检索结果-南通市图书馆

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue li Yang DI Lei CHENG Ranran liU lijuan li hongmei li Yi TANG Zhangrui YAN Yongming LU Tao FU Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

A single degenerated primer significantly improves COX1 barcoding performance in soil nematode community profiling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Soil Ecology Letters 2024年第2期6卷 31-44页

作者： Yincai Ren Dorota L. Porazinska Quanhui Ma Shuhan liu hongmei li Xue Qing Department of Plant Pathology Nanjing Agricultural UniversityNanjing210095China Department of Entomology and Nematology University of FloridaGainesvilleFL32611USA Institute of Grassland Science Key Laboratory of Vegetation Ecology of the Ministry of EducationJilin Songnen Grassland Ecosystem National Observation and Research StationNortheast Normal UniversityChangchun130024China

A new COX1 primer for soil nematode metabarcoding was designed,and this primer outperforms other commonly used COX1 primer pairs in species recovery and quantity of PCR products.•The lack of reference database is the main reason that led to the low species recovery in COX1 metabarcoding.•We expanded current NCBI database by adding 51 newly generated COX1 reference *** nematodes play important roles in soil ecosystems and often serve as bioindicators of soil *** identification of soil nematodes is often difficult due to their limited diagnostic characters and high phenotypic *** barcoding and metabarcoding techniques are promising but lack universal primers,especially for mitochondrial COX1 *** this study a degenerated COX1 forward primer COIFGED was *** primer pair(COIFGED/JB5GED)outperforms other four commonly used COX1 primer pairs in species recovery and quantity of polymerase chain reaction(PCR)*** metabarcoding analysis,the reads obtained from the new primer pair had the highest sequencing saturation threshold and amplicon sequence variant(ASV)diversity in comparison to other COX1 as well as 18S rRNA *** annotation of ASVs suggested the new primer pair initially recovered 9 and 6 out of 25 genera from mock communities,respectively,outperformed other COX1 primers,but underperformed the widely used 18S NF1/18Sr2b primers(16 out of 25 genera).By supplementing the COX1 database with our reference sequences,we recovered an additional 6 mock community species bringing the tally closer to that obtained with 18S *** summary,our newly designed COX1 primers significantly improved species recovery and thus can be supplementary or alternative to the conventional 18S metabarcoding.

关键词： degenerated primers DNA metabarcoding mitochondrial cytochrome oxidase c subunit I gene phylogeny ribosomal RNA gene soil nematodes

Electrocatalysis for sustainable nitrogen management:materials innovation for sensing,removal and upcycling technologies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年

作者： Mei Yi hongmei li Minghao Xie Panpan li Zhaoyu Jin Guihua Yu Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering and College of Chemistry Sichuan University Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at Austin

The global nitrogen cycle holds immense importance due to its crucial role in supporting life, supplying vital nutrients for plant growth, preserving environmental balance, and enabling the proper functioning of ecosystems. However, human activities frequently disrupt this cycle, leading to the accumulation of nitrates and nitrites in water bodies. This accumulation causes environmental pollution and health risks. Traditional methods for treating nitrogen pollution, including biological, physical, and chemical approaches, have inherent limitations. In recent years, electrocatalysis has emerged as a promising and sustainable approach for nitrogen management. This technology offers superior efficiency, high selectivity, and environmental *** not only enables accurate detection of nitrogen pollutants in the environment but also facilitates their conversion into harmless nitrogen gas. Moreover, recent advancements have focused on the upcycling of nitrogen pollutants into valuable compounds,such as ammonia and urea. In this comprehensive review, we showcase the applications of electrocatalysis in sustainable nitrogen management. Specifically, we highlight its use in the sensing, removal, and upcycling of major nitrogen pollutants,including nitrate（NO3-）, nitrite（NO2-）, and nitric oxide（NO）. We discuss the use of catalysts, such as Pd alloys, Cu-based, and Fe-based materials, in electrochemical sensing and catalysis. Additionally, we explore recent advancements in the conversion of nitrogen pollutants into valuable compounds like ammonia and urea. The review also addresses current challenges and future opportunities in the field, including innovations in sensor and catalyst design, as well as large-scale treatment strategies. We anticipate that these perspectives will provide profound insights for effective nitrogen pollution control and sustainable utilization of nitrogen resources.

