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Construction and Genetic Analysis of Murine Hepatitis Virus Strain A59 Nsp16 Temperature Sensitive Mutant and the Revertant Virus

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Virologica Sinica 2011年第1期26卷 19-29页

作者： Guo-hui Chang Bao-jun Luo Pin Lu Lei lin Xiao-yan wu Jing li Yi Hu Qing-yu Zhu state key laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China Changchun Changsheng life sciences limited Changchun 130103 China

Coronaviruses (CoVs) are generally associated with respiratory and enteric infections and have long been recognized as important pathogens of livestock and companion animals. Mouse hepatitis virus (MHV) is a widely studied model system for Coronavirus replication and pathogenesis. In this study,we created a MHV-A59 temperature sensitive (ts) mutant wu"-ts18(cd) using the recombinant vaccinia reverse genetics system. Virus replication assay in 17C1-1 cells showed the plaque phenotype and replication characterization of constructed wu"-ts18(cd) were indistinguishable from the reported ts mutant wu"-ts18. Then we cultured the ts mutant wu"-ts18(cd) at non-permissive temperature 39.5°C,which "forced" the ts recombinant virus to use second-site mutation to revert from a ts to a non-ts phenotype. Sequence analysis showed most of the revertants had the same single amino acid mutation at Nsp16 position 43. The single amino acid mutation at Nsp16 position 76 or position 130 could also revert the ts mutant wu"-ts18 (cd) to non-ts phenotype,an additional independent mutation in Nsp13 position 115 played an important role on plaque size. The results provided us with genetic information on the functional determinants of Nsp16. This allowed us to build up a more reasonable model of CoVs replication-transcription complex.

关键词： Genetic analysis MHV-A59 Temperature-sensitive mutant Revertant Nonstructural proteins (Nsp)

6G-Enabled Edge AI for Metaverse:Challenges, Methods,and Future Research Directions

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Journal of Communications and information Networks 2022年第2期7卷 107-121页

作者： Luyi Chang Zhe Zhang Pei li Shan Xi Wei Guo Yukang Shen Zehui Xiong Jiawen Kang Dusit Niyato Xiuquan Qiao Yi wu School of Data Science and Technology Heilongjiang UniversityHarbin 150080China institute for Cryptology and Network security Heilongjiang UniversityHarbin 150080China SenseTime Group limited Shenzhen 518000China Pillar of information Systems Technology and Design Singapore University of Technology and Design.Singapore 487372Singapore School of Automation.Guangdong University of Technology and Center for Intelligenl Batch Manufacturing based on IoT TechnologyGuangzhou 510006China School of Computer Science and Engineering Nanyang Technological UniversitySingapore 639798.Singapore state key laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications.Beijing 100876China

Sixth generation(6G)enabled edge intelligence opens up a new era of Internet of everything and makes it possible to interconnect people-devices-cloud anytime,*** and more next-generation wireless network smart service applications are changing our way of life and improving our quality of *** the hottest new form of next-generation Internet applications,Metaverse is striving to connect billions of users and create a shared world where virtual and reality ***,limited by resources,computing power,and sensory devices,Metaverse is still far from realizing its full vision of immersion,materialization,and *** this end,this survey aims to realize this vision through the organic integration of 6G-enabled edge artificial intelligence(AI)and ***,we first introduce three new types of edge-Metaverse architectures that use 6G-enabled edge AI to solve resource and computing constraints in *** we summarize technical challenges that these architectures face in Metaverse and the existing ***,we explore how the edge-Metaverse architecture technology helps Metaverse to interact and share digital ***,we discuss future research directions to realize the true vision of Metaverse with 6G-enabled edge AI.

