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Time-dependent matrix metalloproteinases and tissue inhibitor of metalloproteinases expression change in fusarium solani keratitis

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 512-518页

作者： Qian li Xin-Rui Gao Hong-Ping Cui li-li lang Xiu-Wen Xie Qun Chen Department of Ophthalmology Shanghai East HospitalTongji University School of Medicine Department of Ophthalmology Shanghai Tenth People's Hospital Tenth People's Hospital of Tongji University Department of Ophthalmology Changzhou Third People's Hospital Department of Ophthalmology Shanghai Pudong New Area Gongli Hospital

AIM： To investigate matrix metalloproteinases（MMPs）and tissue inhibitor of metalloproteinases（TIMPs）expression during the progress of fusarium solani（***） keratitis in a rat model.· METHODS： A rat model of *** keratitis was produced using corneal scarification and a hand-made contact lens. MMPs and TIMPs expressiond were explored in this rat model of *** keratitis using real-time polymerase chain reaction（PCR） and ***6001（400 μmol/m L） was used to treat infected corneas. The keratitis duration, amount and area of corneal neovascularization（CNV） were evaluated.·RESULTS： MMP-3 expression was 66.3 times higher in infected corneas compared to normal corneas. MMP-8,-9,and-13 expressions were significantly upregulated in the mid-period of the infection, with infected- to-normal ratios of 4.03, 39.86, and 5.94, respectively. MMP-2 and-7expressions increased in the late period, with the infected-to-normal ratios of 5.94 and 16.22, ***-1 expression was upregulated in the early period,and it was 43.17 times higher in infected compared to normal corneas, but TIMP-2,-3, and-4 expressions were mildly downregulated or unchanged. The results of DIF were consistent with the result of real-time ***6001, a MMPs inhibitor, decreased the duration of *** infection and the amount and area of CNV.·CONCLUSION： MMPs and TIMPs contributed into the progress of *** keratitis.

关键词： fungal keratitis fusarium solani metalloproteinases tissue inhibitors of metalloproteinases

Adhesive chitosan-based hydrogel assisted with photothermal antibacterial property to prompt mice infected skin wound healing

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Chinese Chemical Letters 2023年第12期34卷 415-423页

作者： Shuang Cheng Meng Pan Danrong Hu Ruxia Han lang li Zhongwu Bei Yicong li Ao Sun Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center and Collaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu610041China Rehabilitation Medicine Center and Institute of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine in Sichuan Province West China HospitalSichuan UniversityChengdu610041China Department of Pediatric Surgery West China HospitalSichuan UniversityChengdu 610041China

Bacterial infection of wounds is an escalating medical problem,issuing threats to both global public health and personal *** antibacterial technology as a novel sterilization strategy has outstanding sterilization efficiency,high safety and low risk of emergence of drug-resistant *** combining inherent antibacterial activity and light-assisted antibacterial treatment,developing novel multifunctional dressings with synergistic high-efficiency antibacterial effects and also promoting wound healing possesses attractive advantages in the field of treating bacterial wound infections in clinical ***,a multifunctional hydrogel formed by in situ photo-cross linking was designed and prepared by first grafting methacrylic anhydride as a photosensitizer onto chitosan,and then introducing oxidatively synthesized polydopamine(PDA).The physicochemical characterizations of the synthesized hydrogels demonstrated their tunability certainly associated with PDA concentration,including pore size,water swelling,rheological properties and in vitro *** addition,the composite hydrogels exhibited good adhesion,anti-oxidation and photothermal properties due to the existence of *** 10min upon exposure to 808 nm near-infrared(NIR)light irradiation,this hydrogel system displayed outstanding antibacterial activity against Staphylococcus aureus with almost 100%killing efficiency,of which rapid efficient sterilization plays a significant role in wound ***,the hydrogel is capable of cytocompatibility and has low toxicity to murine fibroblasts(L929 and NIH/3T3).In the full-thickness wound defect infection model in mice,the wound closure ratio,inflammatory response,fibroblasts,neovascularization and epithelialization were *** experiments also reveal that the hydrogel assisted with NIR laser irradiation can inhibit effectively infection at an early stage and accelerate the wound healing *** summary,this novel multifunc

