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Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression-like behaviors in 5xFAD mice

Animal Models and Experimental Medicine 2024年第3期7卷 347-361页

作者： Yanju Gong Mingfeng li Min liu Xinghan Wu Yanhong li Chuan Qin ling Zhang iNHC Key Laboratory of Human Disease Comparative Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInternational Center for Technology and lnnovation of Animal ModelComparative Medicine CenterInstitute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PuMC)BeijingChina Changping national Laboratory(CPNL) BeijingChina

Background:Apolipoprotein E4(ApoE4)allele is the strongest genetic risk factor for late-onset Alzheimer's disease,and it can aggravate depressive symptoms in non-AD ***,the impact of ApoE4 on AD-associated depression-l ike behaviors and its underlying pathogenic mechanisms remain ***:This study developed a 5xFAD mouse model overexpressing human ApoE4(E4FAD).Behavioral assessments and synaptic function tests were conducted to explore the effects of ApoE4 on cognition and depression in 5xFAD *** in peripheral and central lipid metabolism,as well as the levels of serotonin(5-HT)andγ-aminobutyric acid(GABA)neurotransmitters in the prefrontal cortex,were *** addition,the protein levels of 24-dehydrocholesterol reductase/glycogen synthase kinase-3 beta/mammalian target of rapamycin(DHCR24/GSK3β/m TOR)and postsynaptic density protein 95/calmodulin-dependent protein kinase II/brain-derived neurotrophic factor(PSD95/CaMK-II/BDNF)were measured to investigate the molecular mechanism underlying the effects of ApoE4 on AD ***:Compared with 5xFAD mice,E4FAD mice exhibited more severe depressionlike behaviors and cognitive *** mice also exhibited increased amyloid-beta deposition in the hippocampus,increased astrocyte numbers,and decreased expression of depression-related neurotransmitters 5-HT and GABA in the prefrontal ***,lipid metabolism disorders were observed in E4FAD,manifesting as elevated low-density lipoprotein cholesterol and reduced high-density lipoprotein cholesterol in peripheral blood,decreased cholesterol level in the prefrontal cortex,and reduced expression of key enzymes and proteins related to cholesterol synthesis and *** expression of proteins related to the DHCR24/GSK3β/m TOR and PSD95/CaMK-II/BDNF pathways was also ***:This study found that ApoE4 overexpression exacerbates depressionlike behaviors in 5xFAD mice and confirmed that ApoE4 reduces co

关键词： 5xFAD mice Alzheimer's disease ApoE4 allele depression like

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Differences and similarities in radial growth of Betula species to climate change

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Journal of Forestry Research 2024年第2期35卷 176-187页

作者： Di liu Yang An Zhao li Zhihui Wang Yinghui Zhao Xiaochun Wang Center for Ecological Research Key Laboratory of Sustainable Forest Ecosystem ManagementMinistry of EducationCollege of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China Changan Park in Shijiazhuang Shijiazhuang 050000People’s Republic of China Shijiazhuang Landscape Greening Engineering Project Construction Center Shijiazhuang 050000People’s Republic of China Heilongjiang Institute of Meteorological Science Harbin 150030People’s Republic of China School of life Qufu Normal UniversityQufu 273100People’s Republic of China

Betula platyphylla and Betula costata are important species in mixed broadleaved-Korean pine(Pinus koraiensis)***,the specific ways in which their growth is affected by warm temperatures and drought remain *** address this issue,60 and 62 tree-ring cores of *** and *** were collected in Yichun,*** dendrochronological methods,the response and adaptation of these species to climate change were examined.A“hysteresis effect”was found in the rings of both species,linked to May–September moisture conditions of the previous *** growth of *** was positively correlated with the standardized precipitation-evapotranspiration index(SPEI),the precipitation from September to October of the previous year,and the relative humidity in October of the previous *** of *** is primarily restricted by moisture conditions from September to *** contrast,*** growth is mainly limited by minimum temperatures in May–June of both the previous and current *** droughts,*** had a faster recovery rate compared to *** the context of rising temperatures since 1980,the correlation between *** growth and monthly SPEI became positive and strengthened over time,while the growth of *** showed no conspicuous *** findings suggest that the growth of *** is already affected by warming temperatures,whereas *** may become limited if warming continues or *** change could disrupt the succession of these species,possibly accelerating the succession of pioneer *** results of this research are of great significance for understanding how the growth changes of birch species under warming and drying conditions,and contribute to understanding the structural adaptation of mixed broadleaved-Korean pine(Pinus koraiensis)forests under climate change.

