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CHOP-like Regimen in Combination with Rituximab and Peginterferon Alpha-2b in Newly-diagnosed Diffuse Large B-cell Non-Hodgkin＇s Lymphoma： Experience in a Chinese Center

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Clinical oncology and cancer researeh 2010年第2期7卷 103-109页

作者： Shu-qing LU Jian-min YANG Xian-min SONG li CHEN wei-ping ZHANG Xiao-qian XU Xiong NI Chong-mei HUANG Yi HE Jian-min WANG Department of Hematology Changhai Hospital Second Military Medical University Shanghai 200433 China.

OBJECTIVE To evaluate the efficacy of rituximab combined with CHOP-like regimen with or without IFN in patients newly diagnosed diffuse large B-cell Non-Hodgkin＇s lymphoma （DLBCL）.METHODS From January 2003 to July 2008, 51 patients received CHOP-like chemotherapy （cyclophosphamide 750 mg/m2, epirubicin 80 mg/m2, vindesine 2.8 mg/m2 on day 1, and prednisolone 100 mg/day on day 1 to day 5）. Thirty-one patients received CHOPR-like treatment （rituximab 375 mg/m2 1 day before CHOP-like chemotherapy）. Twenty patients received CHOP-like regimen in combination with peginterferon （pegIFN）（1μg/kg on day 5） and rituximab （on day 6）.RESULTS -The CR （complete remission） rate in the CHOPR-like （with or without pegIFN） group and in the CHOP-like group was 78.4% and 45.1% （P = 0.005）, respectively. The estimated mean time of overall survival （OS） in the CHOPR-like group and CHOP- like group was 58.7 ± 2.8 and 36.4 ±3.4 months, respectively （P = 0.002）. The rates of CR and OR （overall remission） in CHOPR- like with IFN arm were 85.0% and 95.0%, and the rates of those in CHOPR-like without IFN arm were 74.2% and 87.0% （P 〉 0.05）. The estimated mean time of 4-year-PFS （progression- free survival） in CHOPR-like with IFN arm and in CHOPR-like without IFN arm was 62.9 ±3.0 months and 51.0 ± 4.6 months （P = 0.092）, respectively. In the CHOPR-like with IFN arm, no patient relapsed after achieving CR, while the estimated rate of 4-year- DFS （disease-free survival） in the patients who reached CR in the CHOPR-like without IFN arm was （63.4 ± 19.3）% （P = 0.061）. CONCLUSION Rituximab combined with CHOP-like chemotherapy improved the prognosis of DLBCL patients. The IFN may help to improve the quality and duration of response of DLBCL patients treated with rituximab and CHOP-like regimen.

关键词： CHOP-like rituximab peginte feron alpha-2b non-Hodgkin's lymphoma diffuse large B-cell.

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《申报》关于1927年南京事件报道之分析

安徽史学 2012年第1期 46-53,76页

作者：岳谦厚李卫平山西大学历史文化学院山西太原030006

1927年发生的南京事件是中国近代外交史上的一件大事,亦是北伐过程中国民革命军与西方列强在中国发生的一次具有重大影响的正面冲突。从《申报》报道情形观之,此次事件虽是国民革命军下层官兵无组织行为所致,但折射出民众普遍存在的反... 详细信息

1927年发生的南京事件是中国近代外交史上的一件大事,亦是北伐过程中国民革命军与西方列强在中国发生的一次具有重大影响的正面冲突。从《申报》报道情形观之,此次事件虽是国民革命军下层官兵无组织行为所致,但折射出民众普遍存在的反帝情结。从事件解决结果观之,南京国民政府尽管将肇事责任推给了共产党,但最终承担了对外赔偿之责,而对外舰炮击南京平民之事却"始争终让",不了了之。这反映出南京国民政府当时应对重大外交事件的弱势处境。

关键词：南京事件国民政府列强《申报》

因第三人原因造成的违约与责任承担——兼论《合同法》第121条的理论解构

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山东大学学报（哲学社会科学版） 2017年第5期 24-31页

作者：李永军李伟平中国政法大学民商经济法学院

《合同法》第121条严格恪守债的相对性,规定在因第三人原因导致债务人违约的情况下,债务人应向债权人承担违约责任,仅在向债权人承担违约责任后,债务人才可以向第三人追偿。据此,除不可抗力这一狭窄的免责事由外,债务人近似承担的是一种... 详细信息

《合同法》第121条严格恪守债的相对性,规定在因第三人原因导致债务人违约的情况下,债务人应向债权人承担违约责任,仅在向债权人承担违约责任后,债务人才可以向第三人追偿。据此,除不可抗力这一狭窄的免责事由外,债务人近似承担的是一种"不可思议的超级债务"。过错责任、客观责任两大立法例下的履行障碍或者违约风险的分配结果极为相似且都为债务人的责任承担设置了合适的边界。基于现实的需要与理性的要求,解释上应认为第121条没有完全排除债权人向第三人求偿之可能,在第三人的原因是引起债务人违约的直接原因且第三人主观上存有故意、债务人主观上无过错时,应允许债务人根据具体情形选择适用不可抗力、情势变更、风险负担、合同解除四种方式来免除其责任承担。

