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淋巴细胞亚群联合趋化因子对儿童原发免疫性血小板减少症诊断价值研究

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安徽医科大学学报 2024年第3期59卷 542-546页

作者：沈晨涛夏亚林盛烨萍褚培培李建琴苏州大学附属儿童医院吴江院区血液科苏州215200 苏州大学附属儿童医院血液科苏州215000

目的探讨淋巴细胞亚群联合趋化因子对儿童原发免疫性血小板减少症(ITP)的诊断价值。方法收集拟诊为ITP的132例患儿,根据ITP相关的临床诊断标准诊断结果将患儿分为ITP组与非ITP组。抽取外周静脉血6 ml,以流式细胞仪对CD4^(+)、CD8^(+)及C... 详细信息

目的探讨淋巴细胞亚群联合趋化因子对儿童原发免疫性血小板减少症(ITP)的诊断价值。方法收集拟诊为ITP的132例患儿,根据ITP相关的临床诊断标准诊断结果将患儿分为ITP组与非ITP组。抽取外周静脉血6 ml,以流式细胞仪对CD4^(+)、CD8^(+)及CD3^(+)水平进行检测,以酶联免疫吸附法检测CC类趋化因子配体5(CCL5)、CC类趋化因子配体11(CXCL11)、单核细胞趋化蛋白-1(MCP-1)水平,以全自动细胞分析仪对血小板计数(PLT)进行检测。比较2组患儿淋巴细胞亚群及趋化因子水平,并对淋巴细胞亚群及趋化因子水平与PLT进行相关性分析;采用ROC法评估各指标单独检测与联合检测对ITP的诊断效能。结果ITP组患者CD4^(+)和CD3^(+)水平低于非ITP组,CD8^(+)水平高于非ITP组(P<0.05);ITP组患者CCL5、CXCL11和MCP-1水平均高于非ITP组(P<0.05);相关性分析结果显示ITP组患者CD4^(+)和CD3^(+)与PLT呈正相关(P<0.05),CD8^(+)、CCL5、CXCL11、MCP-1与血小板计数呈负相关(P<0.05);ROC分析结果显示,CD4^(+)、CD8^(+)、CD3^(+)、CCL5、CXCL11和MCP-1对儿童ITP诊断的截断值值分别为27.13%、24.02%、59.88%、41.02 ng/L、30.18 ng/L和188.27 ng/L,AUC分别为0.893、0.880、0.629、0.801、0.892和0.751,六者并联诊断(指并联检测时CD4^(+)、CD3^(+)中的一项及以上低于截断值和/或CD8^(+)、CCL5、CXCL11和MCP-1中的一项及以上高于截断值)的AUC为0.967,其诊断效能高于各指标单独检测(P<0.05)。结论儿童ITP患者与非ITP患者淋巴细胞亚群及趋化因子均具有差异,CD4^(+)、CD8^(+)、CD3^(+)、CCL5、CXCL11和MCP-1可用于儿童ITP的诊断,各指标联合检测可提高检测效能。

关键词：淋巴细胞亚群趋化因子联合检测原发免疫性血小板减少症诊断效能 ROC分析

Current Sheet Formation in Weakly Ionized Plasmas

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Chinese Physics Letters 2001年第6期18卷 788-789页

作者： JI Hai-sheng li Xiao-Qing SONG Mu-Tao Purple Mountain Observatory Chinese Academy of ScienceNanjing 210008 Department of Physics Nanjing Normal UniversityNanjing 210087 National Astronomical Observatories Chinese Academy of SciencesBeijing 100080

Using the two fluid model,the problem of two-dimensional steady-state magnetic reconnection in incompressible resistive weakly ionized plasmas is *** the strong-coupling condition such as in the Sun's photosphere,it allows us to express the current sheet *** this case the current sheet scales as η^(1/2).Then this model is used to understand magnetic flux cancellation which is observed in the Sun's *** account for a canceling flux of 1 × 10^(18)Max in a time interval of 77 min,the width of the current sheet is about ten kilometers.

关键词： weakly Weakly coupling

Carbide Evolution in High Molybdenum Nb-microalloyed H13 Steel during Annealing Process

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Journal of Iron and Steel Research International 2015年第4期22卷 330-336页

作者： Tian-sheng li Fu-ming WANG Chang-rong li Guo-qing ZHANG Qing-yong MENG State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Mechanical Engineering Hunan Institute of Technology School of Materials Science and Engineering University of Science and Technology Beijing

Based on the Thermo-Calc thermodynamic software, the type of equilibrium precipitated carbides and their contents in high Mo Nb-microalloyed H13 steel （NMH13 steel） were calculated. The composition, morphology, and distribution of carbides after spheroidal annealing of two forged experimental steels were comparatively examined by means of optical microscopy （OM）, scanning electron microscopy （SEM）, electron dispersive spectroscopy （EDS） and transmission electron microscopy （TEM）. VC, M23 C6 and M6C are identified in H13 steel after spheroidizing annealing, while （V,Nb）C, M23C6 , M2C and M6C are observed in NMH13 steel. Moreover, it is found that the ad- dition of Nb significantly enhances the stability of MC phase and the high Mo content accelerates the precipitation of small rod-shape M2C phase in NMH13 steel. The amount of the fine carbides in NMH13 steel obviously increased with M2 C and M6 C precipitated from the ferrite phase, which is in accordance with the results of thermodynamic cal- culations.

