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Effects of Hydroxyapatite Nanoparticles on Devitrification Crystallization in Cryoprotectant Solutions

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工程热物理学报 2015年第1期36卷 142-146页

作者： LV Fukou liU Bao-lin li wei-jie Ganesh K.Jaganathan Institute of Biothermal Science and Technology University of Shanghai for Science and technology

To study the effects of Hydroxyapatite(HA) nanoparticles on devitrification in cryoprotectant solutions,the crystallization of glycerol(60%,w/w) and PEG-600(50%,w/w) solutions with HA nanoparticles of different sizes(20 nm、 40 nm、60 nm)and different concentrations(0.1%、 0.5%)during warming were investigated by using differential scanning calorimetry(DSC) combined with *** results showed that the presence of nanoparticles does not change the glass transition temperatures and melting temperatures of quenched solutions,but affects the behavior of devitrification and recrystallization upon *** morphologies of glycerol and PEG-600 solutions are dendritic and spheric respectively,and the structures are not changed by adding *** ice fraction of glycerol solution containing 0.1%60nm HA nanoparticles diminished significantly when comparing to the control *** ice fractions of PEG-600 solutions increased dramatically between-64℃ and-54℃.The findings have significant implications for biomaterial cryopreservation.

关键词： nanoparticles devitrification crystallization DSC cryomicroscope

Studies on the Crystal Structure and Photoluminescence of a Mercury(Ⅱ)Complex Based on a Novel Pyridine ligand

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1029-1032页

作者： WU jie-Ying ZHOU Wen li wei-jie ZHOU Hong-Ping TIAN Yu-Peng Department of Chemistry Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province Anhui University Hefei 230039 China

A novel mercury（H） complex HgL2Br2 was prepared from HgBr2 and the organic ligand 2-（N-methyl-N-（4-（（E）-2-（pyridine-4-yl）vinyl）phenyl）amino）ethanol （L）. The ligand was synthesized and then characterized by FT-IR spectroscopy, tH NMR, mass spectrum and elemental analysis, while the single-crystal diffraction data of the complex were collected on a Siemens Smart CCD diffractometer. The complex crystallizes in triclinic space group PI with a = 5.367（5）, b = 12.466（5）, c = 23.945（5） A, α = 90.812（5）, β = 96.318（4）, γ = 96.093（5）°, Z = 2, Dc = 1.817 ***3,μ = 7.395 mm^-1, S = 0.825, and the final R= 0.0396. The Hg（Ⅱ） ion in the distorted tetrahedral mercury（Ⅱ） complex C32H36HgBr2N4O2 is coordinated by two N atoms from the two ligands together with two bromide ions. Solid-state emission of the ligand and its complex has been investigated at room temperature.

关键词： mercury(Ⅱ) complex single-photon fluorescence crystal structure

Comparison of the Nerve Regeneration Capacity and Characteristics between Sciatic Nerve Crush and Transection Injury Models in Rats

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Biomedical and Environmental Sciences 2023年第2期36卷 160-173页

作者： WANG Bin Bin GUO Chao SUN Sheng Qiao ZHANG Xing Nan li Zhen li wei jie li De Zhi SCHUMACHER Michael liU Song Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China U1195 Inserm et Universite Paris-SaclayLe Kremlin-Bicetre 94276France

Objective To provide useful information for selecting the most appropriate peripheral nerve injury model for different research purposes in nerve injury and repair studies,and to compare nerve regeneration capacity and characteristics between *** Sixty adult SD rats were randomly divided into two groups and underwent crush injury alone(group A,n=30)or transection injury followed by surgical repair(group B,n=30)of the right hind *** group was subjected to the CatWalk test,gastrocnemius muscle evaluation,pain threshold measurement,electrophysiological examination,retrograde neuronal labeling,and quantification of nerve regeneration before and 7,14,21,and 28 days after *** Gait analysis showed that the recovery speed in group A was significantly faster than that in group B at 14 *** 21 days,the compound muscle action potential of the gastrocnemius muscle in group A was significantly higher than that in group B,and the number of labeled motor neurons in group B was lower than that in group *** number of new myelin sheaths and the g-ratio were higher in group A than in group *** was a 7-day time difference in the regeneration rate between the two injury *** The regeneration of nerve fibers was rapid after crush nerve injury,whereas the transection injury was relatively slow,which provides some ideas for the selection of clinical research models.

