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The Synergistic Effect of HT and Complement Regulatory Proteins in Resisting the Immunological Rejection of Heterogenic Transplantation

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Chinese Journal of Biomedical Engineering(English Edition) 2007年第4期16卷 139-147页

作者： li sheng-zhi liu bing-qian wang guang,you zhang yue ma zhi-fang ma teng-xiang Tianjin Institute of Urologic Surgery Tianjin 300211 China

Objective：To establish the polytransgenic mice expressing the human HT and complement regulatory proteins （CRPs） and discuss their ability to resist the hyperacute rejection （HAR） and delayed xenograft rejection （DXR） of heterogenic transplantation. Methods ：Transgenic mice were produced by microinjection to construct gene for human HT, delay acceleration factor （DAF） and/or CD59 into the male pronucleus of zygote. PCR and Southern blot were used to screen the positive trarisgenic mice. Flow cytometry （FCM） was used to detect the expression of HT, ct-Gal and DAF or CD59 on the PBMCs of transgenic mice. The survival time and function of the heart of transgenic mice were determined by a modified Langendorff cardiac perfusion apparatus： The change of proteinosis on IgM,IgG, C3c and C9 from different cardiac vascular iendothelial cells of transgenic mice were detected by immunohistochemistry. Results：HT, DAF or CD59 were highly expressed on the positive transgenic mice by FCM. The deposition of IgM,IgG,C3c or C9 in the cardiac vascular endothelial cells of the positive transgenic mice were de- creased. The survival time and function of the heart of the co-transgenic mice with AB serum perfusion were significantly longer and higher than that of the single HT positive transgenic mice（P 〈0.05）. Conclusion ：The mice co-expressing HT/DAF or HT/CD59 could resist the HAR,which was better than those expressing HT alone. It is feasible to use HT and CRPs co-transgenic methods to resist the HAR and DXR.

关键词： xenotransplantation [ alpha ] 1,2-fucosyltransferase complement regulatory proteins hyperacute rejection

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Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n

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Nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le Yang Zhen‑Dong An Wei Jiang Xian‑Kai li Wei‑Wei Qiu Zheng‑Fa liao Zi‑yue Zhuang Xiao‑Ping zhang sheng‑li Chen Chen‑Chen Guo Er‑Xi Xiao Xiao fang Xin‑xiang li Xin‑Rong Hu bing Jiang Jin‑Cheng wang Jie Ren Wen Luo zhi‑Chao Zhu Hao‑Yang Lan Zong‑Wei Cao Xu ma Ying‑Du liu Pu‑Sen wang Yi Yang Ping Su Xian‑Gai Deng Wan‑bing He Chun‑wang ma Yu‑Ting wang zhi‑Tao Dai Peng‑Qin He Ren‑guang Tang Tao Zhou Jing wang Han Yi yue zhang Yong‑Hao Chen Rui‑Rui Fan Ke‑Qing Gao qiang li Kang Sun zhi‑Xin Tan Min‑Hao Gu Han‑Tao Jing Jing‑Yu Tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of materials Science and Engineering Xiangtan UniversityXiangtan 411100China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and Nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical maxwell average cross sections(maCSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the maCS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value.

关键词： Time-of-flight technique Neutron capture cross sections maxwell average cross sections

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First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering

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Nuclear Science and Techniques 2021年第5期32卷 101-106页

作者： Wei Nan bing Guo Cheng-Jian lin Lei Yang Dong-Xi wang Yang-Ping Shen bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju li Chen Chen li-Hua Chen Qi-Wen Fan Xin-yue li Gang lian Jian-Cheng liu Tian-Peng Luo Nan-Ru ma Rui-Gang ma Xie ma Ying-Jun ma Wei-Ke Nan Dan-Yang Pang you-Bao wang Pei-Wei Wen Feng Yang Yong-Jin Yao sheng Zeng Hao zhang Fu-Peng Zhong Shan-Hao Zhong zhi-Hong li Tian-Jue zhang Wei-Ping liu BRIF Collaboration China Institute of Atomic Energy(CIAE) P.O.Box 275(10)Beijing 102413China Department of Physics Guangxi Normal UniversityGuilin 541004China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China School of Physics Beihang UniversityBeijing 100191China Key Laboratory of Advanced Nuclear materials and Physics Beihang UniversityBeijing 100191China

The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current *** scattering is a useful probe for investigating the size and surface diffuseness of exotic *** development of rare isotope accelerators offers opportunities for such *** date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite *** this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb *** angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same *** work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei.

关键词： BRIF Exotic nuclei Elastic scattering Angular distribution

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Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao zhang li‑Yong zhang Jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑yue li Jian‑Guo wang Long zhang Fu‑qiang Cao zhi‑Cheng zhang Xin‑zhi Jiang Luo‑Huan wang Zi‑Ming li Lu‑Yang Song liang‑Ting Sun Qi Wu Jia‑Qing li Bao‑Qun Cui li‑Hua Chen Rui‑Gang ma Er‑Tao li Gang lian Yao‑De sheng zhi‑Hong li bing Guo Wei‑Ping liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

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Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang zhang sheng-Quan Yan Ming He Qing-zhang Zhao Wen-Hui zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning li Xiao-Fei wang Jian-Cheng liu Zhao-Hua Peng Zhuo liang Ai-ling li Jian Zheng Qi-Wen Fan Yun-Ju li you-Bao wang zhi-Hong li Yang-Ping Shen Ding Nan Wei Nan Yu-qiang zhang Jia-Ying-Hao li Jun-Wen Tian Jiang-lin Hou Chang-Xin Guo zhi-Cheng zhang Ming-Hao Zhu Yu-Wen Chen Yu-Chen Jiang Tao Tian Jin-Long ma Yi-Hui liu Jing-Yu Dong Run-Long liu Mei-yue-Nan ma Yong-Shou Chen Wei-Ping liu bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

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转人α1,2岩藻糖苷转移酶基因猪动脉内皮细胞抗人血清溶破实验

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中华泌尿外科杂志 2006年第8期27卷 537-540页

作者：马志方李胜芝刘秉乾张明王广有马腾骧天津医科大学第二医院泌尿外科天津市泌尿外科研究所

目的研究转入α1,2岩藻糖苷转移酶(HT)基因克服异种移植超急排斥反应(HAR)的作用。方法构建pcDNA3-HTcDNA重组质粒,体外培养猪动脉内皮细胞(PAEC),脂质体转染法将pcDNA3-HTcDNA转染PAEC,新霉素(G418)筛选具有抗性的细胞克隆,PCR检测重... 详细信息

目的研究转入α1,2岩藻糖苷转移酶(HT)基因克服异种移植超急排斥反应(HAR)的作用。方法构建pcDNA3-HTcDNA重组质粒,体外培养猪动脉内皮细胞(PAEC),脂质体转染法将pcDNA3-HTcDNA转染PAEC,新霉素(G418)筛选具有抗性的细胞克隆,PCR检测重组基因的整合,流式细胞术(FCM)检测转染细胞H抗原和异种抗原α—Gal表达。分别以未转染的PAEC和人脐静脉内皮细胞(HUVEC)作对照。将转染细胞和正常细胞分别以20％、40％和60％人血清孵育2 h,比较溶破细胞百分数。结果重组质粒转染PAEC经筛选得到抗性细胞克隆,PCR扩增出人HT基因片段,FCM检测正常PAEC与转染PAEC,α-Gal平均荧光强度由1346．81降至194．44,H抗原平均荧光强度由9．10增至215．93;α—Gal M2区由99．98％降至37．180A,H抗原M2区由13．80％升至78．54％。转染细胞以人血清孵育后溶破细胞百分数较正常细胞降低,分别由(32．32±2．37)％、(59．54±4．56)％和(71．46±5．94)％降至(15．78±2．69)％、(30．16±1．46)％和(40．48±3．77)％,差异均有统计学意义(P值均<0．05)。结论转人HT基因PAECα—Gal表达明显降低,H抗原表达升高,对人血清溶破的耐受性增强。转人HT基因可以一定程度抑制HAR。

关键词：移植,异种岩藻糖基转移酶类

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong xiang-Yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu zhang yue Huang Lu li Xing Wen Fei zhang Jing Duan Chen-Wei wang Dong-li Shi Peng zhang Qi-Bin Yi Chao-Yang li Yan-bing Xu Xiao-Hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu wang sheng Yang Xiao-Jing liu Min Gao mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa wang Rui Qiao xiang ma Xiao-Bo li Ping wang Xin-Ying Song li-Ming Song Shi-Jie Zheng bing li Hong-Mei zhang yue Zhu Wei Chen Jian-Jian He Zhen zhang Jin Hou Hong-Jun wang Yan-Chao Hao xiang-Yu wang Zong-Yuan Yang zhi-Long Wen zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo li Gang li Xu-fang li fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan zhang Chao-yue zhang Cheng-Mo zhang zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-sheng Zhao Dong li Shao-lin Xiong Yan-Qiu zhang Yang Su Wei Chen Yi Zhao Xiao-Bo li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li xiang-Yang Wen li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao yue Huang Shuang-Nan zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo zhi-Wei Guo Jian-Jian He Bin li Chao li Chao-Yang li Gang li Jian-Hui li Lu li Qing-Xin li Yan-Guo li Jing liang Xiao-Hua liang Jin-Yuan liao Xiao-Jing liu Ya-Qing liu Qi Luo xiang ma Bin Meng Ge Ou Dong-li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun you-li Tuo Chen-Wei wang Hui wang Jin wang Jin-Zhou wang Ping wang Wen-Shuai wang Hong Wu sheng-Lun Xie Yan-bing Xu Yu-Peng Xu wang-Chen Xue sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-yue zhang Da-li zhang Fan zhang Fei zhang Hong-Mei zhang Kai zhang Peng zhang Xiao-Lu zhang Zhen zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu yue Huang guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia fang-Jun Lu xiang ma lian Tao Wei zhang li Chen li-Ming Song Ti-Pei li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai zhi Chang Gang Chen Tian-xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin ling-Da Kong bing li Cheng-Kui li Gang li mao-Shun li Wei li Xian li Xiao-Bo li Xu-fang li Yang-Guo li Zheng-Wei li Xiao-Hua liang Jing-Yuan liao Bai-sheng liu Guo-Qing liu Hong-Wei liu Xiao-Jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song liang Sun Ying Tan you-li Tuo Chen wang Guo-Feng wang Juan wang ling-Jun wang Weng-Shuai wang Yu-Sa wang xiang-Yang Wen Bai-Yang Wu Bo-bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He Xu Jia-Wei Yang sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi qian-Qing Yin Yuan you Ai-Mei zhang Cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang Yong-Jie zhang Yuan-Hang zhang yue zhang Zhao zhang zhi zhang Zi-liang zhang Hai-sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding zhi-Dan Xu Lai-Bang Luo li-Bo Sun guang-Ming li Tai-Shi fang Nan Jiang Kun zhang Zhao-Jie Su zhi-Hai Peng Ren Lang Tao Jiang qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo wang Jiang liu qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong Jing-sheng ma Qi-Gen li sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua zhang Xuan wang Zi-qiang li Mu-Jian teng Jun-Jie li Wen-Tao Jiang Jian-Hua li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin wang Kang He qiang Xia Shao-Hua Song zhi-Ren Fu Wei Qiu Guo-yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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