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Surface Acoustic Wave Propagation in Relaxor-Based Ferroelectric Single Crystals 0.93Pb(Zn_(1.3)Nb_(2/3))O_(3)-0.07PbTiO3 Poled along [01.]c

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Chinese Physics Letters 2012年第2期29卷 119-121页

作者： li Xiu-{1. ZHANG Rui HUANG Nai-Xing LU tian-Quan CAO Wen-Wu Condensed Matter Science and Technology Institute Department of PhysicsHarbin Institute of TechnologyHarbin 150080 Physical and Electrical Information Engineering Institute Daqing Normal UniversityDaqing 163712 Materials Research Institute The Pennsylvania State UniversityUniversity ParkPennsylvania16802USA

Surface acoustic wave (SAW) propagation in relaxor-based ferroelectric single crystals 0.93Pb(Zn_(1.3)Nb_(2/3))O_(3)- 0.07Pb TiO_(3) (PZN- 7%PT ) poled along [01.]c has been analyzed *** results show that PZN- 7% PT single crystals have excellent SAW properties,such as low phase velocities,very high electromechanical coupling coefficients and small power flow *** is also found that the SAW properties strongly depend on the propagation direction and the characteristic curves of SAW phase velocity,and the electromechanical coupling coefficients are symmetric with respect to θ =90°.Considering all related factors,the X-cut PZN-7%oPT single crystal has the best *** on our results,the X-cut PZN-7%PT single crystals poled along [01.]c are an excellent candidate for ultra-wide bandwidth low-frequency SAW devices.

关键词： Surface propagation Crystal

矩形壁面微结构对管道内湍流流动特性的影响研究

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化学研究与应用 2018年第6期30卷 1021-1025页

作者：李恩田郑一庞明军胡祥常州大学石油工程学院江苏常州213016 常州大学机械工程学院江苏常州213016

利用PIV测试系统对自行设计的管道流动实验装置进行实验研究,考察了矩形壁面微结构对管道流动阻力的影响及其内在的机理。测试实验了三种矩形壁面微结构,槽宽均为s=1.0mm,槽深分别为h=0.3mm、0.5mm、0.7mm。实验介质为蒸馏水,管内流体... 详细信息

利用PIV测试系统对自行设计的管道流动实验装置进行实验研究,考察了矩形壁面微结构对管道流动阻力的影响及其内在的机理。测试实验了三种矩形壁面微结构,槽宽均为s=1.0mm,槽深分别为h=0.3mm、0.5mm、0.7mm。实验介质为蒸馏水,管内流体流速范围在0.2m·s^(-1.到1.6m·s^(-1.之间,实验管段处于水平。实验结果表明:矩形沟槽的管道压降与槽深h有一定关系,与无量纲槽宽s+有更直接的关系;在一定范围的雷诺数下矩形沟槽管道压降比同工况下光滑平板管道压降要小,此时矩形沟槽具有减阻效果;矩形沟槽结构在无量纲化槽宽1.22情况下具有减阻效果,且槽深h越小,减阻范围越大,最大减阻率越小;比较光滑平板平均速度分布,矩形沟槽使边界层增厚,流向与法向速度均方根速度减小,流向与法向速度脉动减弱、雷诺应力减小,从而达到减小阻力的目的。

关键词：沟槽结构压降减阻雷诺应力

circDNMT1.调节 miR-377-3p/PUM1.轴对三阴性乳腺癌细胞增殖、凋亡和上皮-间质转化的影响

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局解手术学杂志 2024年第1期33卷 1-7页

作者：林明利郑美玲卢宏全林耀庭儋州市人民医院检验科海南儋州571700 海南西部中心医院肿瘤内科海南儋州571700 儋州市人民医院普外科海南儋州571700

目的探讨circDNMT1.节miR-377-3p/PUM1.对三阴性乳腺癌(TNBC)细胞增殖、凋亡和上皮-间质转化(EMT)的影响。方法收集儋州市人民医院201.年至2021.收治的24例TNBC患者的TNBC组织和其邻近正常组织,采用qRT-PCR、Western blot法分别检测... 详细信息

