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Acupuncture on intrauterine growth restriction associated brain injury:case study including use of magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2023年第3期43卷 602-605页

作者： XIN Zhixiong li jiyuan XU Yanni liNG Jing JIANG Min YU Yutian Department of Pediatrics People's Hospital of Sanshui DistrictFoshan 528000China Department of MRI Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Ninth School of Clinical Medicine Peking UniversityBeijing 100038China Foshan Minfound Medical Imaging Diagnostic Center Foshan 528000China Department of Gynecology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China Acupuncture Department Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Brain injury due to intrauterine growth restriction(IUGR) is a thorny clinical problem that often leads to permanent neurological deficits such as cerebral *** practical therapies can treat an IUGR-associated brain *** employed acupuncture to treat a 6-month-old male patient with severe hypoxic-ischemic encephalopathy(HIE) due to IUGR,as confirmed by magnetic resonance imaging(MRI).Three courses of acupuncture treatment significantly improved some of the patient’s clinical characteristics,such as his insensitive responsiveness and motor deficits,with remarkably reversed HIE features on MRI at 1-year of *** case suggests that acupuncture is a potential treatment option for an IUGRassociated brain injury and warrants further investigation.

关键词： acupuncture fetal growth retardation brain injuries hypoxia-ischemia brain magnetic resonance imaging neuronal plasticity

Promoting di-isobutene selectivity over ZnO/ZrO_(2)-SO_(4) in isobutene oligomerization

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Chinese Journal of Chemical Engineering 2021年第10期34卷 165-171页

作者： jiyuan li Mifen Cui Zhuxiu Zhang Xian Chen Qing liu Zhaoyang Fei Jihai Tang Xu Qiao State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM) Nanjing 210009China

Isooctane attracts great interest in recent years because of its promising potential as friendlyenvironmental gasoline,which is obtained by dimerization of isobutene with a hydrogenation ***,a solid acid catalyst sulfated zirconia modified by ZnO was *** oligomerization of isobutene had been investigated over ZrO_(2)-SO_(4) and ZnO(X)/ZrO_(2)-SO_(4) catalyst in order to find efficient catalysts for the production of isobutene *** presence of ZnO obviously enhanced the dimerization of isobutene and ZnO(X)/ZrO_(2)-SO_(4) exhibited the highest di-isobutene yield of 60%.Kinetic studies showed the higher trimerization-to-dimerization activation energy ratios of ZnO(X)/ZrO_(2)-SO_(4) than those of ZrO_(2)-SO_(4) from 353 to 393 *** addition,reaction rate of dimerization was higher than trimerization over ZnO(X)/ZrO_(2)-SO_(4).The high L/B ratio manifested the capability to enhance the selectivity of C8 in isobutene ***,ZnO(X)/ZrO_(2)-SO_(4) exhibited stable conversion for the dimerization of isobutene.

关键词： Sulfated zirconia Zinc oxide Isobutene Selectivity Chemical reaction Catalysis

A MATHEMATICAL ANALYSIS FOR A DIFFUSIVE EPIDEMIC MODEL WITH CRISS-CROSS DYNAMICS

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Applied Mathematics(A Journal of Chinese Universities) 1999年第4期14卷 389-400页

作者： li Zhengyuan\ Tao jiyuan\ Ye Qixiao Dept. of Math. Peking Univ. Beijing Dept. of Appl. Math. Beijing Institute of Technology Beijing

In this paper, an initial boundary value problem with homogeneous Neumann boundary condition is studied for a reaction\|diffusion system which models the spread of infectious diseases within two population groups by means of self and criss\|cross infection mechanism. Existence, uniqueness and boundedness of the nonnegative global solution ( u\-1,u\-2,u\-3,u\-4) , existence of the limit of the solution as t→+∞ ,namely,( u\-1,u\-2,u\-3,u\-4)→(u\+*\-1,0,u\+*\-3,0), are proved.

