检索结果-南通市图书馆

Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi Qing liU li Qun HUANG De Qin WANG Yu Tong li jing jie ZHANG Zheng WANG Xi Xi liU Chuan ling ZHANG Ya Di SHAO Jia Kang ZHU Yi Min CHEN Yi Meng liU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(Plinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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藏东多曲河流域锶富集水化学特征及控制因素

环境科学 2024年第4期45卷 2067-2079页

作者：李敬杰连晟王明国张智印张涛中国地质调查局水文地质环境地质调查中心保定071051

分析高原河流地表水中锶(Sr)富集的水化学特征及其影响因素,有助于指导水资源的合理开发利用和生态环境保护.以金沙江多曲河流域地表水为例,采集地表水样品23组,综合利用相关分析、主成分分析、Gibbs模型和离子比等方法,分析该区地表水... 详细信息

分析高原河流地表水中锶(Sr)富集的水化学特征及其影响因素,有助于指导水资源的合理开发利用和生态环境保护.以金沙江多曲河流域地表水为例,采集地表水样品23组,综合利用相关分析、主成分分析、Gibbs模型和离子比等方法,分析该区地表水中Sr^(2+)富集的水化学特征及控制因素,识别主要离子的物质来源.结果表明,多曲河流域地表水阳离子主要以Ca^(2+)和Mg^(2+)为主,阴离子以HCO_(3)^(-)为主.该流域水化学类型以HCO_(3)-Ca型为主,其次为HCO_(3)-Ca·Mg型.主成分分析揭示了影响多曲河水质演化的3个主成分因子,碳酸盐岩风化溶解是控制多曲河水化学组成的主要因素.ρ(Sr^(2+))超过0.40 mg·L^(-1)的富Sr水点占样品总量的30.43%.区内分布的闪长岩及花岗岩为多曲河流域Sr^(2+)富集提供了物质基础.Sr^(2+)与Ca^(2+)相关性较高,二者存在伴生和共同富集现象.地表水在发生一定的反向离子交换作用Sr^(2+)从围岩中的释出是水体中Sr^(2+)富集的来源之一.工矿活动辰砂矿物的开采是造成附近地表水点SO_(4)^(2-)升高的主要因素,同时也促进了Sr^(2+)在水环境中的富集.受控于岩石风化作用、人类活动及工矿活动的综合影响,沿程Sr^(2+)质量浓度整体上呈现增加趋势.

关键词：多曲河 Sr富集水化学特征离子来源风化溶解人类活动

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和平共处视域下的人类命运共同体构建

哈尔滨师范大学社会科学学报 2024年第4期15卷 28-32页

作者：李晶洁华中师范大学政治与国际关系学院湖北武汉430079 荆楚理工学院马克思主义学院湖北荆门448000

人类命运共同体理念是以相互尊重、相互依赖、包容互鉴、合作共赢等为主要内容的全球价值观。“构建人类命运共同体”是应时代之变提出的中国方案,是回答时代之问的中国答卷,也是和平共处思想在国际关系问题以及全球性问题上的创造性应... 详细信息

人类命运共同体理念是以相互尊重、相互依赖、包容互鉴、合作共赢等为主要内容的全球价值观。“构建人类命运共同体”是应时代之变提出的中国方案,是回答时代之问的中国答卷,也是和平共处思想在国际关系问题以及全球性问题上的创造性应用。在和平共处的理论视域下探寻构建人类命运共同体的实践进路,要秉持平等互利的原则、打造利益共同体,传递国际民主的理念、形成信任共同体,达成安危与共的共识、结成安全共同体,弘扬全人类共同价值、共筑价值共同体,在“共商共建”的基础上建立一个“共享”的国际关系新秩序。

关键词：和平共处人类命运共同体国际关系

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Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of Iron and Steel Research International 2024年第1期31卷 108-120页

作者： Zi-han Wang jing Guo Han-jie Guo Bin li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics Zinc removal Iron reduction High-temperature reduction roasting Integrated utilization

PACS2基因变异致婴儿癫癎性脑病(附1例报告及文献复习)

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中国临床神经科学 2024年第1期32卷 51-56页

作者：刘康王薇刘学芳李静洁孙素真河北医科大学附属河北省儿童医院神经内科石家庄050031 河北省小儿癫癎与神经疾病重点实验室石家庄050031

目的探讨PACS2基因变异致婴儿癫癎性脑病的临床特征及基因变异特点。方法回顾性分析1例PACS2基因变异相关婴儿癫癎性脑病患儿的临床资料,并复习相关文献进行讨论。结果患儿为女性,11月龄,因“反复抽搐发作1个月”入院。患儿起病前发育... 详细信息

