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Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

China Ocean Engineering 2024年第3期38卷 363-378页

作者： ZHAO mi YU Wan-li WANG Pi-guang QU Yang DU Xiu-li Key Laboratory of Urban Security and Disaster Engineering of ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

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Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes

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Food Science and Human Wellness 2024年第1期13卷 287-298页

作者： Hui liu Xuenan li Ziyue Wang Lu li Yucai li Haiyang Yan yuan yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China

Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2.),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).mitochondrial instabi{2.ty or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2.)transfer can result in mitochondrial *** focused on KCs to explore the damage to mitochondria by *** EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS *** experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2.)led to Ca^(2.)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeabi{2.ty transition pore opening,ultimately leading to mitochondrial *** findings confirmed the mechanism that EA induced mitochondrial Ca^(2.)imbalance in KCs via MAM,ultimately leading to mitochondrial ***,EA induced OS and the decrease of MMP and ATP in rat {2.ver,and significant lesions were found in {2.ver *** of the inner mitochondrial cristae and mitochondrial vacuo{2.zation occurred,with a marked increase in {2.pid droplets.

关键词： Elaidic acid(EA) mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum mitochondria dysfunction

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When mRNA meets gene editing

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Nano Research 2024年第8期17卷 7337-7356页

作者： Weijie li Chen Wang yuan Lu Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The critical challenge of gene therapy lies in delivering gene editing *** with DNA,while RNA is less stable and more accessible to degrade,it comes with the benefit of lower off-target effects since permanent insertion is not *** review focuses on mRNA-based delivery of gene editing agents,highlighting novel mRNA delivery *** provide context,a comparison is made between three main gene editing agents:programmable nucleases,base editors,and prime *** potential of Cas\pi and transposons is also discussed in this ***,a summary of four main barriers to mRNAbased in vivo delivery is ***,this review detailedly introduced different delivery systems,both viral(lentivirus)and non-viral vectors(genome editing via oviductal nucleic acids delivery,lipid nanoparticles,polymer-based nanoparticles,viruslike-particles,extracellular vesicles,and migrasome).Each delivery strategy is assessed by comparing its advantages and disadvantages to offer a comprehensive and objective overview of the delivery ***,we emphasized the vital role of the protein corona as a critical regulator for ***,we concluded the challenges of mRNA-based gene editing strategies(RNA stability,targeting,potential immunogenicity,cytotoxicity,heterogeneity,and rational design).The purpose of this review is to guide further research and provide a comprehensive analysis of mRNA-based in vivo delivery of gene editing agents in this promising field.

关键词： gene editing mRNA delivery viral vectors non-viral vectors CRISPR

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Distributed power conditioning unit of large-scale space solar power station

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Chinese Journal of Aeronautics 2024年第8期37卷 421-434页

作者： Xintong li Jianwei mi Yiqun ZHANG Guanheng FAN Jie DU School of Mechano-electronic Engineering Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Space Solar Power Station System Xidian UniversityXi’an 710071China Academy of Advanced Interdisciplinary Research Xidian UniversityXi’an 710071China

In this paper,a multi-bus distributed Power Conditioning Unit(PCU)is proposed for the Space Solar Power Station with large scale photovoltaic(PV)array and power levels reaching MW *** this unit,there are multiple independent PV *** each PV array,there are multiple independent PV *** this paper,a V-P droop control method with adaptive droop coefficient is proposed,which modifies the droop intercept based on the bus voltage deviation and the power per unit value of the PV *** method ensures the accuracy of bus voltage and achieves proportional distribution of power between PV arrays based on the proposed topology structure in this *** the load changes or the output power of the PV array fluctuates,this method can ensure that power is distributed *** principle and control method of the proposed droop control method is analyzed in this *** effectiveness of the method is verified through MATLAB/Simulink simulation and *** and experimental results show that the proposed method can achieve power distributed proportionally when load changes and PV output power fluctuates,reduce bus voltage error caused by line impedance and differences in rated power of different PV arrays,and improve the performance of PV power generation system applied to space.

