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Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy

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Chinese Chemical Letters 2024年第4期35卷 420-425页

作者： Hao Cai Xiaoyan Wu Lei Jiang Feng Yu Yuxiang Yang Yan li xian Zhang Jian liu Zijian li Hong Bi School of Materials Science and Engineering Anhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China

The reactive oxygen species(ROS) generation efficiency is always limited by the extreme tumor microenvironment(TME), leading to unsatisfactory antitumor effects in photodynamic therapy(PDT). As a promising gas therapy molecule, nitric oxide(NO) is independent of oxygen and could even synergize ROS to enhance the therapeutic effect. However, the short half-life, instability, and uncontrollable release of exogenous NO limited the application of tumor synergistic therapy. Herein, we reported a novel kind of red-emissive carbon dots(CDs) that was capable of lysosome-targeted and light-controlled NO delivery. The CDs were synthesized by using metformin and methylene blue(MB) via a hydrothermal *** obtained metformin-MB CDs(MMCDs) exhibited a higher1O2quantum yield and NO generation efficiency under light emitting diode(LED) light irradiation. Noteworthily, the1O2could further in situ oxidize NO into peroxynitrite anions(ONOO-), which own the higher cytotoxicity against cancer *** experiments indicate that MMCDs could destruct lysosome membrane integrity and kill almost 80%of Hep G2 cells under light irradiation while very low cytotoxicity in the dark. Moreover, MMCDs significantly decreased tumor volume and weight after phototherapy in hepatoma Hep G2-bearing mice. Our study provides a new strategy for light-controlled NO generation as well as precise lysosome-targeting for enhancement of PDT efficiency.

关键词： Carbon dots Nitric oxide Lysosome-targeting Photodynamic therapy Cancer

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The model of taking electronic medical records as the core for information construction in hospitals＂

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Chinese Medical Journal 2013年第2期126卷 373-377页

作者： WU Tao XU Ke li Ping li xian-feng XU Wei-guo Xinhua Hospital Shanghai Jiao Tong University School ofMedicine Shanghai 200092 China

The development of hospital information has been carried out for nearly 50 years, and originally started Le hospital information system （HIS）1 So far HIS isas the hospital information system （HIS）J So far HIS is the most widely and deeply used management system for hospitals in China.2 ＂General function standard for hospital information system＂ issued by China＇s Ministry of Health in 2002 defined that ＂The hospital information system refers to using of computer hardware and software technology, network communications technology, and other modem technology to comprehensively manage personnel, logistics, and finance in various departments in hospital. Gather, store, treat, extract, transport, aggregate,and process data in various stages of the medical activities, so that provide comprehensive and automatic information management and service to the hospital.＂

关键词： electronic medical record hospital information construction

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Highly efficient recovery of waste liNi_(x)Co_(y)Mn_(z)O_(2) cathode materials using a process involving pyrometallurgy and hydrometallurgy

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 149-160页

作者： Tianwei Zhang Juanye Dao Jinsong Wang Yuzhong Guo Rundong Wan Chengping li xian Zhou Zhengfu Zhang Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

Substantial environmental and economic benefits can be achieved by recycling used lithium-ion batteries. Hydrometallurgy is often employed to recover waste liNi_(x)Co_(y)Mn_(z)O_(2) cathode materials. As Ni, Co and Mn are transition metals, they exhibit similar properties;therefore, separating them is difficult. Thus, most researchers have focused on leaching processes, while minimal attention has been devoted to the separation of valuable metals from waste liNi_(x)Co_(y)Mn_(z)O_(2) cathode materials. Herein, we propose an environment-friendly, gentle process involving the usage of pyrometallurgy and hydrometallurgy to gradually leach valuable metals and effectively separate them. Interestingly, li is recovered through a reduction roasting and water leaching process using natural graphite powder, Ni and Co are recovered through ammonia leaching and extraction processes and Mn is recovered through acid leaching and evaporation–crystallization processes. Results show that ~87% li, 97.01% Co, 97.08% Ni and 99% Mn can be leached using water, ammonia and acid leaching processes. The result obtained using the response surface methodology shows that the concentration of (NH4)2SO3 is a notable factor affecting the leaching of transition metals. Under optimal conditions, ~97.01% Co, 97.08% Ni and 0.64% Mn can be leached out. The decomposition of liNi_(x)Co_(y)Mn_(z)O_(2) is a two-step process. This study provides valuable insights to develop an environment-friendly, gentle leaching process for efficiently recycling valuable metals, which is vital for the lithium-ion battery recycling industry.

