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Efficacy and safety of galantamine treatment for patients with Alzheimer's disease:a meta-analysis of randomized controlled trials

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Efficacy and safety of galantamine treatment for patients wi...

Functional Transcriptomic Analysis of Female Rat Hippocampus via RNA Seq in Response to Estrogen

2016年广东省药师周大会

作者： Deqi Jiang Xiujuan Yang mingxing li Yan Wang Yong Wang Department of Pharmacy Zhu Jiang HospitalSouthern Medical University Department of Biopharmaceutical Yulin Normal University

Cholinesterase inhibitors treatment is considered as a common therapeutic approach for Alzheimer’s disease(AD) by numerous reported studies,but the role of currently available drugs for AD is still *** study aimed to evaluate the efficacy and safety of galantamine for the treatment of AD,and provide the basis and reference for clinical rational drug *** controlled trials(RCTs) of galantamine for AD published up to April 30,2014 were searched.A random or fixed effect model was used to analyse outcomes which were expressed as risk ratios(RRs) or mean difference(MD) with a 95% confidence interval(CI).Heterogeneity was assessed by Q test and I2 *** outcomes measurements were as follows:the changes of Alzheimer’s Disease Assessment Scale-cognitive subscale(ADAS-cog),Mini-Mental State Examination(MMSE),Activities of Daily living(ADL),Neuropsychiatric Inventory(NPI),Clinicians’ Interview-Based Impression of Change with Caregiver’s Input(CIBIC+),adverse effects and *** articles with 4,074 participants were *** of galantamine for 8-28 weeks(16-40 mg daily) led to significant improvements in ADAS-cog score [Plinical treatment.

关键词： Alzheimer’s disease galantamine efficacy safety meta-analysis

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Functional Transcriptomic Analysis of Female Rat Hippocampus...

中国神经科学学会第十二届全国学术会议

作者： Javed Iqbal Zhi-nei Tan mingxing li Xin-Ming Ma School of life Science Shaanxi Normal University

In the hippocampus, estradiol modulates a wide range of neural functions related to neurotransmission, synaptic plasticity, and neurogenesis. Previous studies showed that synaptic plasticity of female hippocampus cyclically fluctuates across the estrus cycle, but the key genes responsible for mediating these changes are still unknown. Here, we explored the hippocampal transcriptome via RNA-seq using proestrus（PE） and Estrus（ES） stage female rats. At standard fold change selection criteria, 253 genes were differentially expressed in PE vs ES group, and 15 transcripts were identified as the most significant genes during the estrus cycle. The gene ontology（GO） analysis revealed the distinct features of biological adhesion, immune system process, developmental process, biological regulation, response to stimulus, signaling, cellular component organization or biogenesis, metabolic process, and cellular process including neurological system process were enriched and down regulated during PE vs ES stage. Next, we treated ovariectomized（OVX） rats with E2 and analyzed the transcriptome. Total 1903 transcripts were identified as DEGs in OVX and OVX plus E2 treated groups. The significantly upregulated genes were successfully expressed and identified in OVX+E2 group as the plasma E2 level restored to PE stage. This further confirmed the validity of our RNA-seq result in PE vs ES group. All alterations identified were confirmed by realtime PCR. Altogether, the results suggest that E2 upregulates the expression of genes involved in regulating neurite outgrowth, nerve regeneration process, promote synaptic plasticity, neuroprotection;maintaining normal cognitive process, enhancing spatial and reference memory, neural resilience against aging, oligodendrocyte maturation and myelination of the CNS;mediating retinoid signaling, involved in AKT/ERK signaling pathways and neurological disorders.

关键词： Estrogen Estrus Cycle Synaptic plasticity Neuroprotection Myelination Aging

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地孔瞬变电磁超前探测异常体定位技术

煤炭科学技术 2021年第7期49卷 154-161页

作者：苏超姚伟华李明星中煤科工集团西安研究院有限公司陕西西安710077

地孔瞬变电磁法,是一种在地面布设发射回线,在钻孔中接收磁感应强度或者衰减电压三分量信号的探测技术,其观测系统置于钻孔中,可有效降低导电覆盖层的信号屏蔽及地面电磁干扰,接收更靠近异常体,可以获得比地面瞬变电磁法更强的异常响应... 详细信息

