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Systemic therapy in gastrointestinal stromal tumors

Oncology and Translational Medicine 2024年第3期10卷 110-118页

作者： shaoli li Hui Wang Xiaogang Wang Rui Bai Qunan Sun Sujing Jiang lifeng Sun Youping Wang Ying Dong Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Institute Key Laboratory of Cancer Prevention and InterventionMinistry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310009China Department of Pathology the Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Pathology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Respiratory and Critical Care Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuChina Colorectal Surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China.

Gastrointestinal stromal tumors(GISTs)are the most common type of soft tissue sarcoma in the gastrointestinal *** GISTs have been attributed to activated gain-of-function mutations in either KIT or platelet-derived growth factor receptorα,making these molecular features essential targets for therapeutic *** surgery is the standard treatment for localized GISTs,patients often experience relapse and disease progression even after *** recent years,targeted therapy has significantly improved the prognosis of patients with advanced *** mesylate,a KIT inhibitor,is the first-line treatment for advanced GISTs and has revolutionized the treatment of this ***,drug resistance remains a major issue with imatinib treatment,as a significant majority of patients become resistant to imatinib either after initiation or after 2–3 years of ***,novel tyrosine kinase inhibitors such as sunitinib,regorafenib,ripretinib,and avapritinib have been introduced to address drug *** has emerged as a potential approach for the treatment of advanced *** review comprehensively summarizes the pathogenesis of GISTs and the development of targeted therapies and immunotherapies,provides an overview of the emergence of drug resistance in advanced GISTs,and discusses the challenges and prospects associated with the treatment of GISTs.

关键词： Gastrointestinal stromal tumors Pathogenesis Systemic therapy Drug resistance

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马克思主义基本原理同中华优秀传统文化相结合内在逻辑、时代价值与实践向度

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沈阳农业大学学报（社会科学版） 2024年第1期26卷 1-7页

作者：刘广林李少丽沈阳农业大学马克思主义学院辽宁沈阳110866

新时代深入研究马克思主义基本原理同中华优秀传统文化相结合,必须厘清其内在逻辑,明晰其时代价值,把握其实践向度。马克思主义基本原理同中华优秀传统文化在诸多价值理念上相契相通且二者同具理论开放性,中国共产党的领导是实现二者有... 详细信息

新时代深入研究马克思主义基本原理同中华优秀传统文化相结合,必须厘清其内在逻辑,明晰其时代价值,把握其实践向度。马克思主义基本原理同中华优秀传统文化在诸多价值理念上相契相通且二者同具理论开放性,中国共产党的领导是实现二者有机结合的主体条件,实现中华民族伟大复兴是二者有机结合的实现路径,相关内容充分体现了马克思主义基本原理同中华优秀传统文化相结合的内在逻辑。马克思主义基本原理同中华优秀传统文化相结合,是新时代进一步推动马克思主义中国化的必然选择,也是构成中国式现代化道路的重要文化底蕴。从历史考察与实践向度研究马克思主义基本原理同中华优秀传统文化相结合,要旗帜鲜明地坚持马克思主义的根本指导地位,站稳人民立场,增强问题意识,在实践中不断推进二者的有机结合。

关键词：马克思主义基本原理中华优秀传统文化马克思主义中国化时代化

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高职院校扩招人才培养模式研究——基于工程侧量专业

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石家庄铁路职业技术学院学报 2024年第1期23卷 108-111页

作者：刘立荣李少丽石家庄铁路职业技术学院河北石家庄050000

2019年,李克强总理在政府工作报告中提出连续三年高职教育扩招100万人,这给职业教育带来了新的挑战。传统的教学模式、课程体系和评价考核方式是否适合扩招带来的学生,通过政策解读,分析扩招学生的特点,基于工程测量专业,制定新的人才... 详细信息

2019年,李克强总理在政府工作报告中提出连续三年高职教育扩招100万人,这给职业教育带来了新的挑战。传统的教学模式、课程体系和评价考核方式是否适合扩招带来的学生,通过政策解读,分析扩招学生的特点,基于工程测量专业,制定新的人才培养模式,结合专业特点设置模块化课程体系,采用“线上线下学习+企业实践”的教学模式,考核评价采用灵活多变的模式,使人才培养更加灵活高效。

