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ecological hydrograph based on Schizothorax chongi habitat conservation in the dewatered river channel between Jinping cascaded dams

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science china(Technological sciences) 2011年第S1期54卷 54-63页

作者： li ruonan 1,chen qiuwen 1,2.& duan chen 1,3 1 research center for eco-environmental science,chinese academy of sciences,beijing 100085,china 2 china Three Gorges University,Yichang 443002,china 3 Hydraulics Department,Changjiang River Scientific research Institute,Wuhan 430010,china 1. research center for eco-environmental science Chinese Academy of Sciences Beijing 100085 China 2. china Three Gorges University Yichang 443002 China 3. Hydraulics Department Changjiang River Scientific Research Institute Wuhan 430010 China

Hydropower development changes the river hydrological regime,thereby altering river ecosystem *** important measure for reducing degradation of ecosystem is to determine ecological flow and implement it by reservoir *** paper described a method to calculate river ecological flow based on fish habitat conservation and applied it to Jinping River Bend of Yalong *** chongi was selected as target species,and the fish habitat model coupling with water environmental model was developed according to the relationship between fish and water environment ***,improved hydraulic habitat suitability index(IHHS) and habitat fragment index(HFI) varying with discharge were discussed in this *** area representing average annual flow was taken as a reference,and then ecological hydrographs under different habitat conservation levels were calculated considering season variation and life stages of *** to the natural condition,the model results indicated that the reservoir operation clearly influenced the habitat of the target *** was proposed to ensure flow releases to maintain 70%-90% habitat in section after joint while about 60% before joint.

关键词： river habitat habitat assessment ecological flow ecological hydrograph

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Optimizing the operation of the Qingshitan Reservoir in the lijiang River for multiple human interests and quasi-natural flow maintenance

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Journal of environmental sciences 2012年第11期24卷 1923-1928页

作者： qiuwen chen duan chen Ruiguang Han ruonan li Jinfeng Ma Koen Blanckaert research center for eco-environmental sciences Chinese Academy of SciencesBeijing 100085China Three Gorges University Yichang 443002China Changjiang River Scientific research Institute Wuhan 430010China Laboratory of Hydraulic Constructions School of ArchitectureCivil and Environment EngineeringLausanneSwitzerland Haihe Water Conservancy Commission Tianjin 300170China

For reservoir operation, maintaining a quasi-natural flow regime can benefit river ecosystems, but may sacrifice human interests. This study took the Qingshitan Reservoir in the lijiang River as a case, and developed an optimization model to explore a trade-off solution between social-economic interests and nature flow maintenance on a monthly base. The objective function considered irrigation, cruise navigation and water supply aspects. An index of flow alteration degree was proposed to measure the difference between the regulated discharge and the natural flow. The index was then used as an additional constraint in the model besides the conventional constraints on reservoir safety. During model solving, different criteria were applied to the index, representing various degrees of alteration of the natural flow regime in the river. Through the model, a relationship between social-economic interests and flow alteration degree was established. Finally, a trade-off solution of the reservoir operation was defined that led to a favorable social-economic benefit at an acceptable alteration of the natural flow.

关键词： reservoir operation optimization model flow alteration trade-off solution

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ecologically-friendly operation scheme for the Jinping cascaded reservoirs in the Yalongjiang River, china

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Frontiers of Earth science 2014年第2期8卷 282-290页

作者： duan chen qiuwen chen ruonan li Koen BLANCKAERT Desuo CAI research center for eco-environmental sciences Chinese Academy of Sciences Beijing 100085 China Changjiang River Scientific research Institute Wuhan 430010 China Nanjing Hydraulics research Institute Nanjing 210023 China Guangxi Water Conservancy Department Nanning 530023 China

ecologically-friendly reservoir operation pro- cedures aim to conserve key ecosystem properties in the rivers, while minimizing the sacrifice of socioeconomic interests. This study focused on the Jinping cascaded reservoirs as a case study. An optimization model was developed to explore a balance between the ecological flow requirement （EFR） of a target fish species （Schizothorax chongi） in the dewatered natural channel section, and annual power production. The EFR for the channel was determined by the Tennant method and a fish habitat model, respectively. The optimization model was solved by using an adaptive real-coded genetic algorithm. Several operation scenarios corresponding to the ecological flow series were evaluated using the optimization model. Through comparisons, an optimal operational scheme, which combines relatively low power production loss with a preferred ecological flow regime in the dewatered channel, is proposed for the cascaded reservoirs. Under the recommended scheme, the discharge into the Dahewan river reach in the dry season ranges from 36 to 50 m3/s. This will enable at least 50% of the target fish habitats in the channel to be conserved, at a cost of only 2.5% annual power production loss. The study demonstrates that the use of EFRs is an efficient approach to the optimization of reservoir operation in an ecologically friendly way. Similar modeling, for other important fish species and ecosystem functions, supplemented by field validation of results, is needed in order to secure the long-term conservation of the affected river ecosystem.

关键词： ecologically-friendly operation optimizationmodel ecological flow Jinping cascaded reservoirs,Schizothorax chongi

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Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1882-1892页

作者： Peng chen Qibiao Wu Jiao Feng lili Yan Yitian Sun Shuiping liu Yu Xiang Mingming Zhang Ting Pan Xiaying chen Ting duan lijuan Zhai Bingtao Zhai Wengang Wang ruonan Zhang Bi chen Xuemeng Han Yicong li liuxi chen Ying liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui chen Yongqiang li Qiujie li Guohua li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui Holistic Integrative Pharmacy Institutes and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiangChina Institute of chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Elemene Class Anti-cancer chinese Medicine of Zhejiang Province Hangzhou Normal UniversityHangzhouZhejiangChina State Key Laboratory of Quality research in chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacaoP.R.China Zhejiang chinese Medicinal University HangzhouChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina Department of Medical Oncology Zhejiang UniversityHangzhouChina Department of Hematology and Oncology the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiangChina Radiation Detection research center Northwest Institute of Nuclear TechnologyXi’anChina Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingChina

Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including *** ferroptosis in cancer cells may be a potential strategy for cancer ***,ferroptosis-inducing drugs are attracting more attention for cancer ***,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer ***,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH *** ferroptosis inhibitors Fer-1 and lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell ***,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing *** together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment.

关键词： peroxidation lung drugs

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