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Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang jin-E Lu Yan liu Xi Chen Meng-Meng Qu Yang Zhang Wei-Guo Hong Yong-Gang li Junliang Fu Fu-Sheng Wang Out-patient department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

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PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang jingjing Duan Yalu Tan Panlin liao jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as liMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

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Atom-referenced and stabilized soliton microcomb

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan Tian-Peng Hua Wei-Qiang Wang Zheng-Yu Wang jin li Zhu-Bo Wang Ming li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent Elittle Sai Tak Chu Wei Zhao Guang-Can Guo Chang-ling Zou Yun-Feng Xiao Wen-Fu Zhang Chun-Hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China university of Chinese Academy of Sciences Beijing 100049China department of Chemical Physics University of Science and Technology of ChinaHefei 230026China department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser *** this study,we present a system for generating a fully atom-referenced stabilized soliton *** pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)*** pump light is then frequency-doubled and referenced to the atomic transition *** repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 *** a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

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Dissecting the molecular basis of spike traits by integrating gene regulatory networks and genetic variation in wheat

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Plant Communications 2024年第5期5卷 57-74页

作者： Guo Ai Chao He Siteng Bi Ziru Zhou Ankui liu Xin Hu Yanyan liu liujie jin JiaCheng Zhou Heping Zhang Dengxiang Du Hao Chen Xin Gong Sulaiman Saeed Handong Su Caixia Lan Wei Chen Qiang li Hailiang Mao lin li Hao liu Dijun Chen Kerstin Kaufmann Khaled FAlazab Wenhao Yan National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenomeAnalysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China department for Plant Cell and Molecular Biology Institute for BiologyHumboldt-Universitat Zu Berlin10115 BerlinGermany Plant Research department Nuclear Research CenterEgyptian Atomic Energy AuthorityCairo 13759Egypt

Spike architecture inﬂuences both grain weight and grain number per spike,which are the two major components of grain yield in bread wheat(Triticum aestivum L.).However,the complex wheat genome and the inﬂuence of various environmental factors pose challenges in mapping the causal genes that affect spike ***,we systematically identified genes involved in spike trait formation by integrating information on genomic variation and gene regulatory networks controlling young spike development in *** identified 170 loci that are responsible for variations in spike length,spikelet number per spike,and grain number per spike through genome-wide association study and meta-QTL *** constructed gene regulatory networks for young inﬂorescences at the double ridge stage and theﬂoret primordium stage,in which the spikelet meristem and theﬂoret meristem are predominant,respec-tively,by integrating transcriptome,histone modification,chromatin accessibility,eQTL,and protein–pro-tein interactome *** these networks,we identified 169 hub genes located in 76 of the 170 QTL regions whose polymorphisms are significantly associated with variation in spike *** functions of TaZF-B1,VRT-B2,and TaSPL15-A/D in establishment of wheat spike architecture were *** study provides valuable molecular resources for understanding spike traits and demonstrates that combining genetic analysis and developmental regulatory networks is a robust approach for dissection of complex traits.

关键词： bread wheat spike traits genetic variation protein–protein interaction gene regulatory network

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无流体剪切力条件下ADAMTS13裂解内皮细胞上特大血管性血友病因子的研究

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中国实验血液学杂志 2024年第2期32卷 532-540页

作者：赵善琛李华王萌赵艺鸿李先杰金圣宇延边大学附属医院血液内科吉林延吉133000 延边大学附属医院体检科吉林延吉133000 延边大学附属医院中心实验室吉林延吉133000

目的:研究血管性血友病因子裂解酶(ADAMTS13)在无流体剪切力下裂解内皮细胞上特大血管性血友病因子(ULVWF)的分子机制,为探明血栓性血小板减少性紫癜(TTP)和其他血栓性疾病的发病机理提供理论依据。方法:通过免疫荧光显微镜观察ADAMTS1... 详细信息

目的:研究血管性血友病因子裂解酶(ADAMTS13)在无流体剪切力下裂解内皮细胞上特大血管性血友病因子(ULVWF)的分子机制,为探明血栓性血小板减少性紫癜(TTP)和其他血栓性疾病的发病机理提供理论依据。方法:通过免疫荧光显微镜观察ADAMTS13在无流体剪切力下裂解内皮细胞表面上ULVWF的情况,采用EliSA测定不同条件下培养基中VWF抗原量的变化。EliSA和Western blot分别测定有无流体剪切力或凝血因子VIII(FVIII)条件培养基中的VWF和蛋白水解片段的数量。多聚体分析评估ADAMTS13裂解内皮细胞上ULVWF的情况。将组胺刺激的人脐静脉内皮细胞(HUVEC)与ADAMTS13和各种N-和C-末端截断的突变体一起孵育,通过免疫荧光显微镜观察与细胞保持结合的ULVWF,EliSA测定内皮细胞释放出的ULVWF,确定降解内皮细胞上ULVWF所需的ADAMTS13结构域。结果:在无流体剪切力下,重组ADAMTS13和血浆ADAMTS13迅速降解了内皮细胞表面上新形成的ULVWF。ULVWF的蛋白水解过程依赖于培养时间、ADAMTS13浓度和剪切力。ADAMTS13介导的蛋白水解释放的VWF分布与组胺刺激下内皮细胞分泌的VWF分布非常相似,提示ULVWF在内皮细胞表面发生裂解。裂解内皮细胞上ULVWF需要ADAMTS13半胱氨酸富集区(Cys-rich,Cys R)结构域和间隔区结构域,但不需要ADAMTS13的7个TSP1重复序列(TSP12-8)和2个补体结合区(CUB)结构域。结论:内皮细胞上ULVWF聚合物在无流体剪切力下也对ADAMTS13的裂解敏感,这为ADAMTS13裂解内皮细胞结合的ULVWF的分子机制提供了新见解,并可能有助于理解TTP和其他血栓性疾病的发病机理。

