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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-tao li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

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Intestinal glucagon-like peptide-1:A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus

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World Journal of Diabetes 2025年第1期16卷 217-221页

作者： Le-Rong liu Yuan-Yuan Luo Pei-Zhu Su Cong Zhang Zhao-tao li Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Chongqing University Three Gorges HospitalChongqing 404100China Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases Chongqing University Three Gorges HospitalChongqing 404100China Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400013China Department of Gastroenterology The First People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina

In this article,we review the study by Jin et al,which examined the role of intestinal glucagon-like peptide-1(GLP-1)in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus(T1DM).With the global rise of T1DM,there is an increased burden on society and healthcare *** to insulin therapy and islet dysfunction,T1DM patients are highly vulnerable to severe hypoglycemia,a leading cause of *** healthy individuals,counterregulatory mechanisms restore blood glucose during hypoglycemia,but repeated episodes impair these *** et al demonstrated that overexpression of GLP-1 attenuates the sympathetic-adrenal reflex and disrupts the secretion of counterregulatory hormones such as glucagon during hypoglycemia,leading to counterregulatory *** findings highlight the critical role of GLP-1 in the impaired counterregulatory response to hypoglycemia in T1DM patients and provide new insights into the potential application of GLP-1-related therapies in T1DM patients.

关键词： Glucagon-like peptide-1 Impaired counterregulation Type 1 diabetes mellitus Sympathetic-adrenal reflex Glucagon

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Microstructure and Mechanical Properties of 1,000 MPa Ultra-High Strength Hot-Rolled Plate Steel for Coal Mine Refuge Chamber

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Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 422-429页

作者： Changsheng li Biao Ma tao li tao Zhu State Key Laboratory of Rolling and Automation Northeastern University

The 1,000 MPa ultra-high strength hot-rolled plate steel with low-carbon bainitic microstructure was developed in the laboratory for coal mine refuge chamber. The static recrystallization behavior, microstructure evolution, and mechanical properties of this hot-rolled plate steel were investigated by the hot compression, continuous cooling trans- formation, and tensile deformation test. The results show that the developed steel has excellent mechanical properties at both room and elevated temperature, and its microstructure mainly consists of lath bainite, granular bainite, and ferrite after thermal-mechanical control process （TMCP）. The ultra-high strength plate steel is obtained by the TMCP process in hot rolling, strengthened by bainitic transformation, microstructure refinement, and precipitation of alloying elements such as Nb, Ti, Mo, and Cu. The experimental steel has relatively low welding crack sensitivity index and high atmospheric corrosion resistance index. Therefore, the developed steel has a good balance of strength and ductility both at room and elevated temperature, weldability and corrosion resistance, and it can suffice for the basic demands for materials in the manufacture of coal mine refuge chamber.

关键词： Ultra-high strength steel Low-carbon bainite Coal mine refuge chamber Microstructure Mechanical property

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我国未来学习中心建设现状与路径探索

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大学图书情报学刊 2025年第1期43卷 37-42,65页

作者：李小涛解玲南京航空航天大学图书馆 210016 南京航空航天大学经济与管理学院 210016

建设未来学习中心,是推进高等教育数字化转型和高校图书馆服务升级的有效途径。调研未来学习中心建设现状及存在问题,可为我国高等院校未来学习中心建设实践提供参考借鉴。文章运用文献调研和网络调查的方法,从顶层设计、建设理念、空... 详细信息

建设未来学习中心,是推进高等教育数字化转型和高校图书馆服务升级的有效途径。调研未来学习中心建设现状及存在问题,可为我国高等院校未来学习中心建设实践提供参考借鉴。文章运用文献调研和网络调查的方法,从顶层设计、建设理念、空间建设、资源建设、服务创新5个维度对全国高等院校未来学习中心建设实践进行调查,并对调查结果进行归类、统计和分析。研究发现,我国未来学习中心建设正处于起步探索期,在具体实践中存在着顶层设计不足、技术应用与教学模式融合不深等问题。针对这些问题,文章提出了相应的建设路径。

关键词：未来学习中心高校图书馆建设现状网络调研

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A short review of the recent progresses in the study of the cuprate superconductivity

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Chinese Physics B 2021年第10期30卷 14-17页

作者： tao li Department of Physics Renmin University of ChinaBeijing 100872China

The last 15 years have witnessed important progresses in our understanding of the mechanism of superconductivity in the high-Tc *** is now strong evidence that the strange metal behavior is induced by the quantum critical fluctuation at the pseudogap end point,where the Fermi surface changes its topology from hole-like to ***,experiments show that the quantum critical behavior in the high-Tc cuprates is qualitatively different from that observed in the heavy Fermion systems and the iron-based superconductors,in both of which the quantum critical behavior can be attributed to the quantum phase transition toward a symmetry breaking *** fact that the pseudogap exists as a spectral gap without a corresponding symmetry breaking order,together with the fact that the strange metal behavior occurs as a quantum critical behavior without a corresponding symmetry breaking phase transition,exposes the central difficulty of the field:the lack of a universal low energy effective theory description of the high-Tc phenomenology beyond the Landau *** experiments imply that the dualism between the local moment and the itinerant quasiparticle character of the electron in the high-Tc cuprates may serve as an organizing principle to go beyond the Landau paradigm and may hold the key to the mystery of the pseudogap phenomena and the strange metal *** is the purpose of this review to provide an introduction to these recent progresses in the study of the high-Tc cuprate superconductors and their implications on the construction of a coherent picture for the high-Tc problem.