目的探讨PACS2基因变异致婴儿癫癎性脑病的临床特征及基因变异特点。方法回顾性分析1例PACS2基因变异相关婴儿癫癎性脑病患儿的临床资料,并复习相关文献进行讨论。结果患儿为女性,11月龄,因“反复抽搐发作1个月”入院。患儿起病前发育基本正常。入院后相关检查:心肌酶轻度增高,视频脑电图显示醒期和睡期双侧后头部阵发2 Hz慢波,清醒期阵发双侧后颞区快波节律,有时可演变为棘波节律。血、尿遗传代谢病筛查未见异常。家系全外显子组基因测序发现患儿PACS2基因存在c.598G>A(***200Lys)新发杂合变异(NM_001100913.3),Sanger测序验证其父母均未检测到该基因变异。予以左乙拉西坦与丙戊酸钠联合治疗后癫癎发作控制,运动发育基本正常,语言发育显著落后。结论PACS2基因c.598G>A变异是婴儿癫癎性脑病的致病性变异,该变异位点既往未见报道,扩充了PACS2基因变异谱。

关键词： PACS2基因婴儿癫癎性脑病全外显子组测序

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广东省船舶二氧化碳排放驱动因素与减排潜力

环境科学 2024年第1期45卷 115-122页

作者：翁淑娟刘颍颖唐凤沙青娥彭勃王烨嘉陈诚张雪驰李京洁陈豪琪郑君瑜宋献中暨南大学环境与气候研究院广州511443 暨南大学广州区域低碳经济研究基地广州511443 广东省海洋发展规划研究中心广州510220 中国电建集团贵阳勘测设计研究院有限公司贵阳650011 香港科技大学(广州)可持续能源与环境学域广州510000 暨南大学管理学院广州510632

船舶是广东省二氧化碳(CO_(2))的重要排放来源,研究广东省船舶CO_(2)排放的历史变化趋势、驱动因素和减排途径,可为广东省制定碳达峰与碳中和路径提供科学依据.采用排放因子法估算广东省船舶CO_(2)排放量,利用对数平均指数法(LMDI)识别... 详细信息

船舶是广东省二氧化碳(CO_(2))的重要排放来源,研究广东省船舶CO_(2)排放的历史变化趋势、驱动因素和减排途径,可为广东省制定碳达峰与碳中和路径提供科学依据.采用排放因子法估算广东省船舶CO_(2)排放量,利用对数平均指数法(LMDI)识别排放驱动因素,并结合情景分析法探究船舶CO_(2)的减排途径.结果表明:(1)2006~2020年广东省船舶CO_(2)排放量从331.94万t增加至639.29万t,其中干散货船和集装箱船是导致排放增加的主要船型.(2)2006~2020年广东省船舶CO_(2)排放的关键正向驱动因素是运输强度(51%)和经济因素(49%),主要负向驱动因素是能源强度(93%)和货类结构(7%).(3)到2030年,如果广东省船舶运输保持当前政策(基准情景)发展,将无法实现碳达峰.(4)到2060年,同时考虑优化能源结构和降低能源强度(节能低碳情景),相比于基准情景有56.51%的CO_(2)减排潜力.可为广东省制定船舶航运行业碳达峰与碳中和管控策略提供科学依据.

关键词：广东省船舶二氧化碳排放清单驱动因素情景分析

MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

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Current Medical Science 2024年第1期44卷 195-211页

作者： Xiang-li PANG jie li jing WANG Si-si YAN jing YANG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China Reproductive Medical Center Renmin Hospital of Wuhan UniversityWuhan 430060China Clinic Research Center for Assisted Reproductive Technology and Embryonic Development in Hubei Province Wuhan 430060China

Objective Innate lymphoid cells(ILCs)are a class of newly discovered *** 1 ILCs(ILC1s)are identified in the decidua of humans and *** mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related ***,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling *** study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling *** Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different *** targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were *** addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,EliSA,and RT-PCR,***,changes of the NF-κB signaling pathway in ILC1s were examined in the different *** the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling *** The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all Pling pathway(Pling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion

关键词： maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p abortion

Optimal mining sequence for coal faces under a bedding slope:insight from landslide prevention

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Journal of Mountain Science 2024年第5期21卷 1775-1798页

作者： li Qingmiao ZHAO Jianjun li Zhichao DENG jie ZUO jing LAI Qiyi State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