关键词：第三人原因违约责任《合同法》第121条第三人侵害债权

美罗培南治疗神经外科手术后颅内感染病例分析

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中国医院药学杂志 2010年第1期30卷 62-63,69页

作者：徐波李维平深圳市蛇口人民医院广东深圳518067 深圳市第二人民医院广东深圳518035

目的:探讨美罗培南在治疗神经外科手术后合并颅内感染的作用。方法:对2家医院2004年1月-2008年10月,84例神经外科手术后颅内感染病例统计,按静脉应用抗生素不同分A、B2组。A组:静脉滴注美罗培南(meropenem)+鞘内注射治疗46例;B组:静脉... 详细信息

目的:探讨美罗培南在治疗神经外科手术后合并颅内感染的作用。方法:对2家医院2004年1月-2008年10月,84例神经外科手术后颅内感染病例统计,按静脉应用抗生素不同分A、B2组。A组:静脉滴注美罗培南(meropenem)+鞘内注射治疗46例;B组:静脉应用其他抗生素+鞘内注射治疗38例。结果:A组颅内感染治愈43例(93.5%);B组颅内感染治愈17例(44.7%)。A组术后颅内感染治愈率较B组显著提高(P<0.05)。结论:静脉应用美罗培南+鞘内注射治疗可显著提高神经外科术后颅内感染治愈率。

关键词：神经外科手术颅内感染美罗培南

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基于数据挖掘的图书馆读者需求分析

图书馆论坛 2004年第3期24卷 86-88页

作者：李玮平东莞理工学院图书馆广东东莞523106

图书馆数字化发展 ,使数据挖掘等技术在读者需求预测方面得到了广泛使用。可以利用图书馆的借阅数据及调查结果 ,形成一个关于读者需求的数据仓库 ,挖掘出读者需求的规则和模式 ,并进行模糊推理 ,指导藏书建设。

关键词：数据挖掘图书馆读者需求需求分析数据仓库模糊逻辑神经元模糊推理

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基于随机梯度矩阵分解的社会网络推荐算法

计算机应用研究 2014年第6期31卷 1654-1656,1664页

作者：李卫平杨杰武汉理工大学信息工程学院武汉430070 铁道警察学院公安技术系郑州450053

由于传统的矩阵分解算法直接对用户评分矩阵进行分解,这样容易造成推荐的准确性偏低。为了进一步提高系统推荐的准确性,将用户间的社交网络作为辅助信息,提出了一种基于矩阵分解的社会推荐算法。该算法将社交网络与用户评分矩阵构成一... 详细信息

由于传统的矩阵分解算法直接对用户评分矩阵进行分解,这样容易造成推荐的准确性偏低。为了进一步提高系统推荐的准确性,将用户间的社交网络作为辅助信息,提出了一种基于矩阵分解的社会推荐算法。该算法将社交网络与用户评分矩阵构成一个大的矩阵,采用一种随机梯度下降法对该矩阵进行分解。最后通过实验结果验证表明,提出的算法具有较好的预测效果,其性能明显优于现有的相关算法。

关键词：矩阵分解推荐系统社会网络随机梯度

峨眉山大火成岩省地壳横波速度结构特征及其动力学意义

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地球物理学报 2017年第9期60卷 3338-3351页

作者：郭希陈赟李士东邓阳凡徐涛李玮谭萍中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 中国科学院大学北京100049 中国石油天然气股份有限公司华北油田分公司勘探开发研究院河北任丘062552 中国科学院广州地球化学研究所同位素地球化学国家重点实验室广州510640

峨眉山大火成岩省是我国境内最早获得国际学术界广泛认可的大火成岩省,对于认识地幔柱形成与作用机理、生物与环境演化、资源富集与成矿机制等具有重要意义.本文利用峨眉山大火成岩省宽频带地震台阵(COMPASS-EliP)以及云南、四川区域地... 详细信息

峨眉山大火成岩省是我国境内最早获得国际学术界广泛认可的大火成岩省,对于认识地幔柱形成与作用机理、生物与环境演化、资源富集与成矿机制等具有重要意义.本文利用峨眉山大火成岩省宽频带地震台阵(COMPASS-EliP)以及云南、四川区域地震台网的部分台站资料,基于分格加权叠加策略实现接收函数和面波频散在信息来源和分辨尺度方面的协同;进而开展联合反演,重建了峨眉山大火成岩省关键剖面下方的地壳横波速度结构.研究结果显示:研究区地壳平均S波速度,沿剖面呈现自西向东先增大后减小的分带性,内带中、下地壳速度较高,尤其是下地壳存在明显的高速异常(V_s约3.8~4.2 km·s^(-1))丽江—小金河断裂带和水城—紫云断裂带的东西两侧,中上地壳存在低速层(V_s约3.3 km·s^(-1)),尤其是水城—紫云断裂带东西两侧的中地壳低速层尤为明显.结合本文以及现有的系列研究结果,进一步确认内带中、下地壳高速对应二叠纪古地幔柱作用的遗迹,大规模岩浆的底侵和内侵,不仅改造了滇中块体的地壳结构和组分,而且也改变了地壳的流变强度,进而对现今青藏高原东南缘的深部过程产生了深远影响.

