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Therapeutic effect and psychological impact of aspirin plus edaravone on patients with cerebral infarction

World Journal of Psychiatry 2024年第5期14卷 644-652页

作者： Tian-shu Wang li-Jun Jing Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Cerebral infarction(CI)is characterized by a high prevalence,disability,and *** or improper treatment greatly affects patient *** To explore the drug efficacy of aspirin plus edaravone and to explore their effect on quality of life(QOL),anxiety and depression in CI *** We retrospectively analyzed the records of 124 CI patients treated between June 2019 and February 2021 who were assigned to an observation group(OG)(combination therapy of aspirin and edaravone,65 patients)or a control group(CG)(aspirin monotherapy,59 patients).The therapeutic effects,pre-and posttreatment National Institutes of Health Stroke Scale(NIHSS)scores,activities of daily living,degree of cognitive impairment,protein levels of glial fibrillary acidic protein(GFAP),neuron-specific enolase(NSE)and S-100B,occurrence of adverse reactions,and serum high-sensitivity C-reactive protein(hs-CRP),interleukin(IL)-6 and tumor necrosis factor(TNF)-αwere evaluated,detected and compared between the two ***,posttreatment QOL,anxiety,and depression were assessed by the Medical Outcomes Study 36-Item Short Form Health Survey Scale,Self-rating Depression Scale(SDS),and Self-rating Anxiety Scale(SAS),*** Compared with the CG,the OG had markedly better therapeutic effects,greater improvements in activities of daily living,and better alleviation in cognitive dysfunction after treatment,as well as lower posttreatment NIHSS scores and serum NSE,GFAP,S-100B,hs-CRP,IL-6,and TNF-αlevels;the OG was similar to the CG in terms of adverse reactions but was better than the CG in terms of posttreatment QOL;and the OG also had lower SDS and SAS scores than the CG after *** Aspirin plus edaravone had a good curative effect on *** can reverse cranial nerve damage in patients,improve neurological function and prognosis,and alleviate inflammation,anxiety,and depression;thus,it is considered safe and worthy of clinical application.

关键词： Aspirin Edaravone Cerebral infarction Efficacy Quality of life

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Modeling the Interaction between Vacancies and Grain Boundaries during Ductile Fracture

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 2019-2034页

作者： Mingjian li Ping Yang Pengyang zhao Department of Engineering Mechanics School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

The experimental results in previous studies have indicated that during the ductile fracture of pure metals,vacancies aggregate and form voids at grain ***,the physical mechanism underlying this phenomenon remains not fully *** study derives the equilibrium distribution of vacancies analytically by following thermodynamics and the micromechanics of crystal *** derivation suggests that vacancies cluster in regions under hydrostatic compression to minimize the elastic strain ***,a finite element model is developed for examining more general scenarios of interaction between vacancies and grain *** model is first verified and validated through comparison with some available analytical solutions,demonstrating consistency between finite element simulation results and analytical solutions within a specified numerical accuracy.A systematic numerical study is then conducted to investigate the mechanism that might govern the micromechanical interaction between grain boundaries and the profuse vacancies typically generated during plastic *** simulation results indicate that the reduction in total elastic strain energy can indeed drive vacancies toward grain boundaries,potentially facilitating void nucleation in ductile fracture.

关键词： Ductile fracture vacancy grain boundary micromechanical finite element method

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桩基贯入过程中土体大变形分析与流动机理研究

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工程力学 2017年第6期34卷 157-165页

作者：李书兆李亚鲁晓兵中海油研究总院北京100028 中国科学院力学研究所北京100190

土体大变形问题是海洋岩土工程界研究的难点,由于其变形梯度较大、流动机理复杂等特点,常规的岩土工程分析方法在求解该问题时表现出明显的局限性。因此,该文研究了求解土体大变形问题的解析方法,即Strain Path Method(SPM)和Shallow St... 详细信息

土体大变形问题是海洋岩土工程界研究的难点,由于其变形梯度较大、流动机理复杂等特点,常规的岩土工程分析方法在求解该问题时表现出明显的局限性。因此,该文研究了求解土体大变形问题的解析方法,即Strain Path Method(SPM)和Shallow Strain Path Method(SSPM),详细介绍了这两种方法的计算原理;并基于大、小应变理论,采用SSPM分析了理想土性条件下桩基础贯入过程中周围土体的流动机理和位移场变化规律;最后,将SPM和SSPM计算结果进行比较分析,阐明了两者之间的内在关系。基于大应变理论,采用SSPM计算得到的土体位移场与Sagaseta给出的结果具有较好的一致性,验证了计算结果的准确性。研究结果显示桩端上部土体会发生隆起现象,而桩端附近及底部土体具有下沉的位移,且在贯入深度位置处,土体下沉位移达到最大值。在径向位置r/R=3(距桩壁1倍直径)处,基于大、小应变理论计算结果具有较好的一致性。研究成果有助于了解土体的大变形特性,也可为数值计算结果的校验提供基本数据。

关键词：土体大变形桩基贯入 SPM SSPM 应力自由地表面

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Petroleum Science 2024年第4期21卷 2383-2392页

作者： li-Ming zhao Cai-Ping Lu Yang liu Chao-Chao li School of Mines China University of Mining and Technology Henan Institute of Geophysical Space Information

The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D) poroelastic model and the layered White model were investigated. This investigation was conducted under the assumption that the rock was homogenous and isotropic at the mesoscopic scale. For the inherent mechanism, both models resulted from quasi-static flow in a slow P-wave diffusion mode, and the differences between them originated from saturated fluids and boundary conditions. On the other hand, for the characteristic frequencies of the models, the characteristic frequency of the 1D poroelastic model was first modified because the elastic constant and formula for calculating it were misused and then compared to that of the layered White model. Both of them moved towards higher frequencies with increasing permeability and decreasing viscosity and diffusion length. The differences between them were due to the diffusion length. The diffusion length for the 1D poroelastic model was determined by the sample length, whereas that for the layered White model was determined by the length of the representative elementary volume(REV). Subsequently, a numerical example was presented to demonstrate the similarities and differences between the models. Finally, published experimental data were interpreted using the 1D poroelastic model combined with the Cole-Cole *** prediction of the combined model was in good agreement with the experimental data, thereby validating the effectiveness of the 1D poroelastic model. Furthermore, the modified characteristic frequency in our study was much closer to the experimental data than the previous prediction, validating the effectiveness of our modification of the characteristic frequency of the 1D poroelastic model. The investigation provided insight into the internal relationship between wave-induced fluid flow(WIFF)models at macroscopic and mesoscopic scales and can aid in a better understanding of the elastic modulus d

关键词： 1D poroelastic model Layered White model Quasi-static flow Slow P-wave diffusion Characteristic frequency Diffusion length

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Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides

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Chinese Chemical Letters 2024年第6期35卷 263-267页

作者： Chen li Ziyuan zhao Shouyun Yu State Key Laboratory of Analytical Chemistry for life Science Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Glycosyl radicals,produced under mild photoredox conditions,show unique utility in the preparation of C-linked *** herein report the construction of C-glycosidic bonds on α,β-dehydroalanine(DHA)of peptides with easily available glycosyl bromides as glycosyl radical precursors under highly anomeric control,leading to C-glycosylation modifications of *** method not only has outstanding functional group compatibility,but also is feasible in near-physiological conditions(pH~7 and temperature T≤37℃ in aqueous media).

关键词： Glycosylation C-Glycosides Glycopeptides Dehydroalanine Photoredox catalysis

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循环荷载作用下吸力锚基础变形的数值分析方法研究

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岩土工程学报 2016年第12期38卷 2203-2211页

作者：李书兆王建华中海油研究总院北京100028 中国科学院力学研究所北京100190 天津大学岩土工程研究所天津300072

张紧式吸力锚是一种重要的深水海洋浮式平台锚固基础。静荷载与循环荷载共同作用下地基土体产生较大变形,严重影响吸力锚基础的稳定性。介绍了一种能够描述饱和软黏土不排水循环应力应变响应的拟动力黏弹塑性本构模型。该模型将等效黏... 详细信息

张紧式吸力锚是一种重要的深水海洋浮式平台锚固基础。静荷载与循环荷载共同作用下地基土体产生较大变形,严重影响吸力锚基础的稳定性。介绍了一种能够描述饱和软黏土不排水循环应力应变响应的拟动力黏弹塑性本构模型。该模型将等效黏弹性理论和蠕变理论相结合,利用等效黏弹性模型描述土单元循环应力应变关系中的非线性和滞回性,依据蠕变关系描述土单元的循环累积性。基于拟动力黏弹塑性本构模型,提出了一种分析静荷载与循环荷载共同作用下软土中张紧式吸力锚基础变形过程的拟动力黏弹塑性有限元方法。该方法并不详细追踪土单元的循环应力应变响应,而是将循环次数视为时间,通过等效黏弹性分析确定吸力锚基础的循环变形;根据土单元静应力和循环累积应变势,采用初应变法确定吸力锚基础的累积变形。结合循环变形和累积变形,确定吸力锚基础变形随时间的变化关系,即位移时程曲线。最后,将有限元计算结果与1g条件下吸力锚模型试验结果进行比较,结果显示两者基本一致。

关键词：拟动力本构模型吸力锚模型试验循环变形循环累积变形

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Attributes of Specialized Households'Resilience and Its Impact on Rural Industrial Advancement:A Case Study of National Musical Instrument Production Specialized Households in Lankao County,Henan,China

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Chinese Geographical Science 2024年第3期34卷 383-400页

作者： WU Nalin WEI Yike FAN Sizhe li li SUN Yufan ZHANG Yan shu Yan Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of Educa-tion/The College of Geography and Environmental ScienceHenan UniversityKaifeng 475001China College of Urban and Envir-onmental Science Central China Normal UniversityWuhan 430079China Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages and the overall vitality of the rural *** this study,we established a measurement indicator system based on the definition of specialized households’resilience,elucidating the logical connection between specialized households’resilience and rural industrial development in *** musical instrument industry in Lankao County,Henan Province of China,was employed as a case;survey data,the entropy method,and an obstacle diagnosis model were used to examine how instrument production specialized households responded to the challenges posed by Corona Virus Disease 2019(COVID-19)and the tightening of national environmental protection policies,yielding the following key findings:1)there exists substantial variation in the comprehensive resilience levels among different specialized households;2)the ability to learn and adapt is the most significant contributor to the overall resilience level of specialized households;3)technological proficiency and access to skilled talent emerge as pivotal factors influencing specialized households’resilience;4)the positioning of specialized households within the industrial supply chain and the stability of their income have a direct bearing on their resilience *** influence of specialized households’resilience on industrial development primarily manifests in the following ways:stronger resilience correlates with increased stability in production and sales,fostering a more proactive approach to future ***,heightened exposure to the external macroeconomic environment can lead to a higher rate of export *** enhance the development resilience of entities like specialized households and family farms,and to invigorate rural economic development,escalating investments in rural science and technology

关键词： resilience specialized households rural industry Lankao County,China

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Learning Scalable Task Assignment with Imperative-Priori Conflict Resolution in Multi-UAV Adversarial Swarm Defense Problem

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Journal of Systems Science & Complexity 2024年第1期37卷 369-388页

作者： zhao Zhixin CHEN Jie XIN Bin li li JIAO Keming ZHENG Yifan School of Electronics and Information Engineering Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing 100081China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China.

The multi-UAV adversary swarm defense(MUASD)problem is to defend a static base against an adversary UAV swarm by a defensive UAV *** the problem into task assignment and low-level interception strategies is a widely used ***-based approaches for task assignment are a promising *** studies on learning-based methods generally assume decentralized decision-making architecture,which is not beneficial for conflict *** contrast,centralized decision-making architecture is beneficial for conflict resolution while it is often detrimental to *** achieve scalability and conflict resolution simultaneously,inspired by a self-attention-based task assignment method for sensor target coverage problem,a scalable centralized assignment method based on self-attention mechanism together with a defender-attacker pairwise observation preprocessing(DAP-SelfAtt)is ***,an imperative-priori conflict resolution(IPCR)mechanism is proposed to achieve conflict-free ***,the IPCR mechanism is parallelized to enable efficient *** validate the algorithm,a variant of proximal policy optimization algorithm(PPO)is employed for training in scenarios of various *** experimental results show that the proposed algorithm not only achieves conflict-free task assignment but also maintains scalability,and significantly improve the success rate of defense.

关键词： Conflict resolution reinforcement learning scalability task assignment.

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Single-atom catalysts supported on graphene/electride heterostructures for the enhanced sulfur reduction reaction in lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第10期97卷 738-746,I0015页

作者： Siyun Qi Chuanchuan li Gang Chen Mingwen zhao School of Physics and Electronics Shandong Normal UniversityJinan 250358ShandongChina Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 26611ShandongChina School of Physics&State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongChina

Single-atom catalysts(SACs)hold great promise in addressing the sluggish kinetics of the sulfur reduction reaction(SRR)in lithium-sulfur(li-S)batteries for their unique catalytic activity and maximum atom *** these SACs must be dispersed on solid substrates,the underlying support is usually limited to carbon materials that have a poor ability to modulate the coordination environment and electronic structures of single atoms,and consequently their catalytic activity toward the SRR is *** we propose two-dimensional(2D)graphene/electride heterostructu res as substrates to enhance the catalytic activities of SACs for li-S batteries.2D electrides featuring the anionic electron gas on their surface enable efficient electron transfer to SACs,which alters their electronic structures,resulting in the shifts of the d orbital and Fermi *** unique electronic structure decreases the filling of antibonding states such that the bonding with adsorbates at active sites is *** demonstrate the enhanced catalytic performance of SACs in terms of the Gibbs free energy of SRR and li_(2)S *** addition,a universal descriptor for the rapid screening of SACs is established by a linear regression fitting *** work provides a new design strategy to modulate SAC activity through electrides for li-S batteries.

关键词： Electrides DFT calculations Kinetics Universal descriptors Charge transfers

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Long-term ocean temperature trend and marine heatwaves

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Journal of Oceanology and limnology 2024年第4期42卷 1037-1047页

作者： Min ZHANG Yangyan CHENG Gang WANG Qi shu Chang zhao Yuanling ZHANG Fangli QIAO First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Key Laboratory of Marine Sciences and Numerical Modelling Ministry of Natural ResourcesQingdao 266061China Shandong Key Laboratory of Marine Science and Numerical Modeling Qingdao 266061China

Marine heatwaves(MHWs)can cause irreversible damage to marine ecosystems and *** MHW characterization remains difficult,because the choice of a sea surface temperature(SST)temporal baseline strongly influences MHW *** a recent work suggesting that there should be a communicating baseline for long-term ocean temperature trends(LTT)and MHWs,we provided an effective and quantitative solution to calculate LTT and MHWs simultaneously by using the ensemble empirical mode decomposition(EEMD)*** long-term nonlinear trend of SST obtained by EEMD shows superiority over the traditional linear trend in that the data extension does not alter prior *** MHWs identified from the detrended SST data exhibited low sensitivity to the baseline choice,demonstrating the robustness of our *** also derived the total heat exposure(THE)by combining LTT and *** THE was sensitive to the fixed-period baseline choice,with a response to increasing SST that depended on the onset time of a perpetual MHW state(identified MHW days equal to the year length).Subtropical areas,the Indian Ocean,and part of the Southern Ocean were most sensitive to the long-term global warming trend.

关键词： marine heatwaves(MHWs) ensemble empirical mode decomposition(EEMD) long-term temperature(LTT)trend total heat exposure(THE)

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