关键词： Space Solar Power Station Photovoltaics Droop control DC confluence Power conditioning unit

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Effect of wall-disruption on nutrient composition and in vitro digestion of camellia and lotus bee pollens

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Food Science and Human Wellness 2024年第3期13卷 1567-1577页

作者： yuan yuan Shun Zhong Zeyuan Deng Guangyan li Jinwu Zhang Hongyan li State Key Laboratory of Food Science and Resources Nanchang UniversityNanchang 330047China Nanchang Tongxin Zichao Biological Engineering Co. Ltd.Nanchang 330052China

The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen ***,the effect of superfine grinding technology on the release of nutrients from bee pollen were investigated,and their antioxidant activities and in vitro digestion were explored in this *** showed that the content of nutrients in bee pollen increased after wall *** them,fat content increased by 2..55%-8.31%,protein content increased by 0.54%-4.91%,starch content increased by 36.31%-48.64%,soluble sugar content increased by 2..57%-2..67%,total phenolic acid content increased by 11.73%-86.98%and total flavonoids content increased by 14.2.%-2..79%.At the same time,the antioxidant activity increased by 14.84%-46.00%.Furthermore,the active components such as phenolic compounds in the wall-disruption bee pollen were more readily to be released during the in vitro digestion,and easier to be absorbed because of their higher *** activities during in vitro digestion were also improved in walldisruption bee *** findings provide evidence that bee pollen wall disruption was suggested,thus,it is more conducive to exerting the value of bee pollen in functional foods.

关键词： Bee pollen Nutrients Wall disruption Phenolic compounds In vitro digestion

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Protein lipidation in health and disease:molecular basis,physiological function and pathological implication

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1423-1465页

作者： yuan yuan Peiyuan li jianghui li Qiu Zhao Ying Chang Xingxing He Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanChina Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases WuhanChina

Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal *** these,protein lipidations which refer to lipid attachment to proteins are prominent,which primarily encompassing five types including S-palmitoylation,N-myristoylation,S-prenylation,glycosylphosphatidylinositol(GPl)anchor and *** attachment to proteins plays an essential role in the regulation of protein trafficking,localisation,stability,conformation,interactions and signal transduction by enhancing *** evidence from genetic,structural,and biomedical studies has consistently shown that protein lipidation is pivotal in the regulation of broad physiological functions and is inextricably linked to a variety of *** of dedicated research have driven the development of a wide range of drugs targeting protein lipidation,and several agents have been developed and tested in preclinical and clinical studies,some of which,such as asciminib and lonafarnib are FDA-approved for therapeutic use,indicating that targeting protein lipidations represents a promising therapeutic ***,we comprehensively review the known regulatory enzymes and catalytic mechanisms of various protein lipidation types,outline the impact of protein lipidations on physiology and disease,and highlight potential therapeutic targets and clinical research progress,aiming to provide a comprehensive reference for future protein lipidation research.

关键词： lipid ation primarily

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Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats

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Food Science and Human Wellness 2024年第3期13卷 1279-1291页

作者： Hui liu Xuenan li Lu li Yucai li Haiyang Yan Yong Pang Wenliang li yuan yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China School of Public Health Jining Medical UniversityJining 272067China

Previous studies have shown that trans fatty acids(TFA) are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic *** research investigated the effects of elaidic acid(EA),a typical TFA,on the gut microbiota to understand the underlying mechanisms of TFA-related chronic diseases.16S rDNA gene sequencing on faecal samples from Sprague-Dawley rats were performed to explore the composition change of the gut microbiota by EA gavage for 4 *** results showed that the intake of EA increased the abundance of well-documented harmful bacteria,such as Proteobacteria,Anaerotruncus,Oscillibacter and ***,EA induced translocation of lipopolysaccharides(LPS) and the above pathogenic bacteria,disrupted the intestinal barrier,led to gut-liver axis derangement and TLR4 pathway activation in the ***,EA induced intestinal barrier damage and regulated TLR4-MyD88-NF-κB/MAPK pathways in the liver of SD rats,leading to the activation of NLRP3 inflammasome and inflammatory liver damage.