关键词： Tree rings Betula platyphylla Betula costata Climate response Moving correlation Extreme drought

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Influence of secondary lining thickness on mechanical behaviours of double-layer lining in large-diameter shield tunnels

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Underground Space 2024年第5期18卷 130-150页

作者： Shimin Wang Xuhu He Xiaoyu Peng Ya Wang Zhengxin li Zihan Song Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China

In large-diameter shield tunnels,applying the double-layer lining structure can improve the load-bearing properties and maintain the stability of segmental *** secondary lining thickness is a key parameter in the design of a double lining structure,which is worth being *** on an actual large-diameter shield tunnel,loading model tests are carried out to investigate the effect of the secondary lining thickness on the mechanical behaviours of the double lining *** test results show that within the range of secondary lining thicknesses discussed,the load-bearing limit of the double-layer lining increases with growing secondary lining *** a passive support,the secondary lining acts as an auxiliary load-bearing structure by contacting the *** changes in secondary lining thickness have a significant effect on the contact state between the segment and secondary lining,with both the contact pressure level and the contact area between the two *** double-layer lining structures in large-diameter shield tunnels,it is proposed that the stiffness of the secondary lining needs to be matched to the stiffness of the segment,as this allows them to have a coordinated deformation and a good joint load-bearing effect.

关键词： Large-diameter shield tunnels Double-layer lining structure Secondary lining thickness Stiffness matching Similar model test

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Regulating the crystal phase of bismuth-based semiconductors for promoted photocatalytic performance

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Science China Chemistry 2024年第6期67卷 1839-1864页

作者： Zhaohui Wu Mei-Chi Chong Shiying Zhang Junshan li Yongfa Zhu Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha410022China Department of Chemistry Tsinghua UniversityBeijing100084China Institute for Advanced Study Chengdu UniversityChengdu610106China

Numerous bismuth-based semiconductors(BBSs)with sophisticated and desirable structures used as photocatalysts for efficient photocatalytic degradation of water organic contaminants have attracted considerable ***,regulating the crystal phases and phase transition of BBSs for promoted photocatalytic performance is ***,the unique crystal structure and band structure features of each typical BBSs,and the vital roles on phase controlling of each phase were systematically presented based on the classification of ***,the critical factors for the phase transition of BBSs and intrinsic driving forces endowed by phases of BBSs for enhanced photocatalytic performance of organic contaminants removal were also *** review will provide systematical guidelines and horizons for regulating the crystal phase and phase transition of BBSs,promoting photocatalytic degradation and mineralization of organic contaminants.

关键词： bismuth-based semiconductors phase regulation photocatalytic performances organic contaminants

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Cellular V2X-Based Integrated Sensing and Communication System:Feasibility and Performance Analysis

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Chinese Journal of Electronics 2024年第4期33卷 1104-1116页

作者： Yibo li Junhui ZHAO Jieyu liAO Fajin HU School of Electronic and Information Engineering Beijing Jiaotong University

