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Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo

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Regenerative Biomaterials 2016年第5期3卷 285-297页

作者： jinyu li Wei Zhi Taotao Xu Feng Shi Ke Duan JianxinWang Yandong Mu Jie Weng Key Laboratory of Advanced Technologies of Materials(MOE) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China and 2Dental Department Sichuan Province People’s HospitalChengdu 610072People’s Republic of China

The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different *** order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs,hydroxyapatite(HA)scaffolds with three different macro-pore sizes of 500–650,750–900 and 1100–1250 mm were prepared via sugar spheres-leaching process,which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size *** permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore *** cell growth in three scaffolds was not affected by the macro-pore *** in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed *** scaffold with macro-pore sizes of 750–900 mm exhibited much faster angiogenesis and osteogenesis,and much more uniformly distribution of new bone than those with othermacro-pore *** work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis.

关键词： hydroxyapatite scaffolds similar interconnecting structure osteogenesis angiogenesis

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A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery

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The Innovation 2024年第6期5卷 69-79页

作者： Shuaiyin liu Tianqin Ning Junlin Chen Yanzhe Fu Jiebo li jinyu li Xufeng Niu Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Orthopedic Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100007China School of Engineering Medicine Beihang UniversityBeijing 100083China

Effective disease management based on real-time physiological changes presents a significant clinical challenge.A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized *** this study,we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time *** prevent drug leakage,the system incorporates a magnesium(Mg)valve in the outer layer,ensuring zero leakage when drug release is not required.

关键词： electrode system treatment

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Petrogenesis of Jurassic Granitoids on liaodong Peninsula,Northeast China:Constraints on the Evolution of the Mongol-Okhotsk and Pacific Tectonic Regimes

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Journal of Earth Science 2021年第1期32卷 127-143页

作者： jinyu li Ye Qian Leontine Tekoumc Changji Zhao Jinlei Sun Tao Zheng Fengyue Sun Yanjie Shen College of Earth Sciences Jilin UniversityChangchun 130061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Nature ResourcesChangchun 130061China Laboratory of Geology Faculty of SciencesUniversity of N'djamenaN'djamena 1027Republic of Chad

The tectonic setting of Jurassic magmatism in the Northeast China(NE China)is ***,we present new petrological,whole-rock geochemical,zircon U-Pb geochronological,and zircon Lu-Hf isotope data for Jurassic granitoids of the Wulong region,liaodong Peninsula,NE *** ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS)zircon U-Pb data indicate that these granitoids were emplaced at 165-156 *** biotite monzogranite,two-mica monzogranite,monzogranite,granodiorite,biotite granodiorite,and syenogranite are strongly peraluminous(A/CNK=1.09-1.29),contain peraluminous minerals such as muscovite,have high normative corundum abundances(1.26 wt.%-3.28 wt.%),and have high K2_(O)/Na2O ratios(0.76-1.48),all of which indicate an S-type granite ***,the biotite granodiorite and syenogranite have high Sr(391 ppm-570 ppm)and low Y(3.06 ppm-5.94 ppm)contents,with high Sr/Y(65.8-185.9)ratios,and the two-mica monzogranite,monzogranite,and granodiorite have relatively high Sr(138 ppm-379 ppm)and low Y(3.38 ppm-8.71 ppm)contents,with high Sr/Y ratios(19.1-77.9).All of the analyzed samples have negative zircon eHf(t)values(-41.4 to-20.6)with old two-stage Hf model ages(TDM2(Hf)=2.50-3.76 Ga).Therefore,we infer that the biotite monzogranite is the typical feature of S-type granite that was derived by partial melting of *** monzogranite,two-mica monzogranite,granodiorite,biotite granodiorite,and syenogranite exhibit geochemical characteristics of S-type granite with K-rich adakitic features,and were possibly derived by mixing of melts from clastic crustal materials and ada-kitic *** are voluminous Jurassic igneous rocks in the NE *** combining our study with the previous researches,this paper infers that the Jurassic magmatism within the Erguna-Xing'an Massif was related to the southward subduction and closure of the Mongol-Okhotsk Ocean;the Early Jurassic magmatism to the east of the Songliao Basin and in the northern North

