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滋肾育胎丸联合优思明对PCOS不孕症患者子宫内膜容受性、内分泌指标及妊娠结局的影响

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贵州医科大学学报 2024年第1期49卷 151-156页

作者：李素芬黄燕陆军军医大学第二附属医院妇产科重庆400038

目的分析滋肾育胎丸联合优思明对多囊卵巢综合征(PCOS)不孕症患者子宫内膜容受性、内分泌指标及妊娠结局的影响。方法将80例PCOS不孕症患者均分为对照组和观察组,对照采用优思明治疗,观察组采用滋肾育胎丸联合优思明治疗,两组均治疗3... 详细信息

目的分析滋肾育胎丸联合优思明对多囊卵巢综合征(PCOS)不孕症患者子宫内膜容受性、内分泌指标及妊娠结局的影响。方法将80例PCOS不孕症患者均分为对照组和观察组,对照采用优思明治疗,观察组采用滋肾育胎丸联合优思明治疗,两组均治疗3个月;收集患者的临床资料,比较两组患者入院及治疗后的临床疗效、子宫内膜容受性[血流搏动指数(PI)、阻力指数(RI)、子宫内膜血管指数(VI)、血流指数(FI)]、内分泌指标[睾酮(T)、促黄体生成素(LH)、促卵泡刺激素(FSH)、雌二醇(E2)、垂体泌乳素(PRL)、空腹胰岛素(FIN)、空腹血糖(FPG)]、血管内皮生长因子(VEGF)、妊娠结局及不良反应发生率。结果观察组临床有效率高于对照组(P0.05)。结论滋肾育胎丸联合优思明治疗PCOS不孕症患者效果优于单一优思明治疗,可改善患者子宫内膜容受性、内分泌指标,并提高患者的妊娠率及活产率,安全性较好。

关键词：滋肾育胎丸优思明多囊卵巢综合征子宫内膜容受性妊娠结局

碳酸氢钠林格液和复方林格液在控制性低中心静脉压肝切除术中的应用效果比较

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新乡医学院学报 2024年第5期41卷 438-442页

作者：米琰白玉徐刚李素芬卢锡华郑州大学附属肿瘤医院麻醉与围手术期医学科河南郑州450000

目的探讨碳酸氢钠林格液和复方林格液对控制性低中心静脉压(CLCVP)肝切除术患者的酸碱平衡及肝肾功能的影响。方法选择2020年6月至2022年6月在郑州大学附属肿瘤医院行CLCVP肝切除术的60例原发性肝癌患者为研究对象,按随机数字表法将患... 详细信息

目的探讨碳酸氢钠林格液和复方林格液对控制性低中心静脉压(CLCVP)肝切除术患者的酸碱平衡及肝肾功能的影响。方法选择2020年6月至2022年6月在郑州大学附属肿瘤医院行CLCVP肝切除术的60例原发性肝癌患者为研究对象,按随机数字表法将患者分为碳酸氢钠林格液组和复方林格液组,每组30例。在麻醉诱导后至肝实质离断前,碳酸氢钠林格液组患者输注碳酸氢钠林格液,复方林格液组患者输注复方林格液。分别于麻醉诱导前(T_(1))、手术开始时(T_(2))、术中2 h(T_(3))、术中4 h(T_(4))和手术结束时(T_(5)),使用血气分析仪检测2组患者的pH值、碱剩余(BE)、血乳酸(Lac)水平;分别于术前24 h和术后24 h使用全自动生化分析仪检测2组患者血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、血尿素氮(BUN)及血肌酐(Scr)水平;比较2组患者体质量、手术时间、术中输液量、尿量、手术过程中酸碱平衡变化及手术前后肝肾功能变化。结果2组患者体质量、手术时间、术中输液量及尿量比较差异均无统计学意义(P>0.05)。T_(1)时,2组患者pH值、BE、Lac水平比较差异无统计学意义(P>0.05);与T_(1)时比较,复方林格液组患者T_(2)时pH值升高,T_(3)~T_(5)时均降低,T_(2)~T_(5)的BE及Lac水平均升高(P0.05);T_(5)时碳酸氢钠林格液组患者pH值显著高于复方林格液组,BE及Lac水平显著低于复方林格液组(P0.05);2组患者术后24 h与术前24 h时的ALT、AST、BUN及Scr水平比较差异无统计学意义(P>0.05);术后24 h,2组患者的ALT、AST、BUN及Scr水平比较差异无统计学意义(P>0.05)。结论在CLCVP肝切除术中,相较于复方林格液,碳酸氢钠林格液对机体内环境的影响更小,可有效维持机体酸碱平衡稳定,且2种晶体溶液的使用均未对患者肝肾功能产生明显影响。