关键词：

Gas diffusion in catalyst layer of flow cell for CO_(2) electroreduction toward C_(2+) products

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1101-1106页

作者： Xiqing Wang Qin Chen Yajiao Zhou Yao Tan Ye Wang hongmei li Yu Chen Mahmoud Sayed Ramadan A.Geioushy Nageh K.Allam Junwei Fu Yifei Sun Min liu Hunan Joint International Research Center for Carbon Dioxide Resource Utilization School of Physics and ElectronicsCentral South UniversityChangsha 410083China School of Energy and Power Engineering Beihang UniversityBeijing 100191China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China Central Metallurgical Research and Development Institute(CMRDI) P.O.Box 87Helwan 11421CairoEgypt Energy Materials Laboratory School of Sciences and EngineeringThe American University in CairoNew Cairo 11835Egypt Research Center for Advanced Energy and Carbon Neutrality Beihang UniversityBeijing 100191China

The use of gas diffusion electrode(GDE)based flow cell can realize industrial-scale CO_(2) reduction reactions(CO_(2)RRs).Controlling local CO_(2) and CO intermediate diffusion plays a key role in CO_(2)RR toward multi-carbon(C_(2+))*** this work,local CO_(2) and CO intermediate diffusion through the catalyst layer(CL)was investigated for improving CO_(2)RR toward C_(2+)*** gas permeability tests and finite element simulation results indicated CL can balance the CO_(2) gas diffusion and residence time of the CO intermediate,leading to a sufficient CO concentration with a suitable CO_(2)/H_(2)O supply for high C_(2+)*** a result,an excellent selectivity of C_(2+)products~79%at a high current density of 400 mA·cm^(-2) could be obtained on the optimal 500 nm Cu CL(Cu500).This work provides a new insight into the optimization of CO_(2)/H_(2)O supply and local CO concentration by controlling CL for C_(2+)products in CO_(2)RR flow cell.

关键词： gas diffusion electrode CO_(2)reduction Cu mass transfer C_(2)product

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第02期 112-126页

作者： REN Boxue li Yang DI Lei CHENG Ranran liU lijuan li hongmei li Yi TANG Zhangrui YAN Yongming LU Tao FU Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of Pharmacology School of Pharmacy China Pharmaceutical University Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical Sciences Shenzhen University Health Science Center

The tumor suppressor protein p53 is central to cancer biology, with its pathway reactivation emerging as a promising therapeutic strategy in oncology. This study introduced LZ22, a novel compound that selectively inhibits the growth, migration, and metastasis of tumor cells expressing wild-type p53, demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant p53. LZ22's mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 protein. This interaction disrupted the MDM2-p53 binding, consequently stabilizing p53 by shielding it from proteasomal degradation. LZ22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***, LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT, effectively reducing tumor cell migration and distal metastasis. Importantly, LZ22 administration in tumor-bearing mice did not manifest notable side effects. The findings position LZ22 as a structurally unique reactivator of p53, offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词：

中国式现代化引领下基础教育高质量发展的基本内涵与未来路向

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

当代教育论坛 2024年第3期 9-16页

作者：李红梅四川师范大学教育科学学院四川师范大学核心素养教育研究中心成都610068

党的二十大描绘了中国式现代化的宏伟蓝图,开启了中国式现代化的壮丽征程。基础教育作为国民教育体系的根基,在中国式现代化的伟大征程中发挥着支撑性和基础性作用。中国式现代化赋予了基础教育高质量发展新的时代内涵,彰显了基础教育... 详细信息

党的二十大描绘了中国式现代化的宏伟蓝图,开启了中国式现代化的壮丽征程。基础教育作为国民教育体系的根基,在中国式现代化的伟大征程中发挥着支撑性和基础性作用。中国式现代化赋予了基础教育高质量发展新的时代内涵,彰显了基础教育大规模高水平普及、高质量公平、高智能数字化、高标准终身化等时代特征。在中国式现代化引领下,基础教育高质量发展的实践路向要明确“为党育人、为国育才”的根本方向,构建“减负降压、提质增效”的基础教育生态体系,加快推进县域基础教育“优质公平、高质均衡”,依靠“技术增值、赋能创新”推进基础教育数字化转型,优化完善“育人为本、铸魂立德”的大思政课体系,弘扬高尚师德,建设高素质专业化教师队伍。

