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EZH2-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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Performance measurement and evaluation of an ionic liquid electrospray thruster

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Chinese Journal of Aeronautics 2023年第3期36卷 1-15页

作者： Chengjin HUANG Jianling li mu li School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology Center for Advanced Material Diagnostic Technologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118China

As a novel micro-propulsion system for small satellites(from micro to nano),the ionic liquid electro spray propulsion system is a promising ***,performance measurement and evaluation of the Ionic liquid Electrospray Thruster(ILET)is one of the most challenging issues for practical application,due to the difficulties in the development of a prototype and direct measurements of micro-thrust and small flow *** address this issue,a Modular Ionic liquid Electrospray Thruster(MILET)prototype is constructed,and a diagnostic system for thrust and mass flow rate is specially developed based on an analytical balance *** the ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate as the propellant,a series of experiments is carried out on the MILET prototype under a wide operating condition through changing the applied voltage to control the *** different applied voltages,the thrust and the mass flow rate of the propellant are directly *** propulsive performance parameters of the thruster,such as thrust,specific impulse,thrust-to-power ratio,thruster efficiency,etc.,are comprehensively ***,a performance comparison is made between the MILET and other representative *** a relatively low applied voltage ranging from 1550 V to 2000 V,the MILET achieves a quasi-constant specific impulse of 1263 s with the averaged thrust-to-power ratio of 65.2μN/W and thruster efficiency of 40.7%.The performance of ILET is also compared with other typical electric *** results demonstrate that the ILET exhibits an excellent ability of minimalization with high specific impulse and thruster efficiency,which guarantees a great superiority in micro ***,the ways to further improve the performance of ILET are discussed,which further confirms the potential prospect of *** present result helps to advance the development and application of ILET.

关键词： Electrospray thruster Ionic liquids Performance measurement Performance estimation Micro-propulsion

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Secure outsourcing of large matrix determinant computation

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Frontiers of Computer Science 2020年第6期14卷 141-152页

作者： Jiayang liU Jingguo BI mu li Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Beijing Research Institute of Telemetry Beijing 100094China Institute for Advanced Study Tsinghua UniversityBeijing 100084China Space Star Technology Co. LtdBeijing 100086China

Cloud computing provides the capability to con-nect resource-constrained clients with a centralized and shared pool of resources,such as computational power and storage on *** matrix determinant computation is almost ubiquitous in computer science and requires large-scale data ***,techniques for securely outsourcing matrix determinant computations to untrusted servers are of utmost importance,and they have practical value as well as theoretical significance for the scientific *** this study,we propose a secure outsourcing method for large matrix determinant *** em-ploy some transformations for privacy protection based on the original matrix,including permutation and mix-row/mix-column operations,before sending the target matrix to the *** results returned from the cloud need to be de-clypled anul verified U ubtainl te cullett ***1 comparison with previously proposed algorithms,our new al-gorithm achieves a higher security level with greater cloud *** experimental results demonstrate the efficiency and effectiveness of our algorithm.

关键词： cloud computing large-scale data computation matrix determinant computation secure outsourcing

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Ectomycorrhizal communities associated with Tilia amurensis trees in natural versus urban forests of Heilongjiang in northeast China

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Journal of Forestry Research 2016年第2期27卷 401-406页

作者： Lei Cui li-qiang mu College of Forestry Northeast Forestry University

The deciduous linden tree （Tilia amurensis Rupr.） is protected at National Level II in China as a species of ecological and economic importance. The objective of this study was to assess and compare the ectomycorrhizal communities associated with T. amurensis in natural versus urban forests of central Heilongjiang Province. The percentage of T. amurensis colonisation by ectomycorrhiza was more than 60 % in urban forests, compared to 34-49 % in natural forests. Use of a combi- nation of morphological and molecular methods docu- mented 18 ECM （ectomycorrhizal） types among three sites; 12-13 ECM species were identified in the natural sites versus 9 species in the urban site. Four ECM species （Boletus sp., Tuber sp., Inocybe sp.2, Leccinum sp.1） were the dominant mycorrhizal symbionts, and Cenococcum geophilum and Russula sp. were found only in the natural forests.

关键词： Tilia amurensis Rupr Ectomycorrhizalfungi Natural forests Heilongjiang Province

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BSEC Method for Unveiling Open Clusters and its Application to Gaia DR3:83 New Clusters

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Research in Astronomy and Astrophysics 2024年第5期24卷 169-184页

作者： Zhong-mu li Cai-Yan Mao Institute of Astronomy and Information Dali UniversityDali 671003China

Open clusters(OCs) are common in the Milky Way, but most of them remain undiscovered. There are numerous techniques, including some machine-learning algorithms, available for the exploration of OCs. However, each method has its limitations and therefore, different approaches to discovering OCs hold significant values. We develop a comprehensive approach method to automatically explore the data space and identify potential OC candidates with relatively reliable membership determination. This approach combines the techniques of Hierarchical Density-Based Spatial Clustering of Applications with Noise, Gaussian mixture model, and a novel cluster member identification technique, color excess constraint. The new method exhibits efficiency in detecting OCs while ensuring precise determination of cluster memberships. Because the main feature of this technique is to add an extra constraint(EC) for the members of cluster candidates using the homogeneity of color excess,compared to typical blind search codes, it is called Blind Search-Extra Constraint(BSEC) method. It is successfully applied to the Gaia Data Release 3, and 83 new OCs are found, whose color–magnitude diagrams(CMDs) are fitted well to the isochrones. In addition, this study reports 621 new OC candidates with discernible main sequence or red giant branch. It is shown that BSEC technique can discard some false negatives of previous works, which takes about three percentage of known clusters. It shows that as an EC, the color excess(or twocolor) constraint is useful for removing fake cluster member stars from the clusters that are identified from the positions and proper motions of stars, and getting more precise CMDs, when differential reddening of member stars of a cluster is not large(e.g., ΔE(G_(BP)-G_(RP)) < 0.5 mag). It makes the CMDs of 15% clusters clearer(in particular for the region near turnoff) and therefore is helpful for CMD and stellar population studies. Our result suggests that the color excess con