关键词：控制性低中心静脉压肝切除术原发性肝癌碳酸氢钠林格液复方林格液酸碱平衡肝肾功能

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蒸汽爆破米糠膳食纤维对糙米米线品质的影响

食品研究与开发 2024年第16期45卷 13-18页

作者：李素芬田心怡天津商业大学机械工程学院天津300134 天津商业大学生物技术与食品科学学院天津300134

为提高米糠可溶性膳食纤维含量,改善米糠糙米米线的食用品质,该研究探讨蒸汽压力、维压时间及米糠粒度对米糠可溶性膳食纤维含量的影响,以及添加蒸汽爆破处理米糠对米线蒸煮品质、质构特性及感官特性的影响。结果表明,经0.4 MPa、200 s... 详细信息

为提高米糠可溶性膳食纤维含量,改善米糠糙米米线的食用品质,该研究探讨蒸汽压力、维压时间及米糠粒度对米糠可溶性膳食纤维含量的影响,以及添加蒸汽爆破处理米糠对米线蒸煮品质、质构特性及感官特性的影响。结果表明,经0.4 MPa、200 s蒸汽爆破处理的60目米糠的可溶性膳食纤维含量达6.27%,为原米糠的1.95倍。与添加未经蒸汽爆破米糠的米线相比,添加8%蒸汽爆破处理米糠的米线的最佳蒸煮时间、断条率、蒸煮损失率得到改善(0.8 MPa、200 s、60目米糠糙米米线的蒸煮损失率除外),硬度和咀嚼性显著提高(P<0.05)。其中添加0.4 MPa、200 s、60目米糠(可溶性膳食纤维含量6.27%)制作的米线的硬度适中,柔软顺滑,感官品质最好。因此,适宜的蒸汽爆破处理可提高米糠可溶性膳食纤维的含量,改善米糠在糙米米线中的应用效果。

关键词：米糠蒸汽爆破膳食纤维糙米米线食用品质

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基于Geant4的裂变核素中子角关联分布数值模拟

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火箭军工程大学学报

火箭军工程大学学报 2024年第4期38卷 98-107页

作者：王鹏黎素芬王飞李凯乐火箭军工程大学核工程学院

为了打破目前通过实验手段对中子角关联进行测量时受到实验条件限制的问题，使用蒙特卡洛方法，依托Geant4软件搭建了一套中子角关联测量模型，对235U、238U、239Pu、240Pu以及252Cf进行数值模拟，得到了这5种裂变核素的中子角关联分布... 详细信息

为了打破目前通过实验手段对中子角关联进行测量时受到实验条件限制的问题，使用蒙特卡洛方法，依托Geant4软件搭建了一套中子角关联测量模型，对235U、238U、239Pu、240Pu以及252Cf进行数值模拟，得到了这5种裂变核素的中子角关联分布。结果表明：在相同条件下，不同裂变核素之间的中子角关联分布存在差异；使用测量模型得到的不同核素中子角关联分布与国外实验结果重合度较高。

