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Nontrivial homoclinic orbits for second-order singular and periodic Hamiltonian systems

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Chinese Science Bulletin 1999年第2期44卷 123-129页

作者： li Chengyue , fan tianyou TONG MingshengResearch Center of Materials Science, beijing institute of technology, beijing 100081, china department of Mathematics, Central University for Nationalities, beijing 100081, china Computer Center, beijing institute of technology, beijing 100081, china Research Center of Materials Science Beijing Institute of Technology Beijing China department of Mathematics Central University for Nationalities Beijing China Computer Center Beijing Institute of Technology Beijing China

The existence of nontrivial homoclinic orbits of periodic Hamiltonian systems: is proved, where q=（q1,q2,’',qn）, n>2; V（t, q）:R1×Rn\{e}→R1 is a potential With a singularity, i.e. -V（t, q）→+∞, as q→e. The m... 详细信息

关键词： Hamiltonian systems strong force condition homoclinic orbit.

Holographic superfluid ring with a weak link

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Science china(physics,Mechanics & Astronomy) 2024年第11期67卷 29-38页

作者： Zhi-Hong li Huai-fan li department of physics Shanxi Datong UniversityDatong 037009China institute of Theoretical physics Shanxi Datong UniversityDatong 037009China

We explore the generation of topological defects in the course of a dynamical phase transition in a ring with a weak link, i.e., a SSS Josephson junction, from the AdS/CFT correspondence. By setting different parameters of the junction(width, steepness,depth) and the final temperature of the quench, the configurations of the charge density and condensate of the order parameters of the dual field theory are presented. Meanwhile, we observe that in the final equilibrium state, variations in parameters of the junctions only affect the configurations of the charge density and condensate of the order parameters, without altering their values outside the junction. However, variations in the final temperature will directly affect the values of the charge density and condensate of the order parameters outside of the junction. Moreover, in the final equilibrium state, we propose an analytic relation between the gauge-invariant velocity in the two superconducting states in the SSS Josephson junction, which agrees well with the numerical results.

关键词： AdS/CFT correspondence holographic superfluid holographic Josephson junction

Molecular phylogeny of Pneumocystis based on 5.8S rRNA gene and the internal transcribed spacers of rRNA gene sequences

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Science china(life Sciences) 2008年第5期51卷 445-452页

作者： li ZiHui1,2, FENG XianMin1, LU SiQi1, ZHANG fan1, WANG FengYun1 & HUANG Song1 1 department of Pathogenic Biology, Capital Medical University, beijing 100069, china 2 beijing Tuberculosis and Thoracic Tumor Research institute, beijing 101100, china 1. department of Pathogenic Biology Capital Medical University Beijing 100069 China 2. beijing Tuberculosis and Thoracic Tumor Research institute Beijing 101100 China

To clarify the phylogenetic relationships and species status of Pneumocystis, the 5.8S rRNA gene and the internal transcribed spacers (ITS, 1 and 2) of Pneumocystis rRNA derived from rat, gerbil and human were amplified, cloned and sequenced. The genetic distance matrix of six Pneumocystis species compared with other fungi like Taphrina and Saccharomyces indicated that the Pneumocystis genus contained multiple species including Pneumocystis from gerbil. The phylogenetic tree also showed that Pneumocystis from human and monkey formed one group and four rodent Pneumocystis formed another group. Among the four members, Pneumocystis wakefieldiae was most closely related to Pneumocystis murina and Pneumocystis carinii, and was least related to gerbil Pneumocystis.

关键词： Pneumocystis phylogeny 5.8S rRNA gene internal transcribed spacers

Anomalies of Precipitation over china on Days with Tropical Cyclone Activity over the Bay of Bengal: Role of Moisture Transport

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Journal of Meteorological Research 2024年第2期38卷 368-382页

作者： Na WEI Ying li Xiaoting fan Nanjing Joint institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 department of Atmospheric and Oceanic Sciences and institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Bengal(BoBTC)affect the precipitation over china,with distinct seasonal and daily *** study quantitatively examines the daily standardized precipitation anomalies(SPAs)over china on the days with BoBTC activities(storm-days)and related circulations,based on rainfall measurements at surface meteorological stations and ECMWF reanalysis data on a 0.25°×0.25°resolution during *** positive SPA is found over the stations in the two adjacent regions around BoB(Southwest china in May/November and southern Tibetan Plateau in October)and three distant regions(Southeast china and the northeastern boundary of the Qinghai-Tibet Plateau in May,and central North china in October).The SPA distributions are remarkably consistent with the integrated water vapor transport(IVT)*** IVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circulation and low-level monsoonal flow in May(midlevel westerly in winter months).The probabilities of extreme precipitation(EP)occurrences over the above regions all increase on *** adjacent regions,EP is significantly correlated with the northward IVT anomalies to the east of BoBTC circulation,which strengthen the water vapor input through the southern *** IVT anomalies are stronger in May,benefited by the deep monsoonal southwesterlies than those in *** distant regions,EP is more closely related to the IVT anomaly extending back from *** moisture from BoB concentrates along a local low-level convergence line over Southeast china,being further facilitated by coexistence of the BoBTC depression and midlevel westerly trough in *** results highlight the interactions between BoBTCs and local weather systems that influence the general precipitation anomalies and occurrence of EP over china,especially over distant regions.