关键词： Upperandlowersolutions boundedness liapunovfunctionalmethod exponentialdelayestimates

The Influence of Pore Throat Radius on its Internal Oil and Water Wettability

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Acta Geologica Sinica(English Edition) 2015年第A01期89卷 166-167页

作者： TIAN Shansi LU Shuangfang XUE Haitao XIE liujuan li jiyuan China University of Petroleum(Hua Dong) Unconventional oil and gas and New Energy Research Institute

With the rising of energy demand and the dwindling of conventional oil and gas resources, the unconventional oil and gas resources are getting more and more attention, and has become the main contribution of global oi... 详细信息

关键词： SURFACE chemistry RESEARCH WETTING agents DISTILLED water TOLUENE OCTANE

Tissue-specific transcriptomics reveals a central role of CcNST1 in regulating the fruit lignification pattern in Camellia chekiangoleosa,a woody oil-crop

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Forestry Research 2022年第1期2卷 89-98页

作者： Chao Yan Ziyan Nie Zhikang Hu Hu Huang Xianjin Ma Sijia li jiyuan li Xiaohua Yao Hengfu Yin State Key Laboratory of Tree Genetics and Breeding Research Institute of Subtropical ForestryChinese Academy of ForestryHangzhouZhejiang 311400China Key Laboratory of Forest Genetics and Breeding Research Institute of Subtropical ForestryChinese Academy of ForestryHangzhouZhejiang 311400China

Fruit lignification is of significant economic importance because it affects the quality of fruit and the production of seed *** specified lignification pattern in Camellia chekiangoleosa fruits plays critical roles in its seed oil yield,but little is known about how this lignification process is ***,we report on a comprehensive tissue-specific transcriptomics analysis conducted for *** *** mining the differentially expressed genes,we found that lignin biosynthesis and transcriptional regulation pathways were significantly enriched in the lignified *** homolog of NST-like transcription factor,CcNST1,was highly expressed in lignified seed coat and endocarp tissues;transgenic analyses of CcNST1 in Arabidopsis and hybrid poplar revealed the enhanced lignification levels of various *** expression analysis of the transgenic lines uncovered potential downstream genes involved in the regulation of lignin *** work provides a valuable gene expression resource and identified the pivotal role of CcNST1 in regulating the lignin biosynthesis underlying fruit lignification.

关键词： pattern specified specific

Structure-based drug discovery of novel fusedpyrazolone carboxamide derivatives as potent and selective AXL inhibitors

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4918-4933页

作者： Feifei Fang Yang Dai Hao Wang Yinchun Ji Xuewu liang Xia Peng jiyuan li Yangrong Zhao Chunpu li Danyi Wangh Yazhou li Dong Zhang Dan Zhang Meiyu Geng Hong liu Jing Ai Yu Zhou lingang Laboratory Shanghai 200031China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery&Development Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

a novel and promising antitumor target,AXL plays an important role in tumor growth,metastasis,immunosuppression and drug resistance of various malignancies,which has attracted extensive research interest in recent *** this study,by employing the structure-based drug design and bioisosterism strategies,we designed and synthesized in total 54 novel AXL inhibitors featuring a fusedpyrazolone carboxamide scaffold,of which up to 20 compounds exhibited excellent AXL kinase and BaF3/TEL-AXL cell viability ***,compound 59 showed a desirable AXL kinase inhibitory activity(IC_(50):3.5 nmol/L)as well as good kinase selectivity,and it effectively blocked the cellular AXL *** turn,compound 59 could potently inhibit BaF3/TEL-AXL cell viability(IC_(50):1.5 nmol/L)and significantly suppress GAS6/AXL-mediated cancer cell invasion,migration and wound healing at the nanomolar *** importantly,compound 59 oral administration showed good pharmacokinetic profile and in vivo antitumor efficiency,in which we observed significant AXL phosphorylation suppression,and its antitumor efficacy at 20 mg/kg(qd)was comparable to that of BGB324 at 50 mg/kg(bid),the most advanced AXL *** together,this work provided a valuable lead compound as a potential AXL inhibitor for the further antitumor drug development.

关键词： Potential AXL inhibitor Antitumor activity Structure-based drug design Fused-pyrazolone carboxamide

Gadolinium Neutron Capture Reaction-Induced Nucleodynamic Therapy Potentiates Antitumor Immunity

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CCS Chemistry 2023年第11期5卷 2589-2602页

作者： Dongban Duan Yi Han Zhiyu Tu Haoxuan Guo Zizhu Zhang Yaxin Shi jiyuan li Qi Sun Junyi Chen Zhu li Tong liu Daqing Cui Zhibo liu Beijing National Laboratory for Molecular Sciences Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental ScienceNMPA Key Laboratory for Research and Evaluation of RadiopharmaceuticalsKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Department of Radiochemistry China Institute of Atomic EnergyBeijing 102413 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049 Beijing Nuclear Industry Hospital Beijing 100045 Peking University–Tsinghua University Center for life Sciences Peking UniversityBeijing 100871 Key Laboratory of Carcinogenesis and Translational Research Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing Beijing Capture Tech Co.Ltd. Beijing 102413 Department of Materials and Environmental Chemistry Stockholm UniversityStockholm SE-10691 Changping Laboratory Beijing 102206

