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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen Aharonian, F. Axikegu Bai, Y.X. Bao, Y.W. Bastieri, D. Bi, X.J. Bi, Y.J. Bian, W. Bukevich, A.V. Cao, Q. Cao, W.Y. Cao, Zhe Chang, J. Chang, J.F. Chen, A.M. Chen, E.S. Chen, H.X. Chen, liang Chen, lin Chen, Long Chen, M.J. Chen, M.L. Chen, Q.H. Chen, S. Chen, S.H. Chen, S.Z. Chen, T.L. Chen, Y. Cheng, N. Cheng, Y.D. Cui, M.Y. Cui, S.W. Cui, X.H. Cui, Y.D. Dai, B.Z. Dai, H.L. Dai, Z.G. Danzengluobu Dong, X.Q. Duan, K.K. Fan, J.H. Fan, Y.Z. Fang, J. Fang, J.H. Fang, K. Feng, C.F. Feng, H. Feng, L. Feng, S.H. Feng, X.T. Feng, Y. Feng, Y.L. Gabici, S. Gao, B. Gao, C.D. Gao, Q. Gao, W. Gao, W.K. Ge, M.M. Geng, L.S. Giacinti, G. Gong, G.H. Gou, Q.B. Gu, M.H. Guo, F.L. Guo, X.L. Guo, Y.Q. Guo, Y.Y. Han, Y.A. Hasan, M. He, H.H. He, H.N. He, J.Y. He, Y. Hor, Y.K. Hou, B.W. Hou, C. Hou, X. hu, H.B. hu, Q. hu, S.C. huang, D.H. huang, T.Q. huang, W.J. huang, X.T. huang, X.Y. huang, Y. Ji, X.L. jia, H.Y. jia, K. jiang, K. jiang, X.W. jiang, Z.J. Jin, M. Kang, M.M. Karpikov, I. Kuleshov, D. Kurinov, K. li, B.B. li, C.M. li, Cheng li, Cong li, D. li, F. li, H.B. li, H.C. li, jian li, Jie li, K. li, S.D. li, W.L. li, X.R. li, Xin li, Y.Z. li, Zhe li, Zhuo liang, E.W. liang, Y.F. lin, S.J. liu, B. liu, C. liu, D. liu, D.B. liu, H. liu, H.D. liu, J. liu, J.L. liu, M.Y. liu, R.Y. liu, S.M. liu, W. liu, Y. liu, Y.N. Luo, Q. Luo, Y. Lv, H.K. Ma, B.Q. Ma, L.L. Ma, X.H. Mao, J.R. Min, Z. Mitthumsiri, W. Mu, H.J. Nan, Y.C. Neronov, A. Ou, L.J. Pattarakijwanich, P. Pei, Z.Y. Qi, J.C. Qi, M.Y. Qiao, B.Q. Qin, J.J. Raza, A. Ruffolo, D. Sáiz, A. Saeed, M. Semikoz, D. Shao, L. Shchegolev, O. Sheng, X.D. Shu, F.W. Song, H.C. Stenkin, yu.V. Stepanov, V. Su, Y. Sun, D.X. Sun, Q.N. Sun, X.N. Sun, Z.B. Takata, J. Tam, P.H.T. Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China university of Chinese Academy of Sciences Beijing 100049 China TIANFU Cosmic Ray Research Center Chengdu China Dublin Institute for Advanced Studies 31 Fitzwilliam Place 2 Dublin Ireland Max-Planck-Institut for Nuclear Physics P.O. Box 103980 Heidelberg 69029 Germany school of Physical Science and Technology & school of Information Science and Technology Southwest Jiaotong University Chengdu 610031 China school of Astronomy and Space Science Nanjing University Nanjing 210023 China Center for Astrophysics Guangzhou University Guangzhou 510006 China Tsung-Dao Lee Institute & school of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312 Russia Hebei Normal university Shijiazhuang 050024 China university of Science and Technology of china Hefei 230026 China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Center for Astronomical Computing Zhejiang Laboratory Hangzhou 311121 China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China school of Physics and Astronomy Yunnan University Kunming 650091 China Key Laboratory of Cosmic Rays (Tibet university) Ministry of Education Lhasa 850000 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China school of Physics and Astronomy (Zhuhai) & school of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China Institute of Frontier and