关键词： niobium microalloying high molybdenum H13 steel spheroidizing annealing carbide

Discriminating 1D new physics solutions in b→slldecays

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Chinese Physics C 2022年第6期46卷 114-123页

作者： Shuang-Yi li Rui-Xiang Shi li-sheng Geng School of Physics Beihang UniversityBeijing 102206China School of Space and Environment Beihang UniversityBeijing 102206China School of Physics&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

The recent measurements of RK^(+),R_(K_(S)^(O)),RK^(*+),Bs→μ+μ-,a set of CP-averaged angular observables for the B^(0)→K^(*0)μ^(+)μ^(-)decay and its isospin partner B^(+)→K^(*+)μ^(+)μ^(-)by the LHCb Collaboration consistently hint at lepton universality violation in the b→sll *** this work,we first perform global fits to the b→sll data and show that five one-dimensional scenarios,i.e,δC_(9)^(μ),δC_(10)^(μ),δC_(L)^(μ),δC_(9)^(μ)=C_(10)^(μ’),andδC_(9)^(μ)=-C_(9)^(μ’)can best explain the so-called B ***,we explore how these scenarios can be distinguished from each *** this purpose,we first study the combinations of four angular asymmetries Ai(i=3,4,5,9)and find that they cannot distinguish the five new physics *** then show that a newly constructed ratio RS can uniquely discriminate the five new physics scenarios in proper intervals of q^(2) if it can be measured with percent-level precision.

关键词： lepton universality violation rare B meson decays beyond SM physics

Genetic characteristics of a wheat founder parent and a widely planted cultivar derived from the same cross

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Journal of Integrative Agriculture 2018年第4期17卷 775-785页

作者： CHANG li-fang li Hui-hui WU Xiao-yang LU Yu-qing ZHANG Jin-peng YANG Xin-ming li xiu-quan liU Wei-hua li li-hui National Key Facility for Gene Resources and Genetic Improvement/Key Laboratory of Crop Germplasm Utilization Ministry of Agriculture/Institute of Crop Sciences Chinese Academy of Agricultural Sciences

Founder parents have contributed significantly to the improvement of wheat breeding and production. In order to investigate the genetic characteristics of founder parents and widely planted cultivars, Mazhamai(M), Biyumai(B) and six sibling lines(BM1–6) derived from the cross M×B were phenotyped for eight yield-related traits over multiple years and locations and genotyped using the the wheat 90 K single nucleotide polymorphism(SNP) assay. BM4 has been used as a founder parent, and BM1 has been widely planted, whereas BM2, 3, 5, and 6 have not been used extensively for breeding or planting in China. Phenotypic comparisons revealed that BM4 and BM1 displayed a better overall performance than the other sibling lines. BM1 showed higher thousand-grain weight than BM4, whereas BM4 exhibited lower coefficient of variation for most of the yield-related traits across different years and locations, indicating that BM4 was widely adaptable and more stable in different environments. SNP analysis revealed that BM4 and BM1 inherited similar proportions of the M genome but are dissimilar to BM2, 3, 5, and 6. Both BM1 and BM4 have specific alleles that differ from the other BM lines, and most of these alleles are concentrated in specific chromosomal regions that are found to associate with favorable QTLs, these SNPs and their surrounding regions may carry the genetic determinants important for the superior performance of the two lines. But BM4 has more genetic diversity than BM1 with more specific alleles and pleiotropic regions, indicating that the genome of BM4 may be more complex than the other sibling lines and has more favorable gene resources. Our results provide valuable information that can be used to select elite parents for wheat and self-pollinating crop breeding.

关键词： wheat founder parents widely planted cultivars SNP

Polycyclic aromatic hydrocarbon in urban soil from Beijing, China

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Journal of Environmental Sciences 2006年第5期18卷 944-950页

作者： li Xing-hong MA ling-ling liU xiu-fen FU Shan CHENG Hang-xin XU Xiao-bai State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Institute of Geophysical and Geochemical Exploration Langfang 065000 China

Polycyclic aromatic hydrocarbons （EPA-PAHs） in the urban surface soils from Beijing were determined using gas chromatography and mass spectrometry （GC-MS）. It is significantly complementary for understanding the PAHs pollution in soil of integrated Beijing city on the basis of the information known in the outskirts. The total concentration of 16 EPA-PAH was from 0.467 to 5.470 μg/g and was described by the contour map. Compound profiles presented that the 4-, 5- and 6-ring PAHs were major compositions. The correlation analysis showed that PAHs have the similar source in the most sampling sites and BaP might be considered as the indicator of PAHs. Characteristic ratios of anthracene （An）/（An＋ phenanthrene （Phe））, fluoranthene （Flu）/（Flu/ pyrene （Pyr）） and benzo[a]pyrene （BaP）/laenzo[g,h,i]perylene （BghiP） indicated that the PAHs pollutants probably mainly originated from the coal combustion and it was not negligible from vehicular emission. The level of PAHs in our study area was compared with other studies.

