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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG Xin ZHANG Zhao-xin li li-fei he Feng CheN Ming-long liU Ying-ze HUANG Jian-mei MO Kong-lan LUO Juan-juan XIAO Feng ZHU Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

应力对La_(0.83)Sr_(0.17)MnO_3薄膜输运性能的影响

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物理学报 2006年第3期55卷 1435-1440页

作者：江阔李合非宫声凯北京航空航天大学材料学院北京100083

采用溶胶-凝胶方法在Si(111)上制备了LSMO(x=0.17)薄膜.研究了块体材料和不同厚度薄膜R-T曲线、红外光谱和X射线衍射.结果表明,LSMO薄膜属于正交晶体结构,薄膜取向与膜厚度有关,当膜厚度为450nm或680nm时,主要取向〈200〉,而膜厚度为90... 详细信息

采用溶胶-凝胶方法在Si(111)上制备了LSMO(x=0.17)薄膜.研究了块体材料和不同厚度薄膜R-T曲线、红外光谱和X射线衍射.结果表明,LSMO薄膜属于正交晶体结构,薄膜取向与膜厚度有关,当膜厚度为450nm或680nm时,主要取向〈200〉,而膜厚度为900nm时取向为〈020〉:根据离子对相互作用能和谐振子模型,得到了红外吸收与Mn—O—Mn键长和键角关系式,600cm-1附近红外吸收与晶格常数b的变化有关;块体与薄膜的金属—绝缘体转变温度(TMI)存在较大差别,薄膜转变温度显著低于块体,并与厚度有一定关系.认为是LSMO薄膜中的应力诱导了晶格常数变化,引起键角改变及JT效应是转变温度变化的主要原因.

关键词：单晶硅晶格常数金属-绝缘体转变温度应力诱导

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傅里叶函数前缘仿生压气机叶栅性能研究

工程热物理学报 2020年第12期41卷 2936-2941页

作者：李润泽李赫飞姜斌郑群何宏伟哈尔滨工程大学动力与能源工程学院哈尔滨150001 中国航空工业空气动力研究院哈尔滨150001

本文针对仿鲸鳍前缘造型在压气机叶栅中的应用,提出了一种基于傅里叶级数形式的复合函数前缘造型方法。采用数值模拟方法,重点分析了零攻角下仿鲸鳍叶栅流场结构的变化,给出了不同仿鲸鳍前缘在叶栅端区以及叶中部损失抑制的原因和前缘... 详细信息

本文针对仿鲸鳍前缘造型在压气机叶栅中的应用,提出了一种基于傅里叶级数形式的复合函数前缘造型方法。采用数值模拟方法,重点分析了零攻角下仿鲸鳍叶栅流场结构的变化,给出了不同仿鲸鳍前缘在叶栅端区以及叶中部损失抑制的原因和前缘型线特征,优化出一种具有展向非均匀鳍型前缘的仿生叶栅,对非均匀鳍叶栅的性能进行了验证。研究结果表明,仿鲸鳍叶栅在前缘凹陷处形成流向涡对,在凸起处收缩流动形成高能气团,上述流场结构交替出现,抑制了角区及叶中部的分离流动,降低了叶栅的总压损失。基于高阶傅里叶函数的非均匀鳍型能更好地适应叶栅的变攻角特性,非均匀鳍叶栅总压损失系数相比原始叶栅降低了11.45%。

关键词：压气机叶栅仿鲸鳍前缘造型气动性能

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song he li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Mn的价态对La_(0.8)Ba_(0.2)MnO_3电磁性能的影响

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物理学报 2005年第9期54卷 4374-4378页

作者：江阔李合非马文宫声凯北京航空航天大学材料学院北京100083

在2—390K温度之间研究了La0.8Ba0.2MnO3的磁矩、磁电阻与温度的关系.发现以不同价态的Mn元素引入得到的La0.8Ba0.2MnO3,性能虽然都存在金属—绝缘体转变,以及在磁场作用下居里温度附近电阻率变化非常显著的特点,但是价态对磁性转变温度... 详细信息