关键词：血管性血友病因子裂解酶血管性血友病因子血栓性血小板减少性紫癜

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen jing-Yu Tang Rui-Rui Fan Qiang li Gong li Dong liu Zheng-Yao jin Xing-Zhu Cui Tian-xiang Chen Yi-Wei Yang Rong liu Han Yi Yang li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang ling Kang Bo li Chao li Jia-Wen li Xiao li Jie liu Shu-Bin liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu li-Kun Xie Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang xian-Peng Zhang Yu-liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

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Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang jinjing li liuqing Xu Guorong Xu Minting lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-jin Chen Kang Yang department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

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Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 586-603,I0002-I0014页

作者： Yiran li Ziyu Xun Junyu Long Huishan Sun Xu Yang Yanyu Wang Yunchao Wang jingnan Xue Nan Zhang Junwei Zhang jin Bian Jie Shi Xiaobo Yang Hanping Wang Haitao Zhao State Key Laboratory of Complex Severe and Rare Diseases Department of Liver SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College(CAMS&PUMC)BeijingChina Division of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesChinese Academy of Medical Sciences and Peking Union Medical College(CAMS&PUMC)BeijingChina

Background:Hepatocholangiocarcinoma(H-ChC)has the clinicopathological features of both hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)and is a more aggressive subtype of primary hepatic carcinoma than HCC or ***:We sequenced 91,112 single-cell transcriptomes from 16 human samples to elucidate the molecular mechanisms underlying the coexistence of HCC and iCCA components in ***:We observed two molecular subtypes of H-ChC at the whole-transcriptome level(CHP and CIP),where a metabolically active tumour cell subpopulation enriched in CHP was characterized by a cellular pre-differentiation *** define the heterogeneity of tumours and their associated microenvironments,we observe greater tumour diversity in H-ChC than HCC and iCCA.H-ChC exhibits weaker immune cell infiltration and greater CD8+exhausted T cell(Tex)dysfunction than HCC and *** we defined two broad cell states of 6,852 CD8+Tex cells:GZMK+CD8+Tex cells and terminal CD8+Tex ***+CD8+Tex cells exhibited higher infiltration of after treatment in H-ChC,the effector scores and expression of the immune checkpoints of them greatly increased after immunotherapy,which indicated that H-ChC might be more sensitive than HCC or iCCA to ***:In this paper,H-ChC was explored,hoping to contribute to the study of mixed tumours in other cancers.

关键词： Hepatocholangiocarcinoma(H-ChC) biphenotypic plasticity CD8+Tex cells immunosuppression

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C-Type Antiferromagnetic Structure of Topological Semimetal CaMnSb2

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Chinese Physics Letters 2024年第03期41卷 119-125页

作者：李博曾旭涛徐千惠杨帆项俊森钟恒扬邓司浩何伦华徐菊萍殷雯鲁兴业刘慧颖胜献雷金文涛 School of Physics Beihang University Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of Sciences Center for Advanced Quantum Studies and department of Physics Beijing Normal University Spallation Neutron Source Science Center Songshan Lake Materials Laboratory

Determination of the magnetic structure and confirmation of the presence or absence of inversion （P） and time reversal （Τ） symmetry is imperative for correctly understanding the topological magnetic materials. He... 详细信息

关键词： Density functional theory

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Surface Characterization of Laser Surface Melted NiTi Shape Memory Alloy in Hanks' Solution

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材料热处理学报 2004年第5B期25卷 988-991页

作者： CUIZhen-duo ZHUSheng-li MANHauchung YANGxian-jin SchoolofMaterialsScienceandEngineering TianjinUniversityTianjin300072China departmentoflndustrialandSystemsEngineering TheHongKongPolytechnicUniversityHungHomKowloonHongKongChina

The surface of Ti-50.8Ni at% shape memory alloy was melted by an Nd-YAG laser. The Ti/Ni and Ti4+/Ti atomic concentration ratios at the surface were changed significantly. The Ni ion release rate of the laser melted surface was much lower than that of the mechanical polished samples. A calcium-phosphorous layer with high Ca/P ratio was detected after immersion in Hanks’ solution.

关键词：离子释放速率形状记忆合金激光表面熔解生物材料

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