Communication and sensing are basically required in intelligent transportation. The combination of two functions can provide a viable way in alleviating concerns about resource limitations. To achieve this, we propose an integrated sensing and communication(ISAC) system based on cellular vehicle-to-everything(C-V2X). We first analyze the feasibility of new radio(NR) waveform for ISAC system. We discuss the possibility of reusing NR waveform for sensing based on current NR-V2X standards. Ambiguity function is calculated to investigate the sensing performance limitation of NR waveform. A C-V2X-based ISAC system is then designed to realize the two tasks in vehicular network simultaneously. We formulate an integrated framework of vehicular communication and automotive sensing using the already-existing NR-V2X network. Based on the proposed ISAC framework, we develop a receiver algorithm for target detection/estimation and communication with minor modifications. We evaluate the performance of the proposed ISAC system with communication throughput, detection probability, and range/velocity estimation *** show that the proposed system achieves high reliability communication with 99.9999% throughput and high accuracy sensing with errors below 1 m and 1 m/s in vehicle scenarios.

关键词： Accuracy Estimation Receivers Reliability theory Integrated sensing and communication Throughput Task analysis

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系列小分子液体中α弛豫与探针离子电导行为的对比

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物理学报 2024年第14期73卷 239-245页

作者：赵兴宇王丽娜韩宏博尚洁莹伊犁师范大学物理科学与技术学院新疆凝聚态相变与微结构实验室伊宁835000

液体中平动和转动的耦合性是凝聚态物理长期关注的问题之一,本文采用介电谱方法同时获得了系列小分子液体中α弛豫的弛豫时间和探针离子的电导率.样品包括具有不同分子形状和官能团的碳原子数跨度在3—14范围内的15种一元和二元小分子液... 详细信息

液体中平动和转动的耦合性是凝聚态物理长期关注的问题之一,本文采用介电谱方法同时获得了系列小分子液体中α弛豫的弛豫时间和探针离子的电导率.样品包括具有不同分子形状和官能团的碳原子数跨度在3—14范围内的15种一元和二元小分子液体.分析结果表明平动和转动的耦合性与液体分子的官能团并没有直接的对应关系,对分子形状、大小和离子大小也不是十分敏感,但是液体的微观结构是影响平动和转动耦合性的重要因素.也就是,无论在一元还是二元体系中,液体的微观结构没有改变时电导率的倒数和弛豫时间与温度的依赖关系具有一致性,这也为弛豫时间的测量提供了一种方法.研究结果还表明,液体中自身携带的杂质离子与定量掺入离子的电导率的温度依赖关系相同,为电解质溶解度低的有机小分子液体中离子电导率行为的研究提供了思路.本文中单羟基醇的实验结果也与单羟基醇中α弛豫而非Debye弛豫对应于体系结构弛豫的观点相一致.

关键词：平动和转动耦合弛豫时间离子电导率小分子液体

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Belief reliability:a scientific exploration of reliability engineering

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Journal of Systems Engineering and Electronics 2024年第3期35卷 619-643页

作者： ZHANG Qingyuan li Xiaoyang ZU Tianpei KANG Rui International Innovation Institute Beihang UniversityHangzhou 311115China Science and Technology on Reliability and Environmental Engineering Laboratory Beijing 100191China School of Reliability Engineering and Systems Engineering Beihang UniversityBeijing 100191China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

This paper systematically introduces and reviews a scientific exploration of reliability called the belief *** with the origin of reliability engineering,the problems of present theories for reliability engineering are summarized as a query,a dilemma,and a ***,through philosophical reflection,we introduce the theoretical solutions given by belief reliability theory,including scientific principles,basic equations,reliability science experiments,and mathematical *** basic methods and technologies of belief reliability,namely,belief reliability analysis,function-oriented belief reliability design,belief reliability evaluation,and several newly developed methods and technologies are sequentially elaborated and *** on the above investigations,we summarize the significance of belief reliability theory and make some prospects about future research,aiming to promote the development of reliability science and engineering.