关键词： high-Tc superconductivity pseudogap phenomena strange metal behavior

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Data-Driven Direct Adaptive Risk-Sensitive Control of Stochastic Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1446-1469页

作者： QIAO Nan li tao School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

The authors propose a data-driven direct adaptive control law based on the adaptive dynamic programming(ADP) algorithm for continuous-time stochastic linear systems with partially unknown system dynamics and infinite horizon quadratic risk-sensitive *** authors use online data of the system to iteratively solve the generalized algebraic Riccati equation(GARE) and to learn the optimal control law *** the case with measurable system noises,the authors show that the adaptive control law approximates the optimal control law as time goes *** the case with unmeasurable system noises,the authors use the least-square solution calculated only from the measurable data instead of the real solution of the regression equation to iteratively solve the *** authors also study the influences of the intensity of the system noises,the intensity of the exploration noises,the initial iterative matrix,and the sampling period on the convergence of the ADP ***,the authors present two numerical simulation examples to demonstrate the effectiveness of the proposed algorithms.

关键词： Adaptive dynamic programming direct adaptive control generalized algebraic Riccati equation risk-sensitive control

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Traceability model based on improved witness mechanism

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 331-339页

作者： li li tao li School of Information and Computer Engineering Northeast Forestry UniversityHarbinChina

Traceability system is one of the popular applications of graphic ***,there are centralisation problems and a long time for final consistency confirmation in the graphic *** addition,the blockchain system in the traceability application scenario has the problem of insufficient ***,a witness-based graphic blockchain consensus mechanism is *** the consensus mechanism,a verifiable random function is used to screen the publishers of the unit;an SM2 threshold signature is used to sign the unit information to improve the non-repudiation of the traceability information uploaders to the unit information under the supervision of the *** improved consistency algorithm cancels the process of finding a stable main chain and makes relatively many nodes to participate in the consensus *** experimental results show that the graphic blockchain using the improved witness mechanism can reduce the degree of centralisation,shorten the time for new units to reach consensus,and greatly ensure the security and scalability of the blockchain system.

关键词： mechanism witness signature

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Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di Zhang Jin-Feng Wang Wan-lin Lu Jing-Yuan Wang Shi-Feng liang Ran liu Jing-Xin Jiang Hong-tao li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all Plic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

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Study on the X-Ray Re-brightening Signature of GRB 220117A

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Research in Astronomy and Astrophysics 2023年第11期23卷 118-124页

作者： li-tao Zhao School of Mathematics and Science Hebei GEO UniversityShijiazhuang 050016China

The Swift/XRT detected the X-ray afterglow of long burst GRB 220117A,which began to rebrighten 300 s after triggering and followed a single power-law decay segment after thousands of seconds of the orbital observation *** segment is different from the shallow decay segment(plateau)and flare,and may belong to a giant X-ray *** investigated this segment by the fall-back accretion model and found that the model can interpret this segment with reasonable parameter *** this physical model scenario,the fall-back accretion rate reaches a peak value~1.70×10~(-5)M_⊙s~(-1)around 300 s in the central engine frame,which is compatible with the late mass supply rate of some low-metallicity massive progenitor *** initial black hole(BH)spin is a_0=0.64_(-0.26)~(+0.24)and implies that this re-brightening signature requires a larger BH *** total accretion mass during the fall-back process is M_(acc)=(3.09±0.02)×10~(-2)M_⊙.The jet energy from the fall-back accretion is(9.77±0.65)×10~(52)erg,with a ratio of 0.066 to the isotropic-equivalent radiation energies of the GRB prompt phase in the 1-10~4 keV *** fall-back radius r_p corresponding to the peak time of fall-back t_p is(3.16±0.05)×10~(10)cm,which is consistent with the typical radius of Wolf-Rayet *** summary,our results provide additional support for the origin of the long burst from the core collapse of Wolf-Rayet stars,and its late central engine activity is likely due to the fall-back accretion process.

关键词： accretion accretion disks black hole physics (stars:)gamma-ray burst:general

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Fault Diagnosis with Wavelet Packet Transform and Principal Component Analysis for Multi-terminal Hybrid HVDC Network

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1312-1326页

作者： tao li Yongli li Xiaolong Chen IEEE School of Electrical Automation and Information Engineering Tianjin University

In view of the fact that the wavelet packet transform(WPT) can only weakly detect the occurrence of fault, this paper applies a fault diagnosis algorithm including wavelet packet transform and principal component analysis(PCA) to the inverter-side fault diagnosis of multi-terminal hybrid highvoltage direct current(HVDC) network, which can significantly improve the speed and accuracy of fault diagnosis. Firstly, current amplitude and current slope are used to sample the data,and the WPT is used to extract the energy spectrum of the signal. Secondly, an energy matrix is constructed, and the PCA method is used to calculate whether the squared prediction error(SPE) statistics of various signals that can reflect the degree of deviation of the measured value from the principal component model at a certain time exceed the limit to judge the occurrence of the fault. Further, its maximum value is compared to determine the fault types. Finally, based on a large number of MATLAB/Simulink simulation results, it is shown that the PCA method using the current slope as the sampled data can detect the occurrence of a ground fault with small transition resistance within 2 ms, and identify the fault types within 10 ms,without being affected by the sampling frequency.

关键词： Fault diagnosis hybrid high-voltage direct current(HVDC) wavelet packet transform(WPT) principal component analysis(PCA)

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