关键词： Mongol-Okhotsk Ocean Pacific Plate S-type granites adakites Northeast China

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A Visual Analytics Framework for Ocean Scalar Volume Data

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Ocean-Land-Atmosphere Research 2023年第1期2卷 173-189页

作者： jinyu li Tianyi Huang Ping Hu Weicheng Cui Shenghui Cheng Research Center for Industries of the Future and School of Engineering Westlake UniversityHangzhouChina Department of Computer Science Stony Brook UniversityStony BrookNYUSA. Key Laboratory of Coastal of Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhouChina

The processes and phenomena hidden in massive marine data importantly impact heat transportation,material transportation,and climate *** can assist people in mining and understanding marine data to gain ***,oceanographers must study ocean processes and ***,one remaining challenge in the existing visualization methods is efficiently rendering marine data with large volumes and illustrating the internal structure of marine *** solve this problem,we propose a new visual analytics framework involving 4 parts for visualizing extensive marine scalar volume *** first use a single box and double spheres separately as proxy geometries to draw a flat Earth and spherical ***,we design a new ray-casting algorithm based on graphics processing unit to reduce the volume of marine *** algorithm accelerates volume rendering by using an adaptive texture sampling rate and step ***,we use a depth correction algorithm to accurately restore the ocean ***,we develop an internal roaming algorithm to observe the internal structure of marine *** this way,users can dynamically observe the internal structure of marine *** illustrate the effectiveness of our algorithms,we use them to visualize Hybrid Coordinate Ocean Model data and Argo data.

关键词： Visual graphics rendering

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A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 423-434页

作者： Yibin Yu Ruoxi Feng jinyu li Yuanyuan Wang Yiming Song Guoxin Tan Dandan liu Wei liu Xinggang Yang Hao Pan Sanming li Shenyang Pharmaceutical University Shenyang 110016China liaoning Institute of Science and Technology Benxi 117004China Zhengzhou University Zhengzhou 450001China liaoning University Shenyang 110016China

The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery.

关键词： Ocular drug delivery Nanostructured lipid carrier Semi-IPN hydrogel

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Effect of Andalusite Addition on Properties of Chrome-corundum Bricks

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China's Refractories 2020年第2期29卷 21-24页

作者： XIA Wenbin ZHAN Huasheng li jinyu li Yanjing MA Shulong SU Yuzhu ZHANG Jili GAO Changhe Tongda Refractory Technologies Co. Ltd.Beijing 100043China

In order to improve the thermal shock resistance of chrome-corundum bricks,different amounts of andalusite were added to the formulation of chrome-corundum bricks to replace the equivalent white fused corundum with the same particle *** mixing,shaping,drying and firing,the density,the cold strength,the cold wear resistance,the hot modulus of rupture and the thermal shock resistance were ***,SEM and elemental surface scanning were used to characterize the *** results show that:(1)the volume expansion of andalusite mullitization reduces the apparent porosity of chrome-corundum bricks;(2)the density and the hardness of mullite are lower than those of corundum so the decrease of the corundum content in brick leads to the decrease of the bulk density,the strength and the cold wear resistance;(3)the cross-distributed columnar mullite in the matrix can effectively improve the hot modulus of rupture and the thermal shock resistance of the specimens;(4)considering comprehensively,the andalusite addition shall not exceed 18%.

关键词： andalusite chrome-corundum brick hazardous waste processing rotary kiln thermal shock resistance

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Influence of Multi-site Radiation of Carbon Ions on Germination and Free Radical of Sweet Sorghum

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IMP & HIRFL Annual Report 2011年第1期 118-119页

作者： He jinyu li Wenjian

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Application of Traditional Chinese Veterinary Medicine in Sheep Green Breeding

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Animal Husbandry and Feed Science 2017年第5期9卷 293-297,338页

作者： Luo Chaoying li jinyu Wang Guibo Lanzhou Institute of Husbandry & Pharmaceutics Science CAAS Lanzhou 730050 China Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province Lanzhou 730050 China

