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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang lilingxuan Yao Xinyue Xu Yang li Junhui Xue Zuoming Zhang tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Defects‑Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 528-547页

作者： Jiaolong liu Siyu Zhang Dan Qu Xuejiao Zhou Moxuan Yin Chenxuan Wang Xuelin Zhang Sichen li Peijun Zhang Yuqi Zhou Kai tao Mengyang li Bing Wei Hongjing Wu Mengyang li Bing Wei Hongjing Wu School of Physics Xidian UniversityXi’an 710071People’s Republic of China School of Advanced Materials and Nanotechnology State Key Discipline Laboratory of Wide Band Gap Semiconductor TechnologyXidian UniversityXi’an 710071People’s Republic of China School of Microelectronics Xidian UniversityXi’an 710071People’s Republic of China School of Telecommunication Engineering Xidian UniversityXi’an 710071People’s Republic of China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China The Ministry of Education Key Laboratory of Micro and Nano Systems forAerospace School of Mechanical EngineeringNorthwestern PolytechnicalUniversityXi’an 710072People’s Republic of China

Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies,as well as veiled dielectric-responsive character,are instrumental in electromagnetic *** methods,however,constrain their delicate ***,an innovative alternative is proposed:carrageenan-assistant cations-regulated(CACR)strategy,which induces a series of sulfides nanoparticles rooted in situ on the surface of carbon *** unique configuration originates from strategic vacancy formation energy of sulfides and strong sulfides-carbon support interaction,benefiting the delicate construction of defects-rich heterostructures in M_(x)S_(y)/carbon composites(M-CAs).Impressively,these generated sulfur vacancies are firstly found to strengthen electron accumulation/consumption ability at heterointerfaces and,simultaneously,induct local asymmetry of electronic structure to evoke large dipole moment,ultimately leading to polarization coupling,i.e.,defect-type interfacial ***“Janus effect”(Janus effect means versatility,as in the Greek two-headed Janus)of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first ***,the sulfur vacancies-rich heterostructured Co/Ni-CAs displays broad absorption bandwidth of 6.76 GHz at only 1.8 mm,compared to sulfur vacancies-free CAs without any dielectric *** defects-rich heterostructures,this one-pot CACR strategy may steer the design and development of advanced nanomaterials,boosting functionality across diverse application domains beyond electromagnetic response.

关键词： Defects-rich heterointerfaces Sulfides Polarization coupling Electromagnetic wave absorption

A Coding Scheme for Noisy Image Based on Layer Segmentation

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Chinese Journal of Electronics 2016年第4期25卷 700-705页

作者： li tao tian Xin XIONG Chengyi tian Jinwen Nanjing Research Institute of Electronics Technology Wuhan University South–Central University for Nationalities Huazhong University of Science and Technology

Heavy noises distribute in the images when imaging in a poor *** randomness of noises makes pixels distributing singularly,which weakens the1-D piecewise smooth property of original ***,wavelets-based compression method no longer works *** this paper,a layer segmentation based compression scheme is proposed for gray *** textures and some high frequency noises are described in a high frequency layer while the coarse part of the image is described in the low frequency *** high frequency layer is represented by a joint dictionary,and the low frequency layer is coded with the traditional *** proposed scheme is tested on nature images and synthetic *** results show that the proposed scheme achieves better rate-distortion performance compared with several competing compression ***,further degradation of edges is avoided by the proposed compression scheme.

关键词： Image coding Noisy image model Sparse representation Edge detection

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热阴极逸出功非均匀性对本征发射度的影响

电子学报 2019年第3期47卷 643-648页

作者：彭宇飞秦臻陈弹蛋刘平李天涛向军赵伟陈欣杨洁黄刚李建北龙继东石金水中国工程物理研究院流体物理研究所四川绵阳621999

热阴极广泛应用于真空电子器件、加速器、自由电子激光等各类束流装置,热阴极表面状态非均匀性对束流本征发射度有着显著的影响.本文推导了非均匀发射阴极的均方根本征发射度理论形式,并分析了逸出功非均匀性及其统计效应对本征发射度... 详细信息