关键词： tropical cyclone Bay of Bengal precipitation anomaly moisture transport

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

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Genes & Diseases 2024年第5期11卷 315-323页

作者： Jiankun fan Zhigang li li Pei Yu Hou institute of life Sciences Chongqing Medical UniversityChongqing 400016China department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Hematopoiesis represents a meticulously regulated and dynamic biological *** aberrations affecting blood cells,induced by various factors,frequently give rise to hematological *** instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events,including RNA alternative splicing,RNA localization,RNA degradation,and ***,post-transcriptional regulation plays a pivotal role in preserving hematopoietic *** DEAD-Box RNA helicase genes emerge as crucial post-transcriptional regulatory factors,intricately involved in sustaining normal hematopoiesis through diverse mechanisms such as RNA alternative splicing,RNA modification,and ribosome *** review consolidates the existing knowledge on the role of DEAD-box RNA helicases in regulating normal hematopoiesis and underscores the pathogenicity of mutant DEADBox RNA helicases in malignant *** is placed on elucidating both the positive and negative contributions of DEAD-box RNA helicases within the hematopoietic system.

关键词： DEAD-box RNA helicase Hemopoietic system Post-transcriptional regulation Ribosomes assembly RNA alternative splicing

Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan fan Tao Zhang Xin Ding Yushuo Gu Qing li Wei Jiang Kelong fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China department of General Surgery Strategic Support Force Medical CenterBeijing 100101China department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework

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Science china(life Sciences) 2009年第2期52卷 163-172页

作者： ZHANG RuiJie1, li Xia1,2, JIANG YongShuai1, liU GuiYou1, li ChuanXing1, ZHANG fan1, XIAO Yun1 & GONG BinSheng1 1 department of Bioinformatics, Harbin Medical University, Harbin 150086, china 2 Biomedical Engineering institute of CUMS, beijing 100054, china 1. department of Bioinformatics Harbin Medical University Harbin 150086 China 2. Biomedical Engineering institute of CUMS Beijing 100054 China

High-throughout single nucleotide polymorphism detection technology and the existing knowledge provide strong support for mining the disease-related haplotypes and genes. In this study, first, we apply four kinds of haplotype identification methods (Confidence Intervals, Four Gamete Tests, Solid Spine of LD and fusing method of haplotype block) into high-throughout SNP genotype data to identify blocks, then use cluster analysis to verify the effectiveness of the four methods, and select the alco- holism-related SNP haplotypes through risk analysis. Second, we establish a mapping from haplotypes to alcoholism-related genes. Third, we inquire NCBI SNP and gene databases to locate the blocks and identify the candidate genes. In the end, we make gene function annotation by KEGG, Biocarta, and GO database. We find 159 haplotype blocks, which relate to the alcoholism most possibly on chromosome 1~22, including 227 haplotypes, of which 102 SNP haplotypes may increase the risk of alcoholism. We get 121 alcoholism-related genes and verify their reliability by the functional annotation of biology. In a word, we not only can handle the SNP data easily, but also can locate the disease-related genes pre- cisely by combining our novel strategies of mining alcoholism-related haplotypes and genes with ex- isting knowledge framework.

关键词： haplotype block alcoholism gene functional annotation gene location linkage disequilibrium

Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms

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china Ocean Engineering 2024年第2期38卷 352-361页

作者： YU li-na XIONG Kuan GAO Xi-feng li Zhi fan li-long ZHANG Kai institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China china Railway Construction Bridge Engineering Bureau Group Co.LTD Tianjin 300300China School of Civil Engineering Tianjin UniversityTianjin 300072China department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

Phase-Mixture Algorithm Applied to Design of Pure Phase Elements

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Chinese Journal of Lasers 1995年第5期B4卷 447-454页

作者： DENG Xuegong￣1 li Yongping(Y.P.li)￣(1,2)(￣1physics department, University of Science and technology of china, Hefei 230026,china)(￣2 Structure Research Laboratory,Academia Sinica,Hefei 230026, china)QIU Yue fan Dianyuan (Shanghai institute of Optics Univ of Science and technology of China Hefei China

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关键词： pure phase elements phase mixture algorithm