Repetitive mining beneath bedding slopes is identified as a critical factor in geomorphic disturbances, especially landslides and surface subsidence. Prior research has largely concentrated on surface deformation in plains due to multi-seam coal mining and the instability of natural bedding slopes, yet the cumulative impact of different mining sequences on bedding slopes has been less explored. This study combines drone surveys and geological data to construct a comprehensive three-dimensional model of bedding slopes. Utilizing FLAC3D and PFC2D models, derived from laboratory experiments, it simulates stress, deformation, and failure dynamics of slopes under various mining sequences. Incorporating fractal dimension analysis, the research evaluates the stability of slopes in relation to different mining sequences. The findings reveal that mining in an upslope direction minimizes disruption to overlying strata. Initiating extraction from lower segments increases tensile-shear stress in coal pillar overburdens, resulting in greater creep deformation towards the downslope than when starting from upper segments, potentially leading to localized landslides and widespread creep deformation in mined-out areas. The downslope upward mining sequence exhibits the least fractal dimensions, indicating minimal disturbance to both strata and surface. While all five mining scenarios maintain good slope stability under normal conditions, recalibrated stability assessments based on fractal dimensions suggest that downslope upward mining offers the highest stability under rainfall, contrasting with the lower stability and potential instability risks of upslope downward mining. These insights are pivotal for mining operations and geological hazard mitigation in multi-seam coal exploitation on bedding slopes.

关键词： Bedding rock landslides Mining-induced deformation Bedding slope stability Underground mining sequences Fractal-based strength reduction method

Temporal assembly patterns of microbial communities in three parallel bioreactors treating low-concentration coking wastewater with differing carbon source concentrations

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Journal of Environmental Sciences 2024年第3期137卷 455-468页

作者： Weijia li Yu Xia Na li jie Chang jing liu Pei Wang Xuwen He School of Chemical and Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China

Carbon source is an important factor of biological treatment systems, the effects of which on their temporal community assembly patterns are not sufficiently understood *** this study, the temporal dynamics and driving mechanisms of the communities in three parallel bioreactors for low-concentration coking wastewater(CWW) treatment with differing carbon source concentrations(S0 with no glucose addition, S1 with 200 mg/L glucose addition and S2 with 400 mg/L glucose addition) were comprehensively studied. Highthroughput sequencing and bioinformatics analyses including network analysis and Infer Community Assembly Mechanisms by Phylogenetic bin-based null model(iCAMP) were used. The communities of three systems showed turnover rates of 0.0029~0.0034 every 15days. Network analysis results showed that the S0 network showed higher positive correlation proportion(71.43%) and clustering coefficient(0.33), suggesting that carbon source shortage in S0 promoted interactions and cooperation of microbes. The neutral community model analysis showed that the immigration rate increased from 0.5247 in S0 to 0.6478in S2. The iCAMP analysis results showed that drift(45.89%) and homogeneous selection(31.68%) dominated in driving the assembly of all the investigated microbial *** contribution of homogeneous selection increased with the increase of carbon source concentrations, from 27.92% in S0 to 36.08% in S2. The OTUs participating in aerobic respiration and tricarboxylic acid(TCA) cycle were abundant among the bins mainly affected by deterministic processes, while those related to the metabolism of refractory organic pollutants in CWW such as alkanes, benzenes and phenols were abundant in the bins dominated by stochastic processes.

关键词： Coking wastewater treatment Temporal dynamics Network analysis Deterministic processes Stochastic processes

SciCN:A Scientific Dataset for Chinese Named Entity Recognition

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Computers, Materials & Continua 2024年第3期78卷 4303-4315页

作者： jing Yang Bin Ji Shasha li Jun Ma jie Yu College of Computer National University of Defense TechnologyChangsha410073China

Named entity recognition(NER)is a fundamental task of information extraction(IE),and it has attracted considerable research attention in recent *** abundant annotated English NER datasets have significantly promoted the NER research in the English *** contrast,much fewer efforts are made to the Chinese NER research,especially in the scientific domain,due to the scarcity of Chinese NER *** alleviate this problem,we present aChinese scientificNER dataset–SciCN,which contains entity annotations of titles and abstracts derived from 3,500 scientific *** manually annotate a total of 62,059 entities,and these entities are classified into six *** to English scientific NER datasets,SciCN has a larger scale and is more diverse,for it not only contains more paper abstracts but these abstracts are derived from more research *** investigate the properties of SciCN and provide baselines for future research,we adapt a number of previous state-of-theart Chinese NER models to evaluate *** results show that SciCN is more challenging than other Chinese NER *** addition,previous studies have proven the effectiveness of using lexicons to enhance Chinese NER *** by this fact,we provide a scientific domain-specific *** results demonstrate that our lexicon delivers better performance gains than lexicons of other *** hope that the SciCN dataset and the lexicon will enable us to benchmark the NER task regarding the Chinese scientific domain and make progress for future *** dataset and lexicon are available at:https://***/yangjingla/***.

关键词： Named entity recognition dataset scientific information extraction lexicon