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阴虚胃痛胶囊对慢性萎缩性胃炎大鼠胃黏膜超微结构和炎症介质的影响

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世界中医药 2024年第14期19卷 2106-2112页

作者：张晨晨李丹艳朱泠霏李吉磊刘念张声生北京中医药大学北京100029 首都医科大学附属北京中医医院北京100010

目的:观察阴虚胃痛胶囊对慢性萎缩性胃炎(CAG)大鼠胃黏膜超微结构及炎症介质的影响。方法:将72只无特定病原体(SPF)级斯泼累格·多雷(SD)大鼠分为正常组13只和造模组59只,造模组给予N-甲基-N′-硝基-N-亚硝基胍自由饮+灌胃,同时给予饥... 详细信息

目的:观察阴虚胃痛胶囊对慢性萎缩性胃炎(CAG)大鼠胃黏膜超微结构及炎症介质的影响。方法:将72只无特定病原体(SPF)级斯泼累格·多雷(SD)大鼠分为正常组13只和造模组59只,造模组给予N-甲基-N′-硝基-N-亚硝基胍自由饮+灌胃,同时给予饥饱失常法复合因素干预制备CAG大鼠模型。将成模大鼠按随机数字表法分为模型组、维酶素组及阴虚胃痛胶囊低剂量、中剂量、高剂量组。阴虚胃痛胶囊低剂量、中剂量、高剂量组分别给予205.2 mg/kg、410.4 mg/kg、820.8 mg/kg阴虚胃痛胶囊溶液灌胃,维酶素组给予270 mg/kg维酶素溶液灌胃,正常组与模型组给予等剂量生理盐水灌胃,均1次/d,共干预8周。苏木精-伊红(HE)染色观察大鼠胃黏膜病理情况;透射电镜观察大鼠胃黏膜超微结构变化;实时荧光定量聚合酶链反应检测胃组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)的基因表达;蛋白质免疫法检测胃组织中炎症介质TNF-α、IL-1β和抗炎因子白细胞介素-4(IL-4)、白细胞介素-10(IL-10)的蛋白表达。结果:与正常组比较,模型组HE染色显示腺体减少;透射电镜显示壁细胞和主细胞结构被明显破坏,TNF-α、IL-1β的表达高(P<0.05),IL-4、IL-10表达低(P<0.05)。与模型组比较,阴虚胃痛胶囊中剂量、高剂量组及维酶素组HE提示腺体改善,透射电镜提示壁细胞和主细胞结构恢复,胃黏膜中TNF-α、IL-1β表达低(P<0.05),IL-4、IL-10表达高(P<0.05)。结论:阴虚胃痛胶囊可明显促进CAG大鼠胃黏膜异常超微结构的恢复,抑制炎症介质TNF-α、IL-1β表达,促进抗炎因子IL-4、IL-10表达。

关键词：阴虚胃痛胶囊慢性萎缩性胃炎超微结构大鼠肿瘤坏死因子-α 白细胞介素-1β 白细胞介素-4 白细胞介素-10

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Blueschist:A window into high-pressure/low-temperature metamorphism and subduction zone dynamics

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Science China Earth Sciences 2020年第12期63卷 1852-1867页

作者： jilei li Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing100029China

Blueschist is a regional metamorphic rock formed under high-pressure(HP)low-temperature(LT)*** is formed in the subduction zone environment with low geothermal gradients(4-14℃km^(−1)),and is characterized by the presence of HP/LT index minerals like glaucophane,lawsonite,aragonite,jadeite,and *** general,blueschist-facies rocks are stable in subduction zones at depths of 30-60 km,and transform to eclogite-facies rocks at greater *** preservation of blueschists requires a fast exhumation *** on protolith and tectonic setting,blueschists can be grouped into Type-A and Type-B,but some metasomatic blueschists also *** belts distribute mainly as bands along the margins of orogenic belts,and their occurrences within cratons are very *** blueschists,of which the oldest ones are about 800-700 Ma in age,are rare;most of the exposed blueschist terranes are of post-Paleozoic metamorphic *** diagnostic evidence of ancient subduction zones,blueschist plays an important role in understanding plate ***-eclogite transition at cold subduction zones involves dehydration reactions and fluid release,which are of great importance in facilitating slab-mantle wedge water and element recycling,generating arc magmatism,and triggering intermediate-depth earthquakes in the subducting *** P-T paths of blueschists and associated rocks provide key information on constraining the onset of the subduction initiation and subsequent geodynamic *** a cold geothermal indicator,the emergence of blueschist offers robust evidence for the start of modern plate tectonics on the ***-facies metamorphism still represents an important research direction in metamorphic geology,which requires further investigations on determining the beginning of plate tectonics,constraining phase-transition processes,and constructing a global blueschist database.

