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自体软骨联合富血小板血浆移植修复兔关节骨软骨缺损的效果

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广东医学 2018年第24期39卷 3605-3609页

作者：李思云熊隆江黄晓蓬刘华江江西省中西医结合医院骨科江西南昌330003

目的观察自体软骨联合自体富血小板血浆移植后对兔关节骨软骨缺损修复的效果,从而探索一种新的关节内软骨缺损的修复方法。方法采用新西兰大白兔构建关节软骨缺损模型,制备富血小板血浆,将软骨缺损的兔子随机分为3组。对照组1:将单纯自... 详细信息

目的观察自体软骨联合自体富血小板血浆移植后对兔关节骨软骨缺损修复的效果,从而探索一种新的关节内软骨缺损的修复方法。方法采用新西兰大白兔构建关节软骨缺损模型,制备富血小板血浆,将软骨缺损的兔子随机分为3组。对照组1:将单纯自体骨软骨植入软骨缺损处;对照组2:将单纯富血小板血浆植入软骨缺损处;实验组:将自体富血小板血浆与自体骨软骨复合体植入软骨缺损处,每组10只。分别在术后2、4周处死动物取材,进行大体观察和HE染色、番红O固绿染色、Masson染色病理观察,评估关节软骨损伤的修复情况。结果术后活体观察2、4周实验组较对照组1、对照组2动物活动恢复得较快。组织大体观察发现,随着时间的延长,各组缺损软骨部位软骨增多,但实验组缺损处新生软骨较其他组生长更快且质地韧性、有弹性。组织染色观察发现对照组1移植软骨与周围骨质连接不紧密有间隙,对照组2软骨生长慢,软骨陷窝明显,实验组移植软骨与周围骨质融合效果好,软骨缺损恢复快,实验组的软骨缺损处恢复能力高于对照组1和对照组2,修复效果更佳。结论自体软骨联合富血小板血浆移植有效修复兔骨软骨缺损,促进了周围正常软骨高度整合,具有可行性。

关键词：自体软骨富血小板血浆移植关节/损伤

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Effects of different agricultural treatments on narrowing winter wheat yield gap and nitrogen use efficiency in China

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Journal of Integrative Agriculture 2021年第2期20卷 383-394页

作者： YAO Feng-mei li Qin-ying ZENG Rui-yun SHI si-qi College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049P.R.China Zhanjiang Meteorological Bureau Guangdong 524000P.R.China

Under the limited cultivated land area and the pursuit of sustainable agricultural development,it is essential for the safety of grain production to study agricultural management approaches on narrowing the winter wheat yield gap and improving nitrogen use efficiency (NUE) in *** this study,DSSAT-CERES-Wheat Model is used to simulate winter wheat yield under different agricultural treatments,and we analyze yield gaps and NUE with different management scenarios at regional scales and evaluate the suitable approaches for reducing yield gap and increasing *** results show that,the potential of narrowing yield gap ranges 300–900 kg ha^(–1) with soil nutrients increase,400–1 200 kg ha^(–1) with sowing date adjustment and 0–400 kg ha^(–1) with planting density increase as well as 700–2 200 kg ha^(–1) with adding nitrogen *** rates of management measures of soil nutrients,sowing date adjusting,planting density,and nitrogen fertilizers are 5–15%,5–15%,0–4%,and 10–20%,*** in nitrogen partial productivity ranges 3–10 kg kg^(–1) for soil nutrients,1–10 kg kg^(–1) for sowing date adjusting,1–5 kg kg^(–1) for planting density increase,and–12–0 kg kg^(–1) for adding nitrogen fertilizers,*** indicates that four treatments can narrow yield gap and improve the NUE in varying degrees,but increasing nitrogen fertilizer leads to the decrease of NUE.

关键词： winter wheat DSSAT Model yield gap nitrogen use efficiency

Historical and real-time estimation of snow depth in Eurasia based on multiple passive microwave data

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Advances in Climate Change Research 2023年第4期14卷 537-545页

作者： li-yun DAI li-Juan MA Su-Ping NIE si-Yu WEI Tao CHE Key Laboratory of Remote Sensing of Gansu Province Heihe Remote Sensing Experimental Research StationNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China National Climate Centre China Meteorological AdministrationBeijing 1000101China University of Chinese Academy of Sciences Beijing 1000101China

Current snow depth datasets demonstrate large discrepancies in the spatial pattern in Eurasia,and the lagging updates of datasets do not meet the operational requirements of the meteorological service *** study developed a dynamic retrieval method for daily snow depth over Eurasia based on cross-sensor calibrated microwave brightness temperatures to enhance retrieval accuracy and meet the requirements of operational *** brightness temperatures were detected by microwave radiometer imager carried on the Fengyun 3(FY-3)satellite and the special sensor microwave imager/sounder carried on the USA Defense Meteorological Satellite Program series satellites,which use the fewest sensors to provide the longest data and consequently introduce minimal errors during inter-sensor ***,inter-sensor calibration was conducted amongst brightness temperatures collected by the three sensors.A spatiotemporal dynamic relationship between snow depth and microwave brightness temperature gradient was then established,overcoming the large uncertainties induced by varying snow *** relationship can be utilised in FY-3 satellite data for operational service to obtain real-time snow *** generated daily snow depth dataset from 1988 to 2021 presents similar spatial patterns of snow depth to those observed in *** in situ snow depth,the overall bias and root mean square error are−2.04 and 6.49 cm,respectively,facilitating considerable improvements in accuracy compared with the Advanced Microwave Scanning Radiometer 2 snow depth product,which adopts the static *** analysis shows an overall decreasing trend from 1988 to 2021 for annual and monthly mean snow depths,demonstrating a noticeable reduction since around *** reduction in monthly mean snow depth started earlier in shallow snow months than in deep snow months.