关键词： Hydrogel Adhesion Photothermal therapy Antibacterial Wound infection

Microstructural evolution and oxidation inα/βtitanium alloy under fretting fatigue loading

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Friction 2023年第10期11卷 1906-1921页

作者： Hanqing liU Xiaohong SHAO Kai TAN Zhenjie TENG Yaohan DU lang li Qingyuan WANG Qiang CHEN Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province Sichuan UniversityChengdu 610065China Department of Mechanical Engineering Kyushu UniversityFukuoka 819-0395Japan Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute of Physical Chemistry University of MünsterMünster 48149Germany

Coupling effects of fretting wear and cyclic stress could result in significant fatigue strength degradation,thus potentially causing unanticipated catastrophic *** underlying mechanism of microstructural evolutions caused by fretting wear is ambiguous,which obstructs the understanding of fretting fatigue issues,and is unable to guarantee the reliability of structures for long-term ***,fretting wear studies were performed to understand the microstructural evolution and oxidation behavior of anα/βtitanium alloy up to 108 *** surface degradation is mainly caused by surface oxidation and the generation of wear debris during fretting wear within the slip *** grain size in the topmost nanostructured layer could be refined to~40 *** grain refinement process involves the initial grain rotation,the formation of low angle grain boundary(LAGB;2°–5°),the in-situ increments of the misorientation angle,and the final subdivision,which have been unraveled to feature the evolution in dislocation morphologies from slip lines to tangles and *** formation of hetero microstructures regarding the nonequilibrium high angle grain boundary(HAGB)and dislocation arrays gives rise to more oxygen diffusion pathways in the topmost nanostructured layer,thus resulting in the formation of cracking interface to separate the oxidation zone and the adjoining nanostructured domain driven by tribological fatigue ***,it facilitates surface degradation and the formation of catastrophic fractures.

关键词： fretting wear oxygen pick-up dynamic recrystallization grain rotation low angle grain boundary(LAGB) grain refinement

Texture development and properties of Ti-IF steels produced by different hot-rolling processes

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Journal of Iron and Steel Research International 2019年第3期26卷 310-320页

作者： Lei-lei Hao lang li Chen-yang Qiu Jian-gong Wang Xun Zhou Yong-lin Kang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Shougang Jingtang United Iron and Steel Co. Ltd.Tangshan 063200HebeiChina

Texture is a pivotal factor for the deep drawability of interstitial free steel (IF steel). The evolution of microstructure and recrystallization texture of Ti-IF steel through the processing of hot rolling, cold rolling and annealing have been studied. The mechanical properties including strain hardening index n and plastic strain ratio r are also measured. For comparison, ferrite rolling and austenite rolling are both studied. The results show that the intensity of γ-fiber after ferrite rolling is higher than that after austenite rolling. The great balance between the {111}〈110〉 and {111}〈112〉 leads to low △r value after annealing. The size of precipitates in ferrite rolled sample is generally larger than that in austenite rolled sample. Compared to austenite rolled sample, the ferrite rolled and annealed one has better formability and its r value reaches 2.36. Different from laboratory production, the test steels were acquired from industrial trial, and all the result can be used in industrial production directly.

关键词： Ti-IF steel Ferrite rolling Austenite rolling Microstructure Texture

Effect of continuous annealing temperature on microstructure and properties of ferritic rolled interstitial-free steel

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International Journal of Minerals,Metallurgy and Materials 2018年第5期25卷 536-546页

作者： Chen-yang Qiu lang li Lei-lei Hao Jian-gong Wang Xun Zhou Yong-lin Kang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Shougang Jingtang United Iron and Steel Co.Ltd. Tangshan 063200China 不详