The γ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays (CRs) accelerated by the shock of supernova remnant (SNR) W51C and the dense molecular clouds in the adjacent star-forming region, W51B. However, the maximum acceleration capability of W51C for CRs remains elusive. Based on observations conducted with the Large High Altitude Air Shower Observatory (LHAASO), we report a significant detection of γ rays emanating from the W51 complex, with energies from 2 to 200 TeV. The LHAASO measurements, for the first time, extend the γ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of TeV. By combining the "π0-decay bump" featured data from Fermi-LAT, the broadband γ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision model. The observed spectral bending feature suggests an exponential cutoff at ∼400 TeV or a power-law break at ∼200 TeV in the CR proton spectrum, most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV regime. Additionally, two young star clusters within W51B could also be theoretically viable to produce the most energetic γ rays observed by LHAASO. Our findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs. © 2024 Science china Press

关键词： Cosmic rays

Nutritional Assessment of Gynecological Cancer Patients in china

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Journal of Nutritional Oncology 2017年第3期2卷 145-152页

作者： Wen Ying li Guo Lan Gao Chun hua Song Chang Wang Zeng Qing Guo yuan lin Ying Ying Shi Wen hu Yi Ba Su Yi li Zeng Ning li Kun hua Wang Jing Wu Ying He jia Jun Yang Fu Xiang Zhou Cong hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi hua Chen Ming hua Cong jian Xiong Wu Chun ling Zhou Wei Wang Qi Luo ong Mei Shi yu Mei Qi Hai Ping jiang Wen Xian Guan Jun Qiang Chen jia Xin Chen yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao li Jun Wen Ou Qing Chuan Zhao Zhen Ming Fu Hong Xia Xu Wei li Han Ping Shi Investigation on nutrition status and its clinical outcome of common cancers (INSCOC) group Department of Obstetrics and Gynecology Aviation General HospitalChaoyang DistrictBeijingChina Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhui 230031China Department of Clinical Nutrition the First Hospital of Hefei Medical UniversityShijiazhuangHebei 050031China Department of Gastrointestinal Surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Clinical Nutrition the First People’s Hospital of KashiXinjiang 844000China Zhongshan Chenxinghai Hospital(Affiliated ZhongshanChenxinghai Hospital of Guangdong Medical university) ZhongshanGuangdong 528400China Department of Clinical Nutrition Chongqing General HospitalChongqing 40014China Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhouGuangdong 516001China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebei 054031China The First Department of Tumor Hospital of Harbin Medical university HarbinHeilongjiang 150085China College of Medicine Chinese Academy of SciencesHuairou DistrictBeijingChina Department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Oncology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhouHenan 450008China Department of General Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Comprehensive Oncology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Abdominal Surgery Department Cancer Institute and HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100021China The Fourth Affiliated Hospital Harbin Medical UniversityHarbinHeilongjiang 150001China Cancer Center the First People’s Hospital of

Background Malnutrition is common among cancer patients,but few studies have evaluated the nutritional status among gynecological cancer patients in *** study aimed to assess the nutritional status of women with gynecological cancer using the patient-generated subjective global assessment(PG-SGA).Methods Data for gynecological cancer patients treated at 44 tertiary hospitals were retrieved from a multicenter study on tumor *** R software was used for statistical *** analyses of PG-SGA scores were performed using the Chi-squared test for categorical variables and the Wilcoxon-rank sum test or Kruskal-Wallis test for continuous variables,as *** significance level was *** Data for 1962 women with three types of gynecological cancer(cervical,uterine and ovarian cancer)were used for the data *** median PG-SGA score was 4(interquartile range,IQR:1,8),the median participants’age was 51(IQR:46,59)years old,and the patients had a median BMI of 22.9(IQR:20.7,25.4).The percentages of women who had a medical co-morbidity,or had undergone any radical resection,chemotherapy,or radiotherapy were approximately 27.7%,55.4%,52.5%,and 30.2%,*** levels of serum albumin and high density lipoprotein cholesterol(HDL-C)were 40.1g/L(IQR:36.8,43.1)and 1.2mmol/L(IQR:1.0,1.5),*** identified risk factors for malnutrition based on the PG-SGA score were age(0.05±0.01,p=0.002),BMI(-0.34±0.04,p2±0.31,p2±0.35,p=0.001)as indicated by a linear regression *** A higher PG-SGA score is positively associated with the age of the patient,having a medical co-morbidity,and receiving radiotherapy,and is negatively related to the patients’BMI and serum albumin and HDL-C levels.