关键词：中国式现代化基础教育高质量发展中国式教育现代化

在线全文

学校读者我要写书评

暂无评论

何博礼与协和寄生虫学及热带病学研究

协和医学杂志 2024年第3期15卷 724-728页

作者：李红梅李乃适南京农业大学植物病理学系北京100730 中国医学科学院北京协和医院病案科北京100730 世界卫生组织国际分类家族中国合作中心北京100730 中国医学科学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室北京100730

何博礼(Reinhard Hoeppli,1893—1973),著名瑞士籍医学寄生虫学家,于德国完成临床医学训练后从事与寄生虫相关的临床病理学研究并获理学博士,此后曾于美国进行线虫研究。1930—1952年任北京协和医学院(简称“协和”)第二任寄生虫学系主... 详细信息

何博礼(Reinhard Hoeppli,1893—1973),著名瑞士籍医学寄生虫学家,于德国完成临床医学训练后从事与寄生虫相关的临床病理学研究并获理学博士,此后曾于美国进行线虫研究。1930—1952年任北京协和医学院(简称“协和”)第二任寄生虫学系主任并负责北京协和医院的寄生虫相关标本检验工作。何博礼在协和工作期间发现了著名的“何博礼现象”,并为推进中国的医学寄生虫学和热带病学发展贡献颇多。除学术成就外,在协和被日军侵占期间,其以瑞士领事身份为协和作出了卓有成效的外交努力。本文主要就其在协和工作期间对医学寄生虫学发展产生的重要影响及外交贡献进行介绍。

关键词：何博礼何博礼现象北京协和医学院医学寄生虫学

在线全文

学校读者我要写书评

暂无评论

乡村振兴纪录片的审美流变与价值取向

电影评介 2024年第2期 81-86页

作者：李红梅河南大学戏剧学院

乡村兴则国家兴。伴随着脱贫攻坚战的全面胜利,困扰中华民族数千年的绝对贫困问题得到了历史性的解决,乡村振兴政策的衔接与落实已是一种必然。正如习近平总书记所指出的,“全面建成小康社会,最艰巨最繁重的任务在农村、特别是在贫困地... 详细信息

乡村兴则国家兴。伴随着脱贫攻坚战的全面胜利,困扰中华民族数千年的绝对贫困问题得到了历史性的解决,乡村振兴政策的衔接与落实已是一种必然。正如习近平总书记所指出的,“全面建成小康社会,最艰巨最繁重的任务在农村、特别是在贫困地区。没有农村的小康,特别是没有贫困地区的小康,就没有全面建成小康社会。”[1]由此可见,乡村振兴已是当今一项极为重要的时代课题。而纪录片以其真实性的特质常常被视作一种时代与社会的镜像和表征。

关键词：乡村振兴绝对贫困全面建成小康社会审美流变脱贫攻坚战纪录片价值取向贫困地区

学生主体哲学引领下课堂教学变革的创新实践与理论反思

在线全文

学校读者我要写书评

暂无评论

湖南师范大学教育科学学报 2024年第3期23卷 53-59页

作者：李红梅贺慧四川师范大学教育科学学院四川成都610068 成都市锦江区教育科学研究院四川成都610068

伴随着我国基础教育改革的进程,学生主体哲学在课堂教学变革性实践中孕育生成。针对课堂教学实践中“目中无人”和钳制主体性等教育时弊,学生主体哲学主张尊重学生的主体地位、弘扬学生的主体性、突显学生的主体价值,引领着中小学课堂... 详细信息

伴随着我国基础教育改革的进程,学生主体哲学在课堂教学变革性实践中孕育生成。针对课堂教学实践中“目中无人”和钳制主体性等教育时弊,学生主体哲学主张尊重学生的主体地位、弘扬学生的主体性、突显学生的主体价值,引领着中小学课堂教学改革的基本方向。在学生主体哲学的指引下,课堂教学在变革性实践探索中确立了课堂教学实践转型的根本理念,构建起旨在提升课堂生活质量的参与式教学体系和让学习真正发生的“主体学堂”,创生了课堂教学现代发展的基本模式与实践范式。当前,素养培育和全面发展的新阶段赋予了学生主体哲学新的时代价值和历史使命,需要对学生主体哲学引领下的课堂教学变革性实践进行本体论、价值论和方法论的理论阐释。

关键词：学生主体哲学课堂教学变革性实践主体性