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Radix Scrophulariae Extracts Exert Effect on Hyperthyroidism via MST1/Hippo Signaling Pathway

Chinese Journal of Integrative Medicine 2023年第11期29卷 998-1006页

作者： ZHANG Ning YE Tao LU Xu li zi-hui li ling Department of Pharmacy The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(50001)China Department of Chinese Medicine Rehabilitation The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(50001)China College of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang(550025)China College of life and Health Dalian UniversityDalianLiaoning Province(116622)China

Objective:To explore the mechanism of Radix Scrophulariae(RS)extracts in the treatment of hyperthyroidism rats by regulating proliferation,apoptosis,and autophagy of thyroid cell through the mammalian sterile 20-like kinase 1(MST1)/Hippo ***:Twenty-four rats were randomly divided into 4 groups according to a random number table:control,model group,RS,and RS+Hippo inhibitor(XMU-MP-1)groups(n=6 per group).Rats were gavaged with levothyroxine sodium tablet suspension(LST,8μg/kg)for 21 days except for the control ***,rats in the RS group were gavaged with RS extracts at the dose of 1,350 mg/kg,and rats in the RS+XMU-MP-1 group were gavaged with 1,350 mg/kg RS extracts and 1 mg/kg *** 15 days of administration,thyroid gland was taken for gross observation,and histopathological changes were observed by hematoxylin-eosin *** structure of Golgi secretory vesicles in thyroid tissues was observed by transmission electron *** expression of thyrotropin receptor(TSH-R)was observed by ***-deoxynucleoitidyl transferase mediated nick end labeling assay was used to detect cell apoptosis in thyroid ***-time quantity primer chain reaction and Western blot were used to detect the expressions of MST1,p-large tumor suppressor gene 1(LATS1),p-Yes1 associated transcriptional regulator(YAP),proliferating cell nuclear antigen(PCNA),G_(1)/S-specific cyclin-D1(Cyclin D1),B-cell lymphoma-2(Bcl-2),Caspase-3,microtubule-associated proeins light chain 3Ⅱ/Ⅰ(LC3-Ⅱ/Ⅰ),and recombinant human autophagy related 5(ATG5).Thyroxine(T4)level was detected by enzyme-linked immunosorbent ***:The thyroid volume of rats in the model group was significantly increased compared to the normal control group(Plicular epithelial cells,disorderly arrangement,and irregular morphology *** secretion of small vesicles by Golgi apparatus was reduced,and the exp

关键词： Radix inhibited Scr

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Handgrip Strength as a Predictor of Nutritional Status in Chinese Elderly Inpatients at Hospital Admission

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Biomedical and Environmental Sciences 2017年第11期30卷 802-810页

作者： ZHANG Xin Sheng liU Ying Hua ZHANG Yong XU Qing YU Xiao Ming YANG Xue Yan liU Zhao li hui zi li Feng XUE Chang Yong Department of Nutrition Chinese PLA General Hospital Department of Nutrition Chinese PLA General Hospital of Rocket Forces

Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.

关键词： Handgrip strength Elderly inpatients Nutrition assessment Nutrition status Malnutrition

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Caprylic Acid Improves lipid Metabolism, Suppresses the Inflammatory Response and Activates the ABCA1/p-JAK2/pSTAT3 Signaling Pathway in C57BL/6J Mice and RAW264.7 Cells

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Biomedical and Environmental Sciences 2022年第2期35卷 95-106页