关键词：核材料裂变核素中子角关联分布 Geant4软件测量模型

Numerical study on non-uniform heat transfer deterioration of supercritical RP-3 aviation kerosene in a horizontal tube

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1542-1557页

作者： Yanhong Wang Yingnan Lu sufen li Ming Dong School of Energy and Power Engineering Northeast Electric Power UniversityJilin 132012China School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China

The convective heat transfer of supercritical-pressure RP-3(Rocket Propellant 3)aviation kerosene in a horizontal circular tube has been numerically studied,focusing mainly on the non-uniform heat transfer deterioration along the circumferential *** governing equations of mass,momentum and energy have been solved using the pressure-based segregated solver based on the finite volume *** re-normalization group(RNG)k-εturbulence model with an enhanced wall treatment was *** the heat conduction in the solid wall,the mechanism of heat transfer deterioration and the buoyancy effect on deteriorated heat transfer were *** evolution of secondary flow was *** of the outer-wall heat flux,mass flux,pressure and tube thermal conductivity on heat transfer were ***,the buoyancy criterion and the heat transfer correlation were *** indicate that the poor flow performance of near-wall fluid causes the pseudo-film boiling,further leads to the heat transfer *** strong buoyancy has an effect of enhancing the heat transfer at the bottom of tube,and weakening the heat transfer at the top of tube,which results in the non-uniform inner-wall temperature and heat flux *** the ratio of outer-wall heat flux and mass flux,increasing the pressure could weaken the heat transfer difference along the circumferential direction,while the effect of thermal conductivity of tube on the circumferential parameters distributions is more *** the buoyancy criterion of(Grq/Grth)max≤0.8 is satisfied,the effect of buoyancy could be *** new correlations work well for non-uniform heat transfer predictions.

关键词： Supercritical pressure Aviation kerosene Non-uniform heat transfer Heat transfer deterioration Buoyancy Prediction correlation

Numerical study on turbulent two-phase flow in porous medium combustion chamber

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Science China(Technological Sciences) 2009年第6期52卷 1511-1520页

作者： DONG Ming XIE MaoZhao li sufen School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China

To understand the working mechanism of the porous medium(PM)internal combustion engine,effects of a porous medium heat regenerator inserted into a combustion chamber on the turbulent flow char-acteristics and fuel-air mixture formation are studied by numerical *** cylindrical chamber has a constant volume,in which a disk-shaped PM insert is fixed.A simplified model for the random structure of the PM is presented,in which the PM is represented by an assembly of a great number of randomly distributed solid *** simulate flows in the PM a microscopic approach is employed,in which computations are performed on a pore-scale mesh and based on the standard k-ε turbulence model.A spray model,in which the effects of drop breakup,collision and coalescence are taken into account,is introduced to describe spray/wall *** computations are performed for the turbulent flows induced by a fuel spray outside and inside of the PM with different structure *** results show that the spray/PM interaction has substantial and positive influ-ences on the fuel-air mixture formation and homogenization in the combustion chamber,which could be very advantageous in engine applications.

关键词： porous media turbulence fuel spray numerical simulation spray/PM interaction

Cell membrane coated-nanoparticles for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3233-3254页

作者： Yingping Zeng sufen li Shufen Zhang li Wang Hong Yuan Fuqiang Hu College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China

Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of cancer immunotherapy had positive effects on clinical cancer treatment. However, cancer immunotherapy is still restricted by cancer heterogeneity, immune cell disability, tumor immunosuppressive microenvironment and systemic immune toxicity. Cell membrane-coated nanoparticles(CMCNs) inherit abundant source cell-relevant functions, including “self” markers, cross-talking with the immune system, biological targeting, and homing to specific regions. These enable them to possess preferred characteristics, including better biological compatibility, weak immunogenicity, immune escaping, a prolonged circulation, and tumor ***, they are applied to precisely deliver drugs and promote the effect of cancer *** the review, we summarize the latest researches of biomimetic CMCNs for cancer immunotherapy,outline the existing specific cancer immune therapies, explore the unique functions and molecular mechanisms of various cell membrane-coated nanoparticles, and analyze the challenges which CMCNs face in clinical translation.