地孔瞬变电磁法,是一种在地面布设发射回线,在钻孔中接收磁感应强度或者衰减电压三分量信号的探测技术,其观测系统置于钻孔中,可有效降低导电覆盖层的信号屏蔽及地面电磁干扰,接收更靠近异常体,可以获得比地面瞬变电磁法更强的异常响应,是探测深部隐伏地质体最有效的方法之一,可以考虑用于煤矿孔旁异常体的探测。根据等效涡流理论,地孔瞬变电磁探测中,异常体所产生的二次场,可以用等效电流环来表示,其感应磁场强度三分量Bx、By、Bz具有一定的指向性,通过交会Bx、By的合成矢量Bxy及Bx、Bz的合成矢量Bxz,可以大致获得电流环中心位置坐标,从而实现对异常体的定位,但合成Bxz在XZ平面交会结果存在误差。为此,提出了一种浮动系数矢量交会算法,通过计算水平圆形载流回线(电流环)的磁感应强度三分量Bx、By、Bz,分析其合成矢量Bxy及Bxz在XY、XZ平面的矢量分布特征,计算特征点处的Abs(By)/Bz作为参考值并构建系数库,对Bz分量进行系数修正后再与Bx分量进行矢量交会,可以准确计算出电流环中心位置在XZ平面的坐标。理论模型计算和物理试验结果表明:浮动系数矢量交会算法无需先验信息,可以快速、准确定位异常体的中心位置,是一种超前探测的有效方法。

关键词：地孔瞬变电磁等效涡流矢量交会异常体定位

声触诊组织成像定量技术评价正常成人睾丸生精功能

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中国医学影像技术 2019年第1期35卷 117-120页

作者：邝斌李明星西南医科大学附属医院超声科四川泸州646000

目的采用声触诊组织成像定量(VTIQ)技术测量正常成人睾丸剪切波速度(SWV),分析影响睾丸弹性硬度的主要因素,探讨其评价男性睾丸生精功能的价值。方法招募200名正常成年男性志愿者行睾丸常规超声检查,测量双侧睾丸体积。以VTIQ技术测量... 详细信息

目的采用声触诊组织成像定量(VTIQ)技术测量正常成人睾丸剪切波速度(SWV),分析影响睾丸弹性硬度的主要因素,探讨其评价男性睾丸生精功能的价值。方法招募200名正常成年男性志愿者行睾丸常规超声检查,测量双侧睾丸体积。以VTIQ技术测量双侧睾丸上极、中份、下极的SWV,比较双侧睾丸、不同年龄组睾丸SWV差异,并与年龄、睾丸体积和精子活动率和精子密度进行相关性分析。结果200名正常成年男性左右侧睾丸SWV均为(1.23±0.18)m/s,左右侧差异无统计学意义(t=-0.376,P=0.710)。21～30岁组、31～40岁组、41～50岁与51～60岁组间双侧睾丸SWV值总体差异均有统计学意义(P均<0.001)。睾丸SWV与年龄呈正相关(r=0.454,P<0.001),与睾丸体积、精子活动率和精子密度分别呈负相关(r=-0.649、-0.668、-0.675,P均<0.001)。结论 VTIQ技术可定量测量睾丸组织硬度,有望用于初步评估睾丸生精功能。

关键词：睾丸精子发生超声检查声触诊组织成像定量技术

浅埋煤层采空积水区TEM与CSAMT探测优化反演

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煤炭科学技术 2020年第6期48卷 177-183页

作者：苏超李明星王鹏中煤科工集团西安研究院有限公司陕西西安710077

综合物探是圈定浅埋煤层采空积水区的有效方法,常规的中心回线瞬变电磁法(TEM)在反演非中心点数据时,存在计算误差。可控源音频大地电磁法(CSAMT)探测频率范围跨度大,对浅部地质体的分辨能力差。采用大定源TEM一维正演,计算了偏离发射... 详细信息

综合物探是圈定浅埋煤层采空积水区的有效方法,常规的中心回线瞬变电磁法(TEM)在反演非中心点数据时,存在计算误差。可控源音频大地电磁法(CSAMT)探测频率范围跨度大,对浅部地质体的分辨能力差。采用大定源TEM一维正演,计算了偏离发射回线中心不同位置测点的瞬变电磁响应,与中心点相比,偏离距越大,早期信号畸变越严重,以大定源TEM一维正演理论为基础,反演计算了非中心点数据,计算结果准确还原了模型的电性特征;对CSAMT频率进行优化,结合目标层埋深,加密对应埋深范围内的频点,提高CSAMT对浅埋地质体的分辨能力。通过正演模拟和实测数据处理,结果表明:大定源TEM一维反演可以消除偏离距带来的早期信号偏差,还原模型的真实电阻率响应;优化频率的CSAMT采集更丰富的浅部地层信息,实现对浅埋地质体的探测,2种方法综合探测,结果相互验证,消除了单一方法的多解性,探测结果更加可靠,是一种针对浅埋煤层采空积水区精确探查的有效方法,经钻探验证,结果准确。

关键词：综合探测浅埋煤层采空积水区优化频率大定源

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餐厨油脂与低热值污泥联合厌氧消化产气

环境工程学报 2017年第6期11卷 3899-3906页

作者：孙通李明星李莉李果何强古励重庆大学三峡库区生态环境教育部重点实验室重庆400045

低热值污泥单独厌氧消化产气率低,通过投加高有机质含量的餐厨油脂,与污泥形成联合厌氧消化体系,进行了低热值污泥与餐厨油脂联合中温厌氧消化实验,结果发现:1)当油脂的投配量为50%(G/S(Greases/Sludge)=1,以VS计)和66.7%(G/S=2)时,相... 详细信息

