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Energy-saving design and optimization of pressure-swing-assisted ternary heterogenous azeotropic distillations

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Chinese Journal of Chemical Engineering 2024年第4期68卷 1-7页

作者： lianjie Wu Kun Lu qirui li lianghua Xu Yiqing Luo Xigang Yuan Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion College of Chemical and Chemical EngineeringTianjin University of TechnologyTianjin 300384China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300072China

A huge amount of energy is always consumed to separate the ternary azeotropic mixtures by *** heterogeneous azeotropic distillation and the pressure-swing distillation are two kinds of effective technologies to separate heterogeneous azeotropes without entrainer *** give better play to the synergistic energy-saving effect of these two processes,a novel pressure-swing-assisted ternary heterogeneous azeotropic distillation(THAD)process is proposed *** this process,the ternary heterogeneous azeotrope is decanted into two liquid phases before being refluxed into the azeotropic distillation column to avoid the aqueous phase remixing,and three columns'pressures are modified to decrease the flowrates of the recycle *** the dividing wall column and heat integration technologies are introduced to further reduce its energy consumption,and the pressureswing-assisted ternary heterogeneous azeotropic dividing-wall column and its heat integration structure are achieved.A genetic algorithm procedure is used to optimize the proposed *** design results show that the proposed processes have higher energy efficiencies and lower CO_(2)emissions than the published THAD process.

关键词： Distillation Separation Process control Process systems

CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis

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Oncology Research 2024年第3期32卷 529-544页

作者： JIANYUN XIE liNIE LU JIAli ZHANG qirui li WEIDONG CHEN Depatment of Urology The Affliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhouChina Department of Internal Medicine Outpatient ainic The Afliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhouChina

Objective:Circular ribose nudeic acids(circRNAs)are implicated in tumor progression and drug resistance of prostate cancer(PCa).The current work explored the function of circ_0005203(aircTHSD4)in the malignancy and docetaxel(DTX)resistance of ***:circTHSD4 expression within PCa as well as matched non-carcinoma samples was measured through real time reverse transcription quantitative polymerase chain reaction(RT-qPCR).In addition,a subcellular fraction assay was conducted to determine circTHSD4 subcellular localization within PCa *** addition,we performed a Western blot(WB)assay to detect high *** A2 protein(HMGA2)***,functional associations of two molecules were investigated through dual luciferase reporter *** Counting Kit(CCK)-8,colony formation together with Transwell assay was conducted to assess malignant phenotypes of PCa cells,whereas flow cytometry was performed to determine cell ***,a xenograft mouse model was constructed to verify the effect of circTHSD4 on the carcinogenesis of PCa ***:According to RT-qPCR results,circTHSD4 was up-regulated within PCa tissues and cells,which predicted the dismal prognostic outcome of PCa ***4 silencing within PCa cells markedly suppressed cell growth,migration,and colony ***4 silencing remarkably elevated PCa cell apoptosis and carcinogenesis within the xenograft ***,circTHSD4 silencing enhanced docetaxel(DTX)sensitivity in PCa ***,we demonstrated that circTHSD4 modulated the malignancy of PCa cells by regulating HMGA2 expression through sponging miR ***:Together,our findings suggest that cirCTHSD4 overexpression could promote the malignant phenotype and DTX resistance in PCa through the regulation of the miR 203/HMGA2 axis.

关键词： circTHSD4 Docetaxel resistance Prostate cancer miR-203 HMGA2

Integrative Proteomic Analysis of Multiple Posttranslational Modifications in Inflammatory Response

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 163-176页

作者： Feiyang Ji Menghao Zhou Huihui Zhu Zhengyi Jiang qirui li Xiaoxi Ouyang Yiming Lv Sainan Zhang Tian Wu Lanjuan li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China The First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310003China Department of Colorectal Surgery Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Quzhou Second People’s Hospital Quzhou 324000China

Posttranslational modifications(PTMs)of proteins,particularly acetylation,phosphorylation,and ubiquitination,play critical roles in the host innate immune ***’dynamic changes and the crosstalk among them are *** build a comprehensive dynamic network of inflammation-related proteins,we integrated data from the whole-cell proteome(WCP),acetylome,phosphoproteome,and ubiquitinome of human and mouse *** datasets of acetylation,phosphorylation,and ubiquitination sites helped identify PTM crosstalk within and across proteins involved in the inflammatory *** of macrophages by lipopolysaccharide(LPS)resulted in both degradative and non-degradative ***,this study contributes to the interpretation of the roles of known inflammatory molecules and the discovery of novel inflammatory proteins.

