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计算机科学 2007年第10期34卷 217-218,232页

作者：李献礼长江师范学院现代教育技术中心重庆408003

处理非线性最优化问题的常规方法是采用启发式策略,但这些启发式算法多数只能得到局部最优解。本文结合最优化理论及遗传算法,提出了一种新的优化方法,并通过用例对此方法进行了验证。最终实现系统的全局最优解。

关键词：函数优化遗传算法适应度函数

IPv4／IPv6网间的SIP通信的解决方案

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计算机科学 2007年第11期34卷 47-49页

作者：李献礼长江师范学院网络中心重庆408003

在分析SIP协议和的IPv4/IPv6转换机制的基础上,提出了一种应用层网关与NAPT-PT相结合的解决方案并且实现了在不改动终端和原有设备的情况下实现了异类网之间SIP通信。

关键词： SIP IPv6 NAPT—PT ALG

扩展OGSA-DAI数据访问与集成框架的关键技术分析

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重庆大学学报（自然科学版） 2008年第9期31卷 1054-1058页

作者：李献礼长江师范学院网络信息中心重庆涪陵408000

基于OGSA-DAI数据访问模式,以网络服务方式提供对异构数据资源统一访问,更方便地满足特殊的数据源访问、集成。通过编写相应的Activity类操纵数据,创建服务器端Activity负责具体数据处理任务,创建客户端Activity用于生成执行文档和执行... 详细信息

基于OGSA-DAI数据访问模式,以网络服务方式提供对异构数据资源统一访问,更方便地满足特殊的数据源访问、集成。通过编写相应的Activity类操纵数据,创建服务器端Activity负责具体数据处理任务,创建客户端Activity用于生成执行文档和执行数据转换任务,扩展OGSA-DAI以支持异构数据源的集成和访问。

关键词：数据访问与集成 OGSA-DAI 数据源访问类异构

The position of Cathaysia in Nuna and during the Nuna-Rodinia transition

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Science Bulletin 2024年第17期69卷 2693-2697页

作者： Chuan Yang Zheng-xiang li Yang li xian-Hua li State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Earth Evolution and Dynamics Research Center(EDRC) Laoshan LaboratoryQingdao 266237China Earth Dynamics Research Group(EDRG) School of Earth and Planetary SciencesCurtin UniversityPerth WA 6845Australia School of Earth and Space Sciences Peking UniversityBeijing 100871China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

The assembly and breakup of Nuna and Rodinia, two successive supercontinents in the Proterozoic, provide key evidence for the establishment of supercontinent cycles. Reliable palaeogeographic reconstructions at the cores of the two supercontinents are critical for understanding the evolution and geodynamics of the supercontinent cycles. In addition, there are fundamental aspects of the Nuna-Rodinia transition that remain poorly understood, including the ways in which Nuna broke up and Rodinia assembled, either through introversion [1] or extroversion [2].

关键词： continent Rodinia transition

A seismic elastic moduli module for the measurements of low-frequency wave dispersion and attenuation of fluid-saturated rocks under different pressures

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Petroleum Science 2024年第1期21卷 162-181页

作者： Yan-Xiao He Shang-Xu Wang Gen-Yang Tang Chao Sun Hong-Bing li San-Yi Yuan xian Wei li-Deng Gan Xiao-Feng Dai Qiang Ge Peng-Peng Wei Hui-Qing Zhang National Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationCollege of GeophysicsChina University of Petroleum(Beijing)Beijing102249China School of Resources and Geosciences China University of Mining and TechnologyXuzhou221116JiangsuChina Research Institute of Petroleum Exploration and Development CNPCBeijing100083China Beijing Vocational College of Labour and Social Security Beijing100029China PetroChina Dagang Oilfield Exploration and Development Research Institute CNPCTianjin300280China

Knowledge about the seismic elastic modulus dispersion,and associated attenuation,in fluid-saturated rocks is essential for better interpretation of seismic observations taken as part of hydrocarbon identification and time-lapse seismic surveillance of both conventional and unconventional reservoir and overburden performances.A Seismic Elastic Moduli Module has been developed,based on the forced-oscillations method,to experimentally investigate the frequency dependence of Young's modulus and Poisson's ratio,as well as the inferred attenuation,of cylindrical samples under different confining pressure *** with three standard samples showed that the measured elastic moduli were consistent with the published data,indicating that the new apparatus can operate reliably over a wide frequency range of f∈[1-2000,10^(6)]*** Young's modulus and Poisson's ratio of the shale and the tight sandstone samples were measured under axial stress oscillations to assess the frequency-and pressure-dependent *** dry condition,both samples appear to be nearly frequency independent,with weak pressure dependence for the shale and significant pressure dependence for the *** particular,it was found that the tight sandstone with complex pore microstructure exhibited apparent dispersion and attenuation under brine or glycerin saturation conditions,the levels of which were strongly influenced by the increased effective *** addition,the measured Young's moduli results were compared with the theoretical predictions from a scaled poroelastic model with a reasonably good agreement,revealing that the combined fluid flow mechanisms at both mesoscopic and microscopic scales possibly responsible for the measured dispersion.