低热值污泥单独厌氧消化产气率低,通过投加高有机质含量的餐厨油脂,与污泥形成联合厌氧消化体系,进行了低热值污泥与餐厨油脂联合中温厌氧消化实验,结果发现:1)当油脂的投配量为50%(G/S(Greases/Sludge)=1,以VS计)和66.7%(G/S=2)时,相较于污泥单独厌氧消化(160.29 m L CH_4·(g^(-1)VS))),产甲烷能力分别提升至724.52 m L CH_4·(g^(-1)VS))和809.33 m L CH_4·(g^(-1)VS);2)调节初始pH,使(G/S=1和G/S=2)2个工况的初始产甲烷能力得到一定程度的恢复,但对于工况G/S=4,油脂的负荷已经远远超过了共消化系统的承受能力,初始产甲烷能力难以得到恢复;3)污泥与餐厨油脂之间相互促进、协同作用,两者联合厌氧消化可有效提高系统甲烷产率。

关键词：餐厨油脂联合厌氧消化协同作用

Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons

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中国药理通讯 2013年第2期30卷 37-38页

作者： Xiaoyun Wang SusuTang Yanlong Yongqi li mingxing liao Mei Hu Hui Ji Hao Hong Department of Pharmacology Laboratory for Diabetes & Brain Diseases China Pharmaceutical University

Although the pathogenesis of sporadic Alzheimer's disease (AD) is not clearly understood, neuroinflammation has been known to play a role in the pathogenesis of AD. To investigate a functional link between the neuroin... 详细信息

关键词： CADASIL 微血管病理认知障碍

Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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Chinese Chemical Letters 2024年第2期35卷 305-310页

作者： Hongda Zhu Kai Ma Rui Ruan Chaobo Yang Aqin Yan Jing li Qi Yu Hongmei Sun mingxing liu Hongmei Zheng Jing Gao Xiaofang Guan Zhu Dai Yao Sun Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province) Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of TechnologyWuhan 430068China Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China National Key Laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for life Science Ministry of EducationQingdao University of Science and TechnologyQingdao 266000China

Immune checkpoint inhibitors(ICIs)therapy targeting programmed cell death ligand 1(PD-L1)and programmed death protein 1(PD-1)had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer(TNBC).However,the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of ***,the immunomodulator epigallocatechin gallate palmitate(PEGCG)and the immunoadjuvant metformin(MET)self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction,which encapsulated the therapeutic agents doxorubicin(DOX)-loaded PEGCG-MET micelles(PMD)and combined with ICIs(anti-PD-1 antibody)as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive *** results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo,compared with DOX or anti-PD-1 antibody for the therapy of *** micelles might be a potential candidate,which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.

关键词： Immunotherapy Tumor-targeted Self-assembled micelles Metformin Reducing PD-L1 expression TNBC

肾血流参数结合KIM-1评价子痫前期患者肾损伤的临床意义

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中国超声医学杂志 2020年第4期36卷 347-349页

作者：侯超李明星西南医科大学附属医院超声诊断科

目的探讨肾动脉血流参数结合KIM-1评估子痫前期患者肾功能损伤的临床意义。方法选取在我院产科住院并分娩的轻度子痫前期患者30例(A组),慢性高血压合并子痫前期患者30例(B组),重度子痫前期患者30例(C组),健康妊娠妇女30例为对照组(N组)... 详细信息

目的探讨肾动脉血流参数结合KIM-1评估子痫前期患者肾功能损伤的临床意义。方法选取在我院产科住院并分娩的轻度子痫前期患者30例(A组),慢性高血压合并子痫前期患者30例(B组),重度子痫前期患者30例(C组),健康妊娠妇女30例为对照组(N组)。所有受试者测量肾叶间动脉收缩期峰值流速(PSV)、舒张末期流速(EDV)、加速时间(AT)、加速度(SA)等血流参数,同时进行UA、KIM-1等生化指标检测,分析肾血流参数与生化指标的相关性。结果 A、B、C组PSV、EDV、SA均低于N组,AT高于N组(P<0.01);B、C组PSV、EDV、SA低于A组,AT高于A组(P<0.01)。B、C组UA、KIM-1高于N、A组(均P<0.01),A组KIM-1较N组高(P<0.01)。UA、KIM-1分别与PSV、EDV、SA呈负相关,与AT呈正相关(均P<0.01),KIM-1与肾血流参数的相关性高于UA。结论肾动脉血流参数结合KIM-1对评估子痫前期患者的肾功能损伤具有一定临床价值。

关键词：肾血流参数 KIM-1 子痫前期