民党军队政治工作的蜕化

广东社会科学 2024年第1期 104-121,285,286页

作者：李翔哈尔滨工业大学(深圳)马克思主义学院广东深圳518055

“清党”后,国民党军队的政治工作不仅没有像设想的那样振衰起敝,反而加速异化。思想建设上,党与政治工作分离,官兵有意疏离主义与信仰。宣传工作上,政治革命与社会革命的声音快速沉寂下去。军政领袖在党军关系、土地问题等方面言行背离... 详细信息

“清党”后,国民党军队的政治工作不仅没有像设想的那样振衰起敝,反而加速异化。思想建设上,党与政治工作分离,官兵有意疏离主义与信仰。宣传工作上,政治革命与社会革命的声音快速沉寂下去。军政领袖在党军关系、土地问题等方面言行背离,使得军民之间的距离越隔越远。组织工作上,轻视党的建设,迷恋武力,既是党权虚弱的根由,又刺激着军权的进一步独大。在军事领袖的联手打击下,政治工作反而成为国民党中央的眼中钉和弃子。在武力万能的喧嚣声中,“清党”后军队政治工作的蜕化,成为国民党政权覆灭的深层“病灶”。

关键词： “清党” 国民党军队政治工作

论负有照护职责人员性侵罪的规范构造与实践逻辑

在线全文

学校读者我要写书评

暂无评论

华东政法大学学报 2024年第5期27卷 105-115页

作者：李翔华东政法大学刑事法学院、国家安全研究院

负有照护职责人员性侵罪保护的法益不是“性自主决定权”,也不是“不被诱骗的性自决权”。本罪的保护法益应该是复合法益,即低龄未成年女性(已满14周岁不满16周岁)的身心健康和社会的公序良俗。本罪中的“发生性关系”不应该限定为“性... 详细信息

负有照护职责人员性侵罪保护的法益不是“性自主决定权”,也不是“不被诱骗的性自决权”。本罪的保护法益应该是复合法益,即低龄未成年女性(已满14周岁不满16周岁)的身心健康和社会的公序良俗。本罪中的“发生性关系”不应该限定为“性交”,而应该解释为包括“口交”“肛交”等在内的一切性行为,也包括在被害人同意情况下的猥亵行为。本罪的实践逻辑是,应从行为人与被害人的不对等关系及强化行为主体注意义务的角度分析本罪的行为主体,其与强奸罪是竞合关系,但是,在实践中同时应当防止出现司法机关将本罪作为强奸罪堵截性罪名的适用倾向。

关键词：身心健康特殊职责发生性关系罪数关系