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Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus

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Chinese Journal of Natural Medicines 2021年第11期19卷 874-880页

作者： liU Hui-Bo liU Zhao-Ming CHEN Yu-Chan Tan Hai-Bo li sai-ni li Dong-li liU Hong-Xin ZHANG Wei-Min State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Chemical and Environmental Engineering Wuyi UniversityJiangmen 529020China Program for Natural Products Chemical Biology Key Laboratory of Plant Resources Conservation and Sustainable UtilizationGuangdong Provincial Key Laboratory of Applied BotanySouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus *** the structures for these new compounds were fully characterized on the basis of spectroscopic data,NMR spectra,and ECD calculation and single-crystal X-ray diffraction *** potential anti-tumor activities of compounds 1−9 against four tumor cell lines SF-268,MCF-7,HepG-2,and A549 were evaluated using the SRB *** 7 exhibited cytotoxic activity against the SF-268 cell line with an IC50 value of 11.36μmol·L^(−1).

关键词： Deep-see-derived fungus Phomopsis lithocarpus 2 3-Dihydro-1H-indene isomers Benzophenone derivatives

Multigenerational birth cohort study in China:importance,necessity and beyond

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World Journal of Pediatrics 2023年第5期19卷 411-416页

作者： sai‑li ni Wei He Jia‑Kai Zhang Fei Yang Guan‑Nan Bai Die li Wei‑Ze Xu Jia‑Bin li Qiang Shu Shan‑Kuan Zhu Binjiang Institute of Zhejiang University HangzhouChina Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Nutrition and Food Hygiene School of Public HealthChronic Disease Research InstituteZhejiang UniversityHangzhouChina Department of Molecular Genetics University of TorontoTorontoONCanada

A birth cohort study is an epidemiological study that enrolls a group of people who were born during a specifc period of time and follows up with them from the prenatal period to adulthood and even old *** establishment of a birth cohort study enables the exploration of the etiology of diseases and enriches the understanding and awareness of health status among the reproductive ***,it provides evidence-based support for the launch of public health policies and programs and thus practically promotes the health care of women and children,facilitating the early prevention of disease in childhood and adulthood[1].

关键词： prevention diseases birth

Spectrum analysis of interval process model and its application in uncertain vibration analysis

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Science China(Technological Sciences) 2024年第8期67卷 2549-2564页

作者： li JinWu JIANG Chao ni BingYu State Key Laboratory of Advanced Design and Manufacturing Technology for Vehicle College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

In recent years, the authors have extended the traditional interval method into the time dimension to develop a new mathematical tool called the “interval process model” for quantifying time-varying or dynamic uncertainties. This model employs upper and lower bounds instead of precise probability distributions to quantify uncertainty in a parameter at any given time point. It is anticipated to complement the conventional stochastic process model in the coming years owing to its relatively low dependence on experimental samples and ease of understanding for engineers. Building on our previous work, this paper proposes a spectrum analysis method to describe the frequency domain characteristics of an interval process, further strengthening the theoretical foundation of the interval process model and enhancing its applicability for complex engineering problems. In this approach, we first define the zero midpoint function interval process and its auto/cross-power spectral density(PSD) functions. We also deduce the relationship between the auto-PSD function and the auto-covariance function of the stationary zero midpoint function interval process. Next, the auto/cross-PSD function matrices of a general interval process are defined, followed by the introduction of the concepts of PSD function matrix and cross-PSD function matrix for interval process vectors. The spectrum analysis method is then applied to random vibration problems, leading to the creation of a spectrum-analysis-based interval vibration analysis method that determines the PSD function for the system displacement response under stationary interval process excitations. Finally, the effectiveness of the formulated spectrum-analysis-based interval vibration analysis approach is verified through two numerical examples.

关键词： interval process spectrum analysis power spectral density(PSD) time-varying uncertainty uncertain vibration analysis

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Evolution and function of residual solvent in polymer-li_2B_(12)H_(12) composite solid electrolyte

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Rare Metals 2024年第8期43卷 3748-3757页

作者： Xiang-Yang Ye Ke-Pan Bao sai-Nan Luo Xin li Tai-Qiang Chen Shui-Xin Xia Tao Yuan Yue-Peng Pang Shi-You Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Department of Materials Science and Engineering National University of SingaporeSingapore 119077Singapore

Composite solid electrolytes(CSEs) containing polymer matrices and inorganic fillers hold promise for the next generation of solid-state ***,the role of residual solvents in CSEs remains *** study investigated the evolution and function of the residual solvent in a polymer-li_2B_(12)H_(12) CSE.A partial reaction occurred between li_2B_(12)H_(12) and solvent N,N-dimethylformamide(DMF),which produced dimethylaminomethanol(DMAM) in the *** functional theory calculations have revealed that DMA M forms stronger hydrogen bonds with polyvinylidene fluoride chains than DMF,which can have a plasticizing effect on the polymer matrix,leading to lower crystallinity and quicker segment ***,this CSE exhibited improved li-ion conducting properties,enabling the stable cycling of li‖liFePO_(4) solid-state *** study provided insights into the role of residual solvents in CSEs.