作者： ZHANG Xin Sheng ZHANG Peng liU Ying Hua XU Qing ZHANG Yong li hui zi liU Lu liU Yu Meng YANG Xue Yan XUE Chang Yong Department of Nutrition the First Medical Center of PLA General HospitalBeijing 100853China Guizhou Crops of Chinese Armed Police Force Guiyang 550001GuizhouChina Department of Nutrition PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Objective This study aimed to investigate the effects of caprylic acid(C8:0)on lipid metabolism and inflammation,and examine the mechanisms underlying these effects in mice and *** Fifty-six 6-week-old male C57BL/6J mice were randomly allocated to four groups fed a highfat diet(HFD)without or with 2%C8:0,palmitic acid(C16:0)or eicosapentaenoic acid(EPA).RAW246.7 cells were randomly divided into five groups:normal,lipopolysaccharide(LPS),LPS+C8:0,LPS+EPA and LPS+*** serum lipid profiles,inflammatory biomolecules,and ABCA1 and JAK2/STAT3 mRNA and protein expression were *** C8:0 decreased TC and LDL-C,and increased the HDL-C/LDL-C ratio after injection of *** LPS,it decreased TC in mice(Plipid metabolism and the inflammatory response,and the mechanism may be associated with ABCA1 and the p-JAK2/p-STAT3 signaling pathway.

关键词： Caprylic acid Inflammatory cytokine ATP binding cassette transporter A1 Janus kinase 2 Signal transducer and activator of transcription 3

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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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Influence of Surrounding Acupuncture by Cranial MRI Location on Blood Rheology in Apoplectic Patients

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Journal of Acupuncture and Tuina Science 2003年第5期1卷 17-19页

作者： JIANG Gang-hui li Yan-hui ZHUANG zi-qi HUANG Yong li Jian-ping HUANG Guo-qi First Affiliated Hospital of Guangzhou University of TCM Guangzhou China 510405 First Affiliated Hospital of Guangzhou University of TCM Guangzhou China 510405 First Affiliated Hospital of Guangzhou University of TCM Guangzhou China 510405 First Affiliated Hospital of Guangzhou University of TCM Guangzhou China 510405 First Affiliated Hospital of Guangzhou University of TCM Guangzhou China 510405

Purpose: To study the function of surrounding acupuncture located by cranial MRI on ***: Forty cases of the patients diagnosed as cerebral infarction were divided into the group of surrounding acupuncture by MRI location and the group of traditional scalp acupuncture, 20 cases in each group, and were treated respectively with surrounding acupuneture by MRI location and traditional scalp acupuncture, to determine the indexes of blood rheology before and after ***: There was significant difference (Pling techniques have an improving function in various indexes of blood rheology in the apoplectic patients and surrounding acupuncture by MRI location was better than traditional scalp acupuncture in improving blood rheology. Key Words Acupuncture Therapy - Hemodynamics - Cerebral Infarction JIANG Gang-hui, associate professor, has mainly done the clinical study in treating diseases of brain and spinal cord with acupuncture.Translator: HUANG Guoqi

关键词： Acupuncture Therapy Hemodynamics Cerebral Infarction

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai li-hui Cao Xu-Yong Chen Jia-Yu Wang zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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中国对美直接投资:跨越贸易壁垒的视角

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东北师大学报（哲学社会科学版） 2017年第1期 54-62页

作者：史本叶李秭慧吉林大学美国研究所吉林长春130012 吉林大学经济学院吉林长春130012

随着中国"走出去"战略的不断推进,中国已经成为对外投资大国,对美国的直接投资高速增长,与此同时,中国对美出口却频繁受到贸易壁垒的影响。中国对美直接投资的行业分布呈现多元化特征,制造业领域投资比重较高,投资行业领域与遭受美国反... 详细信息

随着中国"走出去"战略的不断推进,中国已经成为对外投资大国,对美国的直接投资高速增长,与此同时,中国对美出口却频繁受到贸易壁垒的影响。中国对美直接投资的行业分布呈现多元化特征,制造业领域投资比重较高,投资行业领域与遭受美国反倾销措施的出口部门呈现一定的重叠性。理论模型和实证分析结果表明,美国对华实施反倾销贸易壁垒对中国对美直接投资具有较强的推动作用,即中国对美直接投资具有较强的贸易壁垒跨越动机,但我国经济发展水平仍是决定对美直接投资的重要变量。我国政府和企业应采取相应的对策措施。

