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World Journal of Gastroenterology 2009年第12期15卷 1528-1529页

作者： Yan Yin li-Hua he Jian-zhong Zhang Department of Diagnosis National Institute for-Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

helicobacter pylori(H pylori),a gastric pathogen,is a major cause of chronic gastritis and peptic ulcer disease,and is an important risk factor for the development of gastric *** of the bacterium from gastric biopsy is essential for the determination of drug resistance of H ***,the isolation rates of H pylori from infected individuals vary from 23.5%to 97% due to a number of factors such as biopsy preparation,cultural environment,medium and the method *** the present case,we found that a prolonged incubation period of up to 19 d allowed successful isolation of H pylori from a patient who received triple therapy that failed to eradicate the bacterium.

关键词： helicobacter pylori Isolation Eradication

DFT Investigations About Pyrazine Molecules on Si(100)-2×1 Surface

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Chemical Research in Chinese Universities 2007年第4期23卷 444-451页

作者： YU Ang-yang QU Yong-quan HAN Ke-li he Guo-zhong Center for Computational Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China

It is important to understand the interface of aromatic molecules on semiconductor surfaces because of the rich functionality of such molecules on semiconductor surfaces. The chemisorption of pyrazine molecules on the Si （100）- 2×1 surface has been investigated using the B3LYP density functional theory with Si9H12 one-dimer and Si15Hl6 two-dimer cluster models. The calculated results predict that N-dative bonded-state, C2=C5 [E4＋2] and the tight- bridgel,2,5,6 products may coexist on the Si（100）-2 × 1 surface.

关键词： Density functional theory Surface Activation energy Adsorption energy

Adherence and invasion of mouse-adapted H pylori in different epithelial cell lines

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World Journal of Gastroenterology 2007年第6期13卷 845-850页

作者： Mao-Jun Zhang Fan-liang Meng Xiao-Yun Ji li-Hua he Jian-zhong Zhang Department of Diagnostics National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Supported by the National Natural Science Foundation of China No. 30370078

AIM： To assess the adhesion and invasion abilities of different mouse adapted H py/or/strains in different cell lines in vitro and investigate their effects on the virulence factors cagA and vacA. METHODS： The adherence and invasion abilities of different N pylori strains in different epithelial cell lines were examined by the gentamycin protection assay. The null mutants of cagA and vacA were processed by direct PCR mutation method. The morphologic changes of different cell lines after N pylori attachment were examined by microscopy. RESULTS： The densities of adherence to and invasion into cells in vitro were different from those in the mouse infection experiments. 88-3887 strain could invade and adhere to cells stronger than SS1 and X47. All tested strains had better adhering and invasive abilities in SCG-7901 cell. CagA and vacA minus mutants had the same invasion and adherent abilities as their wild types. In all strains and cell lines tested, only AGS cell had the significant hummingbird phenotype after inoculation with the 88-3887 wild-type. CONCLUSION： Both the host cells and the bacteria play important parts in the invasion and adhesion abilities of Hpylori. CagA and VacA are not related to the ability of invasion and adhesion of Hpylori in different cell lines in vitro.

关键词： Hpylori Adherence Invasion Cell line

Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathwayin Mice

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Chinese Journal of Integrative Medicine 2024年第2期30卷 135-142页

作者： GU li-mei li he-zhong GAO Lei li Hui WEI Lan-fu PAN Cheng-yu WU Ke-xuan TIAN Yao-zhou Department of Gastrointestinal Endoscopy Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Department of Gastroenterology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To investigate the effect of Huangqin Decoction(HQD)on nuclear factor erythroid 2 related-factor 2(Nrf2)/heme oxygenase(HO-1)signaling pathway by inducing the colitis-associated carcinogenesis(CAC)model mice with azoxymethane(AOM)/dextran sodium sulfate(DSS).Methods:The chemical components of HQD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry(LC-Q-TOF-MS/MS)to determine the molecular constituents of *** 48 C57BL/6J mice were randomly divided into 6 groups by a random number table,including control,model(AOM/DSS),mesalazine(MS),low-,medium-,and high-dose HQD(HQD-L,HQD-M,and HQD-H)groups,8 mice in each *** for the control group,the mice in the other groups were intraperitoneally injected with AOM(10 mg/kg)and administrated with 2.5%DSS orally for 1 week every two weeks(totally 3 rounds of DSS)to construct a colitis-associated carcinogenesis mouse *** mice in the HQD-L,HQD-M and HQD-H groups were given HQD by gavage at doses of 2.925,5.85,and 11.7 g/kg,respectively;the mice in the MS group was given a suspension of MS at a dose of 0.043 g/kg(totally 11 weeks).The serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent *** mRNA and protein expression levels of Nrf2,HO-1,and inhibitory KELCH like ECH-related protein 1(Keap1)in colon tissue were detected by quantitative real-time PCR,immunohistochemistry,and Westem blot,***:LC-Q-TOF-MS/MS analysis revealed that the chemical constituents of HQD include baicalin,paeoniflorin,and glycyrrhizic *** to the control group,significantly higher MDA levels and lower SOD levels were observed in the model group(Phereas the expressions of Nrf2 and HO-1 were significantly decreased,and the expression of Keap1 increased(Phe model group,serum MDA level was decreased and SOD level was increased in the HQD-M,HQD-H and MS groups(Pher expressions of

关键词： Huangqin Decoction colitis-associated carcinogenesis nuclear factor erythroid 2 related-factor 2/heme oxygenase signaling pathway oxidative stress Chinese medicine

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中国港口X-效率测度

系统工程理论与实践 2009年第2期29卷 1-9页

作者：匡海波李和忠大连理工大学管理学院大连116024

结合我国港口现状,从港口企业角度出发,找出影响港口X-效率的主要因素,构建港口X-效率评价指标体系,借助随机边界模型建立了中国港口上市公司X-效率测度模型,弥补现有文献对港口X-效率理论研究的空白.在此基础上,采用代表我国五大港口... 详细信息

结合我国港口现状,从港口企业角度出发,找出影响港口X-效率的主要因素,构建港口X-效率评价指标体系,借助随机边界模型建立了中国港口上市公司X-效率测度模型,弥补现有文献对港口X-效率理论研究的空白.在此基础上,采用代表我国五大港口群的深赤湾A等13家典型港口上市公司相关数据进行实证研究,验证了我国港口上市公司的X-效率的内部激励制度等主要影响因素.最后,提出了从改革员工激励薪酬、企业所有权制度等角度提升我国港口上市公司X-效率的对策.

关键词：港口 X-效率随机边界模型测度

新加坡、印度政府建立人才开发投入机制的经验及其对我国的启示

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湘潭大学学报（哲学社会科学版） 2009年第1期33卷 19-21页

作者：李和中武汉大学政治与公共管理学院湖北武汉430072

创新人才工作体制机制的关键是建立切实可行的人才开发投入机制。而人才开发投入机制的重点是重新构建人才开发中的政府投入机制。文章借鉴了新加坡、印度政府建立人才开发投入机制的经验,提出了:以人才资本优先投入、优先积累的理念主... 详细信息

创新人才工作体制机制的关键是建立切实可行的人才开发投入机制。而人才开发投入机制的重点是重新构建人才开发中的政府投入机制。文章借鉴了新加坡、印度政府建立人才开发投入机制的经验,提出了:以人才资本优先投入、优先积累的理念主导人才开发中的政府投入;通过政府投入导向来引导企业的发展方向,降低人才投入的风险;尽快建立人才资本优先投资的政策体系;加大人才开发的投入力度,逐步提高政府用于人才资源开发的资金的比例;放宽人才开发资金投入途径,实现人才投资体系由政府主导与社会各方力量共同参与相结合;通过人才市场和有关激励机制的运作,提高人才投资的数量与质量诸方面的策略。

关键词：人才开发投入机制新加坡印度经验启示

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超深亚微米PMOS器件的NBTI退化机理

物理学报 2006年第2期55卷 820-824页

作者：李忠贺刘红侠郝跃西安电子科技大学微电子学院宽禁带半导体材料与器件教育部重点实验室西安710071

对超深亚微米PMOS器件的负栅压温度不稳定性(NBTI)退化机理进行了研究.主要集中在对器件施加NBT和随后的PBT应力后器件阈值电压的漂移上.实验证明反型沟道中空穴在栅氧中的俘获以及氢分子在栅氧中的扩散是引起NBTI退化的主要原因.当应... 详细信息

对超深亚微米PMOS器件的负栅压温度不稳定性(NBTI)退化机理进行了研究.主要集中在对器件施加NBT和随后的PBT应力后器件阈值电压的漂移上.实验证明反型沟道中空穴在栅氧中的俘获以及氢分子在栅氧中的扩散是引起NBTI退化的主要原因.当应力条件变为PBT时,陷落的空穴可以快速退陷,但只有部分氢分子可以扩散回栅氧与衬底界面钝化硅悬挂键,这就导致了PBT条件下阈值电压只能部分恢复.

关键词：超深亚微米PMOS器件负偏压温度不稳定性界面陷阱氢气

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song he li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

意识形态网络渗透背景下我国高校意识形态安全建设探析

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北方民族大学学报（哲学社会科学版） 2022年第3期 162-169页

作者：李中和惠州学院马克思主义学院广东惠州516007

网络信息技术的发展及其广泛应用给我国高校意识形态教育带来了新的机遇,同时也给我国高校意识形态安全带来了严峻挑战。西方国家意识形态与价值观网络渗透、网络信息多元化传播、各种社会思潮的冲击及西方敌对势力的渗透等都给我国高... 详细信息

网络信息技术的发展及其广泛应用给我国高校意识形态教育带来了新的机遇,同时也给我国高校意识形态安全带来了严峻挑战。西方国家意识形态与价值观网络渗透、网络信息多元化传播、各种社会思潮的冲击及西方敌对势力的渗透等都给我国高校意识形态安全构成严重威胁。针对当前意识形态领域的复杂形势,高校要站在维护国家意识形态安全的战略高度来加强意识形态安全建设,巩固马克思主义在意识形态领域的指导地位,牢牢掌握意识形态工作的领导权、话语权和管理权。

关键词：网络新媒体社会主义意识形态安全

《唐律疏议》自首制度立法探析--以上官兴醉酒杀人自首案为例

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新疆大学学报（哲学社会科学版） 2010年第5期38卷 53-57页

作者：李中和惠州学院思想政治理论课教学部广东惠州516007

作为中国古代法典范的唐律,对自首制度做了最为详细而全面的规定,形成了完备的自首制度。同时,代表封建正统思想的"礼"渗透于唐律,形成了"礼本刑用"的礼法关系,"礼"对唐律及唐代司法实践具有重大影响。

关键词：唐律自首制度影响