Disease control and health care with traditional Chinese veterinary medicine( TCVM) has attracted more and more attention in sheep green breeding. To promote healthy and smooth development of the work,the relationships between TCVM and antibiotics,and between TCVM and vaccines,were reviewed and analyzed. It was thought that TCVM and western medicine,such as antibiotics and vaccines,etc.,have their own characteristics and advantages,and should be mutually complemented rather than replaced. We should pay attention to the characteristics and advantages of the wholism concept and syndrome differentiation and treatment( diagnosis and treatment based on an overall analysis of the illness and the patient's condition) of TCVM,to develop and use TCVM health care agent or vaccine adjuvant,and their pertinence was improved according to different growth stages and physiological and pathological characteristics. Diagnosis and treatment based on an overall analysis of the illness and the population patient's condition must be attached importance to optimize the mode of administration,in order to adapt to disease prevention and control requirements in intensive and scale breeding of sheep.

关键词： Sheep green breeding Healthcare Traditional Chinese veterinary medicine (TCVM) Antibiotics Vaccines

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Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1092-1105页

作者： Qian Zhao Longqing Shi Weiyi He jinyu li Shijun You Shuai Chen Jing lin Yibin Wang liwen Zhang Guang Yang liette Vasseur Minsheng You State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Institute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhou 350002China Institute of Rice Fujian Academy of Agricultural SciencesFuzhou 350018China Tea Research Institute Fujian Academy of Agricultural SciencesFuzhou 350001China Center for Genomics and Biotechnology Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Biological Sciences Brock UniversitySt.CatharinesON L2S 3A1Canada

Tea green leafhopper(TGL),Empoasca onukii,is of biological and economic *** numerous studies,the mechanisms underlying its adaptation and evolution remain ***,we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded *** complete a chromosome-level assembly and annotation of the *** genome,showing notable expansions of gene families associated with adaptation to chemoreception and *** signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse *** of genetic variations among 54 *** samples unveil the population structure and evolutionary history across different tea-growing regions in *** results demonstrate that the genomic changes in key pathways,including those linked to metabolism,circadian rhythms,and immune system functions,may underlie the successful spread and adaptation of *** work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts,and provides insights into insect adaptation to host plants,which will ultimately facilitate more sustainable pest management.

关键词： Tea green leafhopper Genomic variation Population genetics Local adaptation Evolutionary history

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Investigations on Discharge and Decomposition Characteristics of SF6 Under Various Experimental Conditions

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高电压技术 2013年第8期39卷 1952-1959页

作者： WANG Yuanyuan JI Shengchang li jinyu liU Hao WANG Wei LU Xu State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University Xi'an 710049 China Shenzhen Power Supply Bureau China Southern Power Grid Co. Ltd. Shenzhen 518000 China

Detection of gas decomposition products is widely used for condition diagnosis of SF6-insulated equipment because of its an- ti-electromagnetic-interference ability and high sensitivity. Previous investigations show that the volume of gas chamber influences the types and concentrations of SF6 decomposition products. Therefore using a newly developed dual gas chromatography (GC) detection sys- tem we investigated the discharge and decomposition of SF6 in a discharge chamber with its volume close to that of the real chambers in GIS. Tests in the chamber were performed with different applied voltage, different electrode arrangements, and different defect types. For discharge between needle-to-plane electrodes, the typical gas decomposition products are SO2F2, SO2 and S2OF10. A near linear growth with the increase of voltage duration is found in the concentration of SO2F2, whereas the growth rates of SO2 and S2OF10 concentration decrease with time. Concentrations of SO2F2, SO2 and S2OF10 at the same voltage duration decrease with the decrease of the voltage amplitude and the increase of the needle-to-plane distance. Change of the gas chamber volume affects the generation rates of SO2F2 and SO2, however not S2OF10. For insulator surface defects, the typical gas decomposition products are CF4, CS2 and SO2. Among which, the concentrations of CF4 and SO2 increase with the voltage duration almost linearly. Moreover, a new parameter that represents the degree of SF6 degradation, the SF6 deterioration ratio, is proposed. In the needle-to-plane case, SF6 deterioration ratio is positively correlated to the fitting value of an averaged discharge capacity. However, the maximum value of SF6 deterioration ratio varies with the defect type.

关键词： SF6气体分解特性放电室实验条件气体绝缘设备分解产物平面电极持续时间

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