关键词： Low-frequency measurements Dispersion and attenuation Rock physics Fluid flow

Enhanced photothermal dehydration of methanol over W_(18)O_(49)/Au/SAPO-34 catalysts with broadened light absorption

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Rare Metals 2024年第3期43卷 1139-1152页

作者： Ya-Qin Tang Meng-Xia Yan Chang-Qian Lu Shao-Yuan li Kui-xian Wei Tao Qu Wen-HuiMa Yong-Nian Dai Kong-Zhai li Da-Jun Luo Xue-liang Zhang Yi-Ke liu Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China School of Materials and Energy Engineering Guizhou Institute of TechnologyGuiyang550003China

Methanol-to-olefins(MTO)process is one of the most critical pathways to produce low carbon ***,the reaction is driven by thermal catalysis,which inevitably needs to consume large amounts of fossil *** a new technique to substitute for the fuel burning is urgent for MTO process to improve the industry prospects and ***,we report a novel W_(18)O_(49)/Au/SAPO-34(W/Au/S),a multifunctional photothermal catalyst for the MTO reaction.A high methanol conversion was achieved under xenonum(Xe)lamp irradiation,yielding methyl ether(ME)and ethylene as the main *** optimized W/Au/S catalysts showed ethylene yield as high as 250μmol in 60 min,which was 2.5 times higher than that of Au/*** physiochemical characterization revealed that the SAPO-34 molecular sieves were surrounded by Au and W_(18)O_(49)nanoparticles,which exhibited a strong localized surface plasmon resonance excitation around 540 nm and light absorption beyond 500 *** multifunctional catalysts showed a strong photothermal effect,arising from the broadened light absorption of Au and W_(18)O_(49)nanoparticles,leading to a temperature as high as 250℃on the surface of the *** study showed that the superior ethylene selectivity of W/Au/S catalysts was attributed to the moderating acidic sites of W_(18)O_(49)for methanol dehydration to *** research may provide new insight for designing heterostructures to improve photo-to-chemical conversion performance and is expected to accelerate progress toward the excellent multifunctional photothermal catalysts with broad light absorption for methanol activation and C-C bond formation.

关键词： Methanol conversion Ethylene Photothermal catalysis W_(18)O_(49) BrΦnsted-acid

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： xian li Mengxin Xu Jingyi Yang li Zhou lin liu Min li Shasha Wang Mei-Qin liu Zhixiang Huang Zhen Zhang Shuning liu Yunqi Hu Haofeng lin Bowen liu Ying Sun Qingguo Wu Zheng-li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2225-2232页

作者： xian-Shuai Kou Fan-Fan li Yun Meng Jian-Ming Zhao Sheng-Fen liu Lan Zhang The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Thoracic Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Orthopedics Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus *** prognosis is generally *** case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented *** SUMMARY The patient presented with large HCC complicated by intratumoral *** involved a multidisciplinary approach,providing individualized *** strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody *** months after treatment,the patient achieved complete radiological remission,with significant symptom *** studies showed no lesions or recurrence,and clinical assessments confirmed complete *** report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar *** This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Sorafenib Translational therapy Multidisciplinary team Case report

Comprehensive evaluation of rare case:From diagnosis to treatment of a sigmoid Schwannoma:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 244-250页

作者： Jing-Yi li Xi-Zhuang Gao Jian Zhang xiang-Zheng Meng Yi-xian Cao Kun Zhao Clinical Medical College of Jining Medical University Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Gastroenterology The First People's Hospital of JiningJining 272000Shandong ProvinceChina

BACKGROUND Schwannomas are uncommon tumors originating from Schwann cells,forming the neural *** account for approximately 2%-6%of all mesenchymal tumors and are most commonly identified in peripheral nerve trunks,with rarity in the gastrointestinal *** gastrointestinal locations,the stomach harbors the majority of nerve sheath tumors,while such occurrences in the sigmoid colon are exceptionally *** SUMMARY This study presented a clinical case involving a 60-year-old female patient who,during colonoscopy,was diagnosed with a submucosal lesion that was later identified as a nerve sheath *** patient underwent surgical resection,and the diagnosis was confirmed through *** study highlighted an exceptionally uncommon occurrence of a nerve sheath tumor in the sigmoid colon,which was effectively managed within our ***,a comprehensive review of relevant studies was *** The preoperative diagnosis of nerve sheath tumors poses challenges,as the definitive diagnosis still relies on pathology and *** categorized as benign,these tumors have the potential to demonstrate malignant ***,the optimal treatment approach entails the complete surgical excision of the tumor,ensuring the absence of residual lesions at the margins.

关键词： Schwannoma Gastrointestinal stromal tumors Treatment Sigmoid colon Case report

Hi-Tag:a simple and efficient method for identifying protein-mediated long-range chromatin interactions with low cell numbers

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Science China(life Sciences) 2024年第5期67卷 1027-1034页

作者： Xiaolong Qi Lu Zhang Qiulin Zhao Peng Zhou Sai xian Zhang Jingjin li Zhuqing Zheng Yue xiang Xueting Dai Zhe Jin Yaobang Jian Xinyun li liangliang Fu Shuhong Zhao Key Lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of AgricultureCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070China Hubei Hongshan Laboratory Frontiers Science Center for Animal Breeding and Sustainable ProductionWuhan 430070China

Protein-mediated chromatin interactions can be revealed by coupling proximity-based ligation with chromatin ***,these techniques require complex experimental procedures and millions of cells per experiment,which limits their widespread application in life science ***,we develop a novel method,Hi-Tag,that identifies high-resolution,long-range chromatin interactions through transposase tagmentation and chromatin proximity ligation(with a phosphorothioate-modified linker).Hi-Tag can be implemented using as few as 100,000 cells,involving simple experimental procedures that can be completed within 1.5 ***,Hi-Tag is capable of using its own data to identify the binding sites of specific proteins,based on which,it can acquire accurate interaction *** results suggest that Hi-Tag has great potential for advancing chromatin interaction studies,particularly in the context of limited cell availability.

关键词： Hi-Tag chromatin interactions transposase tagmentation chromatin proximity ligation low cell numbers