关键词： Proteome Crosstalk Inflammation lipopolysaccharide Macrophage

Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation

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Engineering 2020年第11期6卷 1302-1314页

作者： Zhengyi Jiang Zeyu Sun Xiaoxi Ouyang Yalei Zhao Menghao Zhou Baohong Wang qirui li linxiao Fan Sainan Zhang Lanjuan li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China

Primary hepatocytes(PHCs)are widely used in various fields,but the progressive deterioration of liverspecific features in vitro significantly limits their *** the transcriptional regulation and whole cell proteome(WCP)of PHCs have been extensively studied,only a small number of studies have addressed the role of posttranslational modifications in this *** elucidate the underlying mechanisms that induce dedifferentiation,we carried out parallel quantifications of the transcriptome,WCP,ubiquitinome,and phosphoproteome of rat PHCs after 0,6,12,24,and 48 h of in vitro *** data constitute a detailed proteomic analysis of dedifferentiated PHCs including 2196 proteins,2056 ubiquitinated sites,and 4932 phosphorylated *** revealed a low correlation between the transcriptome and WCP during dedifferentiation.A combined analysis of the ubiquitinome with the corresponding WCP indicated that the dedifferentiation of PHCs led to an increase in nondegradative K27 *** analysis of the altered phosphoproteins suggested a significant enrichment in *** all,404 proteins with both ubiquitination and phosphorylation were identified to be involved in critical metabolic ***,Ptbph Hnqjd,Hnrnpu,and Srrm2 were identified as hub *** together,our data provide new insights into proteome dynamics during PHC dedifferentiation and potential targets to inhibit the dedifferentiation process.

关键词： Ubiquitination Phosphoproteome Proteome Dedifferentiation Primary hepatocytes

Treatment of COVID-19 by monoclonal antibodies and the traditional Chinese medicine

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Medicine in Novel Technology and Devices 2022年第3期15卷 144-147页

作者： Yuyan ling Yuxuan Dong qirui li Doudou Huang Zhihui li Meijuan Chen School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing210023China

The mortality rate of the recent global pandemic corona virus disease 2019(COVID-19)is currently as high as 7%.The SARS-CoV-2 virus is the culprit behind ***-CoV-2 is an enveloped single-stranded RNA virus,the genome encodes four types of the structural proteins:S protein,E protein(envelope protein),M protein(matrix protein)and N protein(nucleocapsid protein).In COVID-19,monoclonal antibodies have played a significant role in diagnosis and *** article briefly introduced the development of monoclonal antibodies targeting on S protein and N protein,which represents the main direction of monoclonal antibody drugs used in the diagnosis and treatment of ***,the traditional Chinese medicine also plays important role in the fight against COVID-19 by regulating human *** article introduced the use of traditional Chinese medicine in fighting against COVID-19.

关键词： Monoclonal antibody(mAbs) Corona virus disease 2019(COVID-19) S protein N protein Traditional Chinese medicine

Pore Characteristics and Factors Controlling Lacustrine Shales from the Upper Cretaceous Qingshankou Formation of the Songliao Basin,Northeast China:A Study Combining SEM,Low-temperature Gas Adsorption and MICP Experiments

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 585-601页

作者： HAN Hui DAI Jie GUO Chen ZHONG Ningning PANG Peng DING Zhengang CHEN Jianping HUANG Zhenkai GAO Yuan LUO Jinyu li qirui ZHANG Zhaokun School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Chengdu Center China Geological SurveyChengdu 610081China Key Laboratory of Sedimentary Basin and Oil and Gas Resources Ministry of Natural ResourcesChengdu 610081China State Key Laboratory of Petroleum Resource&Prospecting China University of PetroleumBeijing 102249China Cooperative Innovation Center of Shale Gas Resources and Environments Southwest Petroleum UniversityChengdu 610500China Research Institute of Petroleum Exploration and Development PetroChinaBeijing 1000S 3China Beijing Center for Physical and Chemical Analysis Beijing 100089China

To investigate pore characteristics and the factors controlling lacustrine shales,geochemical,mineralogical and petrophysical experiments were performed on 23 shale samples from the Qingshankou Formation of the Songliao Basin,China.A comparison of mercury injection capillary pressure(MICP)and low-temperature N2 adsorption pore-size distribution showed that MICP has a higher pore-size distribution(PSD)line in its overlapping pore diameter range,which may be elevated by the higher pressure of ***,in the overlapping range,low-temperature N2 adsorption data were preferred in pore *** correlations were observed between pore volumes and TOC content,indicating organic matter pores are not well-developed in the studied *** may be related to their low grade of maturity and type I *** existed negative relationships between pore volumes and S1,which illustrated that liquid hydrocarbons occupied some pore *** volume had a better correlation with S1 than mesopore and macropore volumes,which suggests that liquid hydrocarbons preferentially occur in *** obvious relationships between pore volumes and quartz or feldspar were observed,while pore volumes increased with the increasing clay mineral *** relationships indicate that intraparticle pores in clay minerals represent the principal pore type.