目的探讨circDNMT1.节miR-377-3p/PUM1.对三阴性乳腺癌(TNBC)细胞增殖、凋亡和上皮-间质转化(EMT)的影响。方法收集儋州市人民医院201.年至2021.收治的24例TNBC患者的TNBC组织和其邻近正常组织,采用qRT-PCR、Western blot法分别检测组织及小鼠正常乳腺上皮细胞系HC1.和TNBC细胞系4T1.Eph41.24、JC中circDNMT1.达、miR-377-3p表达、PUM1.白表达。将4T1.胞分为4T1.(未转染)、si-NC组(转染si-NC)、si-DNMT1.(转染si-DNMT1.、si-DNMT1.anti-NC组(同时转染si-DNMT1.anti-NC)、si-DNMT1.anti-miR-377-3p组(同时转染si-DNMT1.anti-miR-377-3p),qRT-PCR检测各组4T1.胞中circDNMT1.miR-377-3p表达;CCK-8检测各组4T1.胞增殖情况;流式细胞术检测各组4T1.胞凋亡情况;Western blot检测各组4T1.胞PUM1.EMT相关蛋白及凋亡相关蛋白表达;TargetScan网站预测miR-377-3p与circDNMT1.PUM1.结合位点,双荧光素酶报告验证miR-377-3p与circDNMT1.PUM1.靶向关系。BALB/c小鼠接种4T1.胞后随机分为空白对照组(注射等量生理盐水)、阴性对照组(尾静脉注射si-NC)、DNMT1.默组(尾静脉注射si-DNMT1.、联合对照组(尾静脉注射si-DNMT1.anti-NC)、联合沉默组(尾静脉注射si-DNMT1.anti-miR-377-3p),记录小鼠肿瘤质量,采用苏木精-伊红染色观察肿瘤形态变化。结果在TNBC组织和细胞中circDNMT1.PUM1.调,miR-377-3p下调,且在4T1.胞中表达差异最显著,因此本研究选择4T1.胞进行后续实验。与4T1.、si-NC组比较,si-DNMT1.4T1.胞中miR-377-3p表达、4T1.胞凋亡率及Bax、cleaved caspase-3、E-cadherin蛋白表达水平显著升高(P1.平、PUM1.白表达水平、24 h和48 h OD值、Bcl-2蛋白表达水平、N-cadherin蛋白表达水平、Vimentin蛋白表达水平均显著减少/降低(P1.、si-DNMT1.anti-NC组比较,si-DNMT1.anti-miR-377-3p组4T1.胞中miR-377-3p表达、4T1.胞凋亡率、Bax蛋白表达水平、cleaved caspase-3蛋白表达水平、E-cadherin蛋白表达水平显著降低(P1.白表达水平、24 h和48 h OD值、Bcl-2蛋白表达水平、N-cadherin蛋白表达水平、Vimentin蛋白表达水平均显著增加/升高(P1.比较,miR-377-3p mimic+WT-circDNMT1.细胞荧光素酶活性显著降低(P1.比较,miR-377-3p mimic+WT-PUM1.细胞荧光素酶活性显著降低(P1.默组、联合对照组肿瘤细胞排列疏松,胞核固缩,细胞碎片增多;联合沉默组小鼠肿瘤细胞排列比较密集,边界趋于清晰。与空白对照组、阴性对照组比较,DNMT1.默组小鼠肿瘤质量显著减少(P1.默组、联合对照组比较,联合沉默组小鼠肿瘤质量显著增加(P1.能通过上调miR-377-3p来抑制PUM1.达,进而抑制TNBC细胞增殖和EMT,促进细胞凋亡。