关键词： Sciatic nerve injury Degeneration Regeneration Myelination

Influence of Ethylene Glycol on the Formation of Calcium Phosphate Nanocrystals

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Journal of Materials Science & Technology 2003年第6期19卷 628-630页

作者： Yi ZUO, Yubao li, jie wei and Yonggang YANResearch Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China Res. Ctr. for Nano-Biomaterials Analytical and Testing Ctr. Sichuan Univ. Chengdu 610064 China

A synthesis route of using calcium hydroxide Ca(OH)2 with ethylene glycol solvent and orthophosphoric acid (H3PO4) as reagents is described. Three ratios of ethylene glycol to distilled water 1:0, 1:1 and 0:1 are used as diluting media for Ca(OH)2. Crystals of different morphology and composition are formed under weak alkaline circumstance at pH 7.0-8.0. Acicular calcium phosphate nanocrystals are prepared in pure ethylene glycol while rod-like calcium phosphate nanocrystals form in pure distilled water. The nanograde size of the former is smaller than that of the latter. Calcium-deficient apatite (CDAP) is obtained with a Ca/P molar ratio of 1.66. Therefore, it was deduced that the usage of ethylene glycol solvent could influence the formation of calcium phosphate crystal lattice.

关键词： Acicular nanocrystals Calcium phosphate Ethylene glycol solvent Weak alkaline circumstance

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

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Cellular & Molecular Immunology 2015年第6期12卷 729-742页

作者： Yang Xiao Fang liu Jingyi Yang Maohua Zhong Ejuan Zhang Yaoming li Dihan Zhou Yuan Cao wei li jie Yu Yi Yang Huimin Yan Mucosal immunity Research Group State Key Laboratory of Virology Wuhan institute of Virology Chinese Academy of Sciences Wuhan China

Flagellin is a potent activator of a broad range of cell types that are involved in innate and adaptive immunity. Therefore, it is a good adjuvant candidate for vaccines, and it might function as a biological protectant against both major acute radiation syndrome during cancer radiotherapy and a mitigator of radiation emergencies. However, accumulating evidence has implicated flagellin in the occurrence of some inflammatory diseases, such as acute lung inflammation, cardiovascular collapse and inflammatory bowel disease. The aim of this study was to elucidate whether only flagellin-TLR5 signaling activation plays a role in the pathophysiology of liver or whether some other flagellin activity also contributes to liver injury either via bacterial infections or during clinical applications. Recombinant flagellin proteins with or without TLR5-stimulating activity were used to evaluate the role of flagellin-TLR5 signaling in liver injury in wild-type and TLR5 KO mice. Gross lesions and large areas of hepatocellular necrosis were observed in liver tissue 12 h after the intraperitoneal administration of 100 or 200 pg flagellin （FliC） in a dose-and time-dependent manner in wild-type mice, but not in TLR5 KO mice. Deletion of the N-terminal or TLR5 binding domain of flagellin inhibited flagellin-induced inflammatory responses and the subsequent acute liver function abnormality and damage. These data confirmed that flagellin is an essential determinant of liver injury and demonstrated that the over-activation of TLR5 signaling by high-dose flagellin caused acute inflammatory responses, neutrophil accumulation and oxidative stress in the liver, which contributes to the progression and severity of flagellin-induced liver injury.

关键词： flagellin liver injury pathological effect TLR5

Advances in brain imaging of neuropathic pain

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Chinese Medical Journal 2008年第7期121卷 653-657页

作者： CHEN Fu-yong TAO wei li Yong-jie Department of Functional Neurosurgery Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital MedicalUniversity Beijing 100053 China

To review the literature on the use of brain imaging, including functional magnetic resonance imaging （fMRI）, positron emission tomography （PET）, magnetic resonance spectroscopy （MRS） and voxel-based morphometry （VBM） in investigation of the activity in diverse brain regions that creates and modulates chronic neuropathic pain. Data sources English literatures from January 1, 2000 to July 31, 2007 that examined human brain activity in chronic neuropathic pain were accessed through MEDliNE/CD ROM, using PET, fMRI, VBM, MRS and receptor binding. Study selection Published articles about the application of fMRI, PET, VBM, MRS and chronic neuropathic pain were selected. Data extraction Data were mainly extracted from 40 representative articles as the research basis. Results The PET studies suggested that spontaneous neuropathic pain is associated with changes in thalamic activity. Both PET and fMRI have been used to investigate the substrate of allodynia. The VBM demonstrated that brain structural changes are involved in chronic neuropathic pain, which is not seen in a matched control group. However, the results obtained had a large variety, which may be due to different pain etiology, pain distribution, lesion tomography, symptoms and stimulation procedures. Conclusions Application of the techniques of brain imaging plays a very important role in the study of structural and functional reorganization in patients with neuropathic pain. However, a unique “pain matrix” has not been defined. Future studies should be conducted using a prospective longitudinal research design, which would guarantee the control for many confounding factors.