关键词：高职扩招,工程测量人才培养模式

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基于标本核酸的肺炎支原体基因分型荧光PCR方法的建立和应用

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中华微生物学和免疫学杂志 2024年第8期44卷 653-659页

作者：张倚玮刘立雍何利华孟凡亮顾瑞雪龚杰李少丽赵飞中国疾病预防控制中心传染病预防控制所传染病溯源预警与智能决策全国重点实验室北京102206 首都儿科研究所转化医学研究室北京100020

目的建立一种基于临床标本核酸的肺炎支原体(Mycoplasma pneumoniae,Mp)核酸检测及基因分型方法。方法通过基因组学比对,选取Mp Genotype 1型和Genotype 2型菌株特异性靶序列设计合成引物和探针,建立Mp双荧光探针PCR检测分型方法,同时... 详细信息

目的建立一种基于临床标本核酸的肺炎支原体(Mycoplasma pneumoniae,Mp)核酸检测及基因分型方法。方法通过基因组学比对,选取Mp Genotype 1型和Genotype 2型菌株特异性靶序列设计合成引物和探针,建立Mp双荧光探针PCR检测分型方法,同时评价该方法的特异度、准确度、检测限和重复性。采用建立的荧光PCR方法对临床标本核酸进行检测,并与已报道的荧光PCR方法进行比对。结果对与Mp种属关系相近的其他种支原体以及常见呼吸道细菌、病毒等18种病原体的核酸进行检测,结果显示均无交叉反应;对90份Mp核酸的检测及分型的准确度为100%。该方法对于Genotype 1型和Genotype 2型Mp检测限均为1.0拷贝/μl的核酸样本,组内、组间重复性实验变异系数均小于2.5%。对88份临床标本核酸的检测中,与已报道的荧光PCR方法RepMp1体系的检测结果相比,Kappa值为0.675,P值为0.267,显示出高度的一致性。结论本研究所建立的Mp核酸检测及基因分型方法敏感度和特异度高,分型准确,可应用于各级省市疾控系统对Mp的监测与防控,促进Mp防控体系的完善,增强监测能力,对Mp的预警预测具有重要意义。

关键词：肺炎支原体 MGB探针分型实时荧光PCR

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北京市通州区2704名6~18岁女童青春期性征发育现状

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中华儿科杂志 2024年第5期62卷 430-437页

作者：张亚钦武华红书文李阳余程东李涛黄贵民侯冬青陈芳芳刘军廷李少丽宗心南首都儿科研究所生长发育研究室北京100020 首都儿科研究所儿童健康大数据研究中心北京100020 首都儿科研究所流行病学研究室北京100020

目的了解北京市通州区6~18岁女童青春期性发育现状,并比较消瘦、正常体重、超重及肥胖女童性发育情况的差异。方法2022年9月至2023年7月对北京市通州区2844名6~18岁女童进行横断面调查,现场测查乳房、阴毛发育分期,询问月经初潮状况,测... 详细信息

