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中心性肥胖和肝癌的关系:两样本孟德尔随机化分析

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肝脏 2024年第4期29卷 387-390页

作者：许姗姗仇丽霞柳雅立张晶首都医科大学附属北京佑安医院肝病中心三科北京100069

目的探讨中心性肥胖与肝癌的关系。方法腰围、经BMI矫正的腰围、臀围、经BMI校正的臀围、腰臀比和经BMI校正的腰臀比相关的全基因组关联分析(genome wide association study,GWAS)数据来自欧洲一个包含224459个样本的大型数据库。内脏... 详细信息

目的探讨中心性肥胖与肝癌的关系。方法腰围、经BMI矫正的腰围、臀围、经BMI校正的臀围、腰臀比和经BMI校正的腰臀比相关的全基因组关联分析(genome wide association study,GWAS)数据来自欧洲一个包含224459个样本的大型数据库。内脏脂肪体积数据集来自欧洲数据库,包括32860名欧洲受试者的9275407个单核苷酸多态性(single nucleotide polymorphism,SNP)位点信息。肝癌的数据集来自英国生物银行数据库,包括372184名欧洲受试者的汇总数据。对获得的数据集进行两样本孟德尔随机化研究。结果逆方差加权法(IVW)分析结果显示,经BMI矫正的腰围会增加肝癌发生风险(OR=1.001,95%CI:1.000~1.001,P=0.024),且被加权中位数(WM)分析(OR=1.001,95%CI:1.000~1.002,P=0.020)证实,但在MR-Egger回归(OR=1.002,95%CI:0.999~1.004,P=0.135)中未被证实。其他中心性肥胖指标与肝癌无关。结论不同中心性肥胖指标与肝癌的相关性存在差异。经BMI矫正的腰围可能会导致肝癌发生,表明在相对较瘦的人群中,中心性肥胖与肝癌发生相关,且可能存在因果关系。

关键词：中心性肥胖肝癌孟德尔随机化分析

Structures and Stabilities of Ni_n(n=31―35) Clusters

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Chemical Research in Chinese Universities 2012年第2期28卷 291-294页

作者： SONG Wei LÜ Wen-cai ZANG Qing-jun li qiu-xia State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryJilin UniversityChangchun 130021P.R.China Laboratory of Fiber Materials and Modern Textile the Growing Base for State Key LaboratoryCollege of PhysicsQingdao UniversityQingdao 266071P.R.China

The lowest-energy structures and properties of neutral nickel clusters Nin（n=31―35） were studied by a combination method of genetic algorithm（GA） searching with a tight-binding potential and the density functional theory（DFT） *** candidates obtained from our GA search were further optimized with first-principles *** typical isomers of lower-energy neutral Nin（n=31―35） clusters were shown,as well as their binding energies per atom（Eb）,second differences in energy and magnetic *** medium-sized nickel clusters in a size range from 31 atoms to 35 atoms were found to favor the distorted double-icosahedron-like *** fragments composed of the central atoms appear as some small stable clusters.

关键词： Nickel cluster Double-icosahedron Magnetic property

支气管镜内生异物取出联合乙酰半胱氨酸雾化吸入对儿童塑型性支气管炎临床疗效及血氧状态的影响

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川北医学院学报 2024年第2期39卷 204-208页

作者：沈勤孙炳霞王千张军王佳佳李秋侠宿迁市第一人民医院儿科江苏宿迁223800

目的:探讨支气管镜内生异物取出联合乙酰半胱氨酸雾化吸入对儿童塑型性支气管炎临床疗效及血氧状态的影响。方法:选取58例塑型性支气管炎患儿为研究对象,根据治疗方式不同,将采用支气管镜内生异物取出治疗的患儿设为异物取出组(n=29);... 详细信息

目的:探讨支气管镜内生异物取出联合乙酰半胱氨酸雾化吸入对儿童塑型性支气管炎临床疗效及血氧状态的影响。方法:选取58例塑型性支气管炎患儿为研究对象,根据治疗方式不同,将采用支气管镜内生异物取出治疗的患儿设为异物取出组(n=29);将采用支气管镜内生异物取出联合乙酰半胱氨酸雾化吸入治疗的患儿设为联合组(n=29)。比较两组患儿临床症状改善情况,观察支气管镜术后7 d两组患儿血氧状态[动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(OI)]、潮气呼吸肺功能[呼吸频率(RR)、每公斤潮气量(VT)、达峰时间比(TPTEF/TE)]、血清炎性因子[白细胞介素4(IL-4)、IL-6、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)]、T淋巴细胞亚群[CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]水平变化。结果:联合组咳嗽、肺部湿啰音、气促消失时间及住院总时间均短于异物取出组(P<0.05);治疗后,联合组PaCO_(2)水平低于异物取出组,PaO_(2)、OI水平均高于异物取出组(P<0.05);RR水平低于异物取出组,VT、TPTEF/TE水平均高于异物取出组(P<0.05);血清TNF-α、IL-4、IL-10、IL-6水平均低于异物取出组(P<0.05);T淋巴细胞CD4^(+)、CD4^(+)/CD8^(+)水平均高于异物取出组(P<0.05)。结论:儿童塑型性支气管炎治疗支气管镜内生异物取出联合乙酰半胱氨酸雾化吸入可改善患儿疾病症状、潮气呼吸肺功能,提高血氧水平,减轻炎性反应,调节机体免疫功能。