关键词： Galaxy stellar content-(Galaxy:)open clusters and associations general-stars fundamental parameters

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Study of 26 Galactic Open Clusters with Extended Main-sequence Turnoffs

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Research in Astronomy and Astrophysics 2024年第6期24卷 28-37页

作者： Yang-Yang Deng Zhong-mu li Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Institute of Astronomy and Information Dali UniversityDali 671003China

Recent studies indicate that some Galactic open clusters(OCs)exhibit extended main-sequence turnoff(eMSTO)in their color–magnitude diagrams(CMDs).However,the number of Galactic OCs with eMSTO structures detected so far is limited,and the reasons for their formation are still *** work identifies 26 Galactic OCs with undiscovered eMSTOs and investigates the causes of these *** population types and fundamental parameters of cluster samples are acquired using CMD fitting *** them,the results of 11 OCs are reliable as the observed CMDs are *** propose the crucial role of stellar binarity and confirm the importance of stellar rotation in reproducing eMSTO *** results also show that the impact of age spread is important,as it can adequately explain the structure of young OCs and fit the observed CMDs of intermediate-age OCs better.

关键词： (stars:)binaries:general Galaxy:fundamental parameters (Galaxy:)open clusters and associations:general (stars:)Hertzsprung Russell and C-M-diagrams

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A database of spectral energy distributions of progenitors of core-collapse supernovae

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Research in Astronomy and Astrophysics 2021年第9期21卷 1-10页

作者： Zhong-mu li Cai-Yan Mao Institute for Astronomy and History of Science and Technology Dali UniversityDali 671003China

This paper presents a database of the spectroscopic-and photometric-spectral energy distributions(spec-SEDs and phot-SEDs respectively)of the progenitors of core-collapse supernovae(CCSNe).Both binary-and single-star progenitors are included in the *** database covers the initial metallicity(Z)range of 0.0001-0.03,mass range of 8-25 M⊙,binary mass ratio range of 0-1,and orbital period range of 0.1-10000 *** low-resolution spec-SEDs and phot-SEDs of single-and binary-star CCSN progenitors are included in the *** data can be used for studying the basic parameters,e.g.,metallicity,age,and initial and final masses of CCSN *** can also be used for studying the effects of different factors on the determination of parameters of CCSN *** the database is utilized for fitting the SEDs of binary-star CCSN progenitors,it is strongly suggested to determine the metallicity and orbital period in advance,but this is not necessary for single-star progenitors.

关键词： (stars:)supernovae:general astronomical databases (stars:)binaries:general

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Feature of Motion Around D-stars

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Chinese Physics Letters 1998年第1期15卷 3-4页

作者： li Jia-mu li Xin-zhou Department of Physics East China University of Science and TechnologyShanghai 200237 East China Institute for Theoretical Physics Shanghai 200237

The motion of test particles around D-stars is investigated by Hamilton-Jacobi method. There may exist bound orbits under certain conditions. The trajector with periastrons at large r are Keplerian in form, except for the periastron shift. The trajectory with periastrons at small r, differ markedly from Keplerian orbits. The radius of the most tightly bound is found.

关键词： conditions stars method

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Fitting formulae for the effects of binary interactions on lick indices and colors of stellar populations

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Chinese Journal of Astronomy and Astrophysics 2009年第2期9卷 191-204页

作者： Zhong-mu li Zhan-Wen Han Dali Uinversity Dali 671003 China National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China

More than about 50% of stars are in binaries, but most stellar population studies take single star stellar population （ssSSP） models, which do not take binary interactions into account. In fact, the integrated peculiarities of ssSSPs are different from those of stellar populations with binary interactions （bsSSPs）. Therefore, it is necessary to investigate the effects of binary interactions on the lick indices and colors of populations in detail. We show some formulae for calculating the difference between the lick indices and colors of bsSSPs, and those of ssSSPs. Twenty-five lick indices and 12 colors are studied in this work. The results can be conveniently used for calculating the effects of binary interactions on stellar population studies and for adding the effects of binary interactions into present ssSSP models. The electronic data and fortran procedures in the paper can be obtained on request from the authors.

关键词： galaxies stellar content -- galaxies elliptical and lenticular, cD

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Monkeypox:epidemiology,pathogenesis,treatment and prevention

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4261-4282页

作者： Yong Huang li mu Wei Wang Department of Biotherapy State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduChina

Monkeypox is a zoonotic disease that was once endemic in west and central Africa caused by monkeypox ***,cases recently have been confirmed in many nonendemic countries outside of *** declared the ongoing monkeypox outbreak to be a public health emergency of international concern on July 23,2022,in the context of the COVID-19 *** rapidly increasing number of confirmed cases could pose a threat to the international ***,we review the epidemiology of monkeypox,monkeypox virus reservoirs,novel transmission patterns,mutations and mechanisms of viral infection,clinical characteristics,laboratory diagnosis and treatment *** addition,strategies for the prevention,such as vaccination of smallpox vaccine,is also *** epidemiological data indicate that high frequency of human-to-human transmission could lead to further outbreaks,especially among men who have sex with *** development of antiviral drugs and vaccines against monkeypox virus is urgently needed,despite some therapeutic effects of currently used drugs in the *** provide useful information to improve the understanding of monkeypox virus and give guidance for the government and relative agency to prevent and control the further spread of monkeypox virus.

关键词： epidemiology prevention drugs treatment

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