In this report,the microstructure,mechanical properties,and textures of warm rolled interstitial-free steel annealed at four different temperatures(730,760,790,and 820°C)were *** overall structural features of specimens were investigated by optical microscopy,and the textures were measured by X-ray diffraction(XRD).Nano-sized precipitates were then observed by a transmission electron microscope(TEM)on carbon extraction *** to the results,with increased annealing temperatures,the ferrite grains grew;in addition,the sizes of Ti_4C_2S_2 and Ti C precipitates also ***,the sizes of Ti N and Ti S precipitates slightly *** the annealing temperature increased from 730 to 820°C,the yield strength(YS)and the ultimate tensile strength(UTS)showed a decreasing ***,elongation and the strain harden exponent(n value)increased to 49.6%and 0.34,*** comparing textures annealed at different temperatures,the intensity of{111}texture annealed at 820°C was the largest,while the difference between the intensity of{111}and{111}was the smallest when the annealing temperature was 820°***,the plastic strain ratio(r value)annealed at 820°C was the highest.

关键词： interstitial-free steel warm rolling texture mechanical properties microstructure

Efficiency and safety of laparoscopic left hemihepatectomy: A study of intrathecal vs extrathecal Glissonean pedicle techniques

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2612-2619页

作者： li-Min Kang Lei Xu Fu-Wei Zhang Fa-Kun Yu li lang Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina Department of Outpatient Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKGROUND Selective hemihepatic vascular occlusion is utilized in both right and left hemihepatectomies to preserve blood supply to the intact lobe,maintain hemo-dynamic stability,and mitigate surgical *** this technique encompasses both intrathecal and extrathecal Glissonean pedicle transection methods,there is a lack of systematic comparative reports on these two *** To retrospectively analyze the clinical data of patients with hepatocellular carcinoma(HCC)undergoing laparoscopic anatomical hepatectomy in our hospital to explore the feasibility,safety,and short-and long-term efficacy of extrathecal and intrathecal Glissonean pedicle transection methods in laparo-scopic left *** A retrospective study was performed to analyze the clinical data of 49 HCC patients who underwent laparoscopic left hemihepatectomy from January 2019 to December 2022 in our *** patients were divided into extrathecal Glissonean pedicle transection(EGP)group(n=24)and intrathecal Glissonean pedicle transection(IGP)group(n=25)according to the different approaches used for selective hemihepatic vascular *** perioperative indicators,liver function indexes,complications,and follow-up findings were compared between these two *** The surgeries were smooth in both groups,and no perioperative death was *** hepatic pedicle transection time and the operation time were(16.1±2.3)minutes and(129.6±19.0)minutes,respectively,in the EGP group,which were significantly shorter than those in the IGP group[(25.5±2.4)minutes and(184.8±26.0)minutes,respectively],both Pling time,and postoperative liver function between the two groups(all P>0.05).The incidence of postoperative complications showed no significant difference[16.67%(4/24)vs 16.0%(4/25),P>0.05].All the 49 HCC patients were followed up after surgery(range:11.2

关键词： Hepatocellular carcinoma Laparoscopy Extra-Glissonian approach Intra-Glissonian approach Surgical efficiency Surgical safety

Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment:A Comprehensive Review

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1045-1055页

作者： liU Gui-hong YAO Ze-qin CHEN Guo-qiang li Ya-lang liANG Bing Department of Urology Sanya Central Hospital(The Third People's Hospital of Hainan Province)Sanya CityHainan Province 572000China Department of Urology Yuzhou People's HospitalXuchang CityHenan Province 461670China

Prostate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment *** tea,a well-known beverage derived from the Camellia sinensis plant,contains bioactive compounds with potential health benefits,including catechins and *** comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing *** tea possesses antioxidant,anti-inflammatory,and anti-carcinogenic properties attributed to its catechins,particularly epigallocatechin *** studies have reported an inverse association between green tea consumption and prostate cancer risk,with potential protection against aggressive forms of the *** studies demonstrate that green tea components inhibit tumor growth,induce apoptosis,and modulate signaling pathways critical to prostate cancer development and *** trials and human studies further support the potential benefits of green *** tea consumption has been found to be associated with a reduction in prostate-specific antigen levels,tumor markers,and played a potential role in slowing disease ***,challenges remain,including optimal dosage determination,formulation standardization,and conducting large-scale,long-term clinical *** review suggests future research should focus on combinatorial approaches with conventional therapies and personalized medicine strategies to identify patient subgroups most likely to benefit from green tea interventions.

关键词： green tea prostate cancer prevention treatment epigallocatechin gallate review

Downregulation of miR-181a-5p alleviates oxidative stress and inflammation in coronary microembolization-induced myocardial damage by directly targeting XIAP

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Journal of Geriatric Cardiology 2021年第6期18卷 426-439页

作者： You ZHOU Man-Yun LONG Zhi-Qing CHEN Jun-Wen HUANG Zhen-Bai QIN lang li Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanningChina Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention NanningChina

BACKGROUND Coronary microembolization(CME)is a complicated problem that commonly arises in the context of coronary *** play crucial roles in cardiovascular ***,the role and mechanism of miR-181a-5p in CME-induced myocardial injury remains *** We established CME rat *** function was detected by ***-basic fuchsin-picric acid staining was used to measure micro-infarction *** samples and cell culture supernatants were evaluated via enzyme-linked immunosorbent *** reactive oxygen species were determined by dichloro-dihydro-fluorescein diacetate assay,and the other oxidative stress related parameters were assayed by *** dual-luciferase reporter(DLR)assay and RNA pulldown were conducted to validate the association between miR-181a-5p and X-linked inhibitor of apoptosis protein(XIAP).The expression of miR-181a-5p and XIAP mRNA were determined by quantitative reverse transcription polymerase chain *** were evaluated via *** viability of the cell was evaluated via cell counting kit-8 *** The miR-181a-5p level was significantly increased in CME myocardial *** of miR-181a-5p improved CME-induced cardiac dysfunction and alleviated myocardial oxidative stress and inflammatory injury,whereas miR-181a-5p exhibited the opposite ***,the DLR assay and RNA pulldown results revealed that miR-181a-5p directly targeting on *** XIAP level was found to be remarkably decreased after *** overexpression attenuated CME-induced myocardial oxidative stress and inflammatory ***,in vitro rescue experiments revealed that knockdown of XIAP could abolish the protective effects of miR-181a-5p knockdown on hypoxia-induced cardiomyocyte oxidative stress and inflammatory *** Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and

关键词： damage XIAP Down

Changes of retinal vessel density in low to moderate myopic eyes with orthokeratology evaluated by optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1512-1520页

作者： Jia-Hui Shi Yi-Ping Zhao Gang liu Xin-Yi Huang li-li lang Wan-Cheng Jia Ji-li Chen Medical College of Anhui University of Science and Technology Huainan 232000Anhui ProvinceChina South Hospital of the Sixth People’s Hospital Shanghai 201400China Shibei Hospital Shanghai 200435China

AIM:To explore the effect of orthokeratology(OK)fitting on retinal vessel density in low to moderate myopia adolescents by using optical coherence tomography ***:Children aged 10 to 14y with a cycloplegic spherical equivalent refraction of−0.50 diopter(D)to−5.00 D and astigmatism with more than−1.50 D were *** enrolled adolescents were divided into OK group and spectacle *** regular followup,adolescents were measured respectively at pre-wear,1,3,and 6mo after *** follow-up included uncorrected distance visual acuity(UDVA),axial length(AL),superficial capillary plexus density(SCPD),deep capillary plexus density(DCPD),central retinal thickness(CRT),foveal avascular zone area(FAZ-A),foveal avascular zone perimeter(FAZ-P)and foveal vessel density in a 300-μmwide region around foveal avascular zone(FD-300).The collected data were analyzed using statistical ***:By one month,SCPD significantly increased in the fovea and superior retina,and DCPD significantly increased inferiorly in OK group compared to spectacle group(P0.05).OK group showed a significant improvement in UDVA after wearing OK,compared to spectacle group(P0.05).CONCLUSION:Short-term OK worn can increase local retinal vessel density in adolescents with low-to-moderate myopia.

关键词： optical coherence tomography angiography orthokeratology myopia axial length retinal capillary plexus density