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Effects of different drying methods on drying kinetics and physicochemical properties of Chrysanthemum morifolium Ramat

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International Journal of Agricultural and Biological Engineering 2019年第3期12卷 187-193页

作者： Borui li Jueyi lin Zhian zheng Hao Duan Dong li Min Wu College of Engineering China Agricultural UniversityBeijing 100083China

The effects of infrared-assisted hot-air drying(IR-HAD),temperature,humidity controlled hot-air drying(THC-HAD),and hot-air drying(HAD)on the drying kinetics,physicochemical properties,chlorogenic acid content and microstructure of chrysanthemum were experimentally *** results showed that the drying time reduced with increasing air drying temperature,with IR-HAD needing the shortest drying time,followed by THC-HAD and *** effective moisture diffusivities(Deff)of chrysanthemum under IR-HAD,THC-HAD,and HAD at 60℃ were 3.22×10^(-9) m^(2)/s,2.19×10^(-9) m^(2)/s,and 2.89×10^(-9) m^(2)/s,***-HAD preserved chrysanthemum surface color better than THC-HAD and HAD,whereas the THC-HAD samples obtained higher water holding capacity(WHC),water binding capacity(WBC),and chlorogenic acid ***,peroxidase(POD)residual activity of the samples decreased with increasing blanching *** current work provides a theoretical basis for the drying of chrysanthemum.

关键词： chrysanthemum drying kinetics Weibull model physicochemical properties peroxidase(POD)residual activity chlorogenic acid content

Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis

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Chinese Journal of Natural Medicines 2018年第11期16卷 846-855页

作者： MENG zheng-Jie WANG Chao MENG ling-Tong BAO Bei-Hua WU Jin-hui HU Yi-Qiao College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University State Key Laboratory of Pharmaceutical Biotechnology Medical School Nanjing University School of Pharmaceutical Sciences Nanjing Tech University Jiangsu Key Laboratory for High Technology of Traditional Chinese Medicine Formulae Research College of Pharmacy Nanjing University of Chinese Medicine

Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate(STS) is a water-soluble derivative of Tanshinone IIA(TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated. STS treatment could significantly decrease the serum levels of C-reactive protein(CRP), procalcitonin(PCT), cardiac troponin Ⅰ(cTn-Ⅰ), cardiac troponin T(cTn-T), and brain natriuretic peptide(BNP) in cecal ligation and puncture(CLP)-induced) septic rats and improve left ventricular function, particularly at 48 and 72 h after CLP. As the pathogenesis of septic myocardial dysfunction is attributable to dysregulated systemic inflammatory responses, several key cytokines, including tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), interleukin-6(IL-6), interleukin-10(IL-10) and high mobility group protein B1(HMGB1), were detected to reveal the possible mechanism of attenuation of septic myocardial dysfunction after being treated by STS. Our study showed that STS, especially at a high dose(15 mg×kg–1), could efficiently suppress inflammatory responses in myocardium and reduce myocardial necrosis through markedly reducing production of myocardial TNF-α, IL-6 and HMGB1. STS significantly improved the 18-day survival rate of rats with sepsis from 0% to 30%(P < 0.05). Therefore, STS could suppress inflammatory responses and improve left ventricular function in rats with sepsis, suggesting that it may be developed for the treatment of sepsis.

关键词： Sodium tanshinone II A sulfonate Sepsis Cardiac dysfunction Cytokine Cecal ligation and puncture model

Theoretical probe into universal tetrad effect for complexation discrepancy between lanthanide elements and organophosphoric extractant diethyl phosphoric acid

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Journal of Rare Earths 2024年第6期42卷 1142-1148,I0006页

作者： Haifeng zheng Yanling li Xuyi Zhang Jinglu Han Songsong li Guolong Wu Qingshi liu Xiaojuan liu Wuping liao State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China

The deep understanding of 4f-correlated electron motion behavior is experimentally limited due to similar physicochemical properties of rare earth elements(REEs).While the solvent extraction behavior originating from the continuous occupation of 4f electrons along the lanthanide family provides a particular platform to probe the 4f electrons motion behavior and its correlations to their versatile ***,the complexation between REEs and the prototypical extractant of diethyl phosphoric acid(DEP)was substantially studied based on quantum mechanical *** results firstly show that the average bond lengths between Ln and six coordinated oxygen atoms are consistent with lanthanide contraction phenomenon,and gadolinium break effect is also obviously ***,the"tetrad effect"is figured out based on the subtle discrepancy of 4f electrons occupation,namely La-Nd,Sm-Eu,Gd-Dy and ***,the main composition is 4f5d6p for La-Nd,while the discrepancy is due to the increasing electrons in the 5d shell,while it is 4f5d for *** Gd-Dy,their 4f orbitals accept little electrons and the donating electrons flow into 6s5d subshells due to the half-filled stability and the enhancement of shielding *** electrons donate into 5d6p subshells due to multiply electrons occupation of 4f orbitals for *** detailed analyses obviously clarify the"tetrad effect"along the lanthanide family due to the different variation of 4f orbital *** is expected that these microscopic understandings provide important guidance for the separation of REEs and the design of new extractants.