关键词： lacustrine shales pore characteristics clay mineral shale oil Upper Cretaceous Songliao Basin

退耕背景下安塞县商品型生态农业系统耦合关系

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农业工程学报 2011年第9期27卷 293-298页

作者：李奇睿王继军西北农林科技大学林学院杨凌712100 中国科学院水利部水土保持研究所杨凌712100

针对退耕还林还草工程实施后商品型生态农业系统耦合关系的变化情况,运用农业生态经济系统耦合度模型,对安塞县商品型生态农业系统耦合演变过程进行了分析。结果表明:商品型生态农业系统耦合演变过程可以划分为4个阶段:协调发展阶段、... 详细信息

针对退耕还林还草工程实施后商品型生态农业系统耦合关系的变化情况,运用农业生态经济系统耦合度模型,对安塞县商品型生态农业系统耦合演变过程进行了分析。结果表明:商品型生态农业系统耦合演变过程可以划分为4个阶段:协调发展阶段、耗损发展阶段、胁迫发展阶段、恢复重建阶段。1998-2008年,安塞县商品型生态农业系统生态、经济综合指数明显增高,系统耦合演变过程经历了"胁迫衰退、恢复重建和协调发展"阶段。依据耦合度拟合曲线及所划分的耦合态势类型,目前安塞县商品型生态农业系统耦合关系处于不断协调过程中,通过优化农业资源结构,提高产业与资源一致性,有望形成良性耦合态势。

关键词：耦合生态经济耦合度耦合态势安塞县

Xylaria spinulosa and X. atrosphaerica from southern China

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Xylaria spinulosa and X. atrosphaerica from southern China

中国菌物学会第七届全国会员代表大会暨2017年学术年会

作者： qirui li lili liu Xu Zhang Xiangchun Shen Jichuan Kang The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China Guizhou University The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability Guizhou Medical University

Although there has been a high interest in Xylaria over the last 30 years, there have been very few reports on the genus from the Chinese mainland. Two species of Xylaria collected from southern China are reported. Xylaria spinulosa is introduced as a new species based on morphology and sequence data analysis. Xylaria spinulosa differs from other species in the genus mainly by its long thorns covering the surface of the stroma. The morphological description is as follows. Saprobic on dead tree trunk, forming on the host surface. Sexual morph: Stromata upright, usually solitary,unbranched, cylindrical or clavate, fertile at apex, texture soft, internally white, whole stromata up to1.8–2.5 cm long × 0.3–0.5 cm broad, 0.5–1 cm long at stipes. Surface of stromata black, covered with long soft thorn. Stalk well defined and easy to distinguish. Perithecia 0.3–0.5 mm diam., spherical,embedded, closely arranged. Ostioles inconspicuous, not clear. Asci 80–214 × 8–12 μm（157 × 10.2μm, n=20）, unitunicate, 8-spored, cylindrical, long-stipitate, the spore-bearing part 60–170 μm *** apparatus 8.5–11.5 μm high × 5–6 μm broad, blue in Melzer’s reagent, ***19–23 × 6.5–8.5 μm（21.3 × 7.6 μm, n=30）, dark brown to black, unicellular, ellipsoid to inequilateral, with broadly rounded ends, smooth-walled. Germ slit half spore-length, oblique to sigmoid, lacking sheath and appendage. Xylaria atrosphaerica is a new record for China.

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法律与文化:法学研究的双向视角

法律科学（西北政法大学学报） 2005年第3期23卷 3-7页

作者：李其瑞西北政法学院陕西西安710063

　把法律认识置于法律与文化之间,不仅为法学研究开辟了一片新天地,还使法学研究增添了一种新方法。对法律的文化解释有一个从单一迈向双向的视角转变,这种让法律与文化在对话中相互提升自己的转变呈现出一种包容和多元的方法态势。同时... 详细信息

　把法律认识置于法律与文化之间,不仅为法学研究开辟了一片新天地,还使法学研究增添了一种新方法。对法律的文化解释有一个从单一迈向双向的视角转变,这种让法律与文化在对话中相互提升自己的转变呈现出一种包容和多元的方法态势。同时,文化方法的法学运用还表现出它在沟通异质法文化与变革传统法文化方面的方法论意义。

关键词：法学研究视角双向方法论意义传统法文化法律认识文化解释新天地