关键词： Albumin Gynecological cancer HDL-C Malnutrition Patient-generated Subjective Global Assessment

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong hui Gong Oleg Gorchakov yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile beijing Institute of Spacecraft Environment Engineering BeijingChina beijing Normal university BeijingChina china Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North china Electric Power university BeijingChina school of Physics Peking UniversityBeijingChina tsinghua university BeijingChina university of Chinese Academy of Sciences BeijingChina Jilin university ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing university ChongqingChina Dongguan university of Technology DongguanChina Jinan university GuangzhouChina Sun Yat-Sen university GuangzhouChina Harbin Institute of Technology HarbinChina university of Science and Technology of china HefeiChina The Radiochemistry and Nuclear Chemistry Group in university of South china HengyangChina Wuyi university JiangmenChina Shandong university JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing university NanjingChina Guangxi university NanningChina East china university of Science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai university TianjinChina Wuhan university WuhanChina Xi’an jiaotong university Xi’anChina Xiamen university XiamenChina school of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung university Hsinchu National United university Miao-Li Department of Physics National T

The jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

基于META分析的肺结核患者按病种支付方式实施效果研究

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中国卫生政策研究 2022年第1期15卷 50-56页

作者：张婧怡高广颖胡星宇邓茜张达田佳帅张礼亮首都医科大学公共卫生学院北京100069

目的:收集近20年来国内外学者发表的按病种支付方式下肺结核患者补偿情况的研究,并进行循证医学分析,探寻支付方式对肺结核患者疾病经济负担的作用效果。方法:以"肺结核/结核病"和"支付方式"为关键词,从中国知网、PubMed等数据库检索文... 详细信息

目的:收集近20年来国内外学者发表的按病种支付方式下肺结核患者补偿情况的研究,并进行循证医学分析,探寻支付方式对肺结核患者疾病经济负担的作用效果。方法:以"肺结核/结核病"和"支付方式"为关键词,从中国知网、PubMed等数据库检索文献,根据纳入排除标准,利用NoteExpress软件对文献进行筛选,采用RevMan5.3软件对符合条件的研究结果进行Meta分析。结果:305篇文献中,仅有10篇文献符合纳入标准,对报销比例这一结局指标进行循证医学分析得到的合并RR值为1.20,95%的可信区间为[1.11,1.30];对个人自付费用指标进行分析,SMD为-5.56,95%的可信区间为[-10.05,-1.06]。但是,对医疗总费用这一结局指标进行分析,发现试点后患者医疗总费用与试点前的差异无统计学意义。结论:按病种支付在一定程度上有利于降低肺结核患者负担,但还应进一步完善其支付模式,探寻适合我国肺结核防控的支付方式。

关键词：肺结核医保支付模式 Meta分析

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong hui Gong yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu yu Gu Mengyun Guan yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth yuekun Heng Rafael Herrera yuenKeung Ho Yerevan Physics Institute YerevanArmenia Universiélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile beijing Institute of Spacecraft Environment Engineering BeijingChina beijing Normal university BeijingChina china Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North china Electric Power university BeijingChina school of Physics Peking UniversityBeijingChina tsinghua university BeijingChina university of Chinese Academy of Sciences BeijingChina Jilin university ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing university ChongqingChina Dongguan university of Technology DongguanChina Jinan university GuangzhouChina Sun Yat-Sen university GuangzhouChina Harbin Institute of Technology HarbinChina university of Science and Technology of china HefeiChina The Radiochemistry and Nuclear Chemistry Group in university of South china HengyangChina Wuyi university JiangmenChina Shandong university JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing university NanjingChina Guangxi university NanningChina East china university of Science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai university TianjinChina Wuhan university WuhanChina Xi'an jiaotong university Xi'anChina Xiamen university XiamenChina school of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

数字化方法复制暂时修复体[牙合]面形态在重度磨耗病例中的应用

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北京大学学报（医学版） 2021年第1期53卷 62-68页

作者：李峥柳玉树王时敏张瑞贾璐叶红强胡文杰赵文艳刘云松周永胜北京大学口腔医学院·口腔医院修复科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院第二门诊部国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院义齿加工中心国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院牙周科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 银川市口腔医院口腔种植科银川750002

目的:探索数字化方法复制暂时修复体牙合面形态在牙齿重度磨耗病例中的应用,以减少最终修复体的调牙合难度,节约临床时间,提升修复的精准度。方法:选择2016年1月至2020年1月因牙齿重度磨耗在北京大学口腔医院修复科就诊的患者12例,实验... 详细信息

目的:探索数字化方法复制暂时修复体牙合面形态在牙齿重度磨耗病例中的应用,以减少最终修复体的调牙合难度,节约临床时间,提升修复的精准度。方法:选择2016年1月至2020年1月因牙齿重度磨耗在北京大学口腔医院修复科就诊的患者12例,实验组(6例)最终修复体制作时应用数字化复制暂时修复体牙合面形态,对照组(6例)应用传统方法制作最终修复体,分别记录两种方法制作最终修复体的调牙合时间、患者复诊次数并进行统计学分析;由患者对初戴修复体和戴用修复体3个月后的咬合舒适度进行评分,比较两种方法制作的最终修复体咬合舒适度的差异。结果:实验组正中牙合和非正中牙合平均每个牙冠调牙合时间的均值均显著低于对照组(P1),实验组患者平均复诊次数低于对照组,差异具有统计学意义(P1);初戴时实验组患者对最终修复体的咬合舒适度评分中位数均高于对照组(P1),戴冠3个月后实验组患者对最终修复体的咬合舒适度评分中位数高于对照组,差异具有统计学意义(P<0.05)。结论:在本研究条件下,应用数字化方法复制暂时修复体牙合面形态的设计方法具有可行性,有利于降低重度磨耗病例修复的调牙合难度并达到可预测的功能和美学效果,对节约临床时间,提升修复精准度有重要意义。

关键词：数字技术计算机辅助设计生物复制功能牙磨耗

国内中医住院病案首页质量分析与影响因素初探

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中国中医药信息杂志 2016年第12期23卷 6-10页

作者：谢佳东赵玉凤胡孔法李国正刘保延南京中医药大学信息技术学院江苏南京210023 中国中医科学院北京100700

目的通过分析国内中医住院病案首页填报质量的影响因素,探索提高中医病案首页填报质量方法。方法首先,根据数据纳入标准,从1800万份中医住院病案首页数据中筛选出3 310 872份;其次,采用SAS9.3软件及指标判定标准,分层统计性别、年龄、... 详细信息

