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蜜蜂杂志 2024年第6期44卷 11-16页

作者：王康莉李婧妍李珊珊胡福良浙江大学动物科学学院

对2023年国内外蜂毒的研究概况进行了回顾，对公开发表的112篇中英文研究性论文的地域分布和研究领域进行了统计分析和评述，并重点介绍了蜂毒在化学成分、质量控制和生物学活性领域的研究新进展。

关键词：蜂毒化学成分质量控制生物学活性

HFNC气道管理对急性低氧性呼吸衰竭床旁无痛纤支镜检查患者氧合状态、血流动力学及肺顺应性的影响

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四川生理科学杂志 2024年第4期46卷 715-717页

作者：冯婉贞王岚李闪闪河南科技大学第一附属医院呼吸科河南洛阳471000

目的:探讨经鼻高流量氧疗(High-flow nasal cannula,HFNC)气道管理对急性低氧性呼吸衰竭(Acute hypoxic respiratory failure,AHRF)床旁无痛纤支镜检查患者氧合状态、血流动力学及肺顺应性的影响。方法:随机将我院2021年12月至2022年12... 详细信息

目的:探讨经鼻高流量氧疗(High-flow nasal cannula,HFNC)气道管理对急性低氧性呼吸衰竭(Acute hypoxic respiratory failure,AHRF)床旁无痛纤支镜检查患者氧合状态、血流动力学及肺顺应性的影响。方法:随机将我院2021年12月至2022年12月的120例拟行床旁无痛纤支镜检查的AHRF患者分为NPPV组和HFNC组,每组60例。NPPV组予以无创正压通气(Noninvasive positive pressure ventilation,NPPV)气道管理,HFNC组予以HFNC气道管理。干预后,比较两组氧合状态、血流动力学水平及肺顺应性。结果:T2时HFNC组氧分压、氧合指数高于NPPV组,二氧化碳分压低于NPPV组(P<0.05);T1、T2时HFNC组血流动力学水平变化小于NPPV组(P<0.05);术后3 d HFNC组总顺应性、肺顺应性及胸廓顺应性水平高于NPPV组(P<0.05)。结论:HFNC气道管理应用于AHRF床旁无痛纤支镜检查患者中可有效改善患者氧合状态、血流动力学及肺顺应性。

关键词：急性低氧性呼吸衰竭无痛纤支镜氧合血流动力学肺顺应性

催化剂作用原理实验设计:碘化钾催化下的L-半胱氨酸氧化反应

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化学教育（中英文） 2024年第8期45卷 36-42页

作者：任成军张程闫双昊赵明李珊珊王健礼游劲松四川大学化学学院四川成都610064

催化剂具有降低反应活化能、加快反应速率等特点。催化化学是物理化学领域的一个重要分支。催化剂的作用原理是催化化学知识体系的基础。为了具象理解该原理,设计了“碘化钾催化下的L-半胱氨酸氧化反应”。该实验通过温度、催化剂2个变... 详细信息

催化剂具有降低反应活化能、加快反应速率等特点。催化化学是物理化学领域的一个重要分支。催化剂的作用原理是催化化学知识体系的基础。为了具象理解该原理,设计了“碘化钾催化下的L-半胱氨酸氧化反应”。该实验通过温度、催化剂2个变量验证了催化剂的作用;通过变色反应检测中间物,理解催化剂改变了反应历程;用原电池电动势测定方法验证了催化剂不改变反应的平衡常数和吉布斯自由能的热力学特性。通过设计创新实验将催化剂作用原理展现得淋漓尽致。该实验将动力学、催化化学和电化学的知识融会贯通,巩固了学生的理论知识水平,锻炼了学生运用知识的能力。设计非金属氧化还原反应电池电动势测定装置,激发了学生的创新能力。

关键词：物理化学动力学催化化学 L-半胱氨酸旋光法变色反应原电池电动势

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针灸协同化疗实现增效的研究进展

针刺研究 2024年第6期49卷 634-640页

作者：杨元祯李姗姗郭义黄锦王佳琦冯怡婷赵素红赵文君徐枝芳天津中医药大学实验针灸学研究中心天津301617 天津中医药大学中医学院天津301617 日本埼玉大学理工学研究科生命科学部日本埼玉330-9301 天津中医药大学针灸推拿学院天津301617

针灸在减轻化疗药物不良反应方面的应用已经得到国内外的广泛认可,而对于其协同化疗增加抗肿瘤疗效的效应及其机制则较少进行归纳总结。本文对近几年针灸联合化疗增效的临床及基础研究进行回顾,结果显示针灸可一定程度协同化疗抑瘤,并... 详细信息

针灸在减轻化疗药物不良反应方面的应用已经得到国内外的广泛认可,而对于其协同化疗增加抗肿瘤疗效的效应及其机制则较少进行归纳总结。本文对近几年针灸联合化疗增效的临床及基础研究进行回顾,结果显示针灸可一定程度协同化疗抑瘤,并改善患者生存质量;其效应机制与针灸联合化疗药物可促进肿瘤细胞凋亡、改善肿瘤免疫及血管微环境、促进肿瘤局部化疗药富集等有关。本文为针灸作为提高化疗疗效的辅助疗法提供证据和研究思路。