在2—390K温度之间研究了La0.8Ba0.2MnO3的磁矩、磁电阻与温度的关系.发现以不同价态的Mn元素引入得到的La0.8Ba0.2MnO3,性能虽然都存在金属—绝缘体转变,以及在磁场作用下居里温度附近电阻率变化非常显著的特点,但是价态对磁性转变温度TC,金属—绝缘体转变温度Tmi,以及磁电阻极大值温度TMR的影响都非常显著.三种价态相比较,使用二价Mn的电阻率最低以及磁性转变温度更接近室温.认为影响材料性能的主要因素是材料制备时引进的Mn元素的价态,由于原料价态的不同而形成的氧空位浓度变化,进而影响了Mn4+Mn3+的比.

关键词：价态磁电阻居里温度金属—绝缘体转变 Mn^3+ 不同价态电磁性能转变温度磁场作用材料制备材料性能浓度变化

基于布鲁姆过滤器的面向IP包识别的CPBF算法

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华南理工大学学报（自然科学版） 2017年第7期45卷 90-97,106页

作者：李龙飞贺占庄史阳春西安微电子技术研究所集成电路设计部陕西西安710065

针对现有布鲁姆过滤器在流识别应用中对每个IP包进行相同的处理,未考虑IP包识别失效代价和硬件开销的问题,提出一种面向IP包识别的算法——CPBF(Classified and Pipelined Bloom Filter).该算法通过引入IP头中服务类型作为识别失效代价... 详细信息

针对现有布鲁姆过滤器在流识别应用中对每个IP包进行相同的处理,未考虑IP包识别失效代价和硬件开销的问题,提出一种面向IP包识别的算法——CPBF(Classified and Pipelined Bloom Filter).该算法通过引入IP头中服务类型作为识别失效代价的判断依据对IP包进行分类,根据分类结果采取不同数目的 Hash函数进行映射,降低高失效代价IP包的识别失效率;同时在Hash计算中采用流水机制加速识别速率;基于概率论、微分方程等相关知识对CPBF算法进行了描述和理论分析,最后在FPGA上对算法进行实现和实验.结果表明,与标准布鲁姆过滤器、多维布鲁姆过滤器相比,CPBF在具有较低的识别失效率和硬件开销的同时,也能保持较高的识别速率.

关键词：布鲁姆过滤器 CPBF算法 IP包识别识别失效代价 Hash函数

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

特殊反应体系中交联β-葡萄糖苷酶聚集体催化合成红景天苷

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过程工程学报 2015年第2期15卷 313-317页

作者：何丽妃薛原楷石贤爱福州大学生物科学与工程学院福建福州350108 福建省医疗器械与医药技术重点实验室福建福州350002

采用具有较高操作稳定性的交联β-葡萄糖苷酶聚集体,在离子液体-混合有机溶剂-缓冲溶液的非常规反应体系中酶催化直接糖基化合成红景天苷,筛选反应体系的组成和各成分的比例.结果表明,反应体系的组成为(%,φ):1,4-二氧六环42.5,离子液体... 详细信息

采用具有较高操作稳定性的交联β-葡萄糖苷酶聚集体,在离子液体-混合有机溶剂-缓冲溶液的非常规反应体系中酶催化直接糖基化合成红景天苷,筛选反应体系的组成和各成分的比例.结果表明,反应体系的组成为(%,φ):1,4-二氧六环42.5,离子液体C4MIm·PF6 8.5,乙酸乙酯34,p H 6.0柠檬酸-磷酸氢二钠缓冲溶液15.0.该体系在水含量高达15%(φ)的条件下水活度为0.66,适合直接糖基化反应.底物β-D-葡萄糖100 g/L、对羟基苯乙醇200 g/L时,在50℃及250 r/min下反应120 h达到平衡,红景天苷最大浓度可达25.32 g/L.

关键词：酶催化交联β-葡萄糖苷酶聚集体红景天苷直接糖基化离子液体

The Protein but not the RNA of the Recombinant TMV CP Induces Necrotic Local Lesions in Susceptible Tobacco Plants

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The Protein but not the RNA of the Recombinant TMV CP Induce...