热阴极广泛应用于真空电子器件、加速器、自由电子激光等各类束流装置,热阴极表面状态非均匀性对束流本征发射度有着显著的影响.本文推导了非均匀发射阴极的均方根本征发射度理论形式,并分析了逸出功非均匀性及其统计效应对本征发射度的影响.针对逸出功径向和一维余弦分布模型,计算了均方根发射度与逸出功非均匀性关系的理论数值解;基于有限差分法粒子仿真技术,开发了专用于阴极仿真的程序YY-PICMC,并验证了理论形式的正确性;针对逸出功二维余弦分布模型进行了理论和仿真分析,结果表明逸出功分布空间频数对均方根发射度涨落有显著影响,当空间频数趋于无限大时,发射度增长系数趋于1,即逸出功均匀阴极的情形;最后,分析了最接近真实阴极表面状态的二维逸出功随机分布模型,仿真结果表明随着空间频数增加,发射度增长系数统计方差逐渐减小,符合余弦模型结果的预期.本文建立的理论形式和仿真方法可以用于评估各类阴极表面逸出功空间非均匀性特征对束流本征发射度的影响程度.

关键词：阴极电子学热阴极 FDTD PIC 本征发射度逸出功分布

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运动对大学生肠道菌群影响的系统综述

中国组织工程研究 2025年第11期29卷 2394-2401页

作者：刘昭志黄丽田浩冬李岚陈晓陶云飞彭莉西南大学体育学院重庆市400715 西南大学体育学院国家体育总局体质评价与运动机能监控重点实验室重庆市400715 山东中医药大学健康学院山东省济南市250000

背景:运动对肠道菌群的调节与人体健康密切相关,但肠道菌群涉及多方面因素影响,国内外研究尚缺乏有关运动对大学生肠道菌群影响的较为一致的证据。目的:探讨运动对大学生肠道菌群多样性和物种组成的影响。方法:通过系统检索PubMed、Web ... 详细信息

背景:运动对肠道菌群的调节与人体健康密切相关,但肠道菌群涉及多方面因素影响,国内外研究尚缺乏有关运动对大学生肠道菌群影响的较为一致的证据。目的:探讨运动对大学生肠道菌群多样性和物种组成的影响。方法:通过系统检索PubMed、Web of Science、Embase、Medline、Cochrane library、中国知网、万方、维普数据库,筛选后纳入8篇实证研究,对其采用半定量的方法进行分析。结果与结论:①在运动改变大学生肠道菌群物种多样性方面,高强度间歇训练和太极拳运动均能显著提升大学生肠道菌群的物种多样性,而有氧运动对大学生肠道菌群多样性的提升效果不显著;②在运动影响肠道菌群物种组成方面,3种运动方式均能显著改变大学生肠道中菌群的组成结构,可以提高瘤胃球菌、普氏粪杆菌、布劳提亚菌等有益菌的丰度,降低埃希氏菌属等有害菌的丰度;相较于高强度间歇训练,有氧运动和太极拳运动引起了更多有益菌丰度的提升;③除肠道菌群特征的变化外,运动还可以改善大学生体成分、心肺功能以及执行功能等,这些健康效益与运动引起的菌群变化密切相关,这些菌群可通过代谢调节、屏障功能以及神经调节对机体产生健康效益;④虽然目前已有研究证实了运动与肠道菌群存在关联,但运动影响肠道菌群的机制尚未明确,同时定位与宿主健康相关的菌群是未来以肠道菌群为治疗靶点的关键,这些均值得学者进一步关注和探究。

关键词：运动干预大学生肠道菌群菌群多样性物种组成

库水位升降下多诺水电站右岸倾倒变形体边坡演化过程研究

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地质灾害与环境保护 2022年第4期33卷 26-32页

作者：李天涛李少波郝盛蓝裴向军地质灾害防治与地质环境保护国家重点实验室(成都理工大学) 成都610059 四川省地质矿产勘查开发局四〇二地质队成都644002

为研究多诺水电站右岸倾倒变形体边坡的演化过程,结合地质资料和监测数据来分析边坡变形影响因素,通过底摩擦模型试验模拟倾倒变形体初始形成过程,最后综合得出库水位升降下多诺水电站右岸倾倒变形体边坡的变形机制和演化过程。结果得出... 详细信息