关键词： Biomimetic Cell membrane-coated nanoparticles Drug delivery “Self”markers Tumor targeting Cancer immunotherapy Cancer vaccines Immune checkpoint blockade inhibitors

归脾汤加减治疗儿童学习困难型多动症的临床研究

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吉林医药学院学报 2024年第3期45卷 200-203页

作者：曲振廷叶关毅李环徐小磊李素芬吉林省吉林中西医结合医院吉林吉林132012 松阳县中医院浙江丽水323400 北华大学公共卫生学院吉林吉林132013 广西中医药大学第一附属医院南宁530022

目的观察归脾汤加减治疗儿童学习困难型多动症的临床疗效。方法91名符合DSM-Ⅳ儿童多动症标准的学习困难儿童,按照治疗方法分为两组,研究组45人,对照组46人。对照组进行心理行为矫正治疗,研究组在心理行为矫正治疗基础上口服加减归脾汤... 详细信息

目的观察归脾汤加减治疗儿童学习困难型多动症的临床疗效。方法91名符合DSM-Ⅳ儿童多动症标准的学习困难儿童,按照治疗方法分为两组,研究组45人,对照组46人。对照组进行心理行为矫正治疗,研究组在心理行为矫正治疗基础上口服加减归脾汤治疗。治疗2个月后,对两组疗效进行观察,采用Conners儿童行为问卷和Weiss功能性缺陷量表对治疗结果进行分析。结果Conners评分结果发现,研究组总有效率(88.89%)明显高于对照组(65.22%)(P0.05),治疗2个月后,研究组Conners评分明显降低(P<0.01);治疗后研究组各项多动症问题得分明显降低,多动症儿童学习困难情况有明显改善(P<0.01)。Weiss评分结果发现,治疗后,研究组的Weiss功能性缺陷量表各项指标评分均低于对照组,差异有统计学意义(P<0.05)。结论归脾汤加减治疗儿童学习困难型多动症有显著疗效,值得进一步推广应用。

关键词：归脾汤多动症学习困难

SC79 promotes efficient entry of GDNF liposomes into brain parenchyma to repair dopamine neurons through reversible regulation of tight junction proteins

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Nano Research 2023年第7期16卷 2695-2705页

作者： Xiaomei Wu li Wang Kai Wang Jia Ke sufen li Tingting Meng Hong Yuan Qirui Zhang Fuqiang Hu College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China College of Pharmaceutical Science Shenyang Pharmaceutical UniversityShenyang 110016China

Glial cell line-derived neurotrophic factor(GDNF),a disease-modifying drug for Parkinson’s disease(PD)is in Phase 2 clinical trials(EudraCT number:2011-003866-34),however it is administered by direct intrastriatal delivery via stereotaxy,which is accompanied with intracranial infection,brain tissue damage,and other *** addition,because of complex administration routes,clinical trials of GDNF have yielded contrary results,largely due to differences in dose and concentration brought by intracranial ***,a small molecular agonist SC79 was screened to open blood-brain barrier(BBB)and promote GDNF liposomes to get into ***79 reversibly reduces the expression of claudin-5,one of dominant tight junctions of *** study showed SC79 promoted liposomes to enter into brain parenchyma 2.43 times more than that of the *** deficits of PD mice receiving SC79 and brain-targeted GDNF liposomes were recovered by 36.70%and tyrosine hydroxylase positive neurons in striatum were restored by 39.90%.Our combination therapy effectively avoids the side effects such as secondary infection and uneven delivery caused by intracranial injection,improving patients’compliance and providing valuable research ideas for the clinic.

关键词： blood-brain barrier brain delivery facilitation tight junction glial cell line-derived neurotrophic factor disease-modifying Parkinson’s disease