A nuclear reaction-induced dynamic therapy,denoted as nucleodynamic therapy(NDT),has been invented that triggers immunogenic cell death and successfully treats metastatic tumors due to its unexpected abscopal *** neutron capture therapy(GdNCT)is binary radiotherapy based on a localized nuclear reaction that produces high-energy radiations(e.g.,Auger electrons,γ-rays,etc.)in cancer cells when^(157Gd)is irradiated with thermal ***,its clinical application has been postponed due to the poor ability of Auger electrons andγ-rays to kill ***,we engineered a^(157Gd)-porphyrin framework that synergizes GdNCT and dynamic therapy to efficiently produce both•OH and immunogenic 1O2 in cancer cells,thereby provoking a strong antitumor immune *** study unveils the fact and mechanism that NDT heats tumor *** unexpected finding is that the Auger electron can be the most effective energy-transfer medium for radiation-induced activation of nanomedicines because its nanoscale trajectory perfectlymatches the size of *** tumormodels,NDT causes nearly complete regression of both primary and distant tumor ***,this^(157Gd)-porphyrin framework radioenhancer endows GdNCT with the exotic function of triggering dynamic therapy;its applicationmay expand in clinics as a new radiotherapy modality that utilizes GdNCT to provoke whole-body antitumor immune response for treating metastases,which are responsible for 90%of all cancer deaths.

关键词： neutron capture therapy radiochemistry radiotherapy immunotherapy

Multi-scale observation and cross-scale mechanistic modeling on terrestrial ecosystem carbon cycle

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Science China Earth Sciences 2005年第z1期48卷 17-32页

作者： CAO Mingkui YU Guirui liU jiyuan li Kerang Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

To predict global climate change and to implement the Kyoto Protocol for stabilizing atmospheric greenhouse gases concentrations require quantifying spatio-temporal variations in the terrestrial carbon sink accurately. During the past decade multi-scale ecological experiment and observation networks have been established using various new technologies (e.g. controlled environmental facilities, eddy covariance techniques and quantitative remote sensing), and have obtained a large amount of data about terrestrial ecosystem carbon cycle. However, uncertainties in the magnitude and spatio-temporal variations of the terrestrial carbon sink and in understanding the underlying mechanisms have not been reduced significantly. One of the major reasons is that the observations and experiments were conducted at individual scales independently, but it is the interactions of factors and processes at different scales that determine the dynamics of the terrestrial carbon sink. Since experiments and observations are always conducted at specific scales, to understand cross-scale interactions requires mechanistic analysis that is best to be achieved by mechanistic modeling. However, mechanistic ecosystem models are mainly based on data from single-scale experiments and observations and hence have no capacity to simulate mechanistic cross-scale interconnection and interactions of ecosystem processes. New-generation mechanistic ecosystem models based on new ecological theoretical framework are needed to quantify the mechanisms from micro-level fast eco-physiological responses to macro-level slow acclimation in the pattern and structure in disturbed ecosystems. Multi-scale data-model fusion is a recently emerging approach to assimilate multi-scale observational data into mechanistic, dynamic modeling, in which the structure and parameters of mechanistic models for simulating cross-scale interactions are optimized using multi-scale observational data. The models are validated and evaluate

关键词： global climate change, terrestrial carbon sink, multi-scale observation, data-model fusion, cross-scale mechanistic modeling.

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基于能量控制的高尔夫臂运动模型的研究

机械传动 2010年第8期34卷 17-20,66页

作者：李积元青海大学机械系青海西宁810016

高尔夫臂机器人是一种通过模拟人击高尔夫球的动作,完成利用机器进行击球的运动机构。为了产生高尔夫臂机器人的运动轨迹,提出了一种基于能量控制的目标动力学方法,利用该方法产生了高尔夫臂机器人的运动轨迹。在实际的研究过程中,根据... 详细信息

高尔夫臂机器人是一种通过模拟人击高尔夫球的动作,完成利用机器进行击球的运动机构。为了产生高尔夫臂机器人的运动轨迹,提出了一种基于能量控制的目标动力学方法,利用该方法产生了高尔夫臂机器人的运动轨迹。在实际的研究过程中,根据不同的边界条件和约束条件,生成了一系列的从瞄准位置到结束位置的轨迹模型。以生成的轨迹作为参考输入和PD控制的规则,进行了有关的实验,试验结果证实该方法是有效的。

关键词：高尔夫臂机器人能量控制运动控制