关键词： Waste liNixCoyMnzO2 cathode materials Leaching Effective separation Series process

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新型波长解调技术在干涉型光纤传感器输出解调中的应用

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光谱学与光谱分析 2017年第9期37卷 2948-2953页

作者：陈宸李仙丽丁晖西安交通大学电力设备电气绝缘国家重点实验室陕西西安710049

提出了一种改进型边缘滤波波长解调技术,解决干涉型或谐振型光纤传感器输出的干涉谱波长的快速解调问题。该波长解调技术基于啁啾光栅和长周期光栅的光谱特点,以啁啾光栅作为矩形滤波器,提取传感器输出干涉谱的一个干涉峰;以长周期作为... 详细信息

提出了一种改进型边缘滤波波长解调技术,解决干涉型或谐振型光纤传感器输出的干涉谱波长的快速解调问题。该波长解调技术基于啁啾光栅和长周期光栅的光谱特点,以啁啾光栅作为矩形滤波器,提取传感器输出干涉谱的一个干涉峰;以长周期作为边缘滤波器,将干涉峰的波长信息转化为光强信息进行检测。该波长解调技术波长解调范围为传感器输出干涉谱的一个自由光谱范围(FSR),解调速度快,克服了当前波长解调技术中存在的测量范围与测量速度难以同时提高的问题,同时还具有系统成本低,体积小,能够灵活多路扩展的特点。详细介绍了解调系统的工作原理以及系统结构,并将其实际应用于一种干涉型光纤电流传感器输出干涉谱的波长解调中。通过实验证明电流传感器工作在工频及脉冲电流(脉冲宽度25μs)情况下,该解调系统对传感器输出干涉谱具有准确、快速的解调效果。该研究对推进干涉或谐振型光纤传感器的实际工程化水平的提高具有重要意义。

关键词：波长解调边缘滤波法干涉型光纤传感器啁啾光栅长周期光栅

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Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi liU Xiao Jia li xian xian Veronica lim CHEN Qi ZHAO Zhong Hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Enhanced hydrogen evolution performance by 3D ordered macroporous Ru-CoP@NC electrocatalysts

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Rare Metals 2024年第3期43卷 1095-1107页

作者： Chen-Chen Zhang Sheng Wei li-xian Sun Yi-Fang Ouyang Fen Xu Hai-liang Chu Hong-GePan li-Xin Chen Xue-Zhang Xiao School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Guangxi UniversityNanning530004China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055GuangdongChina Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an710021China School of Materials Science and Engineering Zhejiang UniversityHangzhou310058China

Electrocatalytic water splitting coupled with sustainable energies is identified as an environmentally friendly and renewable strategy to generate high-quality hydrogen for the fuel ***,the main challenge is to develop high performance,low cost and chemically stable electrocatalysts to decline the energy barriers and enhance the sluggish kinetics of hydrogen evolution reaction(HER).Herein,a three-dimensional hierarchically ordered macroporous Ru-CoP@NC electrocatalyst(3DOM Ru-CoP@NC)derived from ordered macro-microporous metal-organic frameworks has been prepared using the precursor@template and double-solvent *** prepared 3DOM Ru-CoP@NC catalyst exhibits an overpotential of 15 mV(j=10 mA·cm^(-2))and a reaction Tafel slope of 38 mV·dec^(-1)in alkaline electrolyte,which are superior to commercial Pt@C ***,the overpotential and reaction Tafel slope of this catalyst in acidic media are 45 mV and 50 mV·dec^(-1),*** outstanding HER activities of 3DOM Ru-CoP@NC catalysts are ascribed to the 3D highly interconnectedreticular nanospaces that can increase effective reaction active *** N dope d carbon framework improves the electronic properties and ***,the strong interaction of Ru and CoP nanoparticles also boosts the HER *** results indicate that 3DOM Ru-CoP@NC catalysts with high catalytic activities have a broad application prospect in the future.

关键词： Hydrogen evolution reaction Template method 3D ordered macroporous Ru-CoP@NC

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Internal electric field modulation by copper vacancy concentration of cuprous sulfide nanosheets for enhanced selective CO_(2) photoreduction

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Journal of Energy Chemistry 2024年第4期91卷 324-330页

作者： xian Shi Weidong Dai Xiaoqian li Yang Bai Qin Ren Yao Lei Xing'an Dong School of Chemistry and Environmental Engineering Sichuan University of Science&EngineeringZigong 643000SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation School of Oil&Natural Gas EngineeringSouthwest Petroleum UniversityChengdu 610500SichuanChina Chongqing Key Laboratory of Photo-Electric Functional Materials College of Physics and Electronic EngineeringChongqing Normal UniversityChongqing 401331SichuanChina Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731SichuanChina

Although the internal electric field(IEF)of photocatalysts is acknowledged as a potent driving force for photocharge separation,modulating the IEF intensity to achieve enhanced photocatalytic performances remains a ***,cuprous sulfide nanosheets with different Cu vacancy concentration were employed to study IEF modulation and corresponding direct charge *** the samples,Cu_(1.8)S nanosheets possessed intensified IEF intensity compared with those of Cu_(2)S and Cu_(1.95)S nanosheets,suggesting that an enhanced IEF intensity could be achieved by introducing more Cu *** intensified IEF of Cu_(1.8)S nanosheets induced numerous photogenerated electrons to migrate to its surface,and the dissociative electrons were then captured by Cu vacancies,resulting in efficient charge separation *** addition,the Cu vacancies on Cu_(1.8)S nanosheets accumulated electrons as active sites to lower the energy barrier of rate-determining step of CO_(2)photoreduction,leading to the selective conversion of CO_(2)to ***,the manipulation of IEF intensity through Cu vacancy concentration regulation of cuprous sulfide photocatalysts for efficient charge separation has been discussed,providing a scientific strategy to rationally improve photocata lytic performances for solar energy conversion.