关键词：针灸肿瘤化疗增效

Earth Pressure Distribution and Sand Deformation Around Modified Suction Caissons(MSCs) Under Monotonic Lateral Loading

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China Ocean Engineering 2019年第2期33卷 198-206页

作者： li Da-yong li shan-shan ZHANG Yu-kun CHEN Fu-quan College of Civil Engineering Fuzhou University Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and Technology

The modified suction caisson(MSC) is a novel type of foundation for ocean engineering, consisting of a short external closed-top cylinder-shaped structure surrounding the upper part of the regular suction caisson(RSC). The MSC can provide larger lateral bearing capacity and limit the deflection compared with the RSC. Therefore, the MSC can be much more appropriate to use as an offshore wind turbine foundation. Model tests on the MSC in saturated sand subjected to monotonic lateral loading were carried out to investigate the effects of external structure sizes on the sand surface deformation and the earth pressure distribution along the embedded depth. Test results show that the deformation range of the sand surface increases with the increasing width and length of the external structure. The magnitude of sand upheaval around the MSC is smaller than that of the RSC and the sand upheaval value around the MSC in the loading direction decreases with the increasing external structure dimensions. The net earth pressure in the loading direction acting on the internal compartment of the MSC is smaller than that of the RSC at the same embedded depth. The maximum net earth pressure acting on the external structure outer wall in the loading direction is larger than that of the internal compartment, indicating that a considerable amount of the lateral load and moment is resisted by the external skirt structure.

关键词： MSC (modified suction caisson) RSC (regular suction caisson) model tests monotonic lateral loading deformation of sand surface earth pressure distribution

急性髓系白血病CEBPA及GATA2基因共存突变患者的临床特征和预后分析

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中国实验血液学杂志 2024年第5期32卷 1313-1316页

作者：杨雪微李珊珊苏雁华孙嘉悦高玉娟哈尔滨医科大学附属第一医院血液内科黑龙江哈尔滨150000

目的:分析CEBPA基因合并GATA2基因突变患者的临床特征和预后,为临床医生制定更精准的个体化治疗方案提供参考。方法:纳入43例于2017年1月至2022年4月就诊于哈尔滨医科大学附属第一医院的CEBPA双突变和bZIP结构域突变的急性髓系白血病患... 详细信息

目的:分析CEBPA基因合并GATA2基因突变患者的临床特征和预后,为临床医生制定更精准的个体化治疗方案提供参考。方法:纳入43例于2017年1月至2022年4月就诊于哈尔滨医科大学附属第一医院的CEBPA双突变和bZIP结构域突变的急性髓系白血病患者,比较分析其中合并GATA2基因突变患者的临床特征和预后。结果:合并GATA2基因突变患者的中位年龄为48.0岁,显著低于不合并GATA2基因突变患者的57.0岁,比较差异有统计学意义(P0.05)。合并GATA2基因突变患者的中位总生存期、无事件生存期均未达到,不合并GATA2基因突变患者则分别为14.8、8.1个月,比较差异均有统计学意义(均P<0.05)。结论:合并GATA2基因突变患者的中位年龄低于不合并GATA2基因突变的患者。GATA2基因突变进一步延长了患者的生存期。

关键词：急性髓系白血病 CEBPA基因突变 GATA2基因突变共存基因突变

Studies on Suction-Assisted Installation Behavior of Suction Caissons in Clay Under Various Undrained Shear Strengths

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China Ocean Engineering 2023年第6期37卷 989-999页

作者： li Da-yong HOU Xin-yu ZHANG Yu-kun MA Shi-li li shan-shan Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and TechnologyQingdao 266590China College of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao 266580China College of Civil Engineering Weifang UniversityWeifang 261061China

Suction caissons are widely used for anchoring floating platform and offshore wind *** of the suction caisson into the desired position under the combination of its self-weight and applied suction resulted from pumping out the encased water is integral to practical *** tests were carried out to investigate the suctionassisted installation of suction caissons in clay under various undrained shear *** was found that there exists a critical penetration depth *** the penetration depth is smaller than the critical value,the soil plug undrained shear strength is higher than intact clay(i.e.,clay prior to installation).However,when the penetration depth is greater than the critical penetration depth,the undrained shear strength of soil plug is lower than intact *** critical value decreases with the increasing consolidation time and undrained shear strength of *** suction-assisted installation,cracks occur around suction *** installation way has little effect on the crack *** influence range(i.e.,the maximum distance between the crack and the suction caisson edge)was found to increase with the increasing friction coefficient of interface between the suction caisson wall and soil and decreases with the increasing soil undrained shear *** addition,the drained condition of the clay during installation is dominated by the caisson aspect ratio,the undrained shear strength and the friction coefficient between the caisson wall and *** to estimate the penetration resistance and the required suction to install the suction caisson are summarized.