关键词： circDNMT1 miR-377-3p 三阴性乳腺癌细胞增殖细胞凋亡上皮-间质转化

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Gonadal dysgenesis in Turner syndrome with Y-chromosome mosaicism:Two case reports

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World Journal of Clinical Cases 2020年第22期8卷 5737-5743页

作者： Xue-Fei Leng Ke Lei Yi li Fei {1. Qin Yao Qing-Mei zheng Zhi-Hong Chen department of Pediatric Endocrinology Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina department of Laboratory Medicine Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina department of Gastrointestinal Surgery Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina department of Gynecology Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina

BACKGROUND Turner syndrome(TS)has a variety of different karyotypes,with a wide range of phenotypic features,but the specific karyotype may not always predict the *** with Y chromosome mosaicism may have mixed gonadal dysgenesis,and the mosaicism is related to the potential for *** SUMMARY In this case report,we report two cases of TS with different karyotypes and gonadal *** 1.had obvious virilization,and was positive for the SRY gene,but her karyotype in peripheral blood lymphocytes was *** 2 had a mosaic karyotype,45X/46X,dic(Y:Y)(p1..3:p1..2),and the proportion of Y-bearing cells was 50%in peripheral blood lymphocytes,but the patient had {1. female external genitalia and streaky gonads,with no genital *** tissues in the same TS individual may exhibit different ratios of *** gonadal determination and differentiation of mosaic TS are primarily dependent on the predominant cell line in the *** In TS patients with virilization,it is necessary to test at least two to three tissues to search for cryptic Y material.

关键词： Turner syndrome Gonadal dysgenesis Virilization Y chromosome mosaicism Gonadoblastoma Case report

Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation

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Chinese Medical Journal 2018年第22期131卷 2651-2657页

作者： Chen-Guang Ding Yang li Xiao-Hui {1. Xiao-Jun Hu Pu-Xun {1. Xiao-ming Ding He-li Xiang Jin zheng Wu-Jun Xue department of Kidney Transplantation Nephropathy HospitalThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Institute of Organ Transplantation Xi'an Jiaotong UniversityXi'anShaanxi 710061China

Background: Hypothermic machine perfusion(HMP) is being used more often in cardiac death kidney transplantation; however, the significance of assessing organ quality and predicting delayed graft function(DGF) by HMP parameters is still controversial. Therefore,we used a readily available HMP variable to design a scoring model that can identify the highest risk of DGF and provide the guidance and advice for organ allocation and DCD kidney ***: From September 1. 201. to August 31. 201., 366 qualified kidneys were randomly assigned to the development and validation cohorts in a 2:1.distribution. The HMP variables of the development cohort served as candidate univariate predictors for DGF. The independent predictors of DGF were identified by multivariate logistic regression analysis with a P lidation cohort was used to verify the accuracy and reliability of the scoring ***: HMP duration(OR = 1.1.5, 95% confidence interval [CI ]: 1.008–1.360, P = 0.043), resistance(OR = 2.1.0, 95%CI: 1.032–1..20, P 1., and flow rate(OR = 0.931. 95% CI: 0.894–0.967, P = 0.01.) were the independent predictors of identified DGF. The HMP predictive score ranged from 0 to 1., and there was a clear increase in the incidence of DGF, from the low predictive score group to the very high predictive score group. We formed four increasingly serious risk categories(scores 0–3, 4–7, 8–1., and 1.–1.)according to the frequency associated with the different risk scores of DGF. The HMP predictive score indicates good discriminative power with a c?statistic of 0.706 in the validation cohort, and it had significantly better prediction value for DGF compared to both terminal flow(P = 0.01.) and resistance(P = 0.006).Conclusion: The HMP predictive score is a good noninvasive tool for assessing the qu

关键词： Delayed Graft Function Donation after Cardiac Death Hypothermic Machine Perfusion Kidney Transplantation

Etching-courtesy NH_(4)^(+) pre-intercalation enables highly-efficient li^(+) storage of MXenes via the renaissance of interlayer redox