为研究多诺水电站右岸倾倒变形体边坡的演化过程,结合地质资料和监测数据来分析边坡变形影响因素,通过底摩擦模型试验模拟倾倒变形体初始形成过程,最后综合得出库水位升降下多诺水电站右岸倾倒变形体边坡的变形机制和演化过程。结果得出:(1)受坡体结构的控制,边坡在河谷下切阶段容易出现倾倒现象;(2)水库蓄水加速了水位变动区的岩体蠕滑变形;(3)地震致使岩体劣化,进而加速了蓄水作用对边坡变形的影响;(4)倾倒变形体边坡的变形影响因素主要有:卸荷作用、蓄水作用和地震作用。

关键词：倾倒变形体边坡河流下切演化过程底摩擦试验变形因素水库蓄水

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong tao Zhang Jiafeng li Xianli Zhu Ruixiao Zhu lingxu Wang Leyuan Ma Xuehui li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and liTFSI–liDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The li|SGPE|li cell presents highly reversible li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V liCoO_(2)|SGPE|li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface li metal battery

Modal Analysis of Axial Compressor Tip Rotating Instability under Varying Operating Conditions

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Journal of Thermal Science 2023年第4期32卷 1345-1356页

作者： li tao WU Yadong tian Jie OUYANG Hua School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China Engineering Research Centre of Gas Turbine and Civil Aero Engine Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China

The full annulus numerical research was performed on a low-speed compressor rotor to investigate the rotating instability in the tip *** frequency spectra show the existence of rotating instability at narrow stable operating *** the decrease of flow rate,31 cells of flow disturbance can be found in the instantaneous flow *** distribution of vortex suggests that the circumferential propagation of the interaction between tip leakage vortex and adjacent blade brings about these *** dynamic mode decomposition(DMD)method and spatial discrete Fourier transform(SDFT)were applied to obtain the circumferential mode features,and the results indicate that the rotating instability is associated with the 31 cells of flow *** the DMD method was further applied on the pressure data from a circle and an annulus domain,so as to extract different mode components with the corresponding spatial structures,frequencies and *** results suggest that DMD modes can display the flow feature and explore the evolution of each instability source in the tip flow field.

关键词： axial compressor rotating instability flow structure circumferential mode dynamic mode decomposition

冠状动脉旋磨术联合药物洗脱支架置入术治疗冠状动脉严重钙化病变的临床研究

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中国介入心脏病学杂志 2017年第3期25卷 158-162页

作者：赵兵兵李滔田刚孙中华天津中医药大学天津300193 泰达国际心血管病医院心内科

目的回顾性分析泰达国际心血管医院心内科行冠状动脉旋磨术(rotational atherectomy,RA)联合药物洗脱支架(drug-eluting stents,DES)置入术治疗的患者临床资料,评估RA的安全性及预后。方法连续入选2012年9月至2015年9月泰达国际心血管... 详细信息

目的回顾性分析泰达国际心血管医院心内科行冠状动脉旋磨术(rotational atherectomy,RA)联合药物洗脱支架(drug-eluting stents,DES)置入术治疗的患者临床资料,评估RA的安全性及预后。方法连续入选2012年9月至2015年9月泰达国际心血管病医院心内科行RA联合DES置入术治疗的患者共60例65处病变,分析冠状动脉造影(coronary angiography,CAG)资料,收集临床信息,并通过门诊及电话随访评估其预后。结果 60例患者65处病变中成功完成RA并置入DES共62处病变(95.3%),术后狭窄程度由(90.7±6.2)%降至(19.5±6.6)%,术中发生并发症4例(6.7%),经处理均取得较好效果。60例患者中59例完成随访,平均随访时间为(23.3±10.6)个月,1例患者术后10个月发生支架内再狭窄;1例患者术后16个月支架内血栓形成;1例患者术后7个月发生急性心肌梗死;2例患者分别于术后14个月、17个月猝死,考虑为心源性死亡。结论 RA联合DES置入术治疗冠状动脉严重钙化病变手术成功率较高,且具有较高的安全性和良好预后。

关键词：冠状动脉旋磨术药物洗脱支架严重钙化病变