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Mechanical Behavior of a Glass-fiber Reinforced Composite to Steel Joint for Ships

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Journal of Marine Science and Application 2015年第1期14卷 39-45页

作者： Xiaowen li ping li Zhuang lin Dongmei Yang College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China

The use of a glass-fiber reinforced composite in marine structures is becoming more common, particularly due to the potential weight savings. The mechanical response of the joint between a glass-fiber reinforced polymer （GRP） superstructure and a steel hull formed is examined and subsequently modified to improve performance through a combined program of modeling and testing. A finite-element model is developed to predict the response of the joint. The model takes into account the contact at the interface between different materials, progressive damage, large deformation theory, and a non-linear stress-strain relationship. To predict the progressive failure, the analysis combines Hashin failure criteria and maximum stress failure criteria. The results show stress response has a great influence on the strength and bearing of the joint. The Balsawood-steel interface is proved to be critical to the mechanical behavior of the joint. Good agreement between experimental results and numerical predictions is observed.

关键词： glass-fiber reinforced composite marine structure mechanical behavior steel joint finite-element model progressivefailure Hashin failure criteria

Connexin 43 remodeling induced by LMNA gene mutation Glu82Lys in familial dilated cardiomyopathy with atrial ventricular block

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Chinese Medical Journal 2010年第8期123卷 1058-1062页

作者： SUN li-ping WANG lin WANG Hui ZHANG Yin-hui PU Jie-lin Cardiovascular Institute and Fu Wai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background Mutations in the lamin A/C gene （LMNA） may cause familial dilated cardiomyopathy （dilated cardiomyopathy） characterized by early onset atrio-ventricular block （A-V block） before the manifestation of dilated cardiomyopathy and high risk of sudden death due to ventricular arrhythmia, which is very similar to the phenotype of gap junction related heart disease. This study aimed to determine the expression and localization of connexins in neonatal myocytes transfected with wild-type （WT） or mutant LMNA to elucidate how these mutations cause heart diseases. Methods We studied the connexin 43 （Cx43） and connexin 40 （Cx40） expression in cultured neonatal myocytes transfected with wild-type （WT） or mutant LMNA （Glu82Lys （E82K） and Arg644Cys （R644C）） using confocal imaging and Western blotting analysis. Results Cx43 protein expression was reduced by 40% in cells transfected with LMNA E82K than that in cells transfected with WT LMNA cDNA. Confocal imaging showed that the Cx43 located inside the cells by LMNA E82K. By contrast, LMNA E82K mutation had no effect on expression and localization of Cx40. LMNA R644C transfection did not show any significant effects on gap junctions at all. Conclusions Our findings suggest that LMNA E82K significantly reduced the Cx43 expression and altered its localization which may be one of the pathological mechanisms underlying LMNA-related heart disease.

关键词： lamin A/C LMNA mutations connexin 43 atrio-ventricular block

Mass Transfer and Reaction Kinetics of PH3 Absorption with Pd（Ⅱ ）-Cu（ Ⅱ ） in Double-Stirred Cell

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化学发展前沿（中英文版） 2013年第2期3卷 30-35页

作者： Guangfei Qu Yixing Ma Junyan li Yilu lin ping Ning Faculty of Environmental Science and Engineering Kunming University of Science and Technology Kunming 650500 China

晶粒细化对MgB_2超导临界电流密度的作用

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物理学报 2014年第6期63卷 249-254页

作者：郭志超李平林郑州大学物理工程学院河南省量子功能材料国际联合实验室郑州450001

在多晶系统的MgB2超导体中存在晶粒间较小的整体电流和晶粒内大的局域电流.用改变升温速率的方法制备了不同晶粒大小和晶粒连接性的MgB2样品,并对它们的晶粒大小进行了统计.采用一种测量超导临界电流密度的Campbell法,分别测量和计算得... 详细信息

在多晶系统的MgB2超导体中存在晶粒间较小的整体电流和晶粒内大的局域电流.用改变升温速率的方法制备了不同晶粒大小和晶粒连接性的MgB2样品,并对它们的晶粒大小进行了统计.采用一种测量超导临界电流密度的Campbell法,分别测量和计算得到了它们的整体电流和局域电流密度.研究表明:长时间的烧结造成晶粒变大,材料有较大的整体临界电流密度,而短时间烧结的样品则相反;同时发现晶粒细化只提高了样品的局域临界电流密度,而且样品内部缺陷、杂质及晶界等因素是影响MgB2超导体整体电流传输的主要因素.