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Journal of Energy Chemistry 2022年第9期31卷 26-32,I0002页

作者： Junyan li Wei Zhang Xin Ge {1. Lu Xiangxin Xue Zizhun Wang Nailin Yue Junkai Zhang Xingyou Lang Qing Jiang Weitao zheng Key Laboratory of Automobile Materials MOE School of Materials Science&EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012JilinChina The Joint Laboratory of MXene Materials Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationKey Laboratory of Preparation and Application of Environmental Friendly Materials of the Ministry of EducationJilin Normal UniversityChangchun 130103JilinChina

Inspired by a well-known architecture notion that load-bearing walls enable maintaining a highly-stable multiple-floored building,superior advantages are afforded via fabricating the NH_(4)+ions pre-intercalated Mo_(2)CT_(x) MXene(Mo_(2)CT_(x)-N)in a mixed solution of NH_(4)F and HCl via a simple one-step hydrothermal *** a result of the synergistic effects of pillared structure,immobilizing-F groups and unlocking Mo-based redox,the Mo_(2)CT_(x)-N remarkably delivered a reversible capacity of 384.6 mAh ^(g-1. at 200 mA g^(-1. after 1.0 *** work lays a foundation for fully packaging its optimal performance via carding and architecting the chemistry of the MXene layers and between them.

关键词： Mo_(2)CTx MXene Ammonium ions Intercalation lithium storage

Predictive Score Model for Delayed Graft Function Based on Easily Available Variables before Kidney Donation after Cardiac Death

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Chinese Medical Journal 2017年第20期130卷 2429-2434页

作者： Chen-Guang Ding Qian-Hui Tai Feng Han Yang li Xiao-Hui {1. Pu-Xun {1. Xiao-ming Ding Xiao-ming Pan Jin zheng He-li Xiang Wu-Jun Xue department of Renal Transplantation Nephropathy Hospital The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Institute of Organ Transplantation Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background： How to evaluate the quality of donation after cardiac transplantation in{1.. Hence, the aim of this study was to develop kidneys before DCD. death （DCD） kidneys has become a critical problem in kidney a simple donor risk score model to evaluate the quality of DCD Methods： A total of 543 qualified kidneys were randomized in a 2：1.manner to create the development and validation cohorts. The donor variables in the development cohort were considered as candidate univariate predictors of delayed graft function （DGF）. Multivariate logistic regression was then used to identify independent predictors of DGF with P 〈 0.05. Date from validation cohort were used to validate the donor scoring model. Results： Based on the odds ratios, eight identified variables were assigned a weighted integer; the sum of the integer was the total risk score for each kidney. The donor risk score, ranging from 0 to 28, demonstrated good discriminative power with a C-statistic of 0.790. Similar results were obtained from validation cohort with C-statistic of 0.783. Based on the obtained frequencies of DGF in relation to different risk scores, we formed tour risk categories of increasing severity （scores 04, 5 9, 1.-1., and 1. 28）. Conclusions： The scoring model might be a good noninvasive tool for assessing the quality of DCD kidneys before donation and potentially useful for physicians to make optimal decisions about donor organ offers.

关键词： Delayed Graft Function Donation after Cardiac Death Kidney Transplantation Predictive Score

Porous current collector enables carbon superior electrochemical performance for K-ion capacitors

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Rare Metals 2023年第1期42卷 134-145页

作者： Mei-Qi liu Hui-{1. li Zai-Yuan Le Jin-Fu Zhao li-Min Chang Luan Fang Mei-Qi Hou Hai-Rui Wang tian-Hao Xu Ping Nie Key Laboratory of Preparation and Applications of Environmental Friendly Material of the Ministry of Education College of ChemistryJilin Normal UniversityChangchun130103China department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA90095USA