关键词： Snow depth Passive microwave remote sensing Eurasia

基于SBAS-InSAR和光学遥感的天津市北部山区潜在滑坡识别研究

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灾害学 2025年第1期40卷 30-35页

作者：王勇邢振涛李锁闫勇司甜天津城建大学地质与测绘学院天津300384 天津市地质工程勘测设计院有限公司天津300191

以天津市北部山区为研究对象,开展潜在滑坡识别研究,利用差分干涉测量短基线集时序分析技术(SBAS-InSAR)处理2018-01—2022-08的56景Sentinel-1A数据,并结合2018—2022年的Landsat8光学遥感影像,分析形变与光学遥感影像特征以及NDVI,筛... 详细信息

以天津市北部山区为研究对象,开展潜在滑坡识别研究,利用差分干涉测量短基线集时序分析技术(SBAS-InSAR)处理2018-01—2022-08的56景Sentinel-1A数据,并结合2018—2022年的Landsat8光学遥感影像,分析形变与光学遥感影像特征以及NDVI,筛选出潜在滑坡区域。研究结果表明:基于SBAS-InSAR技术识别的天津北部山区的形变较大区域有20处,使用光学遥感影像结合各发育环境要素进行处理确定的区域有19处,其中5处经两种技术确认为滑坡隐患,通过对该5处沉降信息进行识别分析,该5处区域最大年形变速率可达-12 mm/a,需要进行重点监测预警,使用两种技术结合对滑坡隐患区域进行识别可以有效地提高识别准确度,为天津北部山区灾害监测提供新的方式。

关键词：潜在滑坡 SBAS-InSAR 光学遥感影像天津市北部山区

Prediction of freestanding semiconducting bilayer borophenes

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Nano Research 2022年第6期15卷 5752-5757页

作者： Yuan-Yuan Ma Xiao-yun Zhao Wenyan Zan Yuewen Mu Zhuhua Zhang si-Dian li Institute of Molecular Science Shanxi UniversityTaiyuan 030006China Fenyang College of Shanxi Medical University Fenyang 032200China Department of Applied Chemistry Yuncheng UniversityYuncheng 044000China State Key Laboratory of Mechanics and Control of Mechanical Structures and Key Laboratory for Intelligent Nano Materials and Devices of Ministry of EducationNanjing University of Aeronautics and AstronauticsNanjing 210016China

Supported bilayerα-borophene(BL-αborophene)on Ag(111)substrate has been synthesized in recent *** on the experimentally observed quasi-planar C_(6v)B_(36)(1),its monolayer assemblyα^(+)-borophene B_(11)(P6/mmm)(2),and extensive global minimum searches augmented with density functional theory calculations,we predict herein freestanding BL-α^(+)borophenes B_(22)(Cmmm)(3)and B_(22)(C2/m)(4)which,as the most stable BL borophenes reported to date,are composed of interwoven boron triple chains as boron analogs of monolayer graphene(5)consisting of interwoven carbon single *** nearly degenerate eclipsed B_(22)(3)and staggered B_(22)(4)with the hexagonal hole density ofη=1/12 and interlayer bonding density of u=1/4 appear to be two-dimensional semiconductors with the indirect band gaps of 0.952 and 1.144 eV,*** bonding analyses reveal one delocalized 12c-2eπbond over each hexagonal hole in both the B_(22)(3)and B_(22)(4),similar to the situation in monolayer graphene which contains one delocalized 6c-2eπbond over each C_(6)***,these BL-α^(+)borophenes appear to remain highly stable on Ag(111)substrate,presenting the possibility to form supported BL-α+borophenes.

关键词： boron nanomaterials blayer borophenes structures bonding semiconductors

茵陈五苓散联合利拉鲁肽对肥胖型2型糖尿病患者糖脂代谢、胰岛素敏感性和氧化应激的影响

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现代生物医学进展 2024年第1期24卷 162-166页

作者：蔡宏桂姚南珍李思韵吴雯静魏爱生广州中医药大学第八临床医学院/广州中医药大学附属佛山中医院中医内分泌科广东佛山528000 翁源县人民医院内分泌科广东韶关512600

目的:探讨茵陈五苓散联合利拉鲁肽对肥胖型2型糖尿病(T2DM)患者糖脂代谢、胰岛素敏感性和氧化应激的影响。方法:选取2021年12月~2022年12月期间广州中医药大学附属佛山中医院收治的160例痰湿内蕴型肥胖T2DM患者。根据随机数字表法将患... 详细信息

目的:探讨茵陈五苓散联合利拉鲁肽对肥胖型2型糖尿病(T2DM)患者糖脂代谢、胰岛素敏感性和氧化应激的影响。方法:选取2021年12月~2022年12月期间广州中医药大学附属佛山中医院收治的160例痰湿内蕴型肥胖T2DM患者。根据随机数字表法将患者分为对照组(利拉鲁肽治疗,80例)和研究组(茵陈五苓散联合利拉鲁肽治疗,80例)。对比两组疗效、糖脂代谢指标、肥胖相关指标、胰岛素敏感性、氧化应激和不良反应发生情况。结果:与对照组相比,研究组的临床总有效率更高(P0.05)。结论:茵陈五苓散联合利拉鲁肽治疗肥胖型T2DM患者疗效确切,可调节糖脂代谢水平,降低胰岛素敏感性,减轻氧化应激,且具有一定安全性,值得临床借鉴应用。

关键词：茵陈五苓散利拉鲁肽肥胖型2型糖尿病糖脂代谢胰岛素敏感性氧化应激

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment