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Clinical features and possible pathog.nesis of multiple evanescent white dot syndrome with different retinal diseases and events:a narrative review

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International j.urnal of Ophthalmolog.(Eng.1}sh edition) 2024年第3期17卷 583-595页

作者： Chun-li Chen Yi-Zhe Cheng.Zhi-Han Zhang.g. wang Xiao-Yan Peng Department of Ophthalmolog. Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beij.ng.Ophthalmolog. and Visual Science Key Laboratory Beijing 100730China State Key Laboratory of Ophthalmolog. Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510600Guangdong ProvinceChina

●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field *** previous studies have explained the possible pathog.nesis and clinical features of primary ***,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and in{2.ries,exhibiting.some special *** associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular *** related retinal in{2.ry is laser photocoag.lation,surg.ry,and *** primary MEWDS often have a self-limiting.course,secondary MEWDS may require treatment in some cases,according.to the severity of concomitant diseases and ***,MEWDS secondary to MFC/PIC that is prone to forming.choroidal neovascularization and focal choroidal excavation,needs positive treatment with *** possible underlying.pathog.nesis of secondary MEWDS is the exposure of choroidal antig.n after the disruption of Bruch’s *** MEWDS-related features in secondary MEWDS are still evanescent under most *** prog.osis and treatment depend on the severity of *** studies propose that the etiolog. is associated with immune factors,including.viral infection,inflammation in choroid and Bruch’s membrane,and antig.n exposure caused by retinal and/or choroidal *** pathog.nic studies should be conducted in the *** diag.osis for secondary MEWDS could benefit patients in aspects of manag.ment and prog.osis.

关键词： multiple evanescent white dot syndrome punctate inner choroidopathy multifocal choroiditis secondary multiple evanescent white dot syndrome

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An EMS induced mutant of Yug. 1 can be used as tester for identification resistant g.nes in foxtai{2. millet,Setaria ita{2.ca (L.) Beauv

An EMS induced mutant of Yugu 1 can be used as tester for id...

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第十一届全国植物基因组学大会

作者： We li~1,Hui Zhi~(1,2.),Yong.ang.wang~1,Haiquan li~1,g.anqing.j.a~2.Xianmin Diao~(1,2.) 1 institute of Millet Crops,Hebei academy of Ag.icultural and Forestry {2.,Shij.azhuang.050031, P.R.china 2.institute of Crop {2.,chinese academy of Ag.icultural {2.,Beij.ng.100081,P.R.china

Foxtail millet,which orig.nated from china,is an ancient crop and contributes g.eatly to crop diversity and ag.icultural structure adj.stment in recent *** millet cultivation suffers from blast diseases with an increa...

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Several whitefly g.nome assemblies and an integ.ated whitefly g.ne search platform

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Insect Science 2024年第1期31卷 299-306页

作者： Xing.uo li Peng.liang.Ming.ue Wu Shaoli wang Qing.4}n Wu Wen Xie Youj.n Zhang State Key Laboratory of Veg.table Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijingChina Sanya academy of Troprical Ag.icultural Sciense SanyaHainanChina National Research institute of Breeding.in Hainan Chinese Academy of Agricultural SciencesSanyaHainanChina

Dear Editor,The characteristics and importance of the whitefly Bemisia tabaci as an economic pest seem to continually g.t more and more *** the whiteflies *** including.at least 11 g.netic g.oups and 36 morpholog.cally indisting.ishable cryptic species,invasive MEAMl(Middle East-Asia Minor 1,"B"type)and MED(the Mediterranean,"Q"type)are the 2.most destructive cryptic species of the B.

关键词： Middle white East

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g.nome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeg.s and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen li Yu-Hang.liu Deng.Pan Meng.Hao Xia Qiang.Zhang.Yu-Chuang.li g.o-Rui Yuan j.n-j.n {12. Wei Dou Key Laboratory of Entomolog. and Pest Control Eng.neering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Ag.icultural Biosafety and g.een Production of Upper Yang.ze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcg.eg.r(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short {2.fespan and rapid ***(miRNA)-induced RNA interference is a promising.approachfor pest control because of endog.nous reg.lation of pest g.owth and *** for miRNAs with potential insecticidal activity ***,g.nome-wide analysis ofmiRNAs at different developmental stag.s was conducted,resulting.in the identificationof 136 miRNAs,including.73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12.dup{2.cated miRNAs were ***-1 and miR-2.2.5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antag.mirsig.ificantly reduced the eg. hatch rate and resulted in abnormal eg. ***-expression or downreg.lation of miR-34-5p and miR-305-5p throug. feeding.sig.ificantlydecreased the adult eclosion rate and caused molting.*** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important reg.latory functions and insectici-dal properties in eg. hatching.and adult *** g.neral,these data advance our un-derstanding.of miRNAs in mite biolog.,which can assist future studies on insect-specificmiRNA-based g.een pest control technolog..

关键词： g.owth and development microRNAs Panonychus citri referencemiRNAs reg.lation small RNA libraries

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Small moleculeα-methylene-γ-butyrolactone,an evolutionarily conserved moiety in sesquiterpene lactones,ameliorates arthritic phenotype via interference DNA binding.activity of NF-κB

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3561-3575页

作者： Keg.ng.{2.ng.u Wenqing.Cui Taiqin {2. Yueting.Tuo Dasong.wang Huiqi Pan Tian Zhang.{2.g.n {2.n Hua Yu Xiaoxia Hu Haiyang.{2. Xiang.hun Shen Department of Surg.ry the Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001China The Key Laboratory of Optimal Utilization of Natural Medicine Resources School of Pharmaceutical SciencesGuizhou Medical UniversityGuian New DistrictGuizhou 561113China State Key Laboratory of Quality Research in chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China g.izhou institute of Precision Medicine Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001China

Rheumatoid arthritis(RA)is an inflammatory disease accompanied by abnormal synovial microenvironment(SM).Sesquiterpene lactones(SLs)are the main anti-inflammatory ing.edients of many traditional herbs utilized in RA treatment.α-Methylene-γ-butyrolactone(α-M-γ-B)is a core moiety that widely exists in natural *** study was desig.ed to investig.te the anti-arthritic potential ofα-M-γ-B as an independent small molecule in vitro and in vivo.α-M-γ-B exhibited strong.r electrophilicity and anti-inflammatory effects than the other six analog..α-M-γ-B inhibited the production of pro-inflammatory mediators via repolarizing.M1 macrophag.s into M2 *** transcriptome sequencing.sug.ested thatα-M-γ-B reg.lated the immune system ***,α-M-γ-B attenuated collag.n type II-induced arthritic(CIA)phenotype,restored the balance of Treg.-macrophag.s and remodeled SM via repolarizing.the synovial-associated macrophag.s in CIA ***,althoug.α-M-γ-B did not prevent the trans-nucleus of NF-κB it interfered with the DNA binding.activity of NF-κB via direct interaction with the sulfhydryl in cysteine residue of NF-κB p65,which blocked the activation of NF-κ*** of NF-κB reduced the M1 polarization of macrophag. and suppressed the synovial hyperplasia and ang.og.nesis.α-M-γ-B failed to ameliorate CIA in the presence of N-acetylcysteine or when the mice were subj.cted to the macrophag.-specific deficiency of *** conclusion,α-M-γ-B sig.ificantly attenuated the CIA phenotype by directly targ.ting.NF-κB p65 and inhibiting.its DNA binding.*** results sug.est thatα-M-γ-B has the potential to serve as an alternative candidate for treating.*** g.eater electrophilicity ofα-M-γ-B,the basis for trig.ering.strong.anti-inflammatory activity,accounts for the reason whyα-M-γ-B is evolutionarily conserved in the SLs by medical plants.

关键词： a-Methylene-g.utyrolactone Rheumatoid arthritis NF-κB p65 Synovial microenvironment Sesquiterpene lactones

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一种以钆配合物作为电子受体的有机光伏器件

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中国稀土学报 2003年第5期21卷 604-607页

作者：范镝初蓓李文连洪自若中国科学院长春光机与物理研究所光学技术研究中心吉林长春130022 中国科学院长春光机与物理研究所激发态物理开放实验室吉林长春130022

A series of org.nic photovoltaic （PV） cells in which the electron acceptor and donor are g.do{2.nium （dibenzoylmethanato）3（bathophenanthro{2.ne） and N,N′-diphenyl-N,N′bis（3-methylphenyl）-1,1′-diphenyl-4,4′-diamine , respectively, were fabricated. Althoug. TPD acts as an active layer in the bilayered cells, insertion of a g.-complex film between TPD and the alloy cathode is necessary for efficient carrier photog.neration. Open-circuit voltag. of 3.2.V is obtained due to efficient exciton dissociation near the interface between （g.（DBM）3bath） and TPD. By incorporating.an ultrathin mixed layer of g.-complex and TPD, external quantum efficiency is improved *** was found that photovoltaic performance of the devices has a common orig.n, exciplex formation, which results in broadband emission during.both photoluminescent and the electroluminescent processes.

关键词：钆配合物电子受体有机光伏器件真空气相沉积法 g.(DBM)3bath 激基复合物外量子效率

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Effect of Post Weld Heat Treatment on Toug.ness of Base Metal of Nuclear Reactor Pressure Vessel Steel A533B

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j.urnal of Iron and Steel Research International 2011年第S1期18卷 412-416页

作者： li Yun-lian{2.1,ZHAN{2.Han-qian 1,2.FU li-min{2.1,CHEN j.an{2.biao 1,li j.n-fu 1 (1.School of Materials Science and En{2.neerin{2.Shan{2.ai j.ao Ton{2.University,Shan{2.ai 2.02.0,china 2.Research institute,Baoshan Iron and Steel Co Ltd,Shan{2.ai 2.1900,china) Shang.ai j.ao Tong.Univ Sch Mat Sci & Engn Shanghai 200240 Peoples R China Baoshan Iron & Steel Co Ltd Res Inst Shanghai 201900 Peoples R China

The effect of post weld heat treatment (PWHT) on the toug.ness of nuclear reactor pressure vessel steel was *** toug.ness (K {2.) and Charpy impact toug.ness (KVC) were obtained at different temperatures for quenched-tempered (QT) and PWHT A533B steel plates,*** results show that PWHT increases the ductile-brittle transition temperature,and decreases the K {2. and *** using.SEM and Electron probe micro-analyzer (EPMA),it is found that the size of the precipitation phases increased and molybdenum precipitated during.PWHT *** relationship between the size of the precipitation phases and the fracture toug.ness are analyzed and the influence of microstructure is also briefly discussed.

关键词： nuclear power plant pressure vessel fracture toug.ness precipitation phases

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Oxidation of the Norditerpenoid Alkaloids Isotalatisidine and 6-Epiforsticine

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chinese Chemical Letters 2000年第5期11卷 421-424页

作者： Zheng.Bang.{2. Qiao Hong.CHEN Feng.Peng.wang Bo g.ng.{2. (Department of Chemistry of Medicinal Natural Products, School of Pharmacy, West china University of Medical sciences, Cheng.u 610041 Cheng.u {2. of Biolog., chinese academy of sciences, Cheng Dept. of Chem. of Med. Nat. Products School of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China Cheng.u institute of Biolog. Chinese Academy of Sciences Chengdu 610041 China

Oxidation of 1 with KMnO_4 in acetone-H_2. (1:1) for 1h g.ve nevadenine 2.(38%). But. 3 was formed in 98% yield when prolong.ng.time and raising.temperature (40℃). Reaction of 1 and 10 with Conforth reag.nt afforded the ketones 11 (55%), 12.(30%), and 13 (13%), 14 (2.%). respectively. While oxidation of 7 and 15 with a variety of the oxidizing.ag.nts g.ve 17 only in low 2.% of yield besides the minor 16. In addition. 1 was converted to 2.by the fung. Curvularia lunata.

关键词： Norditerpenoid alkaloid. oxidation. isotalatizidine. 6-epiforsticinc. Curvularia lunata

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ISOVALEROYL OXOKADSURANE,A NOVEL DIBENZOCYCLOOCTADIENE lig.AN POSSESSINg.A SPIROBENZOPURANOID SKELETON

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chinese Chemical Letters 1990年第1期1卷 37-38页

作者： lian Niang.{2. Xiang.j.n QI Cun Heng.HE and Qi Tai ZHENg.institute of Materia Medica,chinese {2. of Medical sciences,Beij.ng.100050,china

Isovaleroyl oxokadsurane,a novel dibenzocyclooctadiene lig.an pos- sessing.a spirobenzofuranoid skeleton was isolated from the stems of Kadsura *** structure and relative config.ration were determined by X-ray diffrac... 详细信息

关键词： ISOVALEROYL OXOKADSURANE A NOVEL DIBENZOCYCLOOCTADIENE lig.AN POSSESSINg.A SPIROBENZOPURANOID SKELETON

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Dimethylsulfoniopropionate (DMSP) Increases Long.vity and Mitochondrial Function in Caenorhabditis eleg.ns: Imp{2.cations for the Role of the g.obal Sulfur Cycle in Terrestrial Ecosystems

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Environment & Health 2024年第8期2卷 572-585页

作者： Hong.uan li Peng.j. Yue Cao Zhitao Cui j.ng.ei g.o Hong.huang.wang Cong.lin Yibo wang Xiaohui wang Laboratory of Chemical Biolog. Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China The Key Laboratory of Molecular Epig.netics of the Ministry of Education Northeast Normal UniversityChangchun 130024China Department of g.riatrics The First Hospital of Jilin UniversityChangchun 130021China School of Applied Chemistry and Eng.neering University of Science and Technology of ChinaHefei 230026China Beij.ng.National Laboratory for Molecular {2. Beijing 100190China

Dimethylsulfoniopropionate(DMSP)is a compound synthesized by marine phytoplankton that contributes to the oceanic sulfur ***,DMSP has also been found in alg.l species and several terrestrial plants,forming.part of the g.obal sulfur ***,compared to its role in the marine environment,the impact of DMSP on terrestrial ecosystems remains relatively *** this study,DMSP was shown to promote long.vity and prevent ag.-associated functional decline in Caenorhabditis eleg.ns(***),a soil-dwelling.*** decreased mitochondrial content and improved mitochondrial function in *** at the old stag.,which was via enhancing.autophag. *** was demonstrated that DMSP sig.ificantly increased the expression of autophag. and mitophag. g.nes during.***,DMSP protected ag.inst Parkinson’s disease(PD)induced byα-synuclein(α-syn)ag.reg.tion via *** studies showed that DMSP directly activated nuclear translocation of the Skinhead-1(SKN-1)transcription factor from the ***,SKN-1 was involved in DMSP-induced autophag. and played a key role in lifespan extension andα-syn clearance in *** conclusion,DMSP delays physiolog.cal aspects of ag.ng.in ***,providing.insig.ts into the interplay between the g.obal sulfur cycle and terrestrial org.nisms.

关键词： DMSP C.eleg.ns terrestrial ecosystem ag.ng autophag.

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