关键词： Internal electric field intensity Cuprous sulfide photocatalysts Cu vacancies Charge separation Selective CO_(2) photoreduction

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Dual polarization strategy to enhance CH_(4) uptake in covalent organic frameworks for coal-bed methane purification

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Chinese Chemical Letters 2024年第8期35卷 545-548页

作者： Junhua Wang Xin lian Xichuan Cao Qiao Zhao Baiyan li xian-He Bu School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China School of Materials Science and Engineering National Institute for Advanced MaterialsTKL of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin 300350China

The purification of low-grade coal-bed methane is extremely important,but challenging,due to the very similar physical properties of CH_(4)and ***,we proposed a dual polarization strategy by employing triazine and polyfluoride sites to construct polar pores in COF materials,achieving the efficient separa-tion of CH_(4)from *** expected,the dual polarized F-CTF-1 and F-CTF-2 exhibit higher CH_(4)adsorption capacity and CH_(4)/N_(2)selectivity than CTF-1 and CTF-2,***,the CH4 uptake capacity and CH_(4)/N_(2)selectivity of F-CTF-2 is 1.76 and 1.42 times than that of *** work not only developed promising COF materials for CH4/N_(2)separation,but also provided important guidance for the separation of other adsorbates with similar properties.

关键词： Dual polarization strategy Covalent organic frameworks(COFs) Coal-bed methane purification Chemical/thermal stability Cycling stability

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Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： Guang-Yao Leng Wei Yan Hai-Mu Ye Er-Dong Yao Ji-Bin Duan Zheng-xian Xu Ke-Pei li Jing-Ru Zhang Zhong li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC liaohe Oilfield Gas Storage Co.LTD Panjin124000LiaoningChina CNOOC Research Institute Co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production *** resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable *** injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation *** study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid *** investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing *** flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in *** results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,*** mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor *** epoxy resin containing 30%curing agent exhibited optimal mechanical *** a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy *** brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and *** tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,*** a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow ***,the injection pressure of cement surged dramatically to 2.61 MPa within 5 *** breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's perme

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing

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A micro-crosslinked amphoteric hydrophobic association copolymer as high temperature-and salt-resistance fluid loss reducer for water-based drilling fluids

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Petroleum Science 2024年第3期21卷 1980-1991页

作者： Jian li Yu-Xi Ji Xiao-Xiao Ni Kai-He Lv xian-Bin Huang Jin-Sheng Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Key Laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Qingdao26650ShandongChina Inspection and Testing Center of Huabei Oil Field Company PetroChinaRenqiu062552HebeiChina Drilling Fluid Research Institute CNPC Engineering Technology R&D Company LimitedBeijing102206China

During ultradeep oil and gas drilling,fluid loss reducers are highly important for water-based drilling fluids,while preparing high temperature-and salt-resistance fluid loss reducers with excellent rheology and filtration performance remains a ***,a micro-crosslinked amphoteric hydrophobic association copolymer(i.e.,DADC)was synthesized using N,N-dimethyl acrylamide,diallyl dimethyl ammonium chloride,2-acrylamido-2-methylpropane sulfonic acid,hydrophobic monomer,and pentaerythritol triallyl ether *** to the synergistic effects of hydrogen bonds,electrostatic interaction,hydrophobic association,and micro-crosslinking,the DADC copolymer exhibited outstanding temperature-and *** rheological experiments have shown that the DADC copolymer had excellent shear dilution performance and a certain degree of salt-responsive viscosity-increasing *** DADC copolymer could effectively adsorb on the surface of bentonite particles through electrostatic interaction and hydrogen bonds,which bring more negative charge to the bentonite,thus improving the hydration and dispersion of bentonite particles as well as the colloidal stability of the drilling ***,the drilling fluids constructed based on the DADC copolymer exhibited satisfactory rheological and filtration properties(FLHTHP=12 m L)after aging at high temperatures(up to200℃)and high salinity(saturated salt)***,this work provided new insights into designing and fabricating high-performance drilling fluid treatment agents,demonstrating good potential applications in deep and ultradeep drilling engineering.

关键词： Fluid loss reducer Temperature-and salt-resistance Hydrophobic association Amphoteric Micro-crosslinking

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