关键词： belief reliability performance margin reliability experiment chance measure uncertainty

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碳酸乙烯酯合成过程热力学分析与动力学模拟

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石油炼制与化工 2024年第3期55卷 82-88页

作者：吕全明刘银川李娜贺来宾中石化(上海)石油化工研究院有限公司上海201208

由环氧乙烷(EO)和二氧化碳(CO_(2))酯化加成生产碳酸乙烯酯(EC)是一条优选的“绿色化学”生产路线,可以为新能源汽车动力电池提供优良溶剂,更能开辟一条CO_(2)捕集利用与封存的绿色路线。为了研究此反应发生的可能性和反应程度,通过热... 详细信息

由环氧乙烷(EO)和二氧化碳(CO_(2))酯化加成生产碳酸乙烯酯(EC)是一条优选的“绿色化学”生产路线,可以为新能源汽车动力电池提供优良溶剂,更能开辟一条CO_(2)捕集利用与封存的绿色路线。为了研究此反应发生的可能性和反应程度,通过热力学公式对反应过程进行了热力学分析,同时建立了主反应宏观动力学模型,以指导工业反应器的设计。结果表明:除EC水解副反应为吸热反应外,主反应和其他副反应均为强放热反应;所有副反应均可以自发进行,而主反应受温度影响较大,当温度大于100℃时不能自发进行;通过对试验数据回归得到了该反应的动力学参数,并用工业数据进行了验证;通过动力学模型预测了反应器组合后的产物浓度,双釜串联反应器出口EC摩尔分数为98.91%,模型计算值与工业试验值误差小于0.12%。

关键词：碳酸乙烯酯环氧乙烷热力学分析宏观动力学

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Node Sociability Based Intelligent Routing for Post-Disaster Emergency Networks

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China Communications 2024年第8期21卷 104-114页

作者： li Jiameng Xiong Xuanrui liu Min Amr Tolba School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China Graduate School of Information Production and SystemsWaseda UniversityFukuoka 808-0135Japan School of Communications and Information Engineering Chongqing College of Mobile CommunicationChongqing 401520China Computer Science Department Community CollegeKing Saud UniversityRiyadh 11437Saudi Arabia

In a post-disaster environment characterized by frequent interruptions in communication links,traditional wireless communication networks are *** the“store-carry-forward”mechanism characteristic of Delay Tolerant Networks(DTNs)can transmit data from Internet of things devices to more reliable base stations or data centres,it also suffers from inefficient data transmission and excessive transmission *** address these challenges,we propose an intelligent routing strategy based on node sociability for post-disaster emergency network ***,we introduce an intelligent routing strategy based on node intimacy,which selects more suitable relay nodes and assigns the corresponding number of message copies based on comprehensive utility ***,we present an intelligent routing strategy based on geographical location of nodes to forward message replicas secondarily based on transmission utility ***,experiments demonstrate the effectiveness of our proposed algorithm in terms of message delivery rate,network cost ratio and average transmission delay.

关键词： delay tolerant networks Internet of things node sociability routing strategy

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Effect of the Particle Packing Configuration on Fixed Bed Performance

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 152-160页

作者： li Ziqi Bao Di Zhou Han Tang Xiaojin SINOPEC Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China

Fixed-bed reactors are generally considered the optimal choice for numerous multi-phase catalytic reactions due to their excellent performance and ***,conventional fixed beds often encounter challenges related to inadequate mass transfer and a high pressure drop caused by the non-uniform void fraction *** enhance the overall performance of fixed beds,the impact of different packing configurations on performance was *** and simulation methods were used to investigate the fluid flow and mass transfer performances of various packed beds under different flow *** was found that structured beds exhibited a significantly lower pressure drop per unit length than conventional packed ***,the packing configurations had a critical role in improving the overall performance of fixed ***,structured packed beds,particularly the H-2 packing configuration,effectively reduced the pressure drop per unit length and improved the mass transfer *** H-2 packing configuration consisted of two parallel strips of particles in each layer,with strips arranged perpendicularly between adjacent layers,and the spacing between the strips varied from layer to layer.

关键词： packing configurations fixed bed Computational Fluid Dynamics simulation pressure drop mass transfer

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