关键词： magnetic resonance imaging function positron emission tomography neuropathic pain review

Research and Implementation of a Graphic System for Doppler Radar

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微计算机信息 2007年第22期23卷 307-309页

作者： YE XIAOliNG JI wei li wei BAI jie (Nanjing University of information science and technology) (Institute of Aeronautical Meteorology,Air Force Academy of Equipment)

Doppler radar have become one of the most important instruments for weather now casting,and for meso-scale weather research because of its higher spatial and temporal resolutions. A dealing system for Doppler radar graphic was researched and implemented so as to providing a convenient tool for users. We research and realized CINRAD/XD Doppler radar's graphic system. It contains three important parts:reading,standardization and pretreatment. It can be used very easily and conveniently. Besides,the system can be expanded and transplanted simply.

关键词：多普勒天气雷达图形系统数据处理演示

Numerical simulation research of heating chamber for high performance hydrogen bell-type annealers

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Journal of Energy and Power Engineering 2009年第9期2卷 1-6,16页

作者： li wei-jie LU Ji-dong RUAN Xin-jian State Key Laboratory of Coal Combustion Huazhong University of Science and Technology Wuhan 430074 China Wuhan Steel Company Wuhan 430083 China

The mathematic model of heating chamber for implementing the prediction of the annealing craft and improving the self adapting with the expansion of the new annealing furnace form, new annealing crafts and new kinds of steel coil has been established. The model developed which including the temperature for gas in heating chamber and the heating cover is based on the characteristics of anneal craft and the situations of locale production run. Firstly, the characteristic of the heating cover which limits the temperature was considered. Secondly, the locale production run condition and dispatching condition were considered. Finally, combining with the models and the simulation system, the numerical simulation research of the anneal process for the high performance hydrogen bell-type annealer as well as the spot experiment test were carried out. The results obtained from the developed models, usually finished less than thirty seconds, are in fair agreement with the test values, such as the relative errors of annealing times were within ±5%, and the quality＇ of the annealed steels were guaranteed.

关键词： bell-type annealer numerical simulation heating chamber: production run: field experiment test

LncRNA HCG27 Promotes Glucose Uptake Ability of HUVECs by MiR-378a-3p/MAPK1 Pathway

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Current Medical Science 2023年第4期43卷 784-793页

作者： Jing-yi ZHANG Yi JIANG li-jie wei Xuan ZHOU Sheng-lan ZHU Hui-ting ZHANG Yu-ting CHEN Peng GAO Jun YU Shao-shuai WANG ling FENG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Gestational diabetes mellitus(GDM)is the most common metabolic disorder during *** HLA complex group 27(HCG27)plays a crucial role in various metabolic ***,the relationship between lncRNA HCG27 and GDM is not *** study aimed to verify a competing endogenous RNA(ceRNA)interaction regulation axis of miR-378a-3p/mitogen-activated protein kinase 1(MAPK1)regulated by HCG27 in ***:LncRNA HCG27 and miR-378a-3p were detected by *** expression of MAPK1 in umbilical vein endothelial cells(HUVECs)was detected by RT-qPCR and that in the placenta by Western *** explore the relationship among lncRNA HCG27,miR-378a-3p,MAPK1 and the glucose uptake ability of HUVECs,vector HCG27,si-HCG27,miR-378a-3p mimic and inhibitor were transfected to achieve overexpression and inhibition of HCG27 or *** interaction between miR-378a-3p and lncRNA HCG27 or MAPK1 was confirmed by the dual-luciferase reporter ***,glucose consumption by HUVECs was detected by the glucose assay ***:HCG27 expression was significantly decreased in both the placenta and primary umbilical vein endothelial cells,while the expression of miR-378a-3p was significantly increased in GDM tissues,and the expression of MAPK1 was decreased in GDM *** ceRNA interaction regulation axiswas proved to affect the glucose uptake function of *** transfection of si-HCG27 could significantly reduce the expression of the MAPK1 *** the MAPK1 overexpression plasmid was transfected simultaneously with si-HCG27 transfection,the reduced glucose uptake in HUVECs resulting from the decrease in lncRNA HCG27 was ***-378a-3p mimic can significantly reduce the mRNA expression of MAPK1 in HUVECs,whereas miR-378a-3p inhibitor can significantly increase the mRNA expression of *** inhibition of miR-378a-3p could restore the decreased glucose uptake of HUVECs treated with ***,overexpression of lncRNA HCG27 could

关键词： lncRNA ceRNA gestational diabetes mellitus human umbilical vein endothelial cells