关键词： Composite solid electrolyte Residual solvent lithium borohydride Plasticizing effect

Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： sai Ji Min li Mei liang Zhenning Zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

A deep learning model enabled multi-event recognition for distributed optical fiber sensing

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Science China(Information Sciences) 2024年第3期67卷 291-307页

作者： Yujiao li Xiaomin CAO Wenhao ni Kuanglu YU Institute of Information Science School of Computer and Information TechnologyBeijing Jiaotong University Beijing Key Laboratory of Advanced Information Science and Network Technology Beijing Jiaotong University

Fiber optic sensors that utilize backscattered light offer distributed real-time measurements and have been seen tremendous improvements in sensing distance and spatial resolution over the last ***, these improvements in sensor capabilities lead to a significant increase in the amount of data that needs to be processed. Traditional processing schemes are no longer adequate, so the development of novel signal processing methods is critical. Phase-sensitive optical time domain reflectometry(Φ-OTDR) is now applied in various applications for multi-event recognition, and it would usually be difficult, sometimes even unrealistic to label all the acquired samples due to its real-time and seamless monitoring nature. To fully take advantage of the information contained within the large number of unlabeled samples, which were formerly not utilized and hence wasted, we propose a semi-supervised model to boost the event classification performance of Φ-OTDR. The model extracts respectively the temporal features and the spatial bidirectional features together with a dual attention mechanism. Its classification accuracy has been improved up to 96.9%with only 1230 labeled samples. In addition, our model shows significant advantages when the number of labeled samples is reduced. Importantly, our method improves the accuracy of multi-event classification without any modification to the optical setup.

关键词： $\Phi$-OTDR event recognition semi-supervised learning mean teacher MT-ACNN-SA-BiLSTM

Dietary Supplementation of β-Carotene Reveals miRNAs Involved in the Regulation of Carotenoid Metabolism in Crassostrea gigas

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Journal of Ocean University of China 2024年第4期23卷 1045-1053页

作者： SUN Dongfang WAN sai YU Hong KONG lingfeng li Qi Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266237China

Carotenoids play crucial physiological roles in animals.A comprehensive investigation into the mechanism of carotenoid metabolism in oysters will establish a theoretical foundation for further development of its carotenoid-rich ***,the information on the function of miRNA in β-carotene metabolism in oysters is *** elucidate the mechanisms underlying miRNA regulation of carotenoid metabolism in oysters,we compared the expressions of miRNA in digestive gland tissues of Pacific oyster(Crassostrea gigas)fed with aβ-carotene supplemented diet and a normal diet,respectively.A total of 690 candidate miRNAs in the Pacific oyster digestive gland tissues were identified,including 590 known miRNAs and 111 unknown *** differentially expressed miRNAs were obtained in the carotenoid-fed and normal groups,associated to 137 differentially expressed target ***,the GO enrichment analysis revealed that the differentially expressed target genes were mainly involved in transmembrane transport *** enrichment showed that the differentially expressed target genes were involved in ABC *** of the mRNA-miRNA network revealed that novel0025 played a central role in carotenoid metabolism,and it was negatively correlated with the expression of 46 *** addition,down-regulated expression of novel0025 upregulated the expression of the lipoprotein gene LOC105342186,suggesting a potential regulatory role in carotenoid *** results provide useful information for elucidating the miRNA regulation mechanism during carotenoids metabolism in the Pacific oyster.

关键词： Crassostrea gigas β-carotene microRNA carotenoid metabolism

Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 52-63页

作者： li Zhang sai He Hao Guan Yao Zhao Di Zhang Department of General Surgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Department of Breast Cancer Shaanxi Provincial Cancer HospitalXi’an 710000China

Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths *** evidence shows that the expression of circulating RNA ZFR(circZFR)is upregulated in HCC ***,the molecular mechanism of circZFR in HCC is ***:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to detect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and *** R assay and actinomycin D treatment assay were used to analyze the characteristics of *** functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2-deoxyuridine(EdU)assay,flow cytometry assay and transwell *** blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related *** interactions between miR-624-3p and circZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)*** models were established to determine the role of circZFR in ***:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and *** could sponge miR-624-3p,and WEE1 was a downstream gene of *** of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR624-3p inhibitor restored this *** of WEE1 abolished the inhibitory effect of miR624-3p mimic on HCC ***,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting ***,in vivo studies have illustrated that circZFR knockdown inhibited tumor ***:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might

关键词： Hepatocellular carcinoma circZFR miR-624-3p WEE1 liver cancer

Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying liu Shuai Ye Xin-ni li Wei-Guang li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations