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Chinese journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： LI J. Mei H. li S. Tianjin University China Tsinghua Shenzhen International Graduate School China Lanzhou jiaotong University China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power equipment.The performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new situation.Nondestructive detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the object.

关键词： service Application operation

Rehabilitation management of patients with CoVID-19:lessons learned from the first experience in China

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中华物理医学与康复杂志 2020年第10期42卷 914-914页

作者： LI J Rehabilitation Medical Center the First Affiliated Hospital of Nanjing Medical University Nanjing China -

ABSTRACT Corona virus disease 2019(COVID-19)is a new disease characterized by lung damage and involvement in multiple tissues and organs in the whole bodly.Some of the patients may have long-term impairment and dysfunctions,including pulmonary fibrosis,heart,liver,kidney,nerve and immune system.Rehabilitation has certain beneficial efect in the acute stage,and especially in the recoverystage,including improving respiratory function,exercise endurance,self-care in daily living activities,as well as psychologieal support,etc.Rchabilitation is not ofside or absent.A reasonable rehabilitation program needs scientific research to avoid arbitrary conclusions.

关键词： patients organs involvement

Hardness-thermal stability synergy in nanograined Ni and Ni alloys:Superposition of nanotwin and low-energy columnar boundary

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journal of Materials Science & Technology 2023年第6期137卷 123-131页

作者： F.H.Duan Y.lin Q.li j.H.Luan j.Lu j.Pan Y.li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Laboratory of Nanomaterials&Nanomechanics Department of Mechanical EngineeringCity University of Hong KongHong KongChina State Key Laboratory of Material Processing and Die&Mould Technology and School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Materials Science and Engineering City University of Hong KongHong KongChina Centre for Advanced Structural Materials Greater Bay Joint DivisionShenyang National Laboratory for Materials ScienceCity University of Hong Kong Shenzhen Research InstituteShenzhen 518057China City U-Shenzhen Futian Research Institute Shenzhen 518045China

Refining grains into nanoscale can significantly strengthen and harden metallic materials;however,nanograined metals generally exhibit low thermal stability,hindering their practical applications.In this work,we exploit the superposition of the contribution of nanotwins,low-angle grain boundaries,and microalloying to tailor superior combinations of high hardness and good thermal stability in Ni and Ni alloys.For the nanotwinned Ni having a twin thickness of∼2.9 nm and grain size of 28 nm,it exhibits a hardness over 8.0 GPa and an onset coarsening temperature of 623 K,both of which are well above those of nanograined Ni.Re/Mo microalloying can further improve the onset coarsening temperature to 773 K without comprising hardness.Our analyses reveal that high hardness is achieved via strengthen-ing offered by extremely fine nanotwins.Meanwhile,the superior thermal stability is mainly ascribed to the low driving force for grain growth induced by the low-angle columnar boundary architecture and to the additional pinning effect on the migration of twin/columnar boundaries provided by minor Re/Mo solutes.The present work not only reveals a family of nanotwinned metals possessing the combination of ultra-high hardness and high thermal stability but also provides a strategy for tailoring properties of metallic materials by pairing low-angle grain boundaries and twin boundaries.

关键词： Nanotwin Thermal stability Hardness Low-angle grain boundary Microalloying

Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2110-2124页

作者： jin li Diane j.Burgess Department of Pharmaceutical Sciences University of ConnecticutStorrsCT 06269-3092USA

The complex tumor microenvironment is a most important factor in cancer development.The biological microenvironment is composed of a variety of barriers including the extracellular matrix and associated cells such as endothelia cells,pericytes,and cancer-associated fibroblasts.Different strategies can be utilized to enhance nanoparticle-based drug delivery and distribution into tumor tissues addressing the extracellular matrix or cellular components.In addition to the biological microenvironment,the immunological conditions around the tumor tissue can be very complicated and cancer cells have various ways of evading immune surveillance.Nanoparticle drug delivery systems can enhance cancer immunotherapy by tuning the immunological response and memory of various immune cells such as T cells,B cells,macrophages,and dendritic cells.In this review,the main components in the tumor biological and immunological environment are discussed.The focus is on recent advances in nanoparticle-based drug delivery systems towards targets within the tumor microenvironment to improve cancer chemotherapy and immunotherapy.

关键词： Tumor microenvironment Nanoparticles Drug delivery Tumor immunology Tumor treatment Tumor targeting Immunotherapy Combinational therapy

Experimental study on the degree and damage-control mechanisms of fuzzy-ball-induced damage in single and multi-layer commingled tight reservoirs

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Petroleum Science 2023年第6期20卷 3598-3609页

作者： Chinedu j.Okere james j.Sheng li-Kun Fan Xiao-Wei Huang li-Hui Zheng Pan-Feng Wei Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityTXUSA College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China China Changqing Oilfield Company CNPCXi'an710018ShaanxiChina Beijing lihuiLab Energy Technology Co. Ltd.Beijing102200China

Fuzzy-ball working fluids(FBWFs)have been successfully applied in different development phases of tight reservoirs.Field reports revealed that FBWFs satisfactorily met all the operational and reservoir damage control requirements during their application.However,the damage-control mechanisms and degree of formation damage caused by fuzzy-ball fluids have not been investigated in lab-scale studies so far.In this study,the degree of fuzzy-ball-induced damage in single-and double-layer reservoirs was evaluated through core flooding experiments that were based on permeability and flow rate indexes.Additionally,its damage mechanisms were observed via scanning electron microscope and energy-dispersive spectroscopy tests.The results show that:(1)For single-layer reservoirs,the FBWF induced weak damage on coals and medium-to-weak damage on sandstones,and the difference of the damage in permeability or flow rate index on coals and sandstones is below 1%.Moreover,the minimum permeability recovery rate was above 66%.(2)For double-layer commingled reservoirs,the flow rate index revealed weak damage and the overall damage in double-layer was lower than the single-layer reservoirs.(3)There is no significant alteration in the microscopic structure of fuzzy-ball saturated cores with no evidence of fines migration.The dissolution of lead and sulfur occurred in coal samples,while tellurium in sandstone,aluminum,and magnesium in carbonate.However,the precipitation of aluminum,magnesium,and sodium occurred in sandstone but no precipitates found in coal and carbonate.The temporal plugging and dispersion characteristics of the FBWFs enable the generation of reservoir protection layers that will minimize formation damage due to solid and fluid invasion.

关键词： Drilling Fracture Fuzzy-ball fluids Formation damage analysis Muti-layer tight reservoirs Permeability damage index Flow rate damage index

《城市规划与发展》期刊专刊——为了城市可持续发展的绿色基础设施

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城市规划学刊 2016年第1期 124-125页

作者： BREUSTE j ARTMANN M LI J

以城市公园、森林、行道树、屋项绿化、花园为代表的绿色基础设施,因其承载城市生态服务功能的重要性以及改善城市居民生活质量的提升价值,在城镇化发展中至关重要,在近20年的研究中向来被视为城市生态系统中的重要组成部分。有关城市... 详细信息

以城市公园、森林、行道树、屋项绿化、花园为代表的绿色基础设施,因其承载城市生态服务功能的重要性以及改善城市居民生活质量的提升价值,在城镇化发展中至关重要,在近20年的研究中向来被视为城市生态系统中的重要组成部分。有关城市绿色基础设施的研究往往聚焦于探讨其作为

关键词：绿色基础设施生态系统服务城市可持续发展规划长远计划专刊期刊报刊

BMC Family Practice论文摘要汇编——大城市和乡村地区基层医疗机构进行AF-SMART心房颤动筛查项目的实施效果评估

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中国全科医学 2020年第8期23卷 979-979页

作者： ORCHARD j LI J GALLAGHER R 本刊编辑部 Heart Research Institute/Charles Perkins Centre University of Sydney Sydney Australia Susan Wakil School of Nursing Faculty of Medicine and Health/Charles Perkins Centre University of Sydney Sydney Australia Edinburgh Napier University Edinburgh UK

背景国际指南建议对65岁及以上人群进行心房颤动筛查。本研究组于2016年11月—2019年6月在16个大城市和农村地区进行了机会性心房颤动筛查以进行心房颤动筛查、管理和指南推荐治疗研究(AF-SMART)。在这些研究中试用了定制的电子健康工... 详细信息

背景国际指南建议对65岁及以上人群进行心房颤动筛查。本研究组于2016年11月—2019年6月在16个大城市和农村地区进行了机会性心房颤动筛查以进行心房颤动筛查、管理和指南推荐治疗研究(AF-SMART)。在这些研究中试用了定制的电子健康工具支持各个阶段的心房颤动筛查。方法对AF-SMART项目的实施效果进行评价,并以此为依据决定是否需要扩大筛查人口比例。项目实施的最初理论是基于本研究组以前的研究结果、政策文件和其他相关筛查研究。在本研究中,本研究组对所选诊所的全科医生、护士和管理者进行了45场半结构式访谈。通过访谈收集了观察数据和定量数据,并进行分析和阐释以完善AF-SMART项目理论。结果全科医生和护士均喜欢使用这些电子健康工具,尽管有时候出现了技术性问题会使筛查过程中断。但是筛查耗时较久,因此筛查系统需要改进变得更加有效。由资深全科医生尤其是来自护理团队的资深全科医生领导的筛查小组的筛查范围更大。定期反馈筛查数据有助于提高筛查质量和激励筛查的进行。在分级诊疗过程中,筛查效果较好的以护士为主导的小组需要对筛查结果异常的人群制定明确的随访方案。参与实施AF-SMART项目能获得更多益处,比如增加对心房颤动的了解、更多了解心血管疾病预防范畴等。在诊所能有效安排职员工作时间的情况下,对目标人群进行短期集中筛查(工作模式类似在短期内集中接种流感疫苗)能获得较好的效果。结论当筛查小组由资深全科医生领导,有为异常筛查结果人群制定的随访方案并且筛查人群可定期向医务人员反馈随访数据的情况下,心房颤动筛查能够比较成功的实施。而这些与筛查成功相关的因素和激励机制、领导权、护士授权和有效的筛查系统相关。这些因素和机制有助于长期提高心房颤动筛查和治疗比例,被指南推荐为预防心房颤动相关脑卒中的关键策略。

关键词：全科医生基层医疗机构电子健康国际指南分级诊疗筛查结果心房颤动定量数据

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Mixing of miscible shear-thinning fluids in a lid-driven cavity

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Chinese journal of Chemical Engineering 2023年第6期58卷 112-123页

作者： junhao Wang Shugang Ma Peng Chen Zhipeng li Zhengming Gao j.j.Derksen Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Chemical Resource Engineering School of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China PetroChina Petrochemical Research Institute Beijing 102206China School of Engineering University of AberdeenAberdeen AB243UEUK

The concentration and velocity fields of two refractive index matched miscible shear-thinning fluids in a lid-driven cavity were investigated by using planar laser-induced fluorescence and particle image velocimetry,as well by computational fluid dynamics.Quantitative analyses show that the results obtained by flow simulations with the species transport model are in good agreement with the experimental results.The effects of different parameters were studied by using the intensity of segregation.For two fluids with the same rheological parameters,the relative amounts of liquids H_(1)/H and the power-law index n dominate the mixing process while the Reynolds number Re plays a marginal role.As for two fluids with density difference,buoyancy has significant influence on the mixing process.The dimensionless group Ar/Re(redefined such as to include shear thinning behavior)is proposed for assessing the effect of buoyancy and rheological properties on the mixing of miscible shear-thinning fluids.

关键词： Shear-thinning fluid Mixing of miscible fluids Particle image velocimetry Planar laser-induced fluorescence Species transport model lid-driven cavity

Population-scale genetic control of alternative polyadenylation and its association with human diseases

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Quantitative Biology 2022年第1期10卷 44-54页

作者： Lei li Yumei li Xudong Zou Fuduan Peng Ya Cui Eric j.Wagner Wei li Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518055China Division of Computational Biomedicine Department of Biological ChemistrySchool of MedicineUniversity of CaliforniaIrvineCA 92697USA Department of Biochemistry&Molecular Biology University of Texas Medical BranchGalvestonTX 77555USA

Background:Genome-wide association studies(GWAS)have identified thousands of genomic non-coding variants statistically associated with many human traits and diseases,including cancer.However,the functional interpretation of these non-coding variants remains a significant challenge in the post-GWAS era.Alternative polyadenylation(APA)plays an essential role in post-transcriptional regulation for most human genes.By employing different poly(A)sites,genes can either shorten or extend the 3'-UTRs that contain cu-regulatory elements such as miRNAs or RNA-binding protein binding sites.Therefore,APA can affect the mRNA stability,translation,and cellular localization of proteins.Population-scale studies have revealed many inherited genetic variants that potentially impact APA to further influence disease susceptibility and phenotypic diversity,but systematic computational investigations to delineate the connections are in their earliest states.Results:Here,we discuss the evolving definitions of the genetic basis of APA and the modern genomics tools to identify,characterize,and validate the genetic influences of APA events in human populations.We also explore the emerging and surprisingly complex molecular mechanisms that regulate APA and summarize the genetic control of APA that is associated with complex human diseases and traits.Conclusion:APA is an intermediate molecular phenotype that can translate human common non-coding variants to individual phenotypic variability and disease susceptibility.

关键词： GWAS eQTL disease alternative polyadenylation

Effect of carrier gases on the entrainment defects within AZ91 alloy castings

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journal of Magnesium and Alloys 2022年第1期10卷 142-159页

作者： Tian li j.M.T.Davies Xiangzhen Zhu University of Birmingham Birmingham 8152TTUnited Kingdom Grainger and Worrall Ltd Bridgnorth WV155HPUnited Kingdom Brunel Centre for Advanced Solidification Technology Brunel University LondonKingston LnLondonUxbridge UB83PHUnited Kingdom

An entrainment defect(also known as a double oxide film defect or bifilm) acts a void containing an entrapped gas when submerged into a light-alloy melt, thus reducing the quality and reproducibility of the final castings. Previous publications, carried out with Al-alloy castings, reported that this trapped gas could be subsequently consumed by the reaction with the surrounding melt, thus reducing the void volume and negative effect of entrainment defects. Compared with Al-alloys, the entrapped gas within Mg-alloy might be more efficiently consumed due to the relatively high reactivity of magnesium. However, research into the entrainment defects within Mg alloys has been significantly limited. In the present work, AZ91 alloy castings were produced under different carrier gas atmospheres(i.e., SF6/CO2, SF6/air).The evolution processes of the entrainment defects contained in AZ91 alloy were suggested according to the microstructure inspections and thermodynamic calculations. The defects formed in the different atmospheres have a similar sandwich-like structure, but their oxide films contained different combinations of compounds. The use of carrier gases, which were associated with different entrained-gas consumption rates, affected the reproducibility of AZ91 castings.

关键词： Magnesium alloy Casting Oxide film,Bifilm,Entrainment defect,Reproducibility