关键词： suction caisson suction-assisted installation model tests undrained shear strength of clay soil deformation

Resistance Factor of Caisson-Tip with Internal Fillet for Suction Caissons Penetrating into Clay

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China Ocean Engineering 2023年第3期37卷 525-532页

作者： WU Yu-qi li Da-yong ZHANG Yu-kun ZHANG Yu li shan-shan College of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao 266580China College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Weifang Key Laboratory of Coastal and Offshore Engineering Weifang UniversityWeifang 261061China

This paper presents failure mechanisms of the soil at the caisson-tip with fillet during suction-assisted penetration of suction caissons in undrained *** solutions of resistance factor N_c of the caisson-tip are obtained in terms of the caisson-tip geometry ratio of the flat section of the caisson-tip to the caisson wall thickness m/t and adhesion factorsα_i along inside of caisson wall andα_b at the base of the *** is indicated that the factor N_c increases with the increase of m/t,α_i and a_*** resistance factors N_c for the rough base(α_b=1)are larger by 0.57than that for the smooth base(α_b=0).Besides,the factors N_c of caisson-tip with flat base(m=t)are larger by 1.14 than that with full internal fillet(m=0).The required suction to penetrate suction caissons with various fillets is obtained in terms of the force equilibrium in vertical *** finite element limit analysis and centrifuge model test results are used to verify the rationality of the presented failure mechanisms and theoretical predictions.

关键词： suction caissons suction-assisted penetration internal fillet resistance factor undrained clay

Effect of Interaction of Non-residual Fractions on Adsorption of Atrazine onto Surficial Sediments and Natural Surface Coating Samples

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Chemical Research in Chinese Universities 2011年第2期27卷 212-216页

作者： li Yu li shan-shan GAO Qian WANG Ao Sino-Canada Research Academy of Energy and Environmental Studies North China Electric Power University Beijing 102206 P. R. China Jilin Provincial Center for Sanitary Inspection and Test Changchun 130062 P. R. China College of Environment and Resources Jilin University Changchun 130012 P. R. China

To quantify the effect of the interaction of non-residual fractions[Fe oxides（Fe）, Mn oxide（Mn）, organic materials（OMs）] in the surficial sediments and the natural surface coating samples on the adsorption of atrazine（AT）, an AT multiple regression adsorption model（AT-MRAM） was developed. The AT-MRAM improves upon the previous AT additional adsorption model（AT-AAM） with superior goodness-of-fit test（adjusted R2=ca.1.000）, F-test and t-test（P〈0.01）, and reveals the effect of the interaction among the components in the surficial sediments（SSs） and na- tural surface coatings samples（NSCSs） on the adsorption of AT, which was neglected by the AT-AAM. Meanwhile, the AT-MRAM was also verified through adsorption experiments of AT and the relative deviation between predicted maximum adsorption of AT and the experimental one is less than 15%. The resulted information shows that Mn is prone to interact with other non-residual components, the total maximum adsorption of AT is inversly proportional to the level of Mn, and Fe and OMs facilitate the adsorption of AT. The results also indicate that the adsorption of AT is not only dominated by Fe, OMs, Fe/OMs, but also restrained by Fe/Mn, Fe/Mn/OMs, with lesser roles attributed to Mn, and the estimated AT distributions among the components do not agree with that previously predicted by the AT-AAM, especially with the relative contribution of Mn to the adsorption of AT, revealing significant contribution of the interactions among non-residual components in controlling the behavior of AT in aquatic environments.

关键词： Atrazine Interaction adsorption Mn oxide Surficial sediment Multiple linear regression

捏脊疗法联合穴位点按对小儿功能性消化不良的护理干预研究

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商洛学院学报 2024年第4期38卷 76-80,96页

作者：曹若菡李珊珊郭耀东商洛学院健康管理学院/秦岭康养产业“四主体一联合”校企联合研究中心陕西商洛726000

为探讨捏脊疗法联合穴位点按对小儿功能性消化不良的护理效果。选取陕西省商洛市某三级医院及某专科医院2023年1月—2024年1月间65例符合标准的功能性消化不良的小儿,运用随机数字法分为干预组(32例)与对照组(33例)。对照组采取饮食管... 详细信息

为探讨捏脊疗法联合穴位点按对小儿功能性消化不良的护理效果。选取陕西省商洛市某三级医院及某专科医院2023年1月—2024年1月间65例符合标准的功能性消化不良的小儿,运用随机数字法分为干预组(32例)与对照组(33例)。对照组采取饮食管理、运动管理等常规护理方法。干预组在常规护理基础上增加捏脊和穴位点按疗法,两组患者均治疗4周。结果表明,治疗4周后两组患者的症状积分均有所改善(P0.05)。可见,捏脊联合穴位点按疗法对小儿功能性消化不良的护理干预有明显改善作用,具有临床推广应用价值。

关键词：小儿功能性消化不良捏脊疗法穴位点按中医护理