目的通过分析国内中医住院病案首页填报质量的影响因素,探索提高中医病案首页填报质量方法。方法首先,根据数据纳入标准,从1800万份中医住院病案首页数据中筛选出3 310 872份;其次,采用SAS9.3软件及指标判定标准,分层统计性别、年龄、入院科室、住院时间、出院科室、总费用、中医临床路径、中医诊疗设备、中西医主要诊断编码指标的缺失构成比与正确构成比,从病案首页基本信息、住院基本信息、费用信息、中医特色信息、诊断手术信息5个方面概述中医病案首页填报质量;最后,通过鱼骨图法,分析影响病案首页填报质量因素,并给出可以提高病案首页填报质量方法。结果性别缺失率0.000 0%、正确率99.993 2%,年龄缺失率0.116 2%、正确率99.868 3%,入院科室缺失率1.131 9%、正确率97.818 3%,住院时间缺失率0.243 0%、正确率99.749 2%,出院科室缺失率0.522 2%、正确率97.932 6%,总费用缺失率0.419 2%、正确率97.917 2%,中医临床路径缺失率0.662 6%、正确率99.130 2%,中医诊疗设备缺失率0.000 0%、正确率99.999 8%。结论国内中医住院病案首页中基本信息、住院基本信息、费用信息、中医特色信息的填报缺失率较低、正确率较高,而中西医诊断手术、中西医主要诊断编码等信息填报缺失率较高、正确率较低。

关键词：中医病案首页质量分析影响因素鱼骨图

基于“通路-疾病”交互网络的葛根芩连汤及其指标成分组合物干预小鼠溃疡性结肠炎相关结肠癌的作用

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中草药 2020年第19期51卷 4991-4998页

作者：徐蓓蕾吴迪杨娜娜韩晓宇刘晶晶胡扬杨波热增才旦孙向明阎新佳孙志伟张琰梁伟李文兰哈尔滨商业大学药学院黑龙江哈尔滨150076 抗肿瘤天然药物教育部工程研究中心黑龙江哈尔滨150076 黑龙江省预防与治疗老年性疾病药物研究重点实验室黑龙江哈尔滨150076 中国食品药品检定研究院北京100050 青海民族大学药学院青海西宁810007

目的建立溃疡性结肠炎相关结肠癌(UCRCC)与NF-κB信号通路的网络模型,预测UCRCC的关键炎性靶标,明确葛根芩连汤及其指标成分组合物对这些靶标的影响。方法采用HPLC法,流动相为乙腈-0.2%磷酸水溶液,梯度洗脱,测定10种指标成分;检索Pubmed... 详细信息

目的建立溃疡性结肠炎相关结肠癌(UCRCC)与NF-κB信号通路的网络模型,预测UCRCC的关键炎性靶标,明确葛根芩连汤及其指标成分组合物对这些靶标的影响。方法采用HPLC法,流动相为乙腈-0.2%磷酸水溶液,梯度洗脱,测定10种指标成分;检索Pubmed、ScienceDirect等数据库,分别查阅UCRCC疾病、NF-κB通路的上下游蛋白,采用Cytoscape软件,预测UCRCC的关键炎性靶标;在AOM/DSS诱导的UCRCC小鼠模型中,通过免疫组化、EliSA方法明确葛根芩连汤及其指标成分组合物对关键炎性靶标的影响。结果葛根芩连汤中葛根素、大豆苷、甘草苷、药根碱、黄芩苷、巴马汀、小檗碱、黄芩素、甘草酸、汉黄芩素的含量分别为1.677、0.154、0.159、0.045、0.448、0.035、0.095、0.013、0.111、0.006μg/g。交互网络中综合排名较高的前8位炎症因子分别是NF-κBp65、i NOS、COX-2、Bcl-2、TNF-α、IL-1β、ICAM-1和VCAM-1。与模型组比较,葛根芩连汤低、中、高剂量组及其指标成分组合物组、美沙拉秦肠溶片(5-ASA)组均显著下调UCRCC模型小鼠结肠组织中NF-κBp65、i NOS、Bcl-2、COX-2蛋白表达(P1),并显著降低血清中TNF-α、IL-1β、ICAM-1、VCAM-1水平(P1)。结论葛根芩连汤及其指标成分组合物能够改善UCRCC小鼠结肠组织病理情况,并下调炎性因子的表达,对UCRCC具有一定的干预作用,为确定葛根芩连汤质量标志物(Q-marker)奠定了基础。

关键词：葛根芩连汤溃疡性结肠炎相关结肠癌 NF-κB通路指标成分组合物网络药理学质量标志物