关键词： edge artificial intelligence artificial intelli-gence 6G metaverse federated learning

Rapid synthesis of Pd single‐atom/cluster as highly active catalysts for Suzuki coupling reactions

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chinese Journal of Catalysis 2022年第4期43卷 1058-1065页

作者： Hehe Wei Xiaoyang li Bohan Deng Jialiang Lang Ya Huang Xingyu Hua Yida Qiao Binghui Ge Jun Ge hui wu state key laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China key Lab for Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China institutes of Physical Science and information Technology Anhui UniversityHefei 230601AnhuiChina key laboratory for Advanced Materials Center for Computational Chemistry and Research Institute of Industrial CatalysisEast China University of Science and TechnologyShanghai 200237China

Palladium(Pd)‐based catalysts are essential to drive high‐performance Suzuki coupling reactions,which are powerful tools for the synthesis of functional organic ***,we developed a solution‐rapid‐annealing process to stabilize nitrogen‐mesoporous carbon supported Pd single‐atom/cluster(Pd/NMC)material,which provided a catalyst with superior performance for Suzuki coupling *** comparison with commercial palladium/carbon(Pd/C)catalysts,the Pd/NMC catalyst exhibited significantly boosted activity(100%selectivity and 95%yield)and excellent stability(almost no decay in activity after 10 reuse cycles)for the Suzuki coupling reactions of chlorobenzenes,together with superior yield and excellent selectivity in the fields of the board scope of the ***,our newly developed rapid annealing process of precursor solutions is applied as a generalized method to stabilize metal clusters(***,Pt,Ru),opening new possibilities in the construction of efficient highly dispersed metal atom and sub‐nanometer cluster catalysts with high performance.

关键词： Pd single‐atom/cluster catalyst Suzuki coupling reactions Solution rapid annealing Energy barrier High yield

关中典型城市及农村夏季PM2.5的化学组成对比

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中国环境科学 2018年第12期38卷 4415-4425页

作者：李瑾李建军吴灿曹聪吴宇航刘浪韩晶王格慧中国科学院地球环境研究所黄土与第四纪地质国家重点实验室中国科学院气溶胶化学与物理重点实验室陕西西安710061 中国科学院大学北京100049 西安交通大学医学部公共卫生学院陕西西安710061 华东师范大学地理科学学院地理信息科学教育部重点实验室上海200241

于2016年7～8月采集了陕西省西安市(城市)及蔺村(农村)夏季昼夜PM_(2.5)样品,分析其有机碳(OC)、元素碳(EC)和无机离子等化学组分的含量,探讨关中平原城市和农村地区PM_(2.5)的化学组成和来源的差异.结果表明,采样期间西安和蔺村的PM_(2... 详细信息

于2016年7～8月采集了陕西省西安市(城市)及蔺村(农村)夏季昼夜PM_(2.5)样品,分析其有机碳(OC)、元素碳(EC)和无机离子等化学组分的含量,探讨关中平原城市和农村地区PM_(2.5)的化学组成和来源的差异.结果表明,采样期间西安和蔺村的PM_(2.5)浓度分别为(49.7±22.8)和(62.6±14.2)μg/m^3.西安PM_(2.5)中OC和EC的浓度[(6.5±2.5)μg/m^3,(3.2±1.8)μg/m^3]与蔺村[(6.8±1.8)μg/m^3,(3.8±2.3)μg/m^3]相当.西安OC/EC比值白天(2.6)高于夜晚(1.9),蔺村反之(白天:1.6;夜晚:2.7),主要是因为夜间城市地区重型卡车运输活动增强导致排放更多EC,而夜间农村地区人为活动较少导致EC排放显著降低.西安和蔺村无机离子总浓度分别为(20.2±14.6)和(30.1±10.5)μg/m^3,占PM_(2.5)浓度的40.6%和47.6%.蔺村SO_4^(2-)的平均浓度高达19.0μg/m^3,占PM_(2.5)浓度的30%以上,远高于西安(9.4μg/m^3和18.9%),主要与农村固体燃料(煤和生物质)使用有关.西安NO_3^-和Ca^(2+)的浓度及其对PM_(2.5)的贡献、NO_3^-/SO_4^(2-)比值均明显大于蔺村,表明城市地区受机动车尾气和扬尘的影响更大.西安K^+与Ca^(2+)和Mg^(2+)的相关性较强,而蔺村K^+与EC的相关性显著强于西安,说明西安市区K^+由粉尘源主导,而农村地区则主要来自生物质燃烧.