关键词： Glaucophane.Blueschist High-pressure metamorphism.Subduction zone Plate tectonics

基于网络药理学及实验验证探讨清化祛瘀健脾方治疗溃疡性结肠炎的作用机制

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天津中医药 2024年第2期41卷 234-241页

作者：屈凡凡沈爱花张声生李吉磊首都医科大学附属北京中医医院北京100010 北京中医药大学北京100029

[目的]旨在从网络药理学和实验验证的角度探讨清化祛瘀健脾方治疗溃疡性结肠炎的潜在药理机制。[方法]通过网络数据库筛选清化祛瘀健脾方与溃疡性结肠炎相关基因,进一步遴选出交集基因,对交集基因进行GO功能和京都基因和基因组百科全书(... 详细信息

[目的]旨在从网络药理学和实验验证的角度探讨清化祛瘀健脾方治疗溃疡性结肠炎的潜在药理机制。[方法]通过网络数据库筛选清化祛瘀健脾方与溃疡性结肠炎相关基因,进一步遴选出交集基因,对交集基因进行GO功能和京都基因和基因组百科全书(KEGG)富集分析,确定清化祛瘀健脾方对溃疡性结肠炎的药理作用;同时建立蛋白-蛋白互作网络,并进行功能模块分析。筛选核心基因,通过分子对接,筛选结合最稳定的分子进行实验验证。最后,采用苏木精-伊红染色、免疫组织化学染色及蛋白质免疫印迹方法验证清化祛瘀健脾方发挥疗效的分子机制。[结果]从清化祛瘀健脾方中筛选出86个活性成分和224个潜在靶点,与疾病靶点取交集获得254个共同靶点。这些共同靶点主要参与炎症反应、DNA转录、蛋白激酶活性、细胞凋亡、细胞增殖调控等过程,表明清化祛瘀健脾方通过影响这些过程来减轻炎症反应。进一步对蛋白-蛋白互作网络进行了核心基因分析及分子对接验证,发现低氧诱导因子-1(HIF1A)、信号转导及转录激活蛋白3(STAT3)、MYC和丝裂原活化蛋白激酶3(MAPK3)可能是清化祛瘀健脾方主要作用靶点。最后,对分子对接预测结合能最稳定的靶标MAPK3进行动物实验验证,发现清化祛瘀健脾方可以明显减轻溃疡性结肠炎模型小鼠结肠炎症反应,促进MAPK3蛋白的表达。[结论]网络药理学及分子对接预测了清化祛瘀健脾方治疗溃疡性结肠炎的功能成分及作用靶点,并通过动物实验证实了该中药复方可能通过激活MAPK信号通路,促进肠黏膜愈合而发挥抗炎作用,为清化祛瘀健脾方等中药复方的深入研究提供了新思路。

关键词：清化祛瘀健脾方溃疡性结肠炎网络药理学分子对接动物实验

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七叶一枝花抗癌临床应用及作用机制研究进展

中国民族民间医药 2024年第13期33卷 42-48页

作者：董晶汪秋颖皮佩仙李继蕾乐佳美上海健康医学院药学院上海201318 上海健康医学院协同科研中心上海201318 南京中医药大学江苏南京210023

七叶一枝花作为我国的传统中药,具有抗炎、抑菌、抗癌等多重药理活性,临床可广泛应用于辅助治疗胃癌、肝癌、肺癌、乳腺癌等恶性肿瘤疾病。研究表明甾体皂苷类成分是七叶一枝花抗癌作用的主要有效成分,其可通过抑制癌细胞增殖、诱导癌... 详细信息

七叶一枝花作为我国的传统中药,具有抗炎、抑菌、抗癌等多重药理活性,临床可广泛应用于辅助治疗胃癌、肝癌、肺癌、乳腺癌等恶性肿瘤疾病。研究表明甾体皂苷类成分是七叶一枝花抗癌作用的主要有效成分,其可通过抑制癌细胞增殖、诱导癌细胞凋亡、调控上皮间质转化过程、抗癌细胞血管生成以及诱导癌细胞的自噬等多方面发挥良好的抗癌作用。文章通过对七叶一枝花抗癌临床应用及作用机制的研究进展进行综述,为未来七叶一枝花及其有效成分进一步开发应用于抗癌临床治疗提供参考依据。

关键词：七叶一枝花抗癌作用甾体皂苷临床应用

A subduction channel model for exhumation of oceanic-type high-pressure to ultrahigh-pressure eclogite-facies metamorphic rocks in SW Tianshan,China

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Science China Earth Sciences 2016年第12期59卷 2339-2354页

作者： li jilei GAO Jun WANG XinShui Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences

High-pressure(HP) and ultrahigh-pressure(UHP) eclogites exposed in collisional orogens are widely regarded to record the history of crustal rocks that were subducted to mantle depths and exhumed back to the *** into subduction and exhumation processes plays an important role in understanding the nature and evolution of subduction zones,geodynamics and plate *** contrast to continental-type HP to UHP metamorphic rocks that are dominated by felsic lithology,oceanic-type HP to UHP metamorphic rocks are dominated by mafic eclogites and thus have greater density,and their exhumation needs to overcome large barriers and may involve complicated tectonic *** exhumation of HP to UHP rocks is mainly influenced by the internal buoyancy,however,the external tectonic forces(such as channel flow) also act as effective exhumation drivers;in addition,effects of tectonic settings(such as slab rollback and breakoff) should take into *** HP-UHP metamorphic terrane in Southwestern Tianshan,which mainly comprises of metasediments with interlayered metamafic lenses and blocks,represents a typical accretionary melange associated with deep subduction of oceanic ***,the exhumation mechanisms of these once deeply buried HP-UHP rocks are still under *** on the field occurrences,petrographic features,peak metamorphic P-T conditions and ages of the eclogites/blueschists and their metasedimentary country rocks,a "sediment-type subduction channel" model is advocated in this study to appraise/decipher the formation and evolution of Southwestern Tianshan HP-UHP metamorphic ***-cyclic metamorphic eclogites record the multistage burial-exhumation cycling manipulated by convective flow in a channel-like interface between the plates,giving robust evidence for the presence of a subduction *** addition,this study summarizes some remaining geotectonic problems and research perspectives concerning the Southwestern Tianshan HP-UHP me

关键词： Eclogite High-pressure metamorphism Oceanic crust Exhumation Subduction channel Southwestern Tianshan

Mechanism of slag pellets sticking on the wall of reduction pot in magnesium production by Pidgeon process

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Journal of Magnesium and Alloys 2024年第6期12卷 2397-2412页

作者： jilei Xu Jinhui liu Dong Guo Mao Chen Peixu Yang Rongbin li Shaojun Zhang School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Henan Province Industrial Technology Research Institute of Resources and Materials Zhengzhou UniversityZhengzhou 450001China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

In the preparation of magnesium by Pidgeon process,the phenomenon slag pellets sticking on the wall of reduction pot always appear,and the glaze sticking on the inner wall of the reduction pot is difficult to *** mechanism of this phenomenon is studied in this work by X-ray fluorescence spectrometer(XRF)measurement,electron probe microanalyzer scanning(EPMA)analysis,differential scanning calorimetry(DSC)analysis,and thermodynamic *** main components of the glaze are MgO,Ca_(12)Al_(14)F_(2)O_(32),CaF_(2),CaO,and a small amount of Ca_(4)Si_(2)O_(7)F_(2).The solid-liquid transition temperature of Ca_(12)Al_(14)F_(2)O_(32)and CaF_(2)is close to the production temperature of Pidgeon process,which leads to the bonding between the slag pellets and the pot *** loss of CaF_(2)in glaze layer will reduce the total amount of liquid phase and increase the temperature at which Ca_(12)Al_(14)F_(2)O_(32)is completely transformed into liquid phase,which causes glaze layer sticking on the inner wall of the reduction pot.

关键词： Pidgeon process Glaze Ca_(12)Al_(14)F_(2)O_(32) CaF_(2) Solid-liquid transition

基于Bak/Bax/Caspase-9通路探讨小檗碱对溃疡性结肠炎小鼠疗效的机制研究

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中国中西医结合消化杂志 2024年第3期32卷 233-238页

作者：李吉磊刘念王一冲王瑞昕赵鲁卿张声生首都医科大学附属北京中医医院消化中心北京100010 北京中医药大学

目的探讨小檗碱通过Bak/Bax/Caspase-9通路对溃疡性结肠炎(ulcerative colitis,UC)小鼠保护作用的机制。方法将32只C57BL/6小鼠随机分为正常组、模型组、美沙拉嗪组、小檗碱组,每组8只。除正常组外,其余组予以3%葡聚糖硫酸钠盐(dextran ... 详细信息