关键词：塑型性支气管炎内生异物支气管镜乙酰半胱氨酸血氧状态

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Development and validation of a novel model to predict liver-related mortality in patients with idiosyncratic drug-induced liver injury

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 584-593页

作者： Yan Wang Cai-Lun Zou Jing Zhang li-xia qiu Yong-Fa Huang Xin-Yan Zhao Zheng-Sheng Zou Ji-Dong Jia liver Research Center Beijing Friendship HospitalCapital Medical UniversityKey Laboratory on Translational Medicine on CirrhosisNational Clinical Research Center for Digestive DiseasesBeijing 100050China The Third Unit Department of HepatologyBeijing You’an HospitalCapital Medical UniversityBeijing 100069China liver Transplantation Center Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing 100050China Clinical Center for Pediatric liver Transplantation Capital Medical UniversityBeijing 100050China Senior Department of Hepatology the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

Background: Early identification of patients with high mortality risk is critical for optimizing the clinical management of drug-induced liver injury(DIli). We aimed to develop and validate a new prognostic model to predict death within 6 months in DIli patients. Methods: This multicenter study retrospectively reviewed the medical records of DIli patients admitted to three hospitals. A DIli mortality predictive score was developed using multivariate logistic regression and was validated with area under the receiver operating characteristic curve(AUC). A high-mortality-risk subgroup was identified according to the score. Results: Three independent DIli cohorts, including one derivation cohort( n = 741) and two validation cohorts( n = 650, n = 617) were recruited. The DIli mortality predictive(DMP) score was calculated using parameters at disease onset as follows: 1.913 × international normalized ratio + 0.060 × total bilirubin(mg/d L) + 0.439 × aspartate aminotransferase/alanine aminotransferase – 1.579 × albumin(g/d L) –0.006 × platelet count(109/L) + 9.662. The predictive performance for 6-month mortality of DMP score was desirable, with an AUC of 0.941(95% CI: 0.922-0.957), 0.931(0.908-0.949) and 0.960(0.942-0.974) in the derivation, validation cohorts 1 and 2, respectively. DIli patients with a DMP score ≥ 8.5 were stratified into high-risk group, whose mortality rates were 23-, 36-, and 45-fold higher than those of other patients in the three cohorts. Conclusions: The novel model based on common laboratory findings can accurately predict mortality within 6 months in DIli patients, which should serve as an effective guidance for management of DIli in clinical practice.

关键词： liver injury Prognostic score Risk stratification Mortality

Bioactive constituents and action mechanism of xiaoyao San for treatment of non-alcoholic fatty liver disease

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World Journal of Hepatology 2024年第10期16卷 1213-1215页

作者： xiao-xia qiu Zheng li Department of Research and Education Shulan(Hangzhou)HospitalAffiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

xiaoyao San(XYS)is a classic Chinese medicine *** is traditionally used to relieve syndrome of“liver stagnation and spleen deficiency”,a common syndrome type in traditional Chinese medicine,through soothing liver,tonifying spleen,and nourishing ***,XYS has long application in the treatment of depression,dyspepsia and liver *** the rising of cutting-edge researches on XYS,there’s a significant need to diligently uncover the bioactive constituents and action mechanisms of XYS for treating non-alcoholic fatty liver disease accordingly.

关键词： xiaoyao San Bioactive constituents Mechanisms Non-alcoholic fatty liver disease Fibrosis

Morphological Classification of Infrared Galaxies Based on WISE

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Research in Astronomy and Astrophysics 2024年第4期24卷 222-236页

作者： Zhi-Ren Pan Bo qiu Cui-xiang liu A-li Luo xia Jiang xiao-Yu Guo School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

This study introduces a novel convolutional neural network,the WISE Galaxy Classification Network(WGC),for classifying spiral and elliptical galaxies using Wide-field Infrared Survey Explorer(WISE)*** attains an accuracy of 89.03%,surpassing the combined use of K-means or SVM with the Color-Color method in more accurately identifying galaxy *** enhanced variant,WGC_mag,integrates magnitude parameters with image features,further boosting the accuracy to 89.89%.The research also delves into the criteria for galaxy classification,discovering that WGC primarily categorizes dust-rich images as elliptical galaxies,corresponding to their lower star formation rates,and classifies less dusty images as spiral *** paper explores the consistency and complementarity of WISE infrared images with SDSS optical images in galaxy morphology *** SDSS Galaxy Classification Network(SGC),trained on SDSS images,achieved an accuracy of 94.64%.The accuracy reached 99.30% when predictions from SGC and WGC were *** the complementarity of features in WISE and SDSS images,a novel variant of a classifier,namely the Multi-band Galaxy Morphology Integrated Classifier,has been *** classifier elevates the overall prediction accuracy to 95.39%.Lastly,the versatility of WGC was validated in other data *** the HyperLEDA data set,the distinction between elliptical galaxies and Sc,Scd and Sd spiral galaxies was most pronounced,achieving an accuracy of 90%,surpassing the classification results of the Galaxy Zoo 2 labeled WISE data *** research not only demonstrates the effectiveness of WISE images in galaxy morphology classification but also represents an attempt to integrate multi-band astronomical data to enhance understanding of galaxy structures and evolution.

