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Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： Zi-Ang Ma li-Xin Wang Hui Zhang Han-Zhou li li Dong Qing-Hai Wang Yuan-Song Wang Bao-ChaoPan shu-fang Zhang Huan-Tian Cui shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

Uniqueness on Difference Operators of Meromorphic Functions of Infinite Order

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Acta Mathematica Sinica,English Series 2024年第2期40卷 511-527页

作者： Hui li Ming liang fang Xiao YAO School of Science China University of Mining and TechnologyBeijing 100083P.R.China Institute of Mathematics Academy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100190P.R.China School of Sciences Hangzhou Dianzi UniversityHangzhou 310012P.R.China School of Mathematical sciences and LPMC Nankai UniversityTianjin 300071P.R.China

We investigate the uniqueness problems of meromorphic functions and their difference operators by using a new *** is proved that if a non-constant meromorphic function f shares a non-zero constant and ∞ counting multiplicities with its difference operators Δcf(z) and Δ_(c)^(2)f(z), thenΔcf(z)≡Δ_(c)^(2)f(z).In particular,we give a difference analogue of a result of *** method has two distinct features:(ⅰ) It converts the relations between functions into the corresponding *** makes it possible to deal with the uniqueness problem by linear algebra and combinatorics.(ⅱ) It circumvents the obstacle of the difference logarithmic derivative lemma for meromorphic functions of infinite order,since this method does not depend on the growth of the ***,the idea in this paper can also be applied to the case for several variables.

关键词： Uniqueness meromorphic functions difference operators infinite order

Diophantine equations and Fermat's last theorem for multivariate(skew-)polynomials

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 159-173页

作者： PAN Jie JIA Yu-ming li fang School of Mathematical Sciences Zhejiang UniversityHangzhou 310058China Henan Experimental High School Zhengzhou 450003China

Fermat’s Last Theorem is a famous theorem in number theory which is diﬃcult to ***,it is known that the version of polynomials with one variable of Fermat’s Last Theorem over C can be proved very *** aim of this paper is to study the similar problems about Fermat’s Last Theorem for multivariate(skew)-polynomials with any characteristic.

关键词： Fermat's last theorem polynomial ring skew polynomial ring

Winter-spring minimum temperature variations inferred from tree-ring δ^(13)C in southeastern China

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Journal of Forestry Research 2024年第5期35卷 182-190页

作者： Wenli li Feifei Zhou Heng Zhang Keyan fang Key Laboratory of Humid Subtropical Eco-Geographical Process(MOE) College of Geographic SciencesFujian Normal UniversityFuzhou 350007People’s Republic of China

Long-term temperature variations inferred from high-resolution proxies provide an important context to evaluate the intensity of current ***,tem-perature reconstructions in humid southeastern China are scarce and particularly lack long-term data,limiting us to obtain a complete picture of regional temperature *** this study,we present a well-verified reconstruction of winter-spring(January–April)minimum temperatures over southeastern China based on stable carbon isotopic(δ^(13)C)records of tree rings from Taxus wallichiana *** from 1860 to *** reconstruction accounted for 56.4%of the total observed *** periods occurred during the 1860s–1910s and 1960s–*** temperatures have had an upward trend since the 1920s,most of the cold extremes were in recent *** El Niño-Southern Oscillation(ENSO)variance acted as a key modulator of regional winter-spring minimum temperature ***,teleconnections between them were a nonlinear process,i.e.,a reduced or enhanced ENSO variance may result in a weakened or intensified temperature-ENSO relationship.

关键词： Tree rings Carbon isotope Southeastern China Extreme coldness El nino-southern oscillation

Optimal Operation with Dynamic Partitioning Strategy for Centralized Shared Energy Storage Station with Integration of Large-scale Renewable Energy

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 359-370页

作者： Jianlin li Zhijin fang Qian Wang Mengyuan Zhang Yaxin li Weijun Zhang Beijing Future Technology Innovation Centre for Electrochemical Energy Storage System Integration North China University of Technology Beijing China State Grid Fujian Electric Power Research Institute Fuzhou China

As renewable energy continues to be integrated into the grid,energy storage has become a vital technique supporting power system *** effectively promote the efficiency and economics of energy storage,centralized shared energy storage(SES)station with multiple energy storage batteries is developed to enable energy trading among a group of *** this paper,we propose the optimal operation with dynamic partitioning strategy for the centralized SES station,considering the day-ahead demands of large-scale renewable energy power *** implement a multi-entity cooperative optimization operation model based on Nash bargaining *** model is decomposed into two subproblems:the operation profit maximization problem with energy trading and the leasing payment bargaining *** distributed alternating direction multiplier method(ADMM)is employed to address the subproblems *** reveal that the optimal operation with a dynamic partitioning strategy improves the tracking of planned output of renewable energy entities,enhances the actual utilization rate of energy storage,and increases the profits of each participating *** results confirm the practicality and effectiveness of the strategy.

关键词： Shared energy storage(SES) dynamic partitioning strategy optimal operation Nash bargaining theory actual utilization rate of energy storage

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中国精准农业推广对策研究

科学管理研究 2019年第4期37卷 125-130页

作者：李淑芳湖北省行政学院

精准农业不仅可以提高农民的收入和农产品的产量、质量,促进农业高质量发展,而且可以促进农业可持续性发展,可以成为推进农业农村现代化的重要突破口。然而,我国农业的小规模种植特点制约了精准农业的应用,中国农民对精准农业的接受度... 详细信息

精准农业不仅可以提高农民的收入和农产品的产量、质量,促进农业高质量发展,而且可以促进农业可持续性发展,可以成为推进农业农村现代化的重要突破口。然而,我国农业的小规模种植特点制约了精准农业的应用,中国农民对精准农业的接受度普遍不高,前期的大量投资也制约了精准农业在我国的推广应用。意大利在推广精准农业的过程中,注重为农业生产提供沟通平台、资金支持和技术支持,农民则秉持创新精神从事农业。中国应借鉴意大利的有益经验,破除土地流转制约因素,促进农业适度规模经营,为农业提供多元化的沟通合作平台,培育新型职业农民,将更多的资金投入到精准农业领域,推进中国农业农村现代化。

关键词：精准农业意大利农业适度规模经营新型职业农民农村生产发展资金

Domain wall network:A dual solution for gravitational waves and Hubble tension?

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 39-46页

作者： ligong Bian shuailiang Ge Changhong li Jing shu Junchao Zong Department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China Center for High Energy Physics Peking UniversityBeijing 100871China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceSchool of Physics and AstronomyYunnan UniversityKunming 650091China Beijing Laser Acceleration Innovation Center Beijing 101400China Department of Physics Nanjing UniversityNanjing 210093China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

We explore the possibility that domain wall networks generate the stochastic gravitational wave background(SGWB) observed as a strong common power-law process in the Data Release-2 of Parkes Pulsar Timing Array. We find that a broad range of parameters, specifically wall tension around σ_(DW)^(29-414 TeV)^(3) and wall-decay temperature within T_(d) ~ 20-257 MeV, can explain this phenomenon at a 68% credible level. Meanwhile, the same parameters could ease the Hubble tension if particles from these domain wall networks decay into dark radiation. We establish a direct analytical relationship, ΩGW(f_(p), T_(0))h^(2)~ Ω_(rad)h^(2)(Ω_νΩN_(eff))^(2),to illustrate this coincidence, underlining its importance in the underlying physics and potential applicability to a wider range of models and data. Conversely, if the common power-law process is not attributed to domain wall networks, our findings impose tight limits on the wall tension and decay temperature.

关键词： domain wall gravitational waves Hubble tension

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets

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Chinese Journal of Integrative Medicine 2024年第7期30卷 664-672页

作者： liU Su-su YU Tong QIAO Yan-fang GU shu-xiao CHAI Xin-lou School of Traditional Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing102401China

The prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulating low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol homeostasis through endocytosis. In contrast, proprotein convertase subtilisin/kexin type 9 (PCSK9) mediates LDLR degradation via the intracellular and extracellular pathways, leading to hyperlipidemia. Targeting PCSK9-synthesizing transcription factors and downstream molecules are important for development of new lipid-lowering drugs. Clinical trials regarding PCSK9 inhibitors have demonstrated a reduction in atherosclerotic cardiovascular disease events. The purpose of this review was to explore the target and mechanism of intracellular and extracellular pathways in degradation of LDLR and related drugs by PCSK9 in order to open up a new pathway for the development of new lipid-lowering drugs.

关键词： hyperlipidemia proprotein convertase subtilisin/kexin type 9 low-density lipoprotein receptor intracellular pathway extracellular pathway

Concept, configuration, and application of on-board nanogrids for use in electric vehicles

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Science China(Technological Sciences) 2024年第7期67卷 2053-2073页

作者： ZHAO Bing li Yong WU fang WAN JiangHu CAI JiuQing YANG HaiTao liU fang College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Wuhan Second Ship Design and Research Institute Wuhan 430000China School of Automation Central South UniversityChangsha 410083China

Against the backdrop of increasingly serious climate change, researchers are attempting to extend macroscale carbon reduction research to smaller scales. With the rapid development and widespread application of electric vehicles(EVs), an effective approach for carbon reduction based on EVs has the potential to be developed. To coordinate and manage the EV platform in diverse application scenarios, the concept of an on-board nanogrid(OBNG), in which a nanogrid is combined with the EV, is proposed and defined, and the characteristics summarized. A configuration that includes a physical layer with the on-board hardware system;an information layer for logical control, energy management, and communication coordination;and an application layer that can cope with different working environments is proposed. A detailed introduction to the basic architecture and management mode of each layer is provided along with information concerning the relevant technologies for coordinated operation. New ideas and approaches to improve the existing performance are proposed, and finally, combined with a background of smart and low-carbon cities, major application scenarios are envisioned.

关键词： electric vehicle nanogrid energy management hybrid energy storage power electronics converter