关键词： Theoretical calculation Rare earths 4f electron Tetrad effect Gadolinium break

Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses

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World Journal of Gastroenterology 2013年第29期19卷 4702-4717页

作者： Qian-Qian Chen li Yan Chang-zheng Wang Wei-Hua Wang hui Shi Bin-Bin Su Qing-Huan Zeng Hai-Tao Du Jun Wan Department of Gastroenterology Chinese PLA General Hospital Medical College of PLA Department of Gastroenterology Chinese PLA General Hospital

AIM: To investigate the potential therapeutic effects of mesenchymal stem cells (MSCs) in inflammatory bowel disease (IBD), we transplanted MSCs into an experimental model of IBD. METHODS: A rectal enema of trinitrobenzene sulfonic acid (TNBS) (100 mg/kg body weight) was administered to female BALB/c mice. Bone marrow mesenchymal stem cells (BMSCs) were derived from male green fluorescent protein (GFP) transgenic mice and were transplanted intravenously into the experimental animals after disease onset. Clinical activity scores and histological changes were evaluated. GFP and Sex determining region Y gene (SRY ) expression were used for cell tracking. Ki67 positive cells and Lgr5-expressing cells were determined to measure proliferative activity. Inflammatory response was determined by mea-suring the levels of different inflammatory mediators in the colon and serum. The inflammatory cytokines included tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-2 (IL-2), IL-6, IL-17, IL-4, IL-10, and transforming growth factor (TGF-β). Master regulators of Th1 cells (T-box expressed in T cells, T-bet), Th17 cells (retinoid related orphan receptor gamma(t), RORγt), Th2 cells (GATA family of transcription factors 3, GATA3) and regulatory T cells (forkhead box P3, Foxp3) were also determined. RESULTS: Systemic infusion of GFP-BMSCs ameliorated the clinical and histopathologic severity of colitis, including body weight loss, diarrhea and inflammation, and increased survival (P liferation of intestinal epithelial cells and differentiation of intestinal stem cells (P < 0.01). This therapeutic effect was mainly mediated by downregulation of both Th1-Th17-driven autoimmune and inflammatory responses (IL-2, TNF-α, IFN-γ, T-bet; IL-6, IL-17, RORγt), and by up-regulation of Th2 activities (IL-4, IL-10, GATA-3) (P < 0.05). MSCs also induced activated CD4 + CD25 + Foxp3 + regulat

关键词： Mesenchymal stem cells Transplantation Inflammatory bowel disease Inflammatory response Immunomodulation Trinitrobenzene sulfonic acid colitis Therapy

Developing big ocean system in support of Sustainable Development Goals:challenges and countermeasures

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Big Earth Data 2021年第4期5卷 557-575页

作者： Bin Zhang Fuchao li Gang zheng Yanjun Wang Zhetao Tan Xiaofeng li Institute of Oceanology Chinese Academy of SciencesQingdaoChina Center for Ocean Mega-Science Chinese Academy of SciencesQingdaoChina State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhouChina International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

The ocean is a critical part of the global *** marine ecosystem balance is crucial for human survival and sustainable ***,due to the impacts of global climate change and human activities,the ocean is rapidly changing,which poses an enormous threat to human health and the econ-omy.“Conserve and sustainably use the oceans,seas and marine resources”is one of the 17 Sustainable Development Goals(SDGs).Therefore,it is urgent to construct a transformative marine scientific solution to promote sustainable *** data is the basis of ocean cognition and *** science has ush-ered in the era of big data with continuous advances in modern marine data *** big data provides a large amount of data for SDG research,it simultaneously brings unprecedented *** study introduces an overall framework of a system for solving the current problems faced by marine data serving SDGs from the perspective of marine data management and ***,it articulates how the system helps the SDGs through two application cases of managing fragmented marine data and developing global climate change data products.