关键词：峨眉山大火成岩省青藏高原东南缘古地幔柱横波速度接收函数环境噪声

Percutaneous aortic valve replacement using a W-model valved stent： a preliminary feasibility study in sheep

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Chinese Medical Journal 2009年第6期122卷 655-658页

作者： BAI Yuan ZONG Gang-jun WANG Yan-yan JIANG Hai-bin li wei-ping WU Hong ZHAO Xian-xian QIN Yong-wen Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Ultrasonography Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Cardiology 101 Hospital of PLA Wuxi Jiangsu 210044 China Department of' Internal' Medicine Zhongshan Hospital Fudan University Shanghai 200032 China

Background Percutaneous aortic valve replacement is a promising strategy in the treatment of patients with aortic valve stenosis. And many kinds of valved stents have been implanted in selected patients worldwide. However, the clinical experience is still limited. We developed a W-model valved stent and evaluated the feasibility and safety of percutaneous implantation of the device in the native aortic valve position.Methods A self expanding nitinol stent with W-model, containing porcine pericardium valves in its proximal part, was implanted in six sheep by means of a 14 French catheter through the right common iliac artery under guidance of fluoroscopy. During stent deployment the original aortic valve was pushed against the aortic wall by the self expanding force of the stent while the new valve was expanded. These sheep were followed up shortly after procedure with supra-aortic angiogram and left ventriculography. Additionally, one sheep was sacrificed after the procedure for anatomic evaluation.Results It was possible to replace the aortic valve in the beating heart in four sheep. The procedure failed in two sheep due to coronary orifice occlusion in one case and severe aortic valve regurgitation in the other case. One sheep was killed one hour after percutaneous aortic valve replacement for anatomic evaluation. There were no signs of damage of the aortic JntJma, or of obstruction of the coronary orifice,Conclusions Percutaneous aortic valve replacement with a W-model valved stent in the beating heart is possible. Further studies are mandatory to assess safety and efficacy of this kind of valved stent in larger sample size and by longer follow-up period.

关键词： percutaneous aortic valve valved stent bioprosthesis

Percutaneous establishment of tricuspid regurgitation： an experimental model for transcatheter tricuspid valve replacement

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Chinese Medical Journal 2010年第7期123卷 806-809页

作者： BAI Yuan CHEN Hai-yan ZONG Gang-jun JIANG Hai-bing li wei-ping WU Hong ZHAO Xian-xian QIN Yong-wen Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433China Department of Cardiology Changzheng Hospital Second Military Medical University Shanghai 200003 China Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433China Department of Ultrasonography Changhai Hospital Second Military Medical University Shanghai 200433China

Background Valve replacement or repair Is recommended in patients with tricuspid regurgitation when deterioration of their clinical status occurs as a consequence of right ventricular dysfunction. Percutaneous valve replacement was developed in recent years. To investigate the feasibility, effectiveness and long-term results of percutaneous tricuspid valve replacement, an experimental model with tricuspid regurgitation is needed. We developed a simple and reproducible percutaneous approach for the creation of tricuspid regurgitation in *** A specially designed grasping forceps were used to grasp chordae tendineae or the tricuspid valve leaflets through a catheter. Transcatheter creation of tricuspid regurgitation was performed on 7 healthy sheep. These sheep were followed up shortly after the procedure and at 6th month post-procedure with echocardiography. Additionally, all the sheep were sacrificed for anatomic evaluation at 6th month after the *** Creation of tricuspid regurgitation was successfully accomplished in all sheep. Necropsy confirmed that damage was done to the tricuspid valve apparatus in all animals （tearing of the anterior leaflet of the tricuspid valve in five animals and posterior leaflet of the tricuspid valve in two animals）. At the six-month follow-up, there was no significant increase in the right ventricle dimension and ejection fraction measured by echocardiography. Autopsy examinations demonstrated the tearing of tricuspid valve *** The creation of an animal model of tricuspid regurgitation via a percutaneous approach using forceps to sever one or more tricuspid leaflets is feasible and will allow investigation of devices designed replace the tricuspid valve via a percutaneous approach. Despite significant tricuspid regurgitation, the hemodynamics did not change during the follow-up period in this model.

关键词： tricuspid regurgitation percutaneous, animal model