关键词：晶粒细化 Campbell法 MgB2超导体整体电流和局域电流

Isolation and Characterization of Pepsin-Solubilized Collagen from the Skin of Black Carp (<i>Mylopharyngdon piceus</i>)

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Advances in Bioscience and Biotechnology 2014年第7期5卷 642-650页

作者： Guo ping Wu Xiao Ming Wang li ping lin Su Hua Chen Qing Qing Wu College of Food Science and Engineering Jiangxi Agricultural University Nanchang China Key Laboratory of Jiangxi Province for Persistant Pollutants Control and Resources Recycle Nanchang Hangkong University Nanchang China

To make more effective use of underutilized resources, pepsin-solubilized collagen (PSC) was successfully extracted from the skin of black carp (Mylopharyngdon piceus) with a yield of 45.7% based on dry weight. The PSC comprising two identical α1-chains and one α2-chain with no disulfide bond was characterized as type I, and it contained 195 imino acid residues vs. 1000 amino acid residues. The collagen showed an absorption edge around 218 nm, which was lower than the maximum absorption wavelength of other PSC. The denaturation temperature of PSC was 25.6°C, which was lower than that of porcine collagen by approximately 11°C. The isoelectric point (pI) was estimated to be 8.23, and the collagen was soluble at an acidic pH as well as below 40 g/L NaCl. It is thought that the high yield and stability of PSC from the skin of black carp warrant its application as a new source of collagen for industrial purposes.

关键词： Pepsin-Solubilized Collagen (PSC) Characterization Black Carp Fish Skin

Management of life-threatening celiac-hepatic arterial hemorrhage after pancreaticoduodenectomy： usefulness of temporary balloon occlusion

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Chinese Medical Journal 2011年第23期124卷 4115-4118页

作者： WANG Mao-qiang GUO li-ping lin Han-ying DUAN Feng liU Feng-yong WANG Zhi-jun Department of Interventional Radiology Chinese People＇s Liberation Army General Hospital Beijing 100853 China

When a large visceral artery is ruptured, uncontrolled bleeding may lead to hemodynamic collapse. Use of endovascular occlusion balloon catheter may provide rapid control of hemorrhage and facilitate definitive therapy. We reported two patients with massive hemorrhage from ruptured celiac-hepatic artery after pancreaticoduodenectomy, who were initially treated percutaneously by temporary selective balloon occlusion. They became critically hemodynamic unstable during the angiographic procedure. Through an 8Fr sheath, a 6Fr compliant latex occlusion balloon was placed proximal to the celiac trunk and inflated, and upon patient stabilization surgical revision and stent-graft placement were successfully performed in the two patients, respectively. Temporary selective balloon occlusion provides fast and effective bleeding control for patient with critically uncontrollable visceral arterial hemorrhage, permitting subsequent use of conventional techniques for management of the arterial bleeding source.

关键词： postoperative bleeding shock, hemorrhagic balloon occlusion pancreaticoduodenectomy radiology, interventional

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我国绿色投资现状与对策分析

生态经济 2006年第7期22卷 75-77页

作者：李林平西安财经学院学报编辑部西安710061

“绿色投资”是最能体现以人为本和经济社会可持续发展的投资,是最能体现科学发展观的投资。我国要实现绿色经济的战略,就要引导绿色投资。先进的科学技术是绿色投资核心竞争力,完善与绿色投资相关的政策法规,是使绿色投资健康发展的制... 详细信息