关键词：关中平原 PM2.5 有机碳元素碳无机离子

Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among chinese Older Adults

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Biomedical and Environmental sciences 2021年第11期34卷 859-870页

作者： wu Bing LYU Yue Bin CAO Zhao Jin WEI Yuan SHI Wan Ying GAO Xiang ZHOU Jin hui KRAUS Virginia Byers ZHAO Feng CHEN Xin LU Feng ZHANG Ming Yuan liU Ying Chun TAN Qi Yue SONG Shi Xun QU Ying li ZHENG Xu lin SHEN Chong MAO Chen SHI Xiao Ming Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina china CDC key laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China School of Public Health Jilin UniversityChangchun 130012JilinChina Department of Nutritional sciences Pennsylvania State UniversityUniversity ParkPA19019USA Duke Molecular Physiology institute and Department of Medicine Duke University School of MedicineDurhamNorth Carolina27701USA beijing Municipal Health Commission information Center Beijing 100034China Division of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina

Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among chinese older *** Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort *** impairment was assessed by the chinese Mini-Mental state *** strength was calculated from the means of the right and left hand *** circumference was measured at the site of maximum circumference of the non-dominant *** formula developed by Ishii was used to define *** logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive *** The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q_(2),Q_(3),and Q_(4))were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),*** with individuals in Q1 of handgrip strength,the adjusted ORs for Q_(2),Q_(3),and Q_(4) were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),*** Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment.

关键词： Sarcopenia Cognitive impairment Handgrip strength Calf circumference Older adults

复杂山区工程建设物资运输无人机巡航模型构建与实证研究

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交通运输系统工程与信息 2023年第3期23卷 290-299页

作者：康柳江李浩孙会君吴建军北京交通大学交通运输学院北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044

基于某复杂山区YA-LZ段的铁路工程建设物资运输计划,本文研究无人机巡航规划及机队管理问题。首先,考虑无人机飞行高度限制和山区飞行轨迹,提出近似飞行距离算法计算山区无人机实际飞行距离。其次,通过建立以无人机基地建设成本、无人... 详细信息

基于某复杂山区YA-LZ段的铁路工程建设物资运输计划,本文研究无人机巡航规划及机队管理问题。首先,考虑无人机飞行高度限制和山区飞行轨迹,提出近似飞行距离算法计算山区无人机实际飞行距离。其次,通过建立以无人机基地建设成本、无人机固定成本与巡航成本最小化为目标的复杂艰险山区无人机巡航优化模型,决策无人机基地坐标、巡航范围以及机队配置需求。针对模型的非线性特点,设计自适应聚类-空间移动算法,通过有限次迭代快速划分巡航范围,进而搜索全局最优的无人机基地坐标,并计算最小机队配置需求。最后,将无人机巡航模型与自适应聚类-空间移动算法应用于YA-LZ段物资运输路线案例。通过与传统算法比较发现,计算结果可降低约20%的巡航成本。

关键词：交通工程无人机巡航数学建模物资运输网络自适应聚类-空间移动算法

DeST 3.0:A new-generation building performance simulation platform

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Building Simulation 2022年第11期15卷 1849-1868页

作者： Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang hui Zhou Kuining Qiu Jing liu Yan liu Honglian li Lei Zhang Hong Dong lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng Building Energy Research Center School of ArchitectureTsinghua UniversityBeijing 100084China School of Architecture Southeast UniversityNanjingJiangsu 210096China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China College of Civil Engineering Hunan UniversityChangshaHunan 410082China School of Mechanical Engineering Tongji UniversityShanghai200092China beijing key Lab of Heating Gas SupplyVentilating and Air Conditioning EngineeringBeijing University of Civil Engineering and ArchitectureBeijing 100044China china state Construction Technology Center Beijing 101320China School of Architecture Harbin Institute of TechnologyHarbinHeilongjiang 150090China School of Architecture Xi'an University of Architecture and TechnologyXi'anShaanxi 710055China School of Architecture South China University of TechnologyGuangzhouGuangdong 510641China institute of Building Environment and Energy China Academy of Building ResearchBeijing 100013China beijing key laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China key Lab of Built Environment and Energy of Tianjin School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Civil Engineering Guangzhou UniversityGuangzhou 510006China Faculty of Computing Harbin Institute of TechnologyHarbinHeilongjiang 150001China beijing Glory PKPM Technology Co. Ltd.Beijing 100013China beijing Tangent software Co. LtdBeijing 100081China Shanghai Huadianyuan information Technology Co. LtdShanghai200092China Luoyang Hongye information Technology Co. Ltd.LuoyangHenan 471822China