关键词： Marine big data Sustainable Development Goals data management EasyDM

Cultural competence of nurses in Pudong New Area,Shanghai:a mixed-method study

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Frontiers of Nursing 2020年第2期7卷 119-128页

作者： li-li Ma hui Jiang You-Qing Peng Shanghai East Hospital School of MedicineTongji UniversityPudong New AreaShanghai 200120China Shanghai Maternity and Infant Hospital School of MedicineTongji UniversityPudong New AreaShanghai 201203China

Objective:Cultural competence has gradually attracted attention from many countries,including *** study was undertaken to determine the cultural competence of registered nurses in Shanghai,China,and to identify the cultural competence among registered nurses in Pudong New Area,***:Qualitative interviews were conducted in combination with a quantitative *** clinical nurses were interviewed,and 1088 clinical nurses were recruited for the survey with cultural competence scale for registered nurses,based on the results of the qualitative and quantitative ***:The overall level of cultural competence among registered nurses in Shanghai's Pudong New Area was *** the seven dimensions,cultural encounter had the highest score,followed by cultural practice,cultural awareness,cultural desire,cultural skill,cultural experience,and cultural ***,level of hospital care,mastery of secondary level,and studying overseas were the influencing ***:Hospitals and universities should be aware of the importance of studying cultural *** competencerelated courses should be increased,and various forms of training should be undertaken to enhance the interest of nurses.

关键词： cultural competence China education health care hospital nurse

A Deep Double-Channel Dense Network for Hyperspectral Image Classifica-tion

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Journal of Geodesy and Geoinformation Science 2021年第4期4卷 46-62页

作者： Kexian WANG Shunyi zheng Rui li li GUI School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430079China School of Electronic Information Wuhan UniversityWuhan 430072China

Hyperspectral Image(HSI)classification based on deep learning has been an attractive area in recent ***,as a kind of data-driven algorithm,the deep learning method usually requires numerous computational resources and high-quality labelled datasets,while the expenditures of high-performance computing and data annotation are *** this paper,to reduce the dependence on massive calculation and labelled samples,we propose a deep Double-Channel dense network(DDCD)for Hyperspectral Image ***,we design a 3D Double-Channel dense layer to capture the local and global features of the *** we propose a linear Attention Mechanism that is approximate to dot-product attention with much less memory and computational *** number of parameters and the consumptions of calculation are observably less than contrapositive deep learning methods,which means DDCD owns simpler architecture and higher efficiency.A series of quantitative experiences on 6 widely used hyperspectral datasets show that the proposed DDCD obtains state-of-the-art performance,even though when the absence of labelled samples is severe.

关键词： 3D Double-Channel dense layer linear Attention Mechanism Deep Learning(DL) hyperspectral classification

MoS_(2) reinforced PEEK composite for improved aqueous boundary lubrication

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Friction 2023年第9期11卷 1660-1672页

作者： Xin HOU Pengpeng BAI Jingyang li Yuanzhe li hui CAO Xiangli WEN Yonggang MENG liran MA Yu TIAN State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Polyether-etherketone(PEEK)is a corrosion-resistant material that has been widely used in aqueous ***,its anti-wear performance must be improved for its application in the *** this study,to improve the anti-wear performance of PEEK for aqueous boundary lubrication,PEEK/MoS_(2)composites were prepared by ball-milling and spark plasma sintering processes.A competitive MoS_(2)mechanism between the low shear strength property and the role of promoting wear debris generation influences the anti-wear performance of PEEK/MoS_(2)*** demonstrated that the coefficients of friction(COF)and wear rate of PEEK composite with 0.25 wt%MoS_(2)were significantly reduced 68%and 94%,***,this was the first time that a PEEK composite could achieve a COF of less than 0.05 in aqueous boundary *** anti-wear performance was verified to be better than that of PEEK/carbon fiber(CF)and Thordon *** PEEK/MoS_(2)composite may be a potential material for underwater equipment because of its outstanding anti-wear performance in aqueous boundary lubrication.

关键词： polyether-etherketone(PEEK)composite MoS_(2) anti-wear performance aqueous lubrication boundary lubrication

Two-stent strategy for renal artery stenosis with bifurcation lesion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 561-567页

作者： Hong-bing YAN Bin zheng zheng WU Jian WANG Han-jun ZHAO li SONG Yun-peng CHI Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Renal artery stenosis(RAS) with a bifurcation lesion is a challenge for interventional *** aim of this study is to summarize our experience in RAS with a bifurcation *** patients with RAS involving bifurcation lesion are *** cases 1 to 3,a single-stent strategy was first ***,these three patients were converted to a two-stent strategy for bailout stent implantation in the side *** cases 4 and 5,a simultaneous kissing stent technique was *** showed that the reference vascular diameter of the main branch was much larger than those of the side *** obvious residual stenosis existed in cases 1 to 3 after stent implantation,no obvious residual stenosis was seen in cases 4 and *** artery duplex sonography was performed in cases 1 through 5 at 6,7,7,8,and 6 months,respectively,after the *** evidence of restenosis or occlusion was *** conclusion,stent implantation with the simultaneous kissing stent technique may result in more simple and more satisfactory immediate angiographic results.

关键词： Peripheral atherosclerotic artery disease Angioplasty Stents Renal artery stenosis