“绿色投资”是最能体现以人为本和经济社会可持续发展的投资,是最能体现科学发展观的投资。我国要实现绿色经济的战略,就要引导绿色投资。先进的科学技术是绿色投资核心竞争力,完善与绿色投资相关的政策法规,是使绿色投资健康发展的制度保证。

关键词：投资环保财税政策

Allele-specific real-time PCR testing for minor HIV-1 drug resistance mutations： assay preparation and application to reveal dynamic of mutations in vivo

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Chinese Medical Journal 2010年第23期123卷 3389-3395页

作者： GUO Dong-xing li Han-ping li lin ZHUANG Dao-min JIAO li-yan WANG Zheng BAO Zuo-yi liU Si-yang liU Yong-jian li Jing-yun State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071China

Background It is very important for the clinical management to test for minor HIV-1 resistance mutations accurately and sensitively. The conventional genotypic assays of HIV drug resistance detection based on sequencing can only discriminate the mutations which present in more than 20%-30%. The aim of this study was to evaluate allele-specific real-time PCR （ASPCR） to detect the resistance-related mutations located at positions 103, 184 and *** We developed the allele-specific PCR assay, using the most common drug resistance mutations in Chinese AIDS patients, K103N, M184V/I, T215F/Y as a model system. The standards were constructed by cloning the wild-type and mutant DNA fragments into the T-vector. We designed specific primers to discriminate mutant templates in the real-time PCR using SYBR green as a fluorescence reporter. And then we evaluated the ASPCR assay and tested 140clinical samples using this *** The sensitivities of ASPCR assay were 0.04% for K103N, 0.30% for M1841, 0.40% for M184V, 0.03% for T215F and 0.02% for T215Y. The intra-assay and inter-assay coefficients of variation were less than 0.42. One hundred and forty plasma samples were tested by ASPCR and dynamic resistance curves of ten patients were *** Drug resistance emerged half a year after the start of antiretroviral therapy. The mutation of T215Yemerged 1 to 1.5 years after starting treatment and then increased rapidly. The ASPCR assay we developed was a sensitive, accurate and rapid method to detect the minor HIV-1 variants and it can provide earlier and more drug-resistance information for HIV research and AIDS antiretroviral therapy.

关键词： allele-specific real-time PCR minor populations drug resistance human immunodeficiency virus

《中华儿科杂志》1950至2009年发文及引文计量学分析

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中华儿科杂志 2011年第1期49卷 41-48页

作者：冷婧胡燕平李林平重庆医科大学附属儿童医院图书馆 400014

目的统计分析〈中华儿科杂志〉的载文情况、作者情况和引文情况,揭示创刊60年来各阶段发展特点.方法采用文献计量学方法,对该刊1950至2009年刊载论文的作者发文量、合作情况、地区分布、核心作者、通信作者、高产机构,引文数量、类型... 详细信息

目的统计分析〈中华儿科杂志〉的载文情况、作者情况和引文情况,揭示创刊60年来各阶段发展特点.方法采用文献计量学方法,对该刊1950至2009年刊载论文的作者发文量、合作情况、地区分布、核心作者、通信作者、高产机构,引文数量、类型、语种、普赖斯指数、自引率、引用的期刊分布等进行统计分析.结果 60年（48卷）共刊载论文5534篇,其中独著论文865篇（19.29%）,合著论文4669篇（80.71%）,合作度3.87,合作率84.37%.北京地区发文1495篇（27.01%）.15个发文50篇以上的高产机构,合计发文2254篇（40.73%）.有引文的论文4857篇（84.15%）,引文总数48 854条,篇均引文10.06条,普赖斯指数55.57%,自引率6.12%.引用外文文献35 781篇（69.1%）.引文类型以期刊为首,共计43 266条,占引文总数的84.5%.结论该刊作者分布广泛,合作率高,从创刊至今始终拥有一支高水平的核心作者队伍.该刊吸收利用科学情报能力强,载文能客观地反映我国儿科医学科研力量分布和学科发展状况.

关键词：文献计量学期刊儿科学引文分析