关键词： PAHs urban soil source Beijing

Fusion Proteins Cpn10-E^(rns) with Properties of Generating CSFV-Neutralized Antibodies

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Chemical Research in Chinese Universities 2006年第6期22卷 712-716页

作者： CHEN Yue WANG Xuan-jun CONG Xian-ling ZHANG Pei-yin WU xiu-li WEI Hong-fei WANG li WAN Min WANG li-ying YU Yong-li Department of Immunology Jilin University Changchun 130021 P.R. China Department of Molecular Biology Jilin University Changchun 130021 P.R. China College of life Science Jilin University Changchun 130021 P.R. China China-Japan Union Hospital Jilin University Changchun 130021 P.R. China

When pigs are infected with classical swine fever virus （ CSFV）, the antibody primarily targets the structural giycoprotein E^rns of the virus. Previous investigations have demonstrated that ETM has low or no virus neutralizing capacity. In this study, candidate subunit marker vaccine, chaperonin 10 （Cpnl0）-E^rns, which possess the property of generating neutralized antibodies against lethal challenge of virulent CSFV was developed. The gene of ETM was isolated from Hog cholera lapinized virus （HCLV） -infected spleen cells of rabbits via RT-PCR method and fused to the downstream region of the cpn10 gene; the products of recombinant fusion protein （ cpn10-E^rns ） induced expression in Escherichia coli, and the products were purified by affinity chromatography. During the course of vaccination, the candidate vaccines cpn10-E^rns were used for the immunization of guinea pigs, and they induced a strong antibody response against cpn10-E^rns. The antibodies can be immobilized by coating inactivated CSFV particles, indicating that these antibodies can recognize CSFV. Neutralization assay was carried out on rabbits according to National Regulations on Veterinary Drug. The results clearly indicate that the typical fever of rabbits induced by the live attenuated HCLV could be inhibited by preincubation with the antisera （dilution 1： 4） induced by cpn10-E^rns, but not inhibited by preincubation with the antisera induced only by E^rns. Analogous results were observed for the group of the rabbits immunized with cpn10-E^rns, which were protected against the typical fever induced by the challenge with HCLV. The findings of this study formed the basis of a new means for developing subunit marker vaccine against CSFV.

关键词： Classical swine fever virus E^rns Chaperonin Marker vaccine

Giant and controllable Goos—Hänchen shift of a reflective beam off a hyperbolic metasurface of polar crystals

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Chinese Physics B 2024年第1期33卷 428-435页

作者：薛天李宇博宋浩元王相光张强付淑芳周胜王选章 Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Educationand School of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China Department of Basic Courses Guangzhou Maritime UniversityGuangzhou 510725China

We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH *** on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ_(0) is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 10^(8) λ_(0)/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.

关键词： Goos–H?nchen shift black phosphorus surface plasmon phonon polaritons sensitivity metasurfaces

Effect of Cr_2O_3 addition on the oxidation induration mechanism of Hongge vanadium titanomagnetite pellets

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International Journal of Minerals,Metallurgy and Materials 2018年第4期25卷 391-398页

作者： Wei li Nan Wang Gui-qin Fu Man-sheng Chu Miao-yong Zhu School of Metallurgy Northeastern University

As part of a research project to develop a novel clean smelting process for the comprehensive utilization of Hongge vanadium titanomagnetite（HVTM）, in this study, the effect of Cr2O3 addition on the oxidation induration mechanism of HVTM pellets（HVTMPs） was investigated in detail. The results showed that the compressive strength of the HVTMPs was greatly weakened by the Cr2O3 addition, mainly because of a substantial increase in the porosity of the HVTMPs. The Cr2O3 addition marginally affected the phase composition but greatly affected the microstructural changes of the HVTMPs. Increased amounts of Cr2O3 resulted in a decrease in the uniform distribution of the hematite grains and in an increase in the Fe–Cr solid solutions（Fe1.2Cr0.8O3 and Fe0.7Cr1.3O3） embedded in the hematite grains. Moreover, the compact hematite was destroyed by forming a dispersed structure and the hematite recrystallization was hindered during the oxidation induration, which adversely affected the compressive strength. On the basis of these results, a schematic was formulated to describe the oxidation induration mechanism with different amounts of added Cr2O3. This study provides theoretical and technical foundations for the effective production of HVTMPs and a reference for chromium-bearing minerals.

关键词： chromium Hongge vanadium titanomagnetite porosity oxidation induration microstructure