The current collector is an indispensable component in potassium-ion hybrid capacitors,which not only provides mechanical support to load electrode materials,but also collects and outputs the current ***,we investigate the effect of three different current collectors on the electrochemical properties of potassium ion capacitors using carbon black anode as a *** of better adhesion and lower charge transfer resistance,the specific capacity of half-cells assembled using three-dimensional(3D)porous copper foil(PCu)and copper as current collector is better than that of Al foil,which stabilizes at 1.8.2 and 1.2.8 mAh·g^(-1.after 1.0 cycles at 0.05 A·g^(-1..The potassium-ion capacitor assembled using PCu exhibits an excellent energy/power density of 86.1.Wh·kg^(-1.and 4000 W·kg^(-1.,*** work will boost the rational design and provide an effective strategy to improve the performance of potassium-ion capacitors.

关键词： Porous copper Current collector Anode Carbon anode Potassium-ion capacitor(PIC)

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中华实验外科杂志 2024年第3期41卷 491-495页

作者：翟东升李俊张晓梅申铭郑建伟湖北民族大学附属民大医院肝胆外科恩施445000 武汉市第五医院消化内科武汉430051 华中科技大学同济医学院附属同济医院胆胰外科武汉430030

目的探讨腺病毒携带的黑色素瘤分化相关基因-7(***-7)调节胆囊癌细胞生长抑素受体-2(SSTR2)基因表达对胆囊癌细胞SGC-996生长及细胞周期的影响。方法构建携带MDA-7/白细胞介素(IL)-24基因的腺病毒载体,转染胆囊癌细胞SGC-996,使用细胞... 详细信息

目的探讨腺病毒携带的黑色素瘤分化相关基因-7(***-7)调节胆囊癌细胞生长抑素受体-2(SSTR2)基因表达对胆囊癌细胞SGC-996生长及细胞周期的影响。方法构建携带MDA-7/白细胞介素(IL)-24基因的腺病毒载体,转染胆囊癌细胞SGC-996,使用细胞计数试剂盒(CCK-8)法检测胆囊上皮细胞、胆囊癌细胞实验组细胞增殖率,观察各实验组细胞增殖抑制的变化、FCM流失细胞术分析各实验组细胞周期特异性。实时定量聚合酶链反应(Real-time PCR)检测***-7转染后,各实验组细胞MDA-7、SSTR2基因的表达,蛋白质印迹法(Western blot)检测p21.Cyclin A、CDK2、Cyclin B蛋白等细胞周期蛋白(Cyclin)及蛋白激酶B(Akt)细胞通路蛋白的表达。结果***-7可以有效转染胆囊癌细胞SGC-996及胆囊NF细胞,稳定表达MDA-7的mRNA及蛋白。转染MDA-7基因后,胆囊癌细胞SGC-996组细胞存活率[(43.48±9.75)%]低于空白对照组[(89.1.±7.85)%]和阴性***对照组[(87.97±8.63)%],***-7明显受到抑制SGC-996组细胞存活率(P24 h后细胞周期变化,***-7 SGC-996细胞组G 2/M期[(49.62±3.1.)%]高于于空白组[(1..54±1.1.)%]、阴性***对照组[(1..39±6.04)%],***-7 SGC-996实验组细胞周期被阻滞于G_(2)/M期(P2蛋白表达上调,p21.Cyclin A、CDK2、Cyclin B蛋白表达逐渐增加,而Cyclin D1.CDK4、Cyclin D3、CDK6蛋白的表达逐渐减少,诱导肿瘤细胞细胞周期被阻滞于G_(2)/M期。同时,Akt、ERK蛋白的表达呈明显增加,实验组p-Akt、p-ERK、p-JNK蛋白表达量明显下降。结论***-7转染胆囊癌细胞SGC-996后,明显抑制肿瘤细胞的生长,***-7上调SSTR2蛋白的表达,并且通过上调细胞内Akt信号通路蛋白的表达,抑制肿瘤细胞的生长。

关键词：胆囊恶性肿瘤 MDA-7 生长抑素受体-2 细胞周期蛋白