目的探讨小檗碱通过Bak/Bax/Caspase-9通路对溃疡性结肠炎(ulcerative colitis,UC)小鼠保护作用的机制。方法将32只C57BL/6小鼠随机分为正常组、模型组、美沙拉嗪组、小檗碱组,每组8只。除正常组外,其余组予以3%葡聚糖硫酸钠盐(dextran sulfate sodium salt,DSS)构建UC小鼠模型。记录各组小鼠的疾病活动指数(disease activity index,DAI)评分及体重;测量结肠长度、脾脏指数;通过苏木精-伊红染色观察结肠、脾脏组织病理变化;利用qRT-PCR和Western blot法分别检测结肠组织中Bak、Bax、Caspase-9的mRNA和蛋白表达。结果与模型组比较,小檗碱组小鼠的DAI评分与脾脏指数显著降低(P<0.05),结肠及脾脏病理损伤显著缓解,体重变化率和结肠长度显著升高(P<0.01),结肠组织中Bak、Bax、Caspase-9的mRNA和蛋白表达显著降低(P<0.05)。结论小檗碱能够降低UC小鼠的炎症反应,改善结肠和脾脏病理损伤,其作用可能与调控Bak/Bax/Caspase-9通路相关。

关键词：溃疡性结肠炎小檗碱凋亡 Bak Bax Caspase-9通路

Interface engineering strategy via electron-defect trimethyl borate additive toward 4.7 V ultrahigh-nickel liNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)battery

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Journal of Energy Chemistry 2024年第5期92卷 639-647页

作者： Yilin Zhang Yuqing Chen Qiu He Jinlong Ke Wei Wang Jian-Fang Wu Peng Gao Yanhua li jilei liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangsha 410082HunanChina College of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina School of Materials Science and Engineering Hunan Institute of TechnologyHengyang 421002HunanChina

The li metal battery with ultrahigh-nickel cathode(liNi_(x)M_(1-x)O_(2),M=Mn,Co,and x≥0.9)under high-voltage is regarded as one of the most promising approaches to fulfill the ambitious target of 400 Wh/***,the practical application is impeded by the instability of electrode/electrolyte interface and Ni-rich cathode *** we proposed an electron-defect electrolyte additive trimethyl borate(TMB)which is paired with the commercial carbonate electrolyte to construct highly conductive fluorine-and boron-rich cathode electrolyte interface(CEI)on liNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)(NCM90)surface and solid electrolyte interphase(SEI)on lithium metal *** modified CEI effectively mitigates the structural transformation from layered to disordered rock-salt phase,and consequently alleviate the dissolution of transition metal ions(TMs)and its“cross-talk”effect,while the enhanced SEI enables stable lithium plating/striping and thus demonstrated good compatibility between electrolyte and lithium metal *** a result,the common electrolyte with 1 wt%TMB enables 4.7 V NCM90/li cell cycle stably over 100 cycles with 70%capacity *** work highlights the significance of the electron-defect boron compounds for designing desirable interfacial chemistries to achieve high performance NCM90/li battery under high voltage operation.

关键词： NCM90 batteries Electrolyte additive Trimethyl borate

Covalency competition induced selective bond breakage and surface reconstruction in manganese cobaltite towards enhanced electrochemical charge storage

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Green Energy & Environment 2024年第5期9卷 909-918页

作者： Peng Gao Pei Tang Ying Mo Peitao Xiao Wang Zhou Shi Chen Hongliang Dong Ziwei li Chaohe Xu jilei liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangshaHunan410082China Department of Materials Science and Engineering National University of Defense TechnologyChangshaHunan410073China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao999078China Center for High Pressure Science and Technology Advanced Research PudongShanghai201203China College of Aerospace Engineering Chongqing UniversityChongqing400044China

Manganese cobaltite(MnCo_(2)_(4))is a promising electrode material because of its attractive redox chemistry and excellent charge storage *** previous work demonstrated that the octahedrally-coordinated Mn are prone to react with the hydroxyl ions in alkaline electrolyte upon electrochemical cycling and separates on the surface of spinel to reconstruct into d-MnO_(2) nanosheets irreversibly,thus results in a change of the reaction mechanism with Kþion ***,the low capacity has greatly limited its practical ***,we found that the tetrahedrally-coordinated Co_(2) þions were leached when MnCo_(2)_(4) was equilibrated in 1 mol L^(-1) HCl solution,leading to the formation of layered CoOOH on MnCo_(2)_(4) surface which is originated from the covalency competition induced selective breakage of the CoT–O bond in CoT–O–CoO and subsequent rearrangement of free Co_(6) *** as-formed CoOOH is stable upon cycling in alkaline electrolyte,exhibits conversion reaction mechanism with facile proton diffusion and is free of massive structural evolution,thus enables utilization of the bulk electrode material and realizes enhanced speciﬁc capacity as well as facilitated charge transfer and ion *** general,our work not only offers a feasible approach to deliberate modiﬁcation of MnCo_(2)_(4)'s surface structure,but also provides an in-depth understanding of its charge storage mechanism,which enables rational design of the spinel oxides with promising charge storage properties.

关键词： Manganese cobaltite Tetrahedrally-coordinated Co^(2+)leaching Selective bond breakage Surface reconstruction Charge storage mechanisms