目的了解北京市通州区6~18岁女童青春期性发育现状,并比较消瘦、正常体重、超重及肥胖女童性发育情况的差异。方法2022年9月至2023年7月对北京市通州区2844名6~18岁女童进行横断面调查,现场测查乳房、阴毛发育分期,询问月经初潮状况,测量体重和身高,并划分为消瘦组、正常体重组和超重及肥胖组。问卷调查获得家庭及个人基本信息。应用Probit概率单位回归方法计算性征发育各期年龄、月经初潮年龄,计数资料组间比较采用χ^(2)检验。结果共调查2844名女童,符合纳入条件2704名,调查有效率为95.1%,其中6~9岁1105名(40.9%)、10~13岁1053名(38.9%)、14~18岁546名(20.2%)。女童身高Z分值(HAZ)、体重Z分值(WAZ)、体质指数Z分值(BAZ)分别为0.46(-0.23,1.16)、0.69(-0.16,1.67)、0.67(-0.27,1.73);消瘦、超重、肥胖检出率分别为1.7%(45/2704)、17.3%(467/2704)、19.9%(538/2704)。消瘦组45名、正常体重组1654名、超重及肥胖组1005名。乳房发育2期(B2)、阴毛发育2期(P2)、月经初潮年龄分别为9.0(95%CI 8.9~9.1)岁、10.5(95%CI 10.4~10.6)岁、11.4(95%CI 11.3~11.5)岁。发育期女童64.6%(1211/1874)乳房发育分期大于阴毛,32.4%(607/1874)乳房和阴毛发育分期相同,3.0%(56/1874)阴毛发育分期大于乳房。乳房发育B2与B5年龄差4.7(95%CI 4.6~4.8)年;阴毛发育P2与P5年龄差4.5(95%CI 4.4~4.6)年;B2与月经初潮年龄差2.4(95%CI 2.3~2.5)年。消瘦、正常体重、超重及肥胖组B2年龄依次为10.0(95%CI 9.5~10.6)、9.3(95%CI 9.2~9.4)、8.6(95%CI 8.4~8.7)岁,月经初潮年龄依次为13.1(95%CI 12.4~13.7)、11.6(95%CI 11.4~11.7)、11.1(95%CI 11.0~11.2)岁;超重及肥胖组女童B2与B5年龄间隔、P2与P5年龄间隔为4.5、4.1年,正常体重组分别为4.7、4.5年,消瘦组分别为4.6、4.7年。结论北京市通州区女童性征发育各期年龄以及初潮年龄较20年前北京市报道有提前趋势;超重肥胖女童相比于正常体重女童不仅青春期开始发育年龄更早,而且发育进程也有缩短。

关键词：青春期女童性征月经初潮超重肥胖

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Detection of Contamination Defect on Ice Cream Bar Based on Fuzzy Rule and Absolute Neighborhood

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Instrumentation 2017年第3期4卷 24-34页

作者： li shaoli YUAN Weiqi Computer Vision Group Shenyang University of Technology

The contamination proposed in this paper is a defect on the surface of ice cream bar,which is a serious security *** it is essential to detect this defect before launched on the market. A detection method of contamination defect on the ice cream bar surface is proposed,which is based on fuzzy rule and absolute neighborhood feature. Firstly,the ice cream bar surface is divided into several sub-regions via the defined adjacent gray level clustering method. Then the alternative contamination regions are extracted from the sub-regions via the defined fuzzy rule. At last,the real contamination regions are recognized via the relationship between absolute neighborhood gray feature and default threshold. The algorithm was tested in the self-built image database SUT-D. The results show that the accuracy of the method proposed in this paper is 97.32 percent,which increases 2.68 percent at least comparing to the other typical algorithms. It indicates that the superiority proposed in this paper,which is of actual use value.

关键词： Fuzzy Rule Absolute Neighborhood Icecream Bar Contamination Adjacent Dray Level Clustering

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Cancer profiles in China and comparisons with the USA:a comprehensive analysis in the incidence,mortality,survival,staging,and attribution to risk factors

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Science China(life Sciences) 2024年第1期67卷 122-131页

作者： Siyi He Changfa Xia He li Maomao Cao Fan Yang Xinxin Yan shaoli Zhang Yi Teng Qianru li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer *** extracted data in five aspects of cancer incidence,mortality,survival,staging distributions,and attribution to risk factors in China,the USA and worldwide from open-source *** conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects,and compared cancer statistics between China and the USA.A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020,accounting for 25.1%and 30.2%of global cases,***-related cancers including lung cancer,colorectal cancer,and breast cancer showed an upward trend and have been the leading cancer types in China.41.6%of new cancer cases and 49.3%of cancer deaths occurred in digestive-system cancers in China,and the cancers of esophagus,nasopharynx,liver,and stomach in China accounted for over 40%of global ***-related cancers showed the highest population-attributable fractions among Chinese adults,and most cancers could be attributed to behavioral and metabolic *** proportions of stage I for most cancer types were much higher in the USA than in China,except for esophageal cancer(78.2%vs.41.1%).The 5-year relative survival rates in China have improved substantially during 2000–2014,whereas survival for most cancer types in the USA was significantly higher than in China,except for upper gastrointestinal *** findings suggest that although substantial progress has been made in cancer control,especially in digestive system cancers in China,there was still a considerable disparity in cancer burden between China and the *** robust policies on risk factors and standardized screening practices are urgently warranted to curb the cancer growth and improve the prognosis for cancer patients.