关键词： Elaidic acid(EA) Gut microbiota Intestinal barrier Gut-liver axis TLR4-MyD88-NF-κB/MAPK pathways NLRP3 inflammasome

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microglial Calcium Homeostasis Modulator 2.Novel Anti-neuroinflammation Target for the Treatment of Neurodegenerative Diseases

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Neuroscience Bulletin 2024年第4期40卷 553-556页

作者： yuan Dong li Tang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Qingdao Institute of Measurement Technology Qingdao266000China

Neurodegenerative diseases,including Alzheimer's disease(AD)and Parkinson's disease(PD),are the most common causes of *** drugs for such diseases can only provide temporary help with the symptoms,leaving the discovery of new drugs urgently in *** cells are the local immune cells in the nervous system and have been recognized as the key player in neuroinflammation that contributes to the process of neurodegeneration[1],raising the discussion of aiming microg{2.a as the therapeutic target for c{2.nical treatment of neurodegenerative diseases.

关键词： inflammation degenerative drugs

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Coupled Surface Process and Orographic Precipitation Model for the Landscape Evolution of the Himalayas

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Journal of Earth Science 2024年第3期35卷 1063-1068页

作者： Yuqiang li Xiaoping yuan Hubei Key Laboratory of Critical Zone Evolution School of Earth SciencesChina University of GeosciencesWuhan 430074China

0 INTRODUCTION The landscape evolution of mountain belts links rock uplift caused by tectonic deformation in the lithosphere to fluvial erosion and deposition driven by climatic precipitation in the *** Himalayas,one of the most typical mountain belts in the world,are undergoing the strong collision of the Indian and Eurasian plates and the strong South Asian monsoon precipitation(Figure 1a).It is a natural laboratory to research the evolution mechanisms of orogenic growth involving tectonic and climatic *** addition,it is a good prototype to advance and verify many research methods in multiple *** Indian-Eurasian collision initiated since the Early Paleogene(ca.50 Ma)based on geological,stratigraphic,and palaeomagnetic records(Ding et al.,2.2.;van Hinsbergen et al.,2.12.,causing an early slow topographic change in the Himalayas until the Neogene(ca.2. Ma)(Ding et al.,2.2.).

关键词： Eurasian climatic tectonic

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Seismic responses of an intensively constructed metro station-passageway-shaft structure system

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 760-775页

作者： Ruohan li Yong yuan Hong CHEN Xinxing li Emilio BILOTTA Department of Geotechnical Engineering Tongji UniversityShanghai 200092China Department of Civil Architectural and Environmental EngineeringUniversity of Naples Federico IINaples 80125Italy State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China Shanghai Tunnel Engineering&Rail Transit Design and Research Institute Shanghai 200235China

Intensive construction methods offer benefits for metro station development,yet they present challenges for seismic design due to the spatially asymmetric configuration of passageway-shaft *** this study,a detailed numerical model of a station-passageway-shaft structure system built using intensive construction methods was developed and the deformation and damage modes under seismic loadings were *** results indicate that inconsistent deformation between the shaft and the station generates interaction through the connecting passageway,leading to damage near the opening of the station structure and both ends of the connecting passageway Damage is more severe under longitudinal *** with the opening plan that spans four segments,the opening plan that spans five segments exacerbates the overall degree of damage to the structure *** transverse excitation,the presence of interior structures intensifies the damage to the station and connecting passageway,while with such internal structure in place the impact is relatively minor under longitudinal *** with steel segments near the station opening can appreciably attenuate the *** contrast,introducing flexible joints at both ends of the connecting passageway intensifies the ***,reinforcement using steel segments emerges as an optimal seismic mitigation strategy.

关键词： earthquake intensive construction metro station numerical simulation

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