关键词： methods:data analysis infrared:galaxies galaxies:spiral galaxies:elliptical and lenticular cD

Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease:Mechanism,clinical evidence,and prospect

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World Journal of Gastroenterology 2024年第8期30卷 833-842页

作者： xiao-xia qiu Sheng-li Cheng Yan-Hui liu Yu li Rui Zhang Nan-Nan li Zheng li Research and Education Department Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Anhui Provincial Hospital The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina Department of Clinical Pharmacy Anhui Provincial Children’s HospitalHefei 230000Anhui ProvinceChina Department of Pharmacy Taihe County People’s Hospital of Anhui ProvinceFuyang 236600Anhui ProvinceChina Department of Pharmacy The Second People’s Hospital of HefeiHefei Hospital Affiliated to Anhui Medical UniversityHefei 230000Anhui ProvinceChina University of Science and Technology of China The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

The population of non-alcoholic fatty liver disease(NAFLD)patients along with relevant advanced liver disease is projected to continue growing,because currently no medications are approved for *** microbiota transplantation(FMT)is believed a novel and promising therapeutic approach based on the concept of the gut-liver axis in liver *** has been an increase in the number of pre-clinical and clinical studies evaluating FMT in NAFLD treatment,however,existing findings diverge on its ***,we briefly summarized the mechanism of FMT for NAFLD treatment,reviewed randomized controlled trials for evaluating its efficacy in NAFLD,and proposed the prospect of future trials on FMT.

关键词： Non-alcoholic fatty liver disease Fecal microbiota transplantation Randomized controlled trial Mechanism Efficacy

Structural variations of a new fertility restorer gene,Rf20,underlie the restoration of wild abortive-type cytoplasmic male sterility in rice

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Molecular Plant 2024年第8期17卷 1272-1288页

作者： Shufeng Song Yixing li Mudan qiu Na Xu Bin li Longhui Zhang Lei li Weijun Chen Jinglei li Tiankang Wang Yingxin qiu Mengmeng Gong Dong Yu Hao Dong Siqi xia Yi Pan Dingyang Yuan li li State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterHunan Academy of Agricultural SciencesChangsha 410125China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Plant Protection Hunan Agricultural UniversityChangsha 410128China College of Tropical Crops Hainan UniversityHaikou 570228China Longping Branch College of BiologyHunan UniversityChangsha 410125China

The discovery of a wild abortive-type(WA)cytoplasmic male sterile(CMS)line and breeding its restorer line have led to the commercialization of three-line hybrid rice,contributing considerably to global food ***,the molecular mechanisms underlyingfertility abortion and the restoration of CMs-WA lines remain largely *** this study,we cloned a restorer gene,Rf2o,following a genome-wide association study analysis of the core parent lines of three-line hybrid *** found that Rf20 was present in all core parental lines,but different haplotypes and structural variants of its gene resulted in differences in Rf2o expression levels between sterileand restored ***20 could restorepollen fertility in the CMS-WA line and was found to be responsible for fertility restoration in some CMs lines under high *** addition,we found that Rf20 encodes a pentatricopeptide repeat protein that competes with WA352 for binding with *** interaction enhances Cox11's function as a scavenger of reactive oxygen species,which in turn restores ***,ourstudysuggestsanewactionmodeforpentatricopeptide repeatproteins inthe fertilityrestorationofCMs lines,providing an essential theoretical basisforbreedingrobustrestorer lines and for overcoming high temperature-induced fertility recovery of some CMS lines.

关键词： COX11 cytoplasmic male sterility rf20 WA352 wild abortion

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机械用碳石墨材料摩擦机理探讨

炭素 2024年第1期 40-44页

作者：程诺曾昊李秋霞侯玉杰廖小琴王春梅王岗成都中超碳素科技有限公司成都610000

摩擦是一个复杂多变的过程,机械用碳石墨材料是重要的动摩擦密封和轴承材料,机械用碳石墨材料领域的动摩擦研究就是一个非常复杂的过程,并不是所有的碳石墨材料都具备应付复杂工况的能力和优秀的摩擦性能,机械用碳材料动摩擦学理论还在... 详细信息

摩擦是一个复杂多变的过程,机械用碳石墨材料是重要的动摩擦密封和轴承材料,机械用碳石墨材料领域的动摩擦研究就是一个非常复杂的过程,并不是所有的碳石墨材料都具备应付复杂工况的能力和优秀的摩擦性能,机械用碳材料动摩擦学理论还在探讨和建立之中.本文结合碳石墨材料的基本结构分析,用大量的摩擦实验数据,旨在探讨机械用碳的结构与其摩擦性能之间的关系,为材料的选型提供技术参考.

关键词：机械用碳材料结构成膜性研磨性动摩擦性