关键词： cancer burden survival rate neoplasm staging risk factors China

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Several whitefly genome assemblies and an integrated whitefly gene search platform

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Insect Science 2024年第1期31卷 299-306页

作者： Xingnuo li Peng liang Mingyue Wu shaoli Wang Qingjun Wu Wen Xie Youjun Zhang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijingChina Sanya Academy of Troprical Agricultural Sciense SanyaHainanChina National Research Institute of Breeding in Hainan Chinese Academy of Agricultural SciencesSanyaHainanChina

Dear Editor,The characteristics and importance of the whitefly Bemisia tabaci as an economic pest seem to continually get more and more *** the whiteflies *** including,at least 11 genetic groups and 36 morphologically indistinguishable cryptic species,invasive MEAMl(Middle East-Asia Minor 1,"B"type)and MED(the Mediterranean,"Q"type)are the 2 most destructive cryptic species of the B.

关键词： Middle white East

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Cancer statistics for young adults aged 20 to 49 years in China from 2000 to 2017:a population-based registry study

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Science China(life Sciences) 2024年第4期67卷 711-719页

作者： Yi Teng Changfa Xia He li Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao shaoli Zhang Qianru li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

An increasing cancer incidence among adults younger than 50 years has been reported for several types of cancer in multiple *** aimed to report cancer profiles and trends among young adults in *** from the China Cancer Registry Annual Report were used to estimate incidence and mortality among young adults(ages 20–49 years)in China in 2017,and an age-period-cohort model was employed to estimate the average annual percent change(AAPC)in incidence and mortality from 2000 to *** 25 cancer types were grouped into obesity-or overweight-associated cancers(12 cancer types)and additional cancers(13 cancer types).In 2017,there were 681,178new cases and 214,591 cancer deaths among young adults in *** young adults,the most common cancers were thyroid,breast,cervical,liver,lung,and colorectal cancer,and the leading causes of cancer deaths were liver,lung,cervical,stomach,breast,and colorectal *** 2000 to 2017,the cancer incidence increased for all cancers combined among young adults,with the highest AAPC(1.46%)for adults aged 20–24 years,while cancer mortality decreased,with the highest AAPC(-1.63%)for those aged 35–39 *** conclusion,the cancer incidence in China has increased among young adults,while cancer mortality has decreased for nearly all *** control measures,such as obesity control and appropriate screening,may contribute to reducing the increasing cancer burden among young adults.

关键词： young adults incidence mortality trends China

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基于纹理脊线特征融合的木材表面裂缝检测

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仪器仪表学报 2017年第2期38卷 436-444页

作者：苑玮琦李绍丽李德健沈阳工业大学觉检测技术研究所沈阳110870 辽宁省机器视觉重点实验室沈阳110870

裂缝是木材表面一种严重缺陷,对木材的加工和使用影响极大,然而,由于裂缝与木材表面的矿物线具有诸多相似之处,因此如何准确地将裂缝纹理识别出来是一个亟待解决的问题。提出了一种基于纹理脊线特征融合的检测方法,首先建立纹理脊线灰... 详细信息

裂缝是木材表面一种严重缺陷,对木材的加工和使用影响极大,然而,由于裂缝与木材表面的矿物线具有诸多相似之处,因此如何准确地将裂缝纹理识别出来是一个亟待解决的问题。提出了一种基于纹理脊线特征融合的检测方法,首先建立纹理脊线灰度和形态特征提取基本模型;然后分割出木材表面全部纹理区域,并根据模糊规则提取出条状纹理,包括裂缝和矿物线;最后根据建立的模型提取条状纹理的两种脊线特征,并进行特征信息融合得到复合判别因子,最终通过融合结果与预设阈值的数值关系识别裂缝纹理。在自建图库上进行了测试,结果显示所用方法对裂缝缺陷识别的等误率仅为4.64%,相对于其他经典特征提取和纹理识别方法其等误率最少降低了10.06%,表明了本方法的高效性,具有实际应用价值。

关键词：纹理脊线特征特征融合木材裂缝检测模糊规则

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