关键词：对美直接投资贸易壁垒反倾销跨越动机

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结核性脑膜炎实验室诊断现状与展望

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中国防痨杂志 2020年第5期42卷 442-448页

作者：李自慧张宗德首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室101149

结核性脑膜炎是一种最严重和常见的中枢神经系统结核病,快速确诊和及时治疗是改善患者预后和提高患者生存率的关键。但是,由于缺乏有效的检测手段,确诊结核性脑膜炎目前仍非常困难。作者针对结核性脑膜炎实验室诊断的现状、最新研究进展... 详细信息

结核性脑膜炎是一种最严重和常见的中枢神经系统结核病,快速确诊和及时治疗是改善患者预后和提高患者生存率的关键。但是,由于缺乏有效的检测手段,确诊结核性脑膜炎目前仍非常困难。作者针对结核性脑膜炎实验室诊断的现状、最新研究进展,以及所面临的问题和挑战进行论述和讨论,呼吁进一步通过合作加强结核性脑膜炎的实验室诊断研究。

关键词：结核,脑膜实验室技术和方法早期诊断基于问题的学习研究进展

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基于能量法的尾矿土动孔压模型研究

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岩土工程学报 2016年第11期38卷 2051-2058页

作者：刘叔灼李慧子单毅李康巴凌真华南理工大学土木与交通学院广东广州510641 华南理工大学亚热带建筑科学国家重点实验室广东广州510641 广东省重工建筑设计院有限公司广东广州510040

通过应力控制式动三轴不排水循环剪切试验,对饱和尾矿土在循环应力比、轴–径向固结应力比等因素下孔隙水压力与累积能量耗散关系进行研究。研究结果表明孔隙水压力增长与塑性应变累积能量耗散和土体黏滞累积能量耗散密切相关。当循环... 详细信息

通过应力控制式动三轴不排水循环剪切试验,对饱和尾矿土在循环应力比、轴–径向固结应力比等因素下孔隙水压力与累积能量耗散关系进行研究。研究结果表明孔隙水压力增长与塑性应变累积能量耗散和土体黏滞累积能量耗散密切相关。当循环应力比cR介于0.205～0.238、轴–径向固结应力比cK介于1.0～1.3时,孔隙水压力–能量之间存在临界状态。通过非线性回归分析初步建立了循环应力比和轴–径向固结应力比条件下饱和尾矿土的孔隙水压力能量模型,从变化机理上阐述孔隙水压力的变化规律并消除了周次的不确定性对于孔隙水压力模型的影响,对预测循环荷载作用下饱和土的孔隙水压力具有借鉴意义。

关键词：孔隙水压力能量模型饱和尾矿土循环应力比固结应力比

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XH02菌强化反应器脱氮过程中菌群结构的高通量分析

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中国环境科学 2017年第5期37卷 1922-1929页

作者：黄郑郑曹刚李紫惠陈海升莫测辉暨南大学环境学院广东广州510630 广东省污染控制与修复材料工程技术中心广东广州510630

为了强化生物反应器脱氮以及揭示微生物菌群结构随时间的动态变化,以Ochrobactrum anthropi XH02和SBR反应器为研究对象,利用16Sr DNA高通量测序技术,对不同时期反应器中微生物的菌群结构和多样性进行了动态分析.研究结果表明,XH02菌的... 详细信息

为了强化生物反应器脱氮以及揭示微生物菌群结构随时间的动态变化,以Ochrobactrum anthropi XH02和SBR反应器为研究对象,利用16Sr DNA高通量测序技术,对不同时期反应器中微生物的菌群结构和多样性进行了动态分析.研究结果表明,XH02菌的加入使得反应器中TN和COD的去除率分别提升了15%和10%以上;反应器中微生物菌群在属水平上的相对丰度和多样性呈先下降后上升的趋势;XH02的加入对菌群结构产生了较大影响.Acinetobacter、Blvii28和Aquabactenium菌的相对丰度显著下降,而Fontibacter和Treponema菌的相对丰度则在强化过程中显著升高;XH02的相对丰度随着反应器的运行逐渐增加,最后形成了较为稳定的菌群;主成分分析和UPGMA聚类分析大致把反应器运行过程分成4个阶段.

关键词：异养硝化-好氧反硝化生物多样性高通量测序技术 SBR反应器菌群结构

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