Buildings contribute to almost 30%of total energy consumption *** building energy modeling programs is of great significance for lifecycle building performance assessment and *** in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and *** meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and *** structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing *** 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation *** 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study *** 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and *** new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization.

关键词： DeST building performance simulation building energy modeling

丰中子区近^(132)Sn原子核的壳演化研究进展

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科学通报 2021年第27期66卷 3537-3543页

作者：陈志强李智焕吴婧吴鸿毅李湘庆徐川华辉北京大学物理学院核物理与核技术国家重点实验室北京100871

弱束缚区原子核传统幻数的消失和新幻数的产生一直是放射性核束物理的前沿研究方向.近年来,基于世界各地大科学装置的研究已经积累了丰硕的成果.在远离稳定线的轻丰中子区,人们已经发现8,20,28传统中子幻数的消失和新中子幻数14,16,34... 详细信息

弱束缚区原子核传统幻数的消失和新幻数的产生一直是放射性核束物理的前沿研究方向.近年来,基于世界各地大科学装置的研究已经积累了丰硕的成果.在远离稳定线的轻丰中子区,人们已经发现8,20,28传统中子幻数的消失和新中子幻数14,16,34等的出现.在中重丰中子区,已有的实验和理论研究显示,50和82传统中子闭壳随着中质比的增大,有减弱直至消失的趋势.利用日本理化学研究所的放射性束流装置,我们开展了对^(123)Pd和^(125)Pd核的β衰变实验研究,在衰变子核^(123)Ag和^(125)Ag的低激发能区发现了具有β放射性的同核异能态.利用新发现的同核异能态,讨论了奇质量Ag同位素核中由πg9/2和πp1/2两个轨道形成的Z=40亚闭壳能隙在N=82附近的演化,发现在N=82处,Z=40亚闭壳能隙可能存在明显的减小.为进一步了解壳演化的微观机制,使用包含张量力的壳模型计算了这个质量区单粒子轨道的演化.结果显示,相比于N=50处,Z=40亚闭壳能隙在N=82处存在明显的减小,张量力对Ag同位素中πg9/2和πp1/2轨道以及Z=40亚闭壳能隙在接近N=82时的演化起到非常重要的作用.

关键词：幻数远离β稳定线壳演化张量力 N=82壳隙

Dynamic time-correlated single-photon counting laser ranging

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Optoelectronics Letters 2018年第2期14卷 129-132页

作者：彭欢王煜蓉孟文东颜佩琴李召辉李辰潘海峰吴光 key laboratory for Space Laser information Perception Technology of CAST Beijing Institute of Space Mechanics& Electricity state key laboratory of Precision Spectroscopy East China Normal University

We demonstrate a photon counting laser ranging experiment with a four-channel single-photon detector(SPD). The multi-channel SPD improve the counting rate more than 4×10~7 cps, which makes possible for the distance measurement performed even in daylight. However, the time-correlated single-photon counting(TCSPC) technique cannot distill the signal easily while the fast moving targets are submersed in the strong background. We propose a dynamic TCSPC method for fast moving targets measurement by varying coincidence window in real time. In the experiment, we prove that targets with velocity of 5 km/s can be detected according to the method, while the echo rate is 20% with the background counts of more than 1.2×10~7 cps.

关键词： In SPD Dynamic time-correlated single-photon counting laser ranging