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系统化推进城市更新发展路径研究——以无锡市为例

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中国名城 2024年第6期38卷 22-27页

作者：朱蓉蒋崟杰陈济洲李晓斌魏可欣江南大学设计学院中国生态城市研究院零碳建筑所

新型城镇化建设背景下,城市空间作为城市建设的重要载体,承担着产业发展、文化传承、社区管理、空间整合和生态优化等多种功能。在城市发展迈入“存量更新”模式的阶段,针对当前城市建设尤其是二、三线发展中城市的更新旧改需求增加、... 详细信息

新型城镇化建设背景下,城市空间作为城市建设的重要载体,承担着产业发展、文化传承、社区管理、空间整合和生态优化等多种功能。在城市发展迈入“存量更新”模式的阶段,针对当前城市建设尤其是二、三线发展中城市的更新旧改需求增加、城市人口增加、用地指标紧张等现状问题,如何实现城市高质量、系统化发展显得尤为重要。选取江苏省无锡市为案例,基于国内外城市更新发展历程,以促进无锡综合性与整体性发展为目标,立足于“政府部门—区域专家—基层群众”三维群体,构建“统筹机制—施策机制—保障机制”的三层级圈层式高质量城市更新治理体系,为未来二、三线城市规划统筹提供参考。

关键词：城市更新系统化发展路径探索无锡市

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生地黄产地与炮制加工技术研究进展

当代化工研究 2024年第9期 21-24页

作者：唐广陈丽刘威刘军胡兆吉朱纪洲南昌大学资源与环境学院江西330031 江西同善堂中药饮片有限公司江西344700 江西善保堂食品科技有限公司江西330013 江西阔创科技有限公司江西335099 鹰潭市特色资源综合利用与智能装备开发重点实验室江西335099 江西顺福堂中药饮片有限公司江西331409

生地黄具有清热凉血、养阴生津等功效,主要用于温毒发斑、吐血衄血、内热消渴等。本文综述了近年来生地黄产地与炮制加工技术的研究进展,通过归纳总结,阐明了生地黄不同加工方式的科学内涵以及对药材品质的影响,提出了向联合干燥技术和... 详细信息

生地黄具有清热凉血、养阴生津等功效,主要用于温毒发斑、吐血衄血、内热消渴等。本文综述了近年来生地黄产地与炮制加工技术的研究进展,通过归纳总结,阐明了生地黄不同加工方式的科学内涵以及对药材品质的影响,提出了向联合干燥技术和产地与炮制一体化加工技术两个方向发展的理念,可为地黄产地加工和炮制方法的研究以及中药制药企业的绿色制造提供思考和借鉴。

关键词：地黄产地加工炮制干燥一体化

Proteasome alteration and delayed neuronal death in hippocampal CA1 and dentate gyrus regions following transient cerebral ischemia

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Neural Regeneration Research 2009年第10期4卷 744-748页

作者： Pengfei Ge Tianfei Luo jizhou Zhang Haifeng Wang Wenchen li Yongxin Luan Feng ling Yi'nan Luo Department of Neurosurgery First Hospital Jifin University Changchun 130021 Jilin Province China Department of Biochemistry and Molecular Biology Norman Bethune Medical School Jilin University Changchun 130021 Jilin Province China Department of Neurosurgery Xuanwu Hospital Capital University of Medical Science Beijing 100053 China

BACKGROUND： Proteasome dysfunction has been reported to induce abnormal protein aggregation and cell death. OBJECTIVE： To investigate the effect of proteasome changes on delayed neuronal death in CA1 and dentate gyrus （DG） regions of the rat hippocampus following transient cerebral ischemia. DESIGN, TIME AND SETTING： A randomized, controlled animal experiment. The study was performed at the Department of Biochemistry and Molecular Biology, Norman Bethune Medical College of Jilin University, from September 2006 to May 2008. MATERIALS： Rabbit anti-19S S10B polyclonal antibody was purchased from Bioreagents, USA; propidium iodide and fluorescently-labeled goat anti-rabbit IgG were purchased from Jackson Immunoresearch, USA; hematoxylin and eosin staining solution was purchased from Sigma, USA; LSM 510 confocal microscope was purchased from Zeiss, Germany. METHODS： A total of 40 healthy Wistar rats, male, 4 months old, were randomly divided into sham surgery group （n = 8） and model group （n = 32）. Ischemic models were established in the model group by transient clamping of the bilateral carotid arteries and decreased blood pressure. After 20 minutes of global ischemia, the clamp was removed to allow blood flow for 30 minutes, 4, 24 and 72 hours, respectively, with 8 rats at each time point. The bilateral carotid arteries were not ligated in the sham surgery group. MAIN OUTCOME MEASURES： Neuronal death in the CA1 and DG regions was observed by hematoxylin-eosin staining. Proteasome expression in CA1 and DG region neurons was detected by immunohistochemistry. RESULTS： Hematoxylin-eosin staining showed neuronal death in the CA1 region alone at 72 hours of reperfusion following ischemia. In comparison to the sham surgery group, a significant decrease in proteasome expression was observed, by immunohistochemistry, in the CA1 and DG regions in the model group, following 30 minutes, 4, 24, and 72 hours of reperfusion （P 〈 0.01）. After 72 hours of reperfusion following ischemia

关键词： transient cerebral ischemia neuronal death proteasome

Carbonitride MXene Ti_(3)CN(OH)_(x)@MoS_(2)hybrids as efficient electrocatalyst for enhanced hydrogen evolution

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Nano Research 2023年第4期16卷 4656-4663页

作者： jizhou Jiang Fangyi li Saishuai Bai Yongjing Wang Kun Xiang Haitao Wang Jing Zou Jyh-Ping Hsu School of Environmental Ecology and Biological Engineering School of Chemistry and Environmental EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationNovel Catalytic Materials of Hubei Engineering Research CenterWuhan Institute of TechnologyWuhan 430205China Department of Chemical Engineering “National Taiwan University”Taipei 10617

Renewable energy powered electrocatalytic water splitting is a promising strategy for hydrogen generation,and the design and development of high-efficiency and earth-abundant electrocatalysts for hydrogen evolution reaction(HER)are highly ***,MoS2 nanoflowers decorated two-dimensional carbonitride-based MXene Ti3CN(OH)x hybrids have been constructed by etching and post-hydrothermal *** electrochemical performance of the as-obtained Ti_(3)CN(OH)_(x)@MoS_(2)hybrids having a quasi core-shell structure is fascinating:An overpotential of 120 mV and a Tafel slope of 64 mV∙dec^(−1)can be delivered at a current density of 10 mA∙cm^(−2).And after 3,000 cyclic voltammetry cycles,it can be seen that there is no apparent *** the experimental results and density functional theory(DFT)calculations indicate that the synergetic effects between Ti_(3)CN(OH)x and MoS_(2)are responsible for the robust electrochemical HER *** electrons of-OH group in Ti_(3)CN(OH)x are transferred to MoS_(2),making the adsorption energy of the composite for H almost *** metallic Ti_(3)CN(OH)x is also beneficial to the fast charge transfer *** construction of MXene-based hybrids with optimal electronic structure and unique morphology tailored to the applications can be further used in other promising energy storage and conversion devices.

关键词： Ti_(3)CN(OH)x MoS_(2) hydrogen evolution reaction density functional theory(DFT)calculations

Porous 3D carbon-based materials:An emerging platform for efficient hydrogen production

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Nano Research 2023年第1期16卷 127-145页

作者： Fangyi li jizhou Jiang Jiamei Wang Jing Zou Wei Sun Haitao Wang Kun Xiang Pingxiu Wu Jyh-Ping Hsu School of Environmental Ecology and Biological Engineering School of Chemistry and Environmental EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationWuhan Institute of TechnologyWuhan 430205China Semiconductor Electronic Special Gas of Hubei Engineering Research Center Jingzhou 434000China Department of Chemical Engineering “National Taiwan University”Taipei 10617

Due to their unique properties and uninterrupted breakthrough in a myriad of clean energy-related applications,carbon-based materials have received great ***,the low selectivity and poor conductivity are two primary difficulties of traditional carbon-based materials(zero-dimensional(0D)/one-dimensional(1D)/two-dimensional(2D)),enerating inefficient hydrogen production and impeding the future commercialization of carbon-based *** improve hydrogen production,attempts are made to enlarge the surface area of porous three-dimensional(3D)carbon-based materials,achieve uniform interconnected porous channels,and enhance their stability,especially under extreme *** this review,the structural advantages and performance improvements of porous carbon nanotubes(CNTs),g-C_(3)N_(4),covalent organic frameworks(COFs),metal-organic frameworks(MOFs),MXenes,and biomass-derived carbon-based materials are firstly summarized,followed by discussing the mechanisms involved and assessing the performance of the main hydrogen production *** include,for example,photo/electrocatalytic hydrogen production,release from methanolysis of sodium borohydride,methane decomposition,and *** role that the active sites of porous carbon-based materials play in promoting charge transport,and enhancing electrical conductivity and stability,in a hydrogen production process is *** current challenges and future directions are also discussed to provide guidelines for the development of next-generation high-efficiency hydrogen 3D porous carbon-based materials prospected.

关键词： porous three-dimensional(3D)carbon-based materials hydrogen production advanced synthesis

畲药十二时辰醇提物外用对大鼠佐剂性关节炎的抗炎作用研究

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中国民族民间医药 2024年第17期33卷 23-26页

作者：周春权雷婷赵立张继州蒋畅韩静王宫福建省中医药科学院福建福州350003

目的:探讨畲药“十二时辰”醇提物外用对类风湿性关节炎模型大鼠的治疗作用。方法:SD大鼠随机分为正常对照组,模型组,高、低剂量十二时辰治疗组和阳性对照组。采用大鼠右后足趾皮内注射完全弗氏佐剂制作类风湿性关节炎模型,致炎后采用... 详细信息

目的:探讨畲药“十二时辰”醇提物外用对类风湿性关节炎模型大鼠的治疗作用。方法:SD大鼠随机分为正常对照组,模型组,高、低剂量十二时辰治疗组和阳性对照组。采用大鼠右后足趾皮内注射完全弗氏佐剂制作类风湿性关节炎模型,致炎后采用十二时辰醇提液浸泡涂抹方式给药,模型组及阳性对照组分别给予生理盐水或扶他林涂抹,持续给药28 d。于给药前和给药后每7 d测定足趾容积,给药结束,HE染色检测各组大鼠的组织病理学改变,Elisa方法测定血清IL-1β及RF含量。结果:模型组大鼠在各时间点的足趾肿胀度显著高于正常对照组(P<0.05),血清IL-1β及RF含量显著升高(P<0.01),足趾关节病理破坏明显;高剂量十二时辰醇提液外用可显著降低大鼠的足趾肿胀度(P<0.05),降低血清IL-1β及RF含量(P<0.01),改善关节病理损伤。结论:畲药十二时辰醇提液外用可降低佐剂性关节炎大鼠足肿胀,改善病理损伤,降低血清炎症因子IL-1β及RF含量。

关键词：重瓣铁线莲十二时辰外用类风湿性关节炎

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硫掺杂g-C_(3)N_(4)制备及其光催化产氢性能研究

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聊城大学学报（自然科学版） 2024年第1期37卷 70-75页

作者：李星杰孙玮明邱焱刘耀程廖国东王海涛江吉周武汉工程大学新型催化材料湖北省工程研究中心湖北武汉430205

在“双碳”国家战略背景下,氢能的开发备受关注。石墨相氮化碳(g-C_(3)N_(4))因具有制备简便、带隙合适、稳定性高等优势,被认为是一种极具应用前景的产氢光催化剂。然而,在光催化体系中,纯g-C_(3)N_(4)的光生载流子转移速率较慢且易于... 详细信息

在“双碳”国家战略背景下,氢能的开发备受关注。石墨相氮化碳(g-C_(3)N_(4))因具有制备简便、带隙合适、稳定性高等优势,被认为是一种极具应用前景的产氢光催化剂。然而,在光催化体系中,纯g-C_(3)N_(4)的光生载流子转移速率较慢且易于复合,故其产氢性能通常不佳。本研究创造性地利用硫粉与尿素水溶液间的高温热聚反应,开发出一种简便且高效的硫掺杂g-C_(3)N_(4)合成策略,原位合成了二维硫掺杂g-C_(3)N_(4)纳米片(S-g-C_(3)N_(4)),系统研究了硫掺杂对g-C_(3)N_(4)光电化学性质和光催化产氢性能的影响。结果表明,硫掺杂不仅可有效增强g-C_(3)N_(4)的可见光吸收能力,而且还显著提高g-C_(3)N_(4)的光生载流子分离和转移效率。因此,S-g-C_(3)N_(4)的光催化产氢速率比纯g-C_(3)N_(4)高近10倍。

关键词： g-C_(3)N_(4) 硫粉硫掺杂光催化产氢

Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1^(high)CD11b^(+)cells elimination in hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2023年第2期13卷 632-647页

作者： jizhou Tan Ting liu Wenzhe Fan Jialiang Wei Bowen Zhu Yafang liu lingwei liu Xiaokai Zhang Songling Chen Haibiao lin Yuanqing Zhang Jiaping li Department of Interventional Oncology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Stomatology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of TraditionalChinese MedicineGuangzhou 510120China Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510006China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Cryoablation(CRA)and microwave ablation(MWA)are two main local treatments for hepatocellular carcinoma(HCC).However,which one is more curative and suitable for combining with immunotherapy is still ***,CRA induced higher tumoral PD-L1 expression and more T cells infiltration,but less PD-L1^(high)CD11b^(+)myeloid cells infiltration than MWA in ***,CRA had better curative effect than MWA for anti-PD-L1 combination therapy in mouse ***,anti-PD-L1 antibody facilitated infiltration of CD8^(+)T cells by enhancing the secretion of CXCL9 from cDC1 cells after CRA *** the other hand,anti-PD-L1 antibody promoted the infiltration of NK cells to eliminate PD-L1^(high)CD11b^(+)myeloid cells by antibody-dependent cell-mediated cytotoxicity(ADCC)effect after CRA *** aspects relieved the immunosuppressive microenvironment after CRA ***,the wild-type PD-L1 Avelumab(Bavencio),compared to the mutant PD-L1 atezolizumab(Tecentriq),was better at inducing the ADCC effect to target PD-L1^(high)CD11b^(+)myeloid ***,our study uncovered the novel insights that CRA showed superior curative effect than MWA in combining with anti-PD-L1 antibody by strengthening CTL/NK cell immune responses,which provided a strong rationale for combining CRA and PD-L1 blockade in the clinical treatment for HCC.

关键词： Hepatocellular carcinoma Immunotherapy Cryoablation Microwave ablation CXCL9 NK cells Antibody-dependent cell-mediated cytotoxicity Immunosuppressive microenvironment

Surface effects on the wrinkles in a stiff thin film bonded to a compliant